TY  - JOUR
A1  - Miller, Franziska
A1  - Wintzheimer, Susanne
A1  - Prieschl, Johannes
A1  - Strauss, Volker
A1  - Mandel, Karl
T1  - A Supraparticle‐Based Five‐Level‐Identification Tag That Switches Information Upon Readout
JF  - Advanced Optical Materials
N2  - Product identification tags are of great importance in a globalized world with increasingly complex trading routes and networks. Beyond currently used coding strategies, such as QR codes, higher data density, flexible application as well as miniaturization and readout indication are longed for in the next generation of security tags. In this work, micron‐sized supraparticles (SPs) with encoded information (ID) are produced that not only exhibit multiple initially covert identification levels but are also irreversibly marked as “read” upon readout. To achieve this, lanthanide doped CaF\(_{2}\) nanoparticles are assembled in various quantity‐weighted ratios via spray‐drying in presence of a broad‐spectrum stealth fluorophore (StFl), yielding covert spectrally encoded ID‐SPs. Using these as pigments, QR codes, initially dominated by the green fluorescence of the StFl, could be generated. Upon thermal energy input, these particle‐based tags irreversibly switch to an activated state revealing not only multiple luminescent colors but also spectral IDs. This strategy provides the next generation of material‐based security tags with a high data density and security level that switch information upon readout and can be, therefore, used as seal of quality.
KW  - multilevel luminescence identification
KW  - rare earth doped nanoparticles
KW  - security tags
KW  - stealth fluorophores
KW  - supraparticles
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-224469
VL  - 9
IS  - 4
ER  - 
TY  - JOUR
A1  - Herster, Franziska
A1  - Bittner, Zsofia
A1  - Codrea, Marius Cosmin
A1  - Archer, Nathan K.
A1  - Heister, Martin
A1  - Löffler, Markus W.
A1  - Heumos, Simon
A1  - Wegner, Joanna
A1  - Businger, Ramona
A1  - Schindler, Michael
A1  - Stegner, David
A1  - Schäkel, Knut
A1  - Grabbe, Stephan
A1  - Ghoreschi, Kamran
A1  - Miller, Lloyd S.
A1  - Weber, Alexander N. R.
T1  - Platelets Aggregate With Neutrophils and Promote Skin Pathology in Psoriasis
JF  - Frontiers in Immunology
N2  - Psoriasis is a frequent systemic inflammatory autoimmune disease characterized primarily by skin lesions with massive infiltration of leukocytes, but frequently also presents with cardiovascular comorbidities. Especially polymorphonuclear neutrophils (PMNs) abundantly infiltrate psoriatic skin but the cues that prompt PMNs to home to the skin are not well-defined. To identify PMN surface receptors that may explain PMN skin homing in psoriasis patients, we screened 332 surface antigens on primary human blood PMNs from healthy donors and psoriasis patients. We identified platelet surface antigens as a defining feature of psoriasis PMNs, due to a significantly increased aggregation of neutrophils and platelets in the blood of psoriasis patients. Similarly, in the imiquimod-induced experimental in vivo mouse model of psoriasis, disease induction promoted PMN-platelet aggregate formation. In psoriasis patients, disease incidence directly correlated with blood platelet counts and platelets were detected in direct contact with PMNs in psoriatic but not healthy skin. Importantly, depletion of circulating platelets in mice in vivo ameliorated disease severity significantly, indicating that both PMNs and platelets may be relevant for psoriasis pathology and disease severity.
KW  - psoriasis
KW  - neutrophil
KW  - platelet
KW  - platelet-neutrophil complexes (PNCs)
KW  - imiquimod
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-320175
VL  - 10
ER  -