TY - JOUR A1 - Le Provost, Gaëtane A1 - Thiele, Jan A1 - Westphal, Catrin A1 - Penone, Caterina A1 - Allan, Eric A1 - Neyret, Margot A1 - van der Plas, Fons A1 - Ayasse, Manfred A1 - Bardgett, Richard D. A1 - Birkhofer, Klaus A1 - Boch, Steffen A1 - Bonkowski, Michael A1 - Buscot, Francois A1 - Feldhaar, Heike A1 - Gaulton, Rachel A1 - Goldmann, Kezia A1 - Gossner, Martin M. A1 - Klaus, Valentin H. A1 - Kleinebecker, Till A1 - Krauss, Jochen A1 - Renner, Swen A1 - Scherreiks, Pascal A1 - Sikorski, Johannes A1 - Baulechner, Dennis A1 - Blüthgen, Nico A1 - Bolliger, Ralph A1 - Börschig, Carmen A1 - Busch, Verena A1 - Chisté, Melanie A1 - Fiore-Donno, Anna Maria A1 - Fischer, Markus A1 - Arndt, Hartmut A1 - Hoelzel, Norbert A1 - John, Katharina A1 - Jung, Kirsten A1 - Lange, Markus A1 - Marzini, Carlo A1 - Overmann, Jörg A1 - Paŝalić, Esther A1 - Perović, David J. A1 - Prati, Daniel A1 - Schäfer, Deborah A1 - Schöning, Ingo A1 - Schrumpf, Marion A1 - Sonnemann, Ilja A1 - Steffan-Dewenter, Ingolf A1 - Tschapka, Marco A1 - Türke, Manfred A1 - Vogt, Juliane A1 - Wehner, Katja A1 - Weiner, Christiane A1 - Weisser, Wolfgang A1 - Wells, Konstans A1 - Werner, Michael A1 - Wolters, Volkmar A1 - Wubet, Tesfaye A1 - Wurst, Susanne A1 - Zaitsev, Andrey S. A1 - Manning, Peter T1 - Contrasting responses of above- and belowground diversity to multiple components of land-use intensity JF - Nature Communications N2 - Land-use intensification is a major driver of biodiversity loss. However, understanding how different components of land use drive biodiversity loss requires the investigation of multiple trophic levels across spatial scales. Using data from 150 agricultural grasslands in central Europe, we assess the influence of multiple components of local- and landscape-level land use on more than 4,000 above- and belowground taxa, spanning 20 trophic groups. Plot-level land-use intensity is strongly and negatively associated with aboveground trophic groups, but positively or not associated with belowground trophic groups. Meanwhile, both above- and belowground trophic groups respond to landscape-level land use, but to different drivers: aboveground diversity of grasslands is promoted by diverse surrounding land-cover, while belowground diversity is positively related to a high permanent forest cover in the surrounding landscape. These results highlight a role of landscape-level land use in shaping belowground communities, and suggest that revised agroecosystem management strategies are needed to conserve whole-ecosystem biodiversity. KW - biodiversity KW - community ecology KW - grassland ecology Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-371552 VL - 12 ER - TY - JOUR A1 - Proetel, Ulrike A1 - Pletsch, Nadine A1 - Lauseker, Michael A1 - Müller, Martin C. A1 - Hanfstein, Benjamin A1 - Krause, Stefan W. A1 - Kalmanti, Lida A1 - Schreiber, Annette A1 - Heim, Dominik A1 - Baerlocher, Gabriela M. A1 - Hofmann, Wolf-Karsten A1 - Lange, Elisabeth A1 - Einsele, Hermann A1 - Wernli, Martin A1 - Kremers, Stephan A1 - Schlag, Rudolf A1 - Müller, Lothar A1 - Hänel, Mathias A1 - Link, Hartmut A1 - Hertenstein, Bernd A1 - Pfirrmann, Markus A1 - Hochhaus, Andreas A1 - Hasford, Joerg A1 - Hehlmann, Rüdiger A1 - Saußele, Susanne T1 - Older patients with chronic myeloid leukemia (≥65 years) profit more from higher imatinib doses than younger patients: a subanalysis of the randomized CML-Study IV JF - Annals of Hematology N2 - The impact of imatinib dose on response rates and survival in older patients with chronic myeloid leukemia in chronic phase has not been studied well. We analyzed data from the German CML-Study IV, a randomized five-arm treatment optimization study in newly diagnosed BCR-ABL-positive chronic myeloid leukemia in chronic phase. Patients randomized to imatinib 400 mg/day (IM400) or imatinib 800 mg/day (IM800) and stratified according to age (≥65 years vs. <65 years) were compared regarding dose, response, adverse events, rates of progression, and survival. The full 800 mg dose was given after a 6-week run-in period with imatinib 400 mg/day. The dose could then be reduced according to tolerability. A total of 828 patients were randomized to IM400 or IM800. Seven hundred eighty-four patients were evaluable (IM400, 382; IM800, 402). One hundred ten patients (29 %) on IM400 and 83 (21 %) on IM800 were ≥65 years. The median dose per day was lower for patients ≥65 years on IM800, with the highest median dose in the first year (466 mg/day for patients ≥65 years vs. 630 mg/day for patients <65 years). Older patients on IM800 achieved major molecular remission and deep molecular remission as fast as younger patients, in contrast to standard dose imatinib with which older patients achieved remissions much later than younger patients. Grades 3 and 4 adverse events were similar in both age groups. Five-year relative survival for older patients was comparable to that of younger patients. We suggest that the optimal dose for older patients is higher than 400 mg/day. ClinicalTrials.gov identifier: NCT00055874 KW - chronic myeloid leukemia KW - older patients KW - different imatinib dose regimens KW - early applied higher imatinib dosages Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-121574 SN - 0939-5555 VL - 93 IS - 7 ER - TY - JOUR A1 - Mages, Michelle A1 - Shojaa, Mahdieh A1 - Kohl, Matthias A1 - Stengel, Simon von A1 - Becker, Clemens A1 - Gosch, Markus A1 - Jakob, Franz A1 - Kerschan-Schindl, Katharina A1 - Kladny, Bernd A1 - Klöckner, Nicole A1 - Lange, Uwe A1 - Middeldorf, Stefan A1 - Peters, Stefan A1 - Schoene, Daniel A1 - Sieber, Cornel C. A1 - Tholen, Reina A1 - Thomasius, Friederike E. A1 - Uder, Michael A1 - Kemmler, Wolfgang T1 - Exercise effects on Bone Mineral Density in men JF - Nutrients N2 - In contrast to postmenopausal women, evidence for a favorable effect of exercise on Bone Mineral Density (BMD) is still limited for men. This might be due to the paucity of studies, but also to the great variety of participants and study characteristics that may dilute study results. The aim of the present systematic review and meta-analysis was to evaluate the effect of exercise on BMD changes with rational eligibility criteria. A comprehensive search of six electronic databases up to 15 March 2021 was conducted. Briefly, controlled trials ≥6 months that determined changes in areal BMD in men >18 years old, with no apparent diseases or pharmacological therapy that relevantly affect bone metabolism, were included. BMD changes (standardized mean differences: SMD) of the lumbar spine (LS) and femoral neck (FN) were considered as outcomes. Twelve studies with 16 exercise and 12 control groups were identified. The pooled estimate of random-effect analysis was SMD = 0.38, 95%-CI: 0.14–0.61 and SMD = 0.25, 95%-CI: 0.00–0.49, for LS and FN, respectively. Heterogeneity between the trials was low–moderate. Funnel plots and rank and regression correlation tests indicate evidence for small study publication bias for LS but not FN-BMD. Subgroup analyses that focus on study length, type of exercise and methodologic quality revealed no significant difference between each of the three categories. In summary, we provided further evidence for a low but significant effect of exercise on BMD in men. However, we are currently unable to give even rough exercise recommendations for male cohorts. KW - Bone Mineral Density KW - exercise KW - men KW - overview Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-250247 SN - 2072-6643 VL - 13 IS - 12 ER - TY - JOUR A1 - Hirth, Matthias A1 - Seufert, Michael A1 - Lange, Stanislav A1 - Meixner, Markus A1 - Tran-Gia, Phuoc T1 - Performance evaluation of hybrid crowdsensing and fixed sensor systems for event detection in urban environments JF - Sensors N2 - Crowdsensing offers a cost-effective way to collect large amounts of environmental sensor data; however, the spatial distribution of crowdsensing sensors can hardly be influenced, as the participants carry the sensors, and, additionally, the quality of the crowdsensed data can vary significantly. Hybrid systems that use mobile users in conjunction with fixed sensors might help to overcome these limitations, as such systems allow assessing the quality of the submitted crowdsensed data and provide sensor values where no crowdsensing data are typically available. In this work, we first used a simulation study to analyze a simple crowdsensing system concerning the detection performance of spatial events to highlight the potential and limitations of a pure crowdsourcing system. The results indicate that even if only a small share of inhabitants participate in crowdsensing, events that have locations correlated with the population density can be easily and quickly detected using such a system. On the contrary, events with uniformly randomly distributed locations are much harder to detect using a simple crowdsensing-based approach. A second evaluation shows that hybrid systems improve the detection probability and time. Finally, we illustrate how to compute the minimum number of fixed sensors for the given detection time thresholds in our exemplary scenario. KW - crowdsensing KW - event detection KW - detection time simulation KW - performance analysis Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-245245 SN - 1424-8220 VL - 21 IS - 17 ER -