TY - JOUR A1 - Christl, Manfred A1 - Lanzendörfer, U. A1 - Grötsch, M. M. A1 - Hegmann, J. A1 - Ditterich, E. A1 - Hüttner, G. A1 - Peters, K. A1 - Peters, E.-M. A1 - Schnering, H. G. von T1 - Cycloadditionen von 6H-1,3,4-0xadiazin-6-onen (4,5-Diaza-α-pyronen), 12 - Dieckmann-Kondensationen ohne Basen T1 - Cycloadditions of 6H-1,3,4-0xadiazin-6-ones (4,5-Diaza-α-pyrones), 12 - Dieckmann Condensations without Bases N2 - No abstract available KW - Organische Chemie KW - 1 KW - 3 KW - 4-0xadiazine-2-carboxylate KW - methyl 6-oxo-5-phenyl- KW - Diels-Alder reactions KW - Ketenes KW - y-oxo- KW - 1 KW - 2-Cyclopentanedione derivatives KW - Adipic acid KW - substituted 2-oxo- dimethyl esters Y1 - 1993 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-58665 ER - TY - JOUR A1 - Feineis, E. A1 - Schwarz, H. A1 - Hegmann, J. A1 - Christl, Manfred A1 - Peters, K. A1 - Peters, E.-M. A1 - Schnering, H. G. von T1 - Cycloadditionen von 6H-1,3,4-0xadiazin-6-onen (4,5-Diaza-α-pyronen), 13 - Diels-Alder-Reaktionen mit 6H-1,3,4-Oxadiazin-6-onen als Dienophil T1 - Cycloaddltions of 6H-1,3,4-0xadiazin-6-ones (4,5-Diaza-α-pyrones), 13 - Diels-Alder Reactions wtth 6H-1,3,4-0xadiazin-6-ones as Dienophile N2 - No abstract available KW - Organische Chemie KW - 6H-1 KW - 3 KW - 4-0xadiazin-6-ones KW - 1 KW - 2-Bismethylenecyclohexane KW - Diels-Alder reactions KW - [1 KW - 3 KW - 4]0xadiazino[4 KW - 5-b]isoquinolin-1-one derivatives KW - Bicyclo[2.1.l]hexan-5-one KW - highly substituted Y1 - 1993 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-58673 ER - TY - JOUR A1 - Christl, Manfred A1 - Lanzendörfer, F. A1 - Hegmann, J. A1 - Peters, K. A1 - Peters, E.-M. A1 - Schnering, H. G. von T1 - Cycloadditionen von 6-0xo-l,3,4-oxadiazinen (4,5-Diaza-α-pyronen), 3 : Reaktionen von 6-Oxo-2,5-diaryl-1,3,4-oxadiazinen mit Alkenen T1 - Cycloadditions of 6-0xo-l,3,4-oxadiazines (4,5-Diaza-α-pyrones), 3 : Reactions of 6-0xo-2,5--diaryl-l,3,4-oxadiazines with Alkenes N2 - Das bekannte 6-0xo-2,5-diphenyl-6H-l,3,4-oxadiazin (1 a) und die neuen 2,5-Diarylderivate 1 b - g lagern Alkene an, und es entstehen stickstofIfreie Produkte. Im Falle von Cyclopropenen und Cyclobuten bilden sich die a,p-ungesättigten Siebenring-Enollactone 42 -45 bzw. das a,ß-ungesättigte Achtring-Enollacton 47. 42a und d erleiden an basischem Aluminiumoxid die H-Verschiebung zu den ß,y-ungesättigten Siebenring-Enollactonen 46a bzw. d. Bei weiteren Olefinen wurden die 'Y-Ketoketene des Typs 33 als Zwischenprodukte nachgewiesen oder sind aufgrund der Konstitution der Endprodukte wahrscheinlich. Aus 1 a werden mit Norbomen, Norbornadien, Cyc1openten, trans-Cycloocten und Styrol die Sechsring-Enollactone 10, 13, 15, 19 bzw. 21 und 22 erhalten. 10 isomerisiert mit Kalium-tert-butoxid zu 34, und die Methanolyse dieser Enollactone erbringt die diastereomeren Methy]ester 12 bzw. 35. Das y-Ketoketen 16 aus trans-Cycloocten nimmt schneller Wasser und Methanol zu 17 bzw. 18 auf als es zum Enollacton 19 cyclisiert. cis,trans-l,5-Cyc1ooctadien erbringt über die Stufe des nachgewiesenen y-Ketoketens 40 in einer intramolekularen [2 + 2J-Cyc1oaddition den Tricyclus 41. Tetracyclische Verbindungen des Typs 4 gehen aus der Umsetzung von Benzvalen (2) mit 1 hervor. Durch Röntgenstrukturanalysen wurden Konstitution und Konfiguration von 10, 19 und 41 aufgeklärt N2 - Cycloaddition of the known 6-oxo-2,5-diphenyl-6H-1,3,4-oxadiazine (1 a) and the new 2,5- diaryl derivatives 1 b - g with various alkenes yield nitrogen free products. Using cyclopropenes and cyclobutene, a,~-unsaturated seven-membered enollactones 42-45 and the C't,ßunsaturated eight-membered enollactone 47 are formed, respectively. In the presenee of basic aluminium oxide 42a and d undergo a hydrogen migration to form the ß.y-unsaturated enollactones 46a and d, respectively. With other alkenes, y-ketoketenes 33 have been observed, or are assumed to be intennediates, based on the structure of the isolated products. Tbe six-mernbered enollactones 10, 13, 15, 19, and 21 and 22 have been obtained with norbomene, norbornadiene, cyclopentene, trans-cyclooctene, and styrene. Cornpound 10 isomerizes to 34 on treatment with potassium tert-butoxide. The rnethanolyses of these enollactones result in the formation of the diastereomeric methyl esters 12 and 35. The yketoketene 16 forrned from trans-cyc1ooctene gives acid 17 and ester 18 with water and methanol, respectively. These reactions are faster than the cyc1ization to enollactone 19. From cis,trans-l,5-cyclooctadiene the more short-lived y-ketoketene 40 is formed. which undergoes intramolecular [2 + 2] cycloaddition, giving rise to the tricyclic cyclobutanone derivative 41. Tetracyclic products of type 4 are generated from benzvalene (2) and 1. The structures and configurations of compounds 10, 19, and 41 have been determined by means of X -ray analyses. KW - Organische Chemie Y1 - 1985 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-58191 ER - TY - JOUR A1 - Hegmann, J. A1 - Ditterich, E. A1 - Hüttner, G. A1 - Christl, Manfred A1 - Peters, K. A1 - Peters, E.-M. A1 - Schnering, H. G. von T1 - δ-Chlor-δ-lactone aus γ-Oxoketenen N2 - No abstract available KW - Organische Chemie KW - 1 KW - 3 KW - 4-0xadiazine-2-carboxylate KW - methyl 6-oxo-5-phenyl- KW - Diels-Alder reactions KW - Ketenes KW - y-oxo- KW - δ-Lactones KW - δ-chloro- KW - β-Lactones Y1 - 1992 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-58649 ER - TY - JOUR A1 - Hegmann, J. A1 - Christl, Manfred A1 - Peters, K. A1 - Peters, E.-M. A1 - Schnering, H. G. von T1 - Intramolekulare [2+2]-Cycloadditionen von γ-Oxoketenen N2 - The 1-oxoketenes, which are accessible from methyl 1,3,4-oxadiazin-6-one-2-carboxyIate 1 and cycloalkenes, are shown to undergo an intramolecular [2+2] cycloaddition either on heating or on photolysis to give different sterecisemers of ß-lactones of the 3-oxo-2-oxabicyclo[ 2.2.0]hexane-type. KW - Organische Chemie Y1 - 1987 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-58384 ER - TY - JOUR A1 - Christl, Manfred A1 - Hegmann, J. A1 - Reuchlein, H. A1 - Peters, K. A1 - Peters, E.-M. A1 - Schnering, H. G. von T1 - Überbrückte neungliedrige α,β-ungesättigte Enollactone - Synthese aus 5-Phenyl-1,3,4-oxadiazin-6-on-2-carbonsäure-methylester und Konfigurationsanalyse N2 - The γ-oxoketenes, which are formed from oxadiazinone Ja and strained cyclopentene der1vat1ves, are shown to undergo a pericyclic ring enlargement to give the title compounds 2a, 2b, and 5. In the case of 5, two configurations, one having a cis and the other a trans Iactone functionality, are in equilibrium. KW - Organische Chemie Y1 - 1987 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-58395 ER - TY - JOUR A1 - Peters, Marcell K. A1 - Hemp, Andreas A1 - Appelhans, Tim A1 - Behler, Christina A1 - Classen, Alice A1 - Detsch, Florian A1 - Ensslin, Andreas A1 - Ferger, Stefan W. A1 - Frederiksen, Sara B. A1 - Gebert, Frederike A1 - Haas, Michael A1 - Helbig-Bonitz, Maria A1 - Hemp, Claudia A1 - Kindeketa, William J. A1 - Mwangomo, Ephraim A1 - Ngereza, Christine A1 - Otte, Insa A1 - Röder, Juliane A1 - Rutten, Gemma A1 - Costa, David Schellenberger A1 - Tardanico, Joseph A1 - Zancolli, Giulia A1 - Deckert, Jürgen A1 - Eardley, Connal D. A1 - Peters, Ralph S. A1 - Rödel, Mark-Oliver A1 - Schleuning, Matthias A1 - Ssymank, Axel A1 - Kakengi, Victor A1 - Zhang, Jie A1 - Böhning-Gaese, Katrin A1 - Brandl, Roland A1 - Kalko, Elisabeth K.V. A1 - Kleyer, Michael A1 - Nauss, Thomas A1 - Tschapka, Marco A1 - Fischer, Markus A1 - Steffan-Dewenter, Ingolf T1 - Predictors of elevational biodiversity gradients change from single taxa to the multi-taxa community level JF - Nature Communications N2 - The factors determining gradients of biodiversity are a fundamental yet unresolved topic in ecology. While diversity gradients have been analysed for numerous single taxa, progress towards general explanatory models has been hampered by limitations in the phylogenetic coverage of past studies. By parallel sampling of 25 major plant and animal taxa along a 3.7 km elevational gradient on Mt. Kilimanjaro, we quantify cross-taxon consensus in diversity gradients and evaluate predictors of diversity from single taxa to a multi-taxa community level. While single taxa show complex distribution patterns and respond to different environmental factors, scaling up diversity to the community level leads to an unambiguous support for temperature as the main predictor of species richness in both plants and animals. Our findings illuminate the influence of taxonomic coverage for models of diversity gradients and point to the importance of temperature for diversification and species coexistence in plant and animal communities. KW - community ecology KW - macroecology KW - tropical ecology KW - biodiversity Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-169374 VL - 7 ER - TY - JOUR A1 - Kronauer, Daniel J. C. A1 - Peters, Marcell K. A1 - Schoning, Caspar A1 - Boomsma, Jacobus J. T1 - Hybridization in East African swarm-raiding army ants N2 - Background: Hybridization can have complex effects on evolutionary dynamics in ants because of the combination of haplodiploid sex-determination and eusociality. While hybrid non-reproductive workers have been found in a range of species, examples of gene-flow via hybrid queens and males are rare. We studied hybridization in East African army ants (Dorylus subgenus Anomma) using morphology, mitochondrial DNA sequences, and nuclear microsatellites. Results: While the mitochondrial phylogeny had a strong geographic signal, different species were not recovered as monophyletic. At our main study site at Kakamega Forest, a mitochondrial haplotype was shared between a “Dorylus molestus-like” and a “Dorylus wilverthi-like” form. This pattern is best explained by introgression following hybridization between D. molestus and D. wilverthi. Microsatellite data from workers showed that the two morphological forms correspond to two distinct genetic clusters, with a significant proportion of individuals being classified as hybrids. Conclusions: We conclude that hybridization and gene-flow between the two army ant species D. molestus and D. wilverthi has occurred, and that mating between the two forms continues to regularly produce hybrid workers. Hybridization is particularly surprising in army ants because workers have control over which males are allowed to mate with a young virgin queen inside the colony. KW - Zoologie KW - Dorylinae KW - Formicidae KW - introgression KW - microsatellites KW - mtDNA KW - gene flow Y1 - 2011 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-68798 ER - TY - JOUR A1 - Sauerbrei, A. A1 - Langenhan, T. A1 - Brandstädt, A. A1 - Schmidt-Ott, R. A1 - Krumbholz, A. A1 - Girschick, H. A1 - Huppertz, H. A1 - Kaiser, P. A1 - Liese, J. A1 - Streng, A. A1 - Niehues, T. A1 - Peters, J. A1 - Sauerbrey, A. A1 - Schroten, H. A1 - Tenenbaum, T. A1 - Wirth, S. A1 - Wutzler, P. T1 - Prevalence of antibodies against influenza A and B viruses in children in Germany, 2008 to 2010 JF - Eurosurveillance N2 - The prevalence of influenza A and B virus-specific IgG was determined in sera taken between 2008 and 2010 from 1,665 children aged 0-17 years and 400 blood donors in Germany. ELISA on the basis of whole virus antigens was applied. Nearly all children aged nine years and older had antibodies against influenza A. In contrast, 40% of children aged 0-4 years did not have any influenza A virus-specific IgG antibodies. Eighty-six percent of 0-6 year-olds, 47% of 7-12 year-olds and 20% of 13-17 year-olds were serologically naive to influenza B viruses. By the age of 18 years, influenza B seroprevalence reached approximately 90%. There were obvious regional differences in the seroprevalence of influenza B in Germany. In conclusion, seroprevalences of influenza A and influenza B increase gradually during childhood. The majority of children older than eight years have basal immunity to influenza A, while comparable immunity against influenza B is only acquired at the age of 18 years. Children aged 0-6 years, showing an overall seroprevalence of 67% for influenza A and of 14% for influenza B, are especially at risk for primary infections during influenza B seasons. KW - disease KW - healthy children KW - vaccine KW - burden KW - hospitalizations KW - efficacy Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-117347 SN - 1560-7917 VL - 19 IS - 5 ER - TY - JOUR A1 - Dumont, Martine A1 - Weber-Lassalle, Nana A1 - Joly-Beauparlant, Charles A1 - Ernst, Corinna A1 - Droit, Arnaud A1 - Feng, Bing-Jian A1 - Dubois, Stéphane A1 - Collin-Deschesnes, Annie-Claude A1 - Soucy, Penny A1 - Vallée, Maxime A1 - Fournier, Frédéric A1 - Lemaçon, Audrey A1 - Adank, Muriel A. A1 - Allen, Jamie A1 - Altmüller, Janine A1 - Arnold, Norbert A1 - Ausems, Margreet G. E. M. A1 - Berutti, Riccardo A1 - Bolla, Manjeet K. A1 - Bull, Shelley A1 - Carvalho, Sara A1 - Cornelissen, Sten A1 - Dufault, Michael R. A1 - Dunning, Alison M. A1 - Engel, Christoph A1 - Gehrig, Andrea A1 - Geurts-Giele, Willemina R. R. A1 - Gieger, Christian A1 - Green, Jessica A1 - Hackmann, Karl A1 - Helmy, Mohamed A1 - Hentschel, Julia A1 - Hogervorst, Frans B. L. A1 - Hollestelle, Antoinette A1 - Hooning, Maartje J. A1 - Horváth, Judit A1 - Ikram, M. Arfan A1 - Kaulfuß, Silke A1 - Keeman, Renske A1 - Kuang, Da A1 - Luccarini, Craig A1 - Maier, Wolfgang A1 - Martens, John W. M. A1 - Niederacher, Dieter A1 - Nürnberg, Peter A1 - Ott, Claus-Eric A1 - Peters, Annette A1 - Pharoah, Paul D. P. A1 - Ramirez, Alfredo A1 - Ramser, Juliane A1 - Riedel-Heller, Steffi A1 - Schmidt, Gunnar A1 - Shah, Mitul A1 - Scherer, Martin A1 - Stäbler, Antje A1 - Strom, Tim M. A1 - Sutter, Christian A1 - Thiele, Holger A1 - van Asperen, Christi J. A1 - van der Kolk, Lizet A1 - van der Luijt, Rob B. A1 - Volk, Alexander E. A1 - Wagner, Michael A1 - Waisfisz, Quinten A1 - Wang, Qin A1 - Wang-Gohrke, Shan A1 - Weber, Bernhard H. F. A1 - Devilee, Peter A1 - Tavtigian, Sean A1 - Bader, Gary D. A1 - Meindl, Alfons A1 - Goldgar, David E. A1 - Andrulis, Irene L. A1 - Schmutzler, Rita K. A1 - Easton, Douglas F. A1 - Schmidt, Marjanka K. A1 - Hahnen, Eric A1 - Simard, Jacques T1 - Uncovering the contribution of moderate-penetrance susceptibility genes to breast cancer by whole-exome sequencing and targeted enrichment sequencing of candidate genes in women of European ancestry JF - Cancers N2 - Rare variants in at least 10 genes, including BRCA1, BRCA2, PALB2, ATM, and CHEK2, are associated with increased risk of breast cancer; however, these variants, in combination with common variants identified through genome-wide association studies, explain only a fraction of the familial aggregation of the disease. To identify further susceptibility genes, we performed a two-stage whole-exome sequencing study. In the discovery stage, samples from 1528 breast cancer cases enriched for breast cancer susceptibility and 3733 geographically matched unaffected controls were sequenced. Using five different filtering and gene prioritization strategies, 198 genes were selected for further validation. These genes, and a panel of 32 known or suspected breast cancer susceptibility genes, were assessed in a validation set of 6211 cases and 6019 controls for their association with risk of breast cancer overall, and by estrogen receptor (ER) disease subtypes, using gene burden tests applied to loss-of-function and rare missense variants. Twenty genes showed nominal evidence of association (p-value < 0.05) with either overall or subtype-specific breast cancer. Our study had the statistical power to detect susceptibility genes with effect sizes similar to ATM, CHEK2, and PALB2, however, it was underpowered to identify genes in which susceptibility variants are rarer or confer smaller effect sizes. Larger sample sizes would be required in order to identify such genes. KW - breast cancer KW - genetic susceptibility KW - whole-exome sequencing KW - moderate-penetrance genes Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-281768 SN - 2072-6694 VL - 14 IS - 14 ER -