TY  - JOUR
A1  - Jarius, Sven
A1  - Ruprecht, Klemens
A1  - Wildemann, Brigitte
A1  - Kuempfel, Tania
A1  - Ringelstein, Marius
A1  - Geis, Christian
A1  - Kleiter, Ingo
A1  - Kleinschnitz, Christoph
A1  - Berthele, Achim
A1  - Brettschneider, Johannes
A1  - Hellwig, Kerstin
A1  - Hemmer, Bernhard
A1  - Linker, Ralf A.
A1  - Lauda, Florian
A1  - Hayrettin, Christoph A.
A1  - Tumani, Hayrettin
A1  - Melms, Arthur
A1  - Trebst, Corinna
A1  - Stangel, Martin
A1  - Marziniak, Martin
A1  - Hoffmann, Frank
A1  - Schippling, Sven
A1  - Faiss, Jürgen H.
A1  - Neuhaus, Oliver
A1  - Ettrich, Barbara
A1  - Zentner, Christian
A1  - Guthke, Kersten
A1  - Hofstadt-van Oy, Ulrich
A1  - Reuss, Reinhard
A1  - Pellkofer, Hannah
A1  - Ziemann, Ulf
A1  - Kern, Peter
A1  - Wandinger, Klaus P.
A1  - Bergh, Florian Then
A1  - Boettcher, Tobias
A1  - Langel, Stefan
A1  - Liebetrau, Martin
A1  - Rommer, Paulus S.
A1  - Niehaus, Sabine
A1  - Münch, Christoph
A1  - Winkelmann, Alexander
A1  - Zettl, Uwe K
A1  - Metz, Imke
A1  - Veauthier, Christian
A1  - Sieb, Jörn P.
A1  - Wilke, Christian
A1  - Hartung, Hans P.
A1  - Aktas, Orhan
A1  - Paul, Friedemann
T1  - Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients
JF  - Journal of Neuroinflammation
N2  - Background: The diagnostic and pathophysiological relevance of antibodies to aquaporin-4 (AQP4-Ab) in patients with neuromyelitis optica spectrum disorders (NMOSD) has been intensively studied. However, little is known so far about the clinical impact of AQP4-Ab seropositivity. 
Objective: To analyse systematically the clinical and paraclinical features associated with NMO spectrum disorders in Caucasians in a stratified fashion according to the patients' AQP4-Ab serostatus. 
Methods: Retrospective study of 175 Caucasian patients (AQP4-Ab positive in 78.3%). 
Results: Seropositive patients were found to be predominantly female (p < 0.0003), to more often have signs of co-existing autoimmunity (p < 0.00001), and to experience more severe clinical attacks. A visual acuity of <= 0.1 during acute optic neuritis (ON) attacks was more frequent among seropositives (p < 0.002). Similarly, motor symptoms were more common in seropositive patients, the median Medical Research Council scale (MRC) grade worse, and MRC grades <= 2 more frequent, in particular if patients met the 2006 revised criteria (p < 0.005, p < 0.006 and p < 0.01, respectively), the total spinal cord lesion load was higher (p < 0.006), and lesions >= 6 vertebral segments as well as entire spinal cord involvement more frequent (p < 0.003 and p < 0.043). By contrast, bilateral ON at onset was more common in seronegatives (p < 0.007), as was simultaneous ON and myelitis (p < 0.001); accordingly, the time to diagnosis of NMO was shorter in the seronegative group (p < 0.029). The course of disease was more often monophasic in seronegatives (p < 0.008). Seropositives and seronegatives did not differ significantly with regard to age at onset, time to relapse, annualized relapse rates, outcome from relapse (complete, partial, no recovery), annualized EDSS increase, mortality rate, supratentorial brain lesions, brainstem lesions, history of carcinoma, frequency of preceding infections, oligoclonal bands, or CSF pleocytosis. Both the time to relapse and the time to diagnosis was longer if the disease started with ON (p < 0.002 and p < 0.013). Motor symptoms or tetraparesis at first myelitis and > 1 myelitis attacks in the first year were identified as possible predictors of a worse outcome.
KW  - cerebrospinal-fluid
KW  - intractable hiccup
KW  - extensiv transverse myelitis
KW  - multiple sclerosis
KW  - anti-aquaporin-4 antibody
KW  - NMO-IGG
KW  - aquaporin-4 autoantibodies
KW  - immune-response
KW  - myasthenia gravis
KW  - immunoglobulin-G
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-133636
VL  - 9
IS  - 14
ER  - 
TY  - JOUR
A1  - Dech, Stefan
A1  - Holzwarth, Stefanie
A1  - Asam, Sarah
A1  - Andresen, Thorsten
A1  - Bachmann, Martin
A1  - Boettcher, Martin
A1  - Dietz, Andreas
A1  - Eisfelder, Christina
A1  - Frey, Corinne
A1  - Gesell, Gerhard
A1  - Gessner, Ursula
A1  - Hirner, Andreas
A1  - Hofmann, Matthias
A1  - Kirches, Grit
A1  - Klein, Doris
A1  - Klein, Igor
A1  - Kraus, Tanja
A1  - Krause, Detmar
A1  - Plank, Simon
A1  - Popp, Thomas
A1  - Reinermann, Sophie
A1  - Reiners, Philipp
A1  - Roessler, Sebastian
A1  - Ruppert, Thomas
A1  - Scherbachenko, Alexander
A1  - Vignesh, Ranjitha
A1  - Wolfmueller, Meinhard
A1  - Zwenzner, Hendrik
A1  - Kuenzer, Claudia
T1  - Potential and challenges of harmonizing 40 years of AVHRR data: the TIMELINE experience
JF  - Remote Sensing
N2  - Earth Observation satellite data allows for the monitoring of the surface of our planet at predefined intervals covering large areas. However, there is only one medium resolution sensor family in orbit that enables an observation time span of 40 and more years at a daily repeat interval. This is the AVHRR sensor family. If we want to investigate the long-term impacts of climate change on our environment, we can only do so based on data that remains available for several decades. If we then want to investigate processes with respect to climate change, we need very high temporal resolution enabling the generation of long-term time series and the derivation of related statistical parameters such as mean, variability, anomalies, and trends. The challenges to generating a well calibrated and harmonized 40-year-long time series based on AVHRR sensor data flown on 14 different platforms are enormous. However, only extremely thorough pre-processing and harmonization ensures that trends found in the data are real trends and not sensor-related (or other) artefacts. The generation of European-wide time series as a basis for the derivation of a multitude of parameters is therefore an extremely challenging task, the details of which are presented in this paper.
KW  - AVHRR
KW  - Earth Observation
KW  - harmonization
KW  - time series analysis
KW  - climate related trends
KW  - automatic processing
KW  - Europe
KW  - TIMELINE
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-246134
SN  - 2072-4292
VL  - 13
IS  - 18
ER  -