TY  - JOUR
A1  - Sitter, Magdalena
A1  - Pecks, Ulrich
A1  - Rüdiger, Mario
A1  - Friedrich, Sabine
A1  - Fill Malfertheiner, Sara
A1  - Hein, Alexander
A1  - Königbauer, Josefine T.
A1  - Becke-Jakob, Karin
A1  - Zöllkau, Janine
A1  - Ramsauer, Babett
A1  - Rathberger, Katharina
A1  - Pontones, Constanza A.
A1  - Kraft, Katrina
A1  - Meybohm, Patrick
A1  - Härtel, Christoph
A1  - Kranke, Peter
T1  - Pregnant and postpartum women requiring intensive care treatment for COVID-19 — first data from the CRONOS-registry
JF  - Journal of Clinical Medicine
N2  - (1) Background: Data on coronavirus 2 infection during pregnancy vary. We aimed to describe maternal characteristics and clinical presentation of SARS-CoV-2 positive women requiring intensive care treatment for COVID-19 during pregnancy and postpartum period based on data of a comprehensive German surveillance system in obstetric patients. (2) Methods: Data from COVID-19 Related Obstetric and Neonatal Outcome Study (CRONOS), a prospective multicenter registry for SARS-CoV-2 positive pregnant women, was analyzed with respect to ICU treatment. All women requiring intensive care treatment for COVID-19 were included and compared regarding maternal characteristics, course of disease, as well as maternal and neonatal outcomes. (3) Results: Of 2650 cases in CRONOS, 101 women (4%) had a documented ICU stay. Median maternal age was 33 (IQR, 30–36) years. COVID-19 was diagnosed at a median gestational age of 33 (IQR, 28–35) weeks. As the most invasive form of COVID-19 treatment interventions, patients received either continuous monitoring of vital signs without further treatment requirement (n = 6), insufflation of oxygen (n = 30), non-invasive ventilation (n = 22), invasive ventilation (n = 28), or escalation to extracorporeal membrane oxygenation (n = 15). No significant clinical differences were identified between patients receiving different forms of ventilatory support for COVID-19. Prevalence of preterm delivery was significantly higher in women receiving invasive respiratory treatments. Four women died of COVID-19 and six fetuses were stillborn. (4) Conclusions: Our cohort shows that progression of COVID-19 is rare in pregnant and postpartum women treated in the ICU. Preterm birth rate is high and COVID-19 requiring respiratory support increases the risk of poor maternal and neonatal outcome.
KW  - maternal critical care
KW  - COVID-19
KW  - ARDS
KW  - SARS-CoV-2
KW  - pregnancy
KW  - obstetrics
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-255257
SN  - 2077-0383
VL  - 11
IS  - 3
ER  - 
TY  - JOUR
A1  - Fröhlich, Ellen
A1  - Sassenrath, Claudia
A1  - Nadji-Ohl, Minou
A1  - Unteroberdörster, Meike
A1  - Rückriegel, Stefan
A1  - Brelie, Christian von der
A1  - Roder, Constantin
A1  - Forster, Marie-Therese
A1  - Schommer, Stephan
A1  - Löhr, Mario
A1  - Pala, Andrej
A1  - Goebel, Simone
A1  - Mielke, Dorothee
A1  - Gerlach, Rüdiger
A1  - Renovanz, Mirjam
A1  - Wirtz, Christian Rainer
A1  - Onken, Julia
A1  - Czabanka, Marcus
A1  - Tatagiba, Marcos Soares
A1  - Rohde, Veit
A1  - Ernestus, Ralf-Ingo
A1  - Vajkoczy, Peter
A1  - Gansland, Oliver
A1  - Coburger, Jan
T1  - Resilience in lower grade glioma patients
JF  - Cancers
N2  - Current data show that resilience is an important factor in cancer patients’ well-being. We aim to explore the resilience of patients with lower grade glioma (LGG) and the potentially influencing factors. We performed a cross-sectional assessment of adult patients with LGG who were enrolled in the LoG-Glio registry. By phone interview, we administered the following measures: Resilience Scale (RS-13), distress thermometer, Montreal Cognitive Assessment Test for visually impaired patients (MoCA-Blind), internalized stigmatization by brain tumor (ISBI), Eastern Cooperative Oncological Group performance status (ECOG), patients’ perspective questionnaire (PPQ) and typical clinical parameters. We calculated correlations and multivariate regression models. Of 74 patients who were assessed, 38% of those showed a low level of resilience. Our results revealed significant correlations of resilience with distress (p < 0.001, −0.49), MOCA (p = 0.003, 0.342), ECOG (p < 0.001, −0.602), stigmatization (p < 0.001, −0.558), pain (p < 0.001, −0.524), and occupation (p = 0.007, 0.329). In multivariate analyses, resilience was negatively associated with elevated ECOG (p = 0.020, β = −0.383) and stigmatization levels (p = 0.008, β = −0.350). Occupation showed a tendency towards a significant association with resilience (p = 0.088, β = −0.254). Overall, low resilience affected more than one third of our cohort. Low functional status is a specific risk factor for low resilience. The relevant influence of stigmatization on resilience is a novel finding for patients suffering from a glioma and should be routinely identified and targeted in clinical routine.
KW  - resilience
KW  - lower grade glioma
KW  - diffuse astrocytoma
KW  - oligodendroglioma
KW  - RS-13
KW  - distress
KW  - internalized stigmatization
KW  - ISBI
KW  - occupation
KW  - pain
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-297518
SN  - 2072-6694
VL  - 14
IS  - 21
ER  -