TY  - JOUR
A1  - Hirsch, Martin
A1  - Krauss, Manuel E.
A1  - Opferkuch, Toby
A1  - Porod, Werner
A1  - Staub, Florian
T1  - A constrained supersymmetric left-right model
JF  - JOURNAL OF HIGH ENERGY PHYSICS
N2  - We present a supersymmetric left-right model which predicts gauge coupling unification close to the string scale and extra vector bosons at the TeV scale. The subtleties in constructing a model which is in agreement with the measured quark masses and mixing for such a low left-right breaking scale are discussed. It is shown that in the constrained version of this model radiative breaking of the gauge symmetries is possible and a SM-like Higgs is obtained. Additional CP-even scalars of a similar mass or even much lighter are possible. The expected mass hierarchies for the supersymmetric states differ clearly from those of the constrained MSSM. In particular, the lightest down-type squark, which is a mixture of the sbottom and extra vector-like states, is always lighter than the stop. We also comment on the model’s capability to explain current anomalies observed at the LHC.
KW  - supersymmetry
KW  - phenomenology
KW  - LHC
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-168016
VL  - 03
IS  - 009
ER  - 
TY  - JOUR
A1  - Hollenhorst, Monika I.
A1  - Jurastow, Innokentij
A1  - Nandigama, Rajender
A1  - Appenzeller, Silke
A1  - Li, Lei
A1  - Vogel, Jörg
A1  - Wiederhold, Stephanie
A1  - Althaus, Mike
A1  - Empting, Martin
A1  - Altmüller, Janine
A1  - Hirsch, Anna K. H.
A1  - Flockerzi, Veit
A1  - Canning, Brendan J.
A1  - Saliba, Antoine‐Emmanuel
A1  - Krasteva‐Christ, Gabriela
T1  - Tracheal brush cells release acetylcholine in response to bitter tastants for paracrine and autocrine signaling
JF  - The FASEB Journal
N2  - For protection from inhaled pathogens many strategies have evolved in the airways such as mucociliary clearance and cough. We have previously shown that protective respiratory reflexes to locally released bacterial bitter “taste” substances are most probably initiated by tracheal brush cells (BC). Our single‐cell RNA‐seq analysis of murine BC revealed high expression levels of cholinergic and bitter taste signaling transcripts (Tas2r108, Gnat3, Trpm5). We directly demonstrate the secretion of acetylcholine (ACh) from BC upon stimulation with the Tas2R agonist denatonium. Inhibition of the taste transduction cascade abolished the increase in [Ca\(^{2+}\)]\(_{i}\) in BC and subsequent ACh‐release. ACh‐release is regulated in an autocrine manner. While the muscarinic ACh‐receptors M3R and M1R are activating, M2R is inhibitory. Paracrine effects of ACh released in response to denatonium included increased [Ca\(^{2+}\)]\(_{i}\) in ciliated cells. Stimulation by denatonium or with Pseudomonas quinolone signaling molecules led to an increase in mucociliary clearance in explanted tracheae that was Trpm5‐ and M3R‐mediated. We show that ACh‐release from BC via the bitter taste cascade leads to immediate paracrine protective responses that can be boosted in an autocrine manner. This mechanism represents the initial step for the activation of innate immune responses against pathogens in the airways.
KW  - acetylcholine
KW  - brush cells
KW  - mucociliary clearance
KW  - single‐cell RNA‐seq
KW  - taste
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-213516
VL  - 34
IS  - 1
SP  - 316
EP  - 332
ER  -