TY - JOUR A1 - Deltz, E. A1 - Müller-Hermelink, HK A1 - Ulrichs, Karin A1 - Thiede, A. A1 - Müller-Ruchholtz, W. T1 - Development of graft-versus-host reaction in various target organs after small intestine transplantation N2 - The GVHRIL foHowing transplantation of small intestine are different from those found after bone marrow transplantation or spleen cell injections in that they show a remarka ble, significant prevalence of lesions within the intestinal mucosa. These findings are consistent with the observation that jntestinal lymphocytes newly formed in mesenteric lymph nodes predominantly home in on the intestine again.& The degree of histologic alteration within different tissues indicates that the graft and the host may survive the lesions of the lymphatic tissues, whereas the severe intestinal lesions following GVHR may easily cause death of the recipient. With regard to clinical sman bowel transplantation two statements can be made: (l) GVHRIL play a significant role in small bowel trans~ plantation. (2) To minimize their biologic importance, a selective elimination of the graft's Jymph nodes by irradiation or surgical resection should be considered in view of the remarkable difference between GVHRIL in lymph nodes and in the graft's intestinal wall itself. KW - Chirurgie Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45459 ER - TY - JOUR A1 - Eckstein, V. A1 - Ulrichs, K. A1 - Meincke, G. A1 - Müller-Ruchholtz, W. T1 - Natural xenophile antibodies from sera of type I diabetic patients differ strongly in their reactivity against various porcine pancreatic cells N2 - No abstract available KW - Chirurgie Y1 - 1992 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45277 ER - TY - JOUR A1 - Ulrichs, Karin A1 - Nöthling, R. A1 - Keller, R. A1 - Heusermann, U. A1 - Müller-Buchholtz, W. T1 - Genetically determined variation of constitutive major histocompatibility complex class II antigen expression in various rat strains and cell types N2 - No abstract available KW - Chirurgie Y1 - 1987 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-44769 ER - TY - JOUR A1 - Müller-Buchholtz, W. A1 - Leyhausen, G. A1 - Peterson, P. A1 - Schubert, G. A1 - Ulrichs, Karin T1 - A simple methodological principle for large scale extraction and purification of collagenase-digested islets N2 - No abstract available KW - Chirurgie Y1 - 1987 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-44770 ER - TY - JOUR A1 - Breitkreuz, A. A1 - Ulrichs, Karin A1 - Eckstein, V. A1 - Müller-Ruchholz, W. T1 - Long-term suppression of natural and graft-induced xenophile antibodies by short-term antigen-cyclophosphamide treatment N2 - No abstract available KW - Chirurgie Y1 - 1993 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45262 ER - TY - JOUR A1 - Ulrichs, Karin A1 - Euler, HH A1 - Schroeder, JO A1 - Müller-Ruchhholtz, W. T1 - Long-term specific suppression of antibody production by plasmapheresis and a short-term course of cyclophosphamide N2 - No abstract available KW - Chirurgie Y1 - 1992 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45198 ER - TY - CHAP A1 - Eckstein, V. A1 - Ulrichs, Karin A1 - Meincke, G. A1 - Mülller-Ruchholtz, W. T1 - Transplantation of Diabetic Patients With Xenogeneic Pancreatic Islets Has to Consider Natural Xenophile Antibodies (NXA) In Patients Sera As a Major Obstacle to Success N2 - No abstract available KW - Immunbiologie Y1 - 1991 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45707 ER - TY - CHAP A1 - Winoto-Morbach, S. A1 - Ulrichs, Karin A1 - Müller-Ruchholtz, W. T1 - New Developments in Biodegradable Microspheres For Magnetic Separation Techniques N2 - No abstract available KW - Immunbiologie Y1 - 1991 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45712 ER - TY - CHAP A1 - Kaitschick, J. A1 - Ulrichs, K. A1 - Müller-Ruchholtz, W. T1 - The New Immunosuppressant Leflunomide Appears To Be a Potent Inhibitor of Humoral Xeno Sensitization N2 - No abstract available KW - Immunbiologie Y1 - 1991 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45727 ER - TY - JOUR A1 - Ulrichs, Karin A1 - Yu, MY A1 - Duncker, D. A1 - Müller-Ruchholtz, W. T1 - Immunosuppression by cytostatic drugs? N2 - In the present study, an attempt was made to characterize the immunomodulating abilities of the cytostatic drugs cydophosphamide, ifosfamide, vinblastine, vincristine, procarbazine, dacarbazine, 6-mercaptopurine, methotrexate, 5-f/uor-uracil and adriamycine in a defined experimental model. Varying combinations of drug plus transplantation alloantigen, (C3H-lymphocytes) were injected into Balb/c mice at different time intervals in vivo. The resulting T-effector cell reactivity was determined in vitro with the microcytotoxicity assay on day + 5 for primary (r) and day + 7 for secondary (2°) sensitized mice. According to the type of drug (alkylating agent vs. vinca alkaloid vs. antimetabolite vs. cytostatic antibiotic), the dosage (20% LD50 vs. 60% LD50), the state of sensitization (r vs. 2° sensitized recipients), and the time of drug application in relation to the antigen treatment on day 0 (in varying steps from day -6 to day +4), so-called "pharmaconantigen- variation-effects" (PA VE) were established for each of the investigated drugs in form of reaction profiles. The results were as folIows: (1) For almost alt substances, characteristic reaction profiles involving immunostimulation and/or immunosuppression could be established. Similarities in the profiles of different substances made it possible to classify the drugs according to different reaction types. The reaction type however is not definitely correlated to the biochemical mechanism of drug action. (2) The PA VE are decisively inf/uenced by so me of the biological parameters, such as the time of drug application in relation to the antigen treatment and the state of sensitization but relatively !ittle by the dosage of the drug. (3) Considering the different processes occurring du ring primary and secondary immune responses, the PAVE may give hints for a distinct manipulation of the immunoregulation and thus information on the immunobiological mechanism of drug action. KW - Immunologie Y1 - 1984 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45574 ER -