TY  - JOUR
A1  - Zhao, De-Wei
A1  - Yu, Mang
A1  - Hu, Kai
A1  - Wang, Wei
A1  - Yang, Lei
A1  - Wang, Ben-Jie
A1  - Gao, Xiao-Hong
A1  - Guo, Yong-Ming
A1  - Xu, Yong-Qing
A1  - Wei, Yu-Shan
A1  - Tian, Si-Miao
A1  - Yang, Fan
A1  - Wang, Nan
A1  - Huang, Shi-Bo
A1  - Xie, Hui
A1  - Wei, Xiao-Wei
A1  - Jiang, Hai-Shen
A1  - Zang, Yu-Qiang
A1  - Ai, Jun
A1  - Chen, Yuan-Liang
A1  - Lei, Guang-Hua
A1  - Li, Yu-Jin
A1  - Tian, Geng
A1  - Li, Zong-Sheng
A1  - Cao, Yong
A1  - Ma, Li
T1  - Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population: Results from a Nationally Representative Survey
JF  - Chinese Medical Journal
N2  - Background: Nontraumatic osteonecrosis of the femoral head (NONFH) is a debilitating disease that represents a significant financial burden for both individuals and healthcare systems. Despite its significance, however, its prevalence in the Chinese general population remains unknown. This study aimed to investigate the prevalence of NONFH and its associated risk factors in the Chinese population. 
Methods: A nationally representative survey of 30,030 respondents was undertaken from June 2012 to August 2013. All participants underwent a questionnaire investigation, physical examination of hip, and bilateral hip joint X-ray and/or magnetic resonance imaging examination. Blood samples were taken after overnight fasting to test serum total cholesterol, triglyceride, and high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels. We then used multivariate logistic regression analysis to investigate the associations between various metabolic, demographic, and lifestyle-related variables and NONFH. 
Results: NONFH was diagnosed in 218 subjects (0.725%) and the estimated NONFH cases were 8.12 million among Chinese people aged 15 years and over. The prevalence of NONFH was significantly higher in males than in females (1.02% vs. 0.51%, \(\chi^2\) = 24.997, P < 0.001). Among NONFH patients, North residents were subjected to higher prevalence of NONFH than that of South residents (0.85% vs. 0.61%, \(\chi^2\) = 5.847, P = 0.016). Our multivariate regression analysis showed that high blood levels of triglycerides, total cholesterol, LDL-cholesterol, and non-HDL-cholesterol, male, urban residence, family history of osteonecrosis of the femoral head, heavy smoking, alcohol abuse and glucocorticoid intake, overweight, and obesity were all significantly associated with an increased risk of NONFH. 
Conclusions: Our findings highlight that NONFH is a significant public health challenge in China and underscore the need for policy measures on the national level. Furthermore, NONFH shares a number of risk factors with atherosclerosis.
KW  - nontraumatic osteonecrosis of the femoral head
KW  - risk factors
KW  - idiopathic osteonecrosis
KW  - early-stage osteonecrosis
KW  - implantation
KW  - bone
KW  - marrow
KW  - follow-up
KW  - intake
KW  - avascular necrosis
KW  - occupational-status
KW  - cigarette smoking
KW  - alcohol
KW  - prevalence
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-138482
VL  - 128
IS  - 21
ER  - 
TY  - JOUR
A1  - van Koolwijk, Leonieke M. E.
A1  - Ramdas, Wishal D.
A1  - Ikram, M. Kamran
A1  - Jansonius, Nomdo M.
A1  - Pasutto, Francesca
A1  - Hys, Pirro G.
A1  - Macgregor, Stuart
A1  - Janssen, Sarah F.
A1  - Hewitt, Alex W.
A1  - Viswanathan, Ananth C.
A1  - ten Brink, Jacoline B.
A1  - Hosseini, S. Mohsen
A1  - Amin, Najaf
A1  - Despriet, Dominiek D. G.
A1  - Willemse-Assink, Jacqueline J. M.
A1  - Kramer, Rogier
A1  - Rivadeneira, Fernando
A1  - Struchalin, Maksim
A1  - Aulchenko, Yurii S.
A1  - Weisschuh, Nicole
A1  - Zenkel, Matthias
A1  - Mardin, Christian Y.
A1  - Gramer, Eugen
A1  - Welge-Lüssen, Ulrich
A1  - Montgomery, Grant W.
A1  - Carbonaro, Francis
A1  - Young, Terri L.
A1  - Bellenguez, Céline
A1  - McGuffin, Peter
A1  - Foster, Paul J.
A1  - Topouzis, Fotis
A1  - Mitchell, Paul
A1  - Wang, Jie Jin
A1  - Wong, Tien Y.
A1  - Czudowska, Monika A.
A1  - Hofman, Albert
A1  - Uitterlinden, Andre G.
A1  - Wolfs, Roger C. W.
A1  - de Jong, Paulus T. V. M.
A1  - Oostra, Ben A.
A1  - Paterson, Andrew D.
A1  - Mackey, David A.
A1  - Bergen, Arthur A. B.
A1  - Reis, Andre
A1  - Hammond, Christopher J.
A1  - Vingerling, Johannes R.
A1  - Lemij, Hans G.
A1  - Klaver, Caroline C. W.
A1  - van Duijn, Cornelia M.
T1  - Common Genetic Determinants of Intraocular Pressure and Primary Open-Angle Glaucoma
JF  - PLoS Genetics
N2  - Intraocular pressure (IOP) is a highly heritable risk factor for primary open-angle glaucoma and is the only target for current glaucoma therapy. The genetic factors which determine IOP are largely unknown. We performed a genome-wide association study for IOP in 11,972 participants from 4 independent population-based studies in The Netherlands. We replicated our findings in 7,482 participants from 4 additional cohorts from the UK, Australia, Canada, and the Wellcome Trust Case-Control Consortium 2/Blue Mountains Eye Study. IOP was significantly associated with rs11656696, located in GAS7 at 17p13.1 (p = 1.4 x 10\(^{-8}\)), and with rs7555523, located in TMCO1 at 1q24.1 (p = 1.6 x 10\(^{-8}\)). In a meta-analysis of 4 case-control studies (total N = 1,432 glaucoma cases), both variants also showed evidence for association with glaucoma (p = 2.4 x 10\(^{-2}\) for rs11656696 and p = 9.1 x 10\(^{-4}\) for rs7555523). GAS7 and TMCO1 are highly expressed in the ciliary body and trabecular meshwork as well as in the lamina cribrosa, optic nerve, and retina. Both genes functionally interact with known glaucoma disease genes. These data suggest that we have identified two clinically relevant genes involved in IOP regulation.
KW  - expression
KW  - goldmann applanation tonometer
KW  - central corneal thickness
KW  - genome-wide scan
KW  - beaver-dam eye
KW  - to-disc ratio
KW  - onset
KW  - association
KW  - identification
KW  - population
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-131378
VL  - 8
IS  - 5
ER  -