TY  - JOUR
A1  - Duell, Johannes
A1  - Lammers, Philip E.
A1  - Djuretic, Ivana
A1  - Chunyk, Allison G.
A1  - Alekar, Shilpa
A1  - Jacobs, Ira
A1  - Gill, Saar
T1  - Bispecific Antibodies in the Treatment of Hematologic Malignancies
JF  - Clinical Pharmacology & Therapeutics
N2  - Monoclonal antibody therapies are an important approach for the treatment of hematologic malignancies, but typically show low single-agent activity. Bispecific antibodies, however, redirect immune cells to the tumor for subsequent lysis, and preclinical and accruing clinical data support single-agent efficacy of these agents in hematologic malignancies, presaging an exciting era in the development of novel bispecific formats. This review discusses recent developments in this area, highlighting the challenges in delivering effective immunotherapies for patients.
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226392
VL  - 106
ER  -