TY  - JOUR
A1  - Rodríguez-Mari, Adriana
A1  - Wilson, Catherine
A1  - Titus, Tom A.
A1  - Canestro, Cristian
A1  - BreMiller, Ruth A.
A1  - Yan, Yi-Lin
A1  - Nanda, Indrajit
A1  - Johnston, Adam
A1  - Kanki, John P.
A1  - Gray, Erin M.
A1  - He, Xinjun
A1  - Spitsbergen, Jan
A1  - Schindler, Detlev
A1  - Postlethwait, John H.
T1  - Roles of brca2 (fancd1) in Oocyte Nuclear Architecture, Gametogenesis, Gonad Tumors, and Genome Stability in Zebrafish
JF  - PLoS Genetics
N2  - Functional near-infrared spectroscopy (fNIRS) is an established optical neuroimaging method for measuring functional hemodynamic responses to infer neural activation. However, the impact of individual anatomy on the sensitivity of fNIRS measuring hemodynamics within cortical gray matter is still unknown. By means of Monte Carlo simulations and structural MRI of 23 healthy subjects (mean age: (25.0 +/- 2.8) years), we characterized the individual distribution of tissue-specific NIR-light absorption underneath 24 prefrontal fNIRS channels. We, thereby, investigated the impact of scalp-cortex distance (SCD), frontal sinus volume as well as sulcal morphology on gray matter volumes (V(gray)) traversed by NIR-light, i.e. anatomy-dependent fNIRS sensitivity. The NIR-light absorption between optodes was distributed describing a rotational ellipsoid with a mean penetration depth of (23.6 +/- 0.7) mm considering the deepest 5% of light. Of the detected photon packages scalp and bone absorbed (96.4 +/- 9: 7)% and V(gray) absorbed (3.1 +/- 1.8)% of the energy. The mean V(gray) volume (1.1 +/- 0.4)cm(3) was negatively correlated (r = - .76) with the SCD and frontal sinus volume (r = - .57) and was reduced by 41.5% in subjects with relatively large compared to small frontal sinus. Head circumference was significantly positively correlated with the mean SCD (r = .46) and the traversed frontal sinus volume (r = .43). Sulcal morphology had no significant impact on V(gray). Our findings suggest to consider individual SCD and frontal sinus volume as anatomical factors impacting fNIRS sensitivity. Head circumference may represent a practical measure to partly control for these sources of error variance.
KW  - oocytes
KW  - zebrafish
KW  - genetic causes of cancer
KW  - testes
KW  - apoptosis
KW  - gonads
KW  - sperm
KW  - embryos
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-142285
VL  - 7
IS  - 3
ER  - 
TY  - JOUR
A1  - Kim, Bo-Mi
A1  - Amores, Angel
A1  - Kang, Seunghyun
A1  - Ahn, Do-Hwan
A1  - Kim, Jin-Hyoung
A1  - Kim, Il-Chan
A1  - Lee, Jun Hyuck
A1  - Lee, Sung Gu
A1  - Lee, Hyoungseok
A1  - Lee, Jungeun
A1  - Kim, Han-Woo
A1  - Desvignes, Thomas
A1  - Batzel, Peter
A1  - Sydes, Jason
A1  - Titus, Tom
A1  - Wilson, Catherine A.
A1  - Catchen, Julian M.
A1  - Warren, Wesley C.
A1  - Schartl, Manfred
A1  - Detrich, H. William III
A1  - Postlethwait, John H.
A1  - Park, Hyun
T1  - Antarctic blackfin icefish genome reveals adaptations to extreme environments
JF  - Nature Ecology & Evolution
N2  - Icefishes (suborder Notothenioidei; family Channichthyidae) are the only vertebrates that lack functional haemoglobin genes and red blood cells. Here, we report a high-quality genome assembly and linkage map for the Antarctic blackfin icefish Chaenocephalus aceratus, highlighting evolved genomic features for its unique physiology. Phylogenomic analysis revealed that Antarctic fish of the teleost suborder Notothenioidei, including icefishes, diverged from the stickleback lineage about 77 million years ago and subsequently evolved cold-adapted phenotypes as the Southern Ocean cooled to sub-zero temperatures. Our results show that genes involved in protection from ice damage, including genes encoding antifreeze glycoprotein and zona pellucida proteins, are highly expanded in the icefish genome. Furthermore, genes that encode enzymes that help to control cellular redox state, including members of the sod3 and nqo1 gene families, are expanded, probably as evolutionary adaptations to the relatively high concentration of oxygen dissolved in cold Antarctic waters. In contrast, some crucial regulators of circadian homeostasis (cry and per genes) are absent from the icefish genome, suggesting compromised control of biological rhythms in the polar light environment. The availability of the icefish genome sequence will accelerate our understanding of adaptation to extreme Antarctic environments.
KW  - animal physiology
KW  - evolutionary genetics
KW  - genomics
KW  - ichthyology
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-325811
VL  - 3
ER  -