TY  - JOUR
A1  - Koeniger, Tobias
A1  - Bell, Luisa
A1  - Mifka, Anika
A1  - Enders, Michael
A1  - Hautmann, Valentin
A1  - Mekala, Subba Rao
A1  - Kirchner, Philipp
A1  - Ekici, Arif B.
A1  - Schulz, Christian
A1  - Wörsdörfer, Philipp
A1  - Mencl, Stine
A1  - Kleinschnitz, Christoph
A1  - Ergün, Süleyman
A1  - Kuerten, Stefanie
T1  - Bone marrow‐derived myeloid progenitors in the leptomeninges of adult mice
JF  - Stem Cells
N2  - Although the bone marrow contains most hematopoietic activity during adulthood, hematopoietic stem and progenitor cells can be recovered from various extramedullary sites. Cells with hematopoietic progenitor properties have even been reported in the adult brain under steady‐state conditions, but their nature and localization remain insufficiently defined. Here, we describe a heterogeneous population of myeloid progenitors in the leptomeninges of adult C57BL/6 mice. This cell pool included common myeloid, granulocyte/macrophage, and megakaryocyte/erythrocyte progenitors. Accordingly, it gave rise to all major myelo‐erythroid lineages in clonogenic culture assays. Brain‐associated progenitors persisted after tissue perfusion and were partially inaccessible to intravenous antibodies, suggesting their localization behind continuous blood vessel endothelium such as the blood‐arachnoid barrier. Flt3\(^{Cre}\) lineage tracing and bone marrow transplantation showed that the precursors were derived from adult hematopoietic stem cells and were most likely continuously replaced via cell trafficking. Importantly, their occurrence was tied to the immunologic state of the central nervous system (CNS) and was diminished in the context of neuroinflammation and ischemic stroke. Our findings confirm the presence of myeloid progenitors at the meningeal border of the brain and lay the foundation to unravel their possible functions in CNS surveillance and local immune cell production.
KW  - hematopoietic
KW  - meninges
KW  - mouse
KW  - myeloid
KW  - progenitor
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-224452
VL  - 39
IS  - 2
SP  - 227
EP  - 239
ER  - 
TY  - JOUR
A1  - Kirchner, Philipp H.
A1  - Schramm, Louis
A1  - Ivanova, Svetlana
A1  - Shoyama, Kazutaka
A1  - Würthner, Frank
A1  - Beuerle, Florian
T1  - A water-stable boronate ester cage
JF  - Journal of the American Chemical Society
N2  - The reversible condensation of catechols and boronic acids to boronate esters is a paradigm reaction in dynamic covalent chemistry. However, facile backward hydrolysis is detrimental for stability and has so far prevented applications for boronate-based materials. Here, we introduce cubic boronate ester cages 6 derived from hexahydroxy tribenzotriquinacenes and phenylene diboronic acids with ortho-t-butyl substituents. Due to steric shielding, dynamic exchange at the Lewis acidic boron sites is feasible only under acid or base catalysis but fully prevented at neutral conditions. For the first time, boronate ester cages 6 tolerate substantial amounts of water or alcohols both in solution and solid state. The unprecedented applicability of these materials under ambient and aqueous conditions is showcased by efficient encapsulation and on-demand release of β-carotene dyes and heterogeneous water oxidation catalysis after the encapsulation of ruthenium catalysts.
KW  - absorption
KW  - hydrocarbons
KW  - materials
KW  - organic compounds
KW  - stability
KW  - boronate esters
Y1  - 2024
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-361245
SN  - 0002-7863
VL  - 146
IS  - 8
ER  -