TY  - JOUR
A1  - Tornau, Christian
T1  - Formen und Funktionen von Polemik in den Briefen Augustins: Versuch einer Klassifikation
JF  - Zeitschrift für Antikes Christentum
JF  - Journal of Ancient Christianity
N2  - Due to the conventions of late-antique epistolary politeness, it is not always easy to identify polemical passages in Augustine’s correspondence. The present contribution attempts to discern and classify some recurrent techniques and strategies that are characteristic of letters the addressee of which is him- or herself the target of Augustine’s polemics, i. e. in which polemical rhetoric is blended with diplomacy. After describing some more formal techniques, such as polemical hermeneutics and Refraintechnik, I turn to the rhetorical, i. e. persuasive, functions of polemics in Augustine’s anti-pagan, anti-Donatist and anti-Pelagian letters, using the basic distinction between direct polemics (polemics against the addressee in person) and indirect polemics (polemics against the addressee’s group or friends) as a starting point. Another relevant distinction, taken into account throughout, is whether a polemical letter is primarily designed to impress the immediate addressee or to have an effect on the wider readership that Augustine had to reckon with as soon as a letter was dispatched.
KW  - direct and indirect polemics
KW  - rhetoric
KW  - pathos
KW  - polemical hermeneutics
KW  - Refraintechnik
KW  - paganism
KW  - Donatism
KW  - Pelagianism
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-198465
SN  - 1612-961X
SN  - 0949-9571
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 22
IS  - 1
SP  - 5
EP  - 49
ER  - 
TY  - JOUR
A1  - Blättner, Sebastian
A1  - Das, Sudip
A1  - Paprotka, Kerstin
A1  - Eilers, Ursula
A1  - Krischke, Markus
A1  - Kretschmer, Dorothee
A1  - Remmele, Christian W.
A1  - Dittrich, Marcus
A1  - Müller, Tobias
A1  - Schuelein-Voelk, Christina
A1  - Hertlein, Tobias
A1  - Mueller, Martin J.
A1  - Huettel, Bruno
A1  - Reinhardt, Richard
A1  - Ohlsen, Knut
A1  - Rudel, Thomas
A1  - Fraunholz, Martin J.
T1  - Staphylococcus aureus Exploits a Non-ribosomal Cyclic Dipeptide to Modulate Survival within Epithelial Cells and Phagocytes
JF  - PLoS Pathogens
N2  - Community-acquired (CA) Staphylococcus aureus cause various diseases even in healthy individuals. Enhanced virulence of CA-strains is partly attributed to increased production of toxins such as phenol-soluble modulins (PSM). The pathogen is internalized efficiently by mammalian host cells and intracellular S. aureus has recently been shown to contribute to disease. Upon internalization, cytotoxic S. aureus strains can disrupt phagosomal membranes and kill host cells in a PSM-dependent manner. However, PSM are not sufficient for these processes. Here we screened for factors required for intracellular S. aureus virulence. We infected escape reporter host cells with strains from an established transposon mutant library and detected phagosomal escape rates using automated microscopy. We thereby, among other factors, identified a non-ribosomal peptide synthetase (NRPS) to be required for efficient phagosomal escape and intracellular survival of S. aureus as well as induction of host cell death. By genetic complementation as well as supplementation with the synthetic NRPS product, the cyclic dipeptide phevalin, wild-type phenotypes were restored. We further demonstrate that the NRPS is contributing to virulence in a mouse pneumonia model. Together, our data illustrate a hitherto unrecognized function of the S. aureus NRPS and its dipeptide product during S. aureus infection.
KW  - cell death
KW  - cytotoxicity
KW  - Staphylococcus aureus
KW  - host cells
KW  - neutrophils
KW  - macrophages
KW  - transposable elements
KW  - epithelial cells
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-180380
VL  - 12
IS  - 9
ER  - 
TY  - JOUR
A1  - Hansmann, T.
A1  - Heinzmann, J.
A1  - Wrenzycki, C.
A1  - Zechner, U.
A1  - Niemann, H.
A1  - Haaf, T.
T1  - Characterization of Differentially Methylated Regions in 3 Bovine Imprinted Genes: A Model for Studying Human Germ-Cell and Embryo Development
JF  - Cytogenetic and Genome Research
N2  - Correct imprinting is crucial for normal fetal and placental development in mammals. Experimental evidence in animal models and epidemiological studies in humans suggest that assisted reproductive technologies (ARTs) can interfere with imprinted gene regulation in gametogenesis and early embryogenesis. Bos taurus is an agriculturally important species in which ARTs are commonly employed. Because this species exhibits a similar preimplantation development and gestation length as humans, it is increasingly being used as a model for human germ-cell and embryo development. However, in contrast to humans and mice, there is relatively little information on bovine imprinted genes. Here, we characterized the bovine intergenic IGF2-H19 imprinting control region (ICR) spanning approximately 3 kb. We identified a 300-bp differentially methylated region (DMR) approximately 6 kb upstream of the H19 promoter, containing a CpG island with CTCF-binding site and high sequence similarity with the human intergenic ICR. Additional differentially methylated CpG islands lie –6 kb to –3 kb upstream of the promoter, however these are less conserved. Both classical bisulfite sequencing and bisulfite pyrosequencing demonstrated complete methylation of the IGF2-H19 ICR in sperm, complete demethylation in parthenogenetic embryos having only the female genome, and differential methylation in placental and somatic tissues. In addition, we established pyrosequencing assays for the previously reported bovine SNRPN and PEG3 DMRs. The observed methylation patterns were consistent with genomic imprinting in all analyzed tissues/cell types. The identified IGF2-H19 ICR and the developed quantitative methylation assays may prove useful for further studies on the relationship between ARTs and imprinting defects in the bovine model.
KW  - bovine
KW  - differentially methylated region
KW  - IGF2-H19
KW  - imprinting control region
Y1  - 2010
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-199051
SN  - 1424-8581
SN  - 1424-859X
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 132
IS  - 4
ER  - 
TY  - JOUR
A1  - Kraft, Peter
A1  - Drechsler, Christiane
A1  - Gunreben, Ignaz
A1  - Heuschmann, Peter Ulrich
A1  - Kleinschnitz, Christoph
T1  - Regulation of Blood Coagulation Factors XI and XII in Patients with Acute and Chronic Cerebrovascular Disease: A Case-Control Study
JF  - Cerebrovascular Diseases
N2  - Background: Animal models have implicated an integral role for coagulation factors XI (FXI) and XII (FXII) in thrombus formation and propagation of ischemic stroke (IS). However, it is unknown if these molecules contribute to IS pathophysiology in humans, and might be of use as biomarkers for IS risk and severity. This study aimed to identify predictors of altered FXI and FXII levels and to determine whether there are differences in the levels of these coagulation factors between acute cerebrovascular events and chronic cerebrovascular disease (CCD). Methods: In this case-control study, 116 patients with acute ischemic stroke (AIS) or transitory ischemic attack (TIA), 117 patients with CCD, and 104 healthy volunteers (HVs) were enrolled between 2010 and 2013 at our University hospital. Blood sampling was undertaken once in the CCD and HV groups and on days 0, 1, and 3 after stroke onset in patients with AIS or TIA. Correlations between serum FXI and FXII levels and demographic and clinical parameters were tested by linear regression and analysis of variance. Results: The mean age of AIS/TIA patients was 70 ± 12. Baseline clinical severity measured with NIHSS and Barthel Index was 4.8 ± 6.0 and 74 ± 30, respectively. More than half of the patients had an AIS (58%). FXI levels were significantly correlated with different leukocyte subsets (p < 0.05). In contrast, FXII serum levels showed no significant correlation (p > 0.1). Neither FXI nor FXII levels correlated with CRP (p > 0.2). FXII levels were significantly higher in patients with CCD compared with those with AIS/TIA (mean ± SD 106 ± 26% vs. 97 ± 24%; univariate analysis: p < 0.05); these differences did not reach significance in multivariate analysis adjusted for sex and age. FXI levels did not differ significantly between study groups. Sex and age were significantly associated with FXI and/or FXII levels in patients with AIS/TIA (p < 0.05). In contrast, no statistical significant influence was found for treatment modality (thrombolysis or not), pre-treatment with platelet inhibitors, and severity of stroke. Conclusions: In this study, there was no differential regulation of FXI and FXII levels between disease subtypes but biomarker levels were associated with patient and clinical characteristics. FXI and FXII levels might be no valid biomarker for predicting stroke risk.
KW  - biomarker
KW  - factor XI
KW  - factor XII
KW  - ischemic stroke
KW  - chronic cerebrovascular disease
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-199076
SN  - 1015-9770
SN  - 1421-9786
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 38
IS  - 5
ER  - 
TY  - JOUR
A1  - Zahnert, Thomas
A1  - Löwenheim, Hubert
A1  - Beutner, Dirk
A1  - Hagen, Rudolf
A1  - Ernst, Arneborg
A1  - Pau, Hans-Wilhelm
A1  - Zehlicke, Thorsten
A1  - Kühne, Hilke
A1  - Friese, Natascha
A1  - Tropitzsch, Anke
A1  - Lüers, Jan-Christoffer
A1  - Mlynski, Robert
A1  - Todt, Ingo
A1  - Hüttenbrink, Karl-Bernd
T1  - Multicenter Clinical Trial of Vibroplasty Couplers to Treat Mixed/Conductive Hearing Loss: First Results
JF  - Audiology and Neurotology
N2  - Objective: To evaluate the safety and effectiveness of round window (RW), oval window (OW), CliP and Bell couplers for use with an active middle ear implant. Methods: This is a multicenter, long-term, prospective trial with consecutive enrollment, involving 6 university hospitals in Germany. Bone conduction, air conduction, implant-aided warble-tone thresholds and Freiburger monosyllable word recognition scores were compared with unaided preimplantation results in 28 moderate-to-profound hearing-impaired patients after 12 months of follow-up. All patients had previously undergone failed reconstruction surgeries (up to 5 or more). In a subset of patients, additional speech tests at 12 months postoperatively were used to compare the aided with the unaided condition after implantation with the processor switched off. An established quality-of-life questionnaire for hearing aids was used to determine patient satisfaction. Results: Postoperative bone conduction remained stable. Mean functional gain for all couplers was 37 dB HL (RW = 42 dB, OW = 35 dB, Bell = 38 dB, CliP = 27 dB). The mean postoperative Freiburger monosyllable score was 71% at 65 dB SPL. The postimplantation mean SRT<sub>50</sub> (speech reception in quiet for 50% understanding of words in sentences) improved on average by 23 dB over unaided testing and signal-to-noise ratios also improved in all patients. The International Outcome Inventory for Hearing Aids (IOI-HA)quality-of-life questionnaire was scored very positively by all patients. Conclusion: A significant improvement was seen with all couplers, and patients were satisfied with the device at 12 months postoperatively. These results demonstrate that an active implant is an advantage in achieving good hearing benefit in patients with prior failed reconstruction surgery.
KW  - conductive hearing loss
KW  - mixed hearing loss
KW  - vibroplasty
KW  - couplers
KW  - middle ear implant
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-199129
SN  - 1420-3030
SN  - 1421-9700
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 21
IS  - 4
ER  - 
TY  - JOUR
A1  - Schwarzmeier, Hanna
A1  - Leehr, Elisabeth Johanna
A1  - Böhnlein, Joscha
A1  - Seeger, Fabian Reinhard
A1  - Roesmann, Kati
A1  - Gathmann, Bettina
A1  - Herrmann, Martin J.
A1  - Siminski, Niklas
A1  - Junghöfer, Markus
A1  - Straube, Thomas
A1  - Grotegerd, Dominik
A1  - Dannlowski, Udo
T1  - Theranostic markers for personalized therapy of spider phobia: Methods of a bicentric external cross‐validation machine learning approach
JF  - International Journal of Methods in Psychiatric Research
N2  - Objectives
Embedded in the Collaborative Research Center “Fear, Anxiety, Anxiety Disorders” (CRC‐TRR58), this bicentric clinical study aims at identifying biobehavioral markers of treatment (non‐)response by applying machine learning methodology with an external cross‐validation protocol. We hypothesize that a priori prediction of treatment (non‐)response is possible in a second, independent sample based on multimodal markers.

Methods
One‐session virtual reality exposure treatment (VRET) with patients with spider phobia was conducted on two sites. Clinical, neuroimaging, and genetic data were assessed at baseline, post‐treatment and after 6 months. The primary and secondary outcomes defining treatment response are as follows: 30% reduction regarding the individual score in the Spider Phobia Questionnaire and 50% reduction regarding the individual distance in the behavioral avoidance test.

Results
N = 204 patients have been included (n = 100 in Würzburg, n = 104 in Münster). Sample characteristics for both sites are comparable.

Discussion
This study will offer cross‐validated theranostic markers for predicting the individual success of exposure‐based therapy. Findings will support clinical decision‐making on personalized therapy, bridge the gap between basic and clinical research, and bring stratified therapy into reach. The study is registered at ClinicalTrials.gov (ID: NCT03208400).
KW  - machine learning
KW  - spider phobia
KW  - theranostic markers
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-213430
VL  - 29
IS  - 2
ER  - 
TY  - JOUR
A1  - Kotseva, Kornelia
A1  - De Backer, Guy
A1  - De Bacquer, Dirk
A1  - Rydén, Lars
A1  - Hoes, Arno
A1  - Grobbee, Diederick
A1  - Maggioni, Aldo
A1  - Marques-Vidal, Pedro
A1  - Jennings, Catriona
A1  - Abreu, Ana
A1  - Aguiar, Carlos
A1  - Badariene, Jolita
A1  - Bruthans, Jan
A1  - Castro Conde, Almudena
A1  - Cifkova, Renata
A1  - Crowley, Jim
A1  - Davletov, Kairat
A1  - Deckers, Jaap
A1  - De Smedt, Delphine
A1  - De Sutter, Johan
A1  - Dilic, Mirza
A1  - Dolzhenko, Marina
A1  - Dzerve, Vilnis
A1  - Erglis, Andrejs
A1  - Fras, Zlatko
A1  - Gaita, Dan
A1  - Gotcheva, Nina
A1  - Heuschmann, Peter
A1  - Hasan-Ali, Hosam
A1  - Jankowski, Piotr
A1  - Lalic, Nebojsa
A1  - Lehto, Seppo
A1  - Lovic, Dragan
A1  - Mancas, Silvia
A1  - Mellbin, Linda
A1  - Milicic, Davor
A1  - Mirrakhimov, Erkin
A1  - Oganov, Rafael
A1  - Pogosova, Nana
A1  - Reiner, Zeljko
A1  - Stöerk, Stefan
A1  - Tokgözoğlu, Lâle
A1  - Tsioufis, Costas
A1  - Vulic, Dusko
A1  - Wood, David
T1  - Lifestyle and impact on cardiovascular risk factor control in coronary patients across 27 countries: Results from the European Society of Cardiology ESC-EORP EUROASPIRE V registry
JF  - European Journal of Preventive Cardiology
N2  - Aims
The aim of this study was to determine whether the Joint European Societies guidelines on secondary cardiovascular prevention are followed in everyday practice.
	
Design
A cross-sectional ESC-EORP survey (EUROASPIRE V) at 131 centres in 81 regions in 27 countries.
	
Methods
Patients (<80 years old) with verified coronary artery events or interventions were interviewed and examined ≥6 months later.
	
Results
A total of 8261 patients (females 26%) were interviewed. Nineteen per cent smoked and 55% of them were persistent smokers, 38% were obese (body mass index ≥30 kg/m2), 59% were centrally obese (waist circumference: men ≥102 cm; women ≥88 cm) while 66% were physically active <30 min 5 times/week. Forty-two per cent had a blood pressure ≥140/90 mmHg (≥140/85 if diabetic), 71% had low-density lipoprotein cholesterol ≥1.8 mmol/L (≥70 mg/dL) and 29% reported having diabetes. Cardioprotective medication was: anti-platelets 93%, beta-blockers 81%, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers 75% and statins 80%.
	
Conclusion
A large majority of coronary patients have unhealthy lifestyles in terms of smoking, diet and sedentary behaviour, which adversely impacts major cardiovascular risk factors. A majority did not achieve their blood pressure, low-density lipoprotein cholesterol and glucose targets. Cardiovascular prevention requires modern preventive cardiology programmes delivered by interdisciplinary teams of healthcare professionals addressing all aspects of lifestyle and risk factor management, in order to reduce the risk of recurrent cardiovascular events.
KW  - EUROASPIRE
KW  - lifestyle
KW  - cardiovascular risk factors
KW  - secondary prevention
KW  - guidelines
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-205526
SN  - 2047-4873
SN  - 2047-4881
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 26
IS  - 8
ER  - 
TY  - JOUR
A1  - Figueiredo, Ludmilla
A1  - Krauss, Jochen
A1  - Steffan-Dewenter, Ingolf
A1  - Cabral, Juliano Sarmento
T1  - Understanding extinction debts: spatio-temporal scales, mechanisms and a roadmap for future research
JF  - Ecography
N2  - Extinction debt refers to delayed species extinctions expected as a consequence of ecosystem perturbation. Quantifying such extinctions and investigating long‐term consequences of perturbations has proven challenging, because perturbations are not isolated and occur across various spatial and temporal scales, from local habitat losses to global warming. Additionally, the relative importance of eco‐evolutionary processes varies across scales, because levels of ecological organization, i.e. individuals, (meta)populations and (meta)communities, respond hierarchically to perturbations. To summarize our current knowledge of the scales and mechanisms influencing extinction debts, we reviewed recent empirical, theoretical and methodological studies addressing either the spatio–temporal scales of extinction debts or the eco‐evolutionary mechanisms delaying extinctions. Extinction debts were detected across a range of ecosystems and taxonomic groups, with estimates ranging from 9 to 90% of current species richness. The duration over which debts have been sustained varies from 5 to 570 yr, and projections of the total period required to settle a debt can extend to 1000 yr. Reported causes of delayed extinctions are 1) life‐history traits that prolong individual survival, and 2) population and metapopulation dynamics that maintain populations under deteriorated conditions. Other potential factors that may extend survival time such as microevolutionary dynamics, or delayed extinctions of interaction partners, have rarely been analyzed. Therefore, we propose a roadmap for future research with three key avenues: 1) the microevolutionary dynamics of extinction processes, 2) the disjunctive loss of interacting species and 3) the impact of multiple regimes of perturbation on the payment of debts. For their ability to integrate processes occurring at different levels of ecological organization, we highlight mechanistic simulation models as tools to address these knowledge gaps and to deepen our understanding of extinction dynamics.
KW  - Anthropocene
KW  - biotic interaction
KW  - extinction dynamics
KW  - mechanistic modelling
KW  - time lag
KW  - transient dynamics
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-204859
VL  - 42
IS  - 12
ER  - 
TY  - JOUR
A1  - Müller, Christof
A1  - Tornau, Christian
T1  - „Unfreundlichkeit und Polemik im Briefkorpus Augustins“
JF  - Zeitschrift für Antikes Christentum
JF  - Journal of Ancient Christianity
N2  - Kein Abstract verfügbar.
KW  - Briefe
KW  - Augustinus von Hippo
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-198437
SN  - 1612-961X
SN  - 0949-9571
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 22
IS  - 1
SP  - 1
EP  - 4
ER  - 
TY  - JOUR
A1  - Ataee, Mohammad Sadegh
A1  - Maghsoudi, Yasser
A1  - Latifi, Hooman
A1  - Fadaie, Farhad
T1  - Improving estimation accuracy of growing stock by multi-frequency SAR and multi-spectral data over Iran's heterogeneously-structured broadleaf Hyrcanian forests
JF  - Forests
N2  - Via providing various ecosystem services, the old-growth Hyrcanian forests play a crucial role in the environment and anthropogenic aspects of Iran and beyond. The amount of growing stock volume (GSV) is a forest biophysical parameter with great importance in issues like economy, environmental protection, and adaptation to climate change. Thus, accurate and unbiased estimation of GSV is also crucial to be pursued across the Hyrcanian. Our goal was to investigate the potential of ALOS-2 and Sentinel-1's polarimetric features in combination with Sentinel-2 multi-spectral features for the GSV estimation in a portion of heterogeneously-structured and mountainous Hyrcanian forests. We used five different kernels by the support vector regression (nu-SVR) for the GSV estimation. Because each kernel differently models the parameters, we separately selected features for each kernel by a binary genetic algorithm (GA). We simultaneously optimized R\(^2\) and RMSE in a suggested GA fitness function. We calculated R\(^2\), RMSE to evaluate the models. We additionally calculated the standard deviation of validation metrics to estimate the model's stability. Also for models over-fitting or under-fitting analysis, we used mean difference (MD) index. The results suggested the use of polynomial kernel as the final model. Despite multiple methodical challenges raised from the composition and structure of the study site, we conclude that the combined use of polarimetric features (both dual and full) with spectral bands and indices can improve the GSV estimation over mixed broadleaf forests. This was partially supported by the use of proposed evaluation criterion within the GA, which helped to avoid the curse of dimensionality for the applied SVR and lowest over estimation or under estimation.
KW  - GSV
KW  - nu SVR
KW  - uneven-aged mountainous
KW  - polarimetery
KW  - multi-spectral
KW  - optimization
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-197212
SN  - 1999-4907
VL  - 10
IS  - 8
ER  - 
TY  - JOUR
A1  - Gottschlich, Günter
T1  - Synopse der für Deutschland nachgewiesenen Arten und Unterarten der Gattung Hieracium s. l. (Hieracium s. str. und Pilosella), aufgeschlüsselt nach Vorkommen in den einzelnen Bundesländern
T1  - Synopsis of all species and subspecies of the genus Hieracium s. l. (Hieracium s. str. and Pilosella) in Germany according to the records cited in literature for the German federal states
JF  - Forum geobotanicum
N2  - Eine Liste der 205 Arten und 1561 Unterarten der Gattung Hieracium s. l. , die in Deutschland, aufgeschlüsselt nach Bundesländern vorkommen, wird vorgestellt. Da die meisten infraspezifischen Namen unter Hieracium publiziert wurden und um die Zahl der invaliden Namen unter Pilosella in der Liste zu minimieren, wird auf eine Aufteilung in Hieracium und Pilosella verzichtet. Durch Farbmarkierungen wird gekennzeichnet, welche Unterart ursprünglich aus einem Bundesland beschrieben wurde bzw. ob ein Syntypus aus einem Bundesland stammt.
N2  - A list of 205 collective species and 1563 subspecies of the genus Hieracium s. l. detected for Germany and its federal states, is provided. As the most infraspecific taxa were described under Hieracium s.l. and to avoid too much invalid names under Pilosella in the list, a separation of Hieracium and Pilosella is remained undone. By coloured marking additional informations are given whether a subspecies is originally described from a german federal state or its name has a syntype from Germany.
KW  - diversity
KW  - Hieracium
KW  - Asteraceae
KW  - Habichtskraut
KW  - Korbblütler
KW  - Langhaariges Habichtskraut
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-198175
UR  - http://forum-geobotanicum.net/articles/vol_9-2020/gottschlich-synopsis_hieracium/gottschlich-synopsis_hieracium.pdf
SN  - 1867-9315
VL  - 9
ER  - 
TY  - JOUR
A1  - Dunkel, Franz G.
T1  - Ranunculus sarntheinianus Dunkel, spec. nova, eine neue Art aus dem Ranunculus-auricomus-Komplex – seit 135 Jahren im Oberen Inntal bei Innsbruck
T1  - Ranunculus sarntheinianus Dunkel, spec. nova, a new species of the Ranunculus auricomus complex – for 135 years in the Upper Inn valley near Innsbruck
JF  - Forum geobotanicum
N2  - Für das Vorkommen einer Ranunculus auricomus-Sippe im Oberen Inntal bei Innnsbuck, Nordtirol, Österreich, existieren belegte Nachweise seit 135 Jahren. Diese Sippe sammelte L. Sarnthein am 08.06.1884, J. Murr 1887 bei Flaurling. Von beiden Aufsammlungen befinden sich Belege im Tiroler Landesmuseum (Herbarium Ferdinandeum Innsbruck; IBF). Trotz Trockenlegung der Sumpfwiesen und Eutrophierung des Biotops kommt die Art noch aktuell in einem kleinen Nasswiesenrest vor. Sie wird hier als R. sarntheinianus Dunkel beschrieben, abgebildet und ihre Taxonomie wird diskutiert. Der mutmaßlich letzte Wuchsort ist vom Aussterben bedroht. Eine graphische Darstellung soll bei Artbestimmung und Auffinden neuer Wuchsorte behilflich sein.
N2  - In the Upper Inn Valley close to Innsbruck, North Tyrol, Austria, a population of the Ranunculus auricomus complex is existing for more than 135 years. On the 8 Apr 1884, L. Sarnthein collected the taxon near to the municipality of Flaurling, J. Murr in 1887. There are specimens of both collections at the Tiroler Landesmuseum (Herbarium Ferdinandeum Innsbruck; IBF). Although deterioration of the biotope took place by drainage of the swamp meadows and eutrophication of the biotope, a small population still exists in a remnant of a moistsoil meadow. The taxon is described and depicted here as Ranunculus sarntheinianus Dunkel. Its characters and taxonomy are discussed. The probably last site of R. sarntheinianus is critically endangered, and the species faces risk of extinction.
KW  - Ranunculus sarntheinianus
KW  - Ranunculus auricomus
KW  - Hahnenfuß
KW  - Österreich
KW  - Nordtirol
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-198183
UR  - http://forum-geobotanicum.net/articles/vol_9-2020/dunkel-ranunculus_sarntheinianus/dunkel-ranunculus_sarntheinianus.pdf
SN  - 1867-9315
VL  - 9
ER  - 
TY  - JOUR
A1  - Drenckhahn, Detlev
A1  - Weber, Heinrich E.
T1  - Die Nordfriesische Brombeere, Rubus boreofrisicus Drenckhahn & H. E. Weber, eine endemische Rubus-Art der Westküste von Schleswig-Holstein, Deutschland
T1  - The North Frisian bramble, Rubus boreofrisicus Drenckhahn & H. E. Weber, an endemic Rubus species of the West coast of Schleswig-Holstein, Germany
JF  - Forum geobotanicum
N2  - Rubus boreofrisicus Drenckhahn & H. E.Weber ist eine bisher unbeschriebene Rubus-Art der Untergattung Rubus, Serie Discolores. Die Endblättchen der 5-zähligen, handförmigen Schösslingsblätter sind breit eiförmig bis annähernd rund, unterseits grau-weißlich, oberseits dunkelgrün und schwach behaart. Die Schösslinge sind braunrot, kantig bis schwach gefurcht, etwas behaart mit geraden bis schwach gekrümmten, 5−8 mm langen, braunroten Stacheln mit heller Spitzenhälfte. Die Blütenstiele besitzen Stieldrüsen. Rubus boreofrisicus kommt häufig im Waldgürtel und in der angrenzenden Dünenheide der nordfriesischen Insel Amrum vor und ist auch 50 km südlich von Amrum in St. Peter-Ording im Westen der Halbinsel Eiderstedt vertreten.
N2  - Rubus boreofrisicus Drenckhahn & H. E. Weber is an undescribed member of the subgenus Rubus, series Discolores. Stem leaves are 5-nate digitate with broad ovate to roundish terminal leaflets, greyish-white underside and dark green, slightly hairy upper side. Stems are reddish brown, angled, with flat to slightly furrowed sides, covered with few hairs and armed with 5−8 mm long straight or slightly curved reddish brown prickles with lighter tips. Pedicels display few stalked glands. Rubus boreofrisicus is abundant in the forest belt and adjacent dune heath of the North Frisian island of Amrum, (Schleswig-Holstein, Germany) but it also occurs 50 km south in St. Peter-Ording at the West coast of the peninsula Eiderstedt.
KW  - Rubus boreofrisicus
KW  - new Rubus species
KW  - series Discolores
KW  - Rubus
KW  - Art
KW  - Schleswig-Holstein
KW  - Amrum
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-198194
UR  - http://forum-geobotanicum.net/articles/vol_9-2020/drenckhahn-weber-rubus_boreofrisicus/drenckhahn-weber-rubus_boreofrisicus.pdf
SN  - 1867-9315
VL  - 9
ER  - 
TY  - JOUR
A1  - Bauer, Boris
A1  - Goebeler, Matthias
A1  - Weissbrich, Benedikt
A1  - Kerstan, Andreas
T1  - Kerinokeratosis papulosa of childhood
JF  - Dermatology
N2  - Background: Kerinokeratosis papulosa (KP) is considered an extremely rare genodermatosis presenting usually as waxy papules on the trunk in childhood. 
Objective: To describe and analyze the clinical, histological and potential etiopathological aspects of KP. 
Methods: The dermatoscopic features of a new case of KP of childhood are investigated. The presence of human papillomavirus (HPV) DNA in lesional skin was studied by polymerase chain reaction. Furthermore, all cases of KP of childhood reported so far were reviewed. 
Results: As a diagnostic tool, we describe for the first time a dermatoscopic feature, namely a cribriform pattern of KP, in an 11-year-old boy. In addition, we detected HPV (type 57) in his KP lesions. 
Conclusions: Dermatoscopic examination might be a useful tool to distinguish KP from other skin lesions, e.g. common warts. The detection of HPV type 57 might hint to an etiological role of HPV for KP.
KW  - Waxy papulosis of childhood
KW  - Human papillomavirus
KW  - EVER1
KW  - EVER2
KW  - Kerinokeratosis papulosa
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-198997
SN  - 1018-8665
SN  - 1421-9832
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 231
IS  - 1
SP  - 1
EP  - 4
ER  - 
TY  - JOUR
A1  - Schmid, Michael
A1  - Steinlein, Claus
A1  - Winking, Heinz
T1  - Multicolor Spectral Analyses of Mitotic and Meiotic Mouse Chromosomes Involved in Multiple Robertsonian Translocations. I. The CD/Cremona Hybrid Strain
JF  - Cytogenetic and Genome Research
N2  - Multicolor spectral analysis (spectral karyotyping) was applied to mitotic and male diakinetic chromosomes of hybrid mice carrying a unique system of 18 autosomal Robertsonian translocation chromosomes with alternating arm homologies. Only the autosomes 19 and the XY sex chromosomes are excluded from these Robertsonian translocations. The translocations, previously identified by conventional banding analyses, could be verified by spectral karyotyping. Besides the Robertsonian translocations, no other interchromosomal rearrangements were detected. In diakineses of male meiosis, the 18 metacentric Robertsonian translocation chromosomes form a very large meiotic ‘superring'. The predictable, specific order of the chromosomes along this ‘superring' was completely confirmed by multicolor spectral analysis. In the majority of diakineses analyzed, the free autosomal bivalent 19 and the XY sex bivalent form a conspicuous complex which tightly associates with the 12;14 Robertsonian translocation chromosome in the ‘superring'.
KW  - meiotic ‘superring’
KW  - mouse
KW  - Robertsonian translocation chromosomes
KW  - spectral karyotyping
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-199013
SN  - 1424-8581
SN  - 1424-859X
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 147
IS  - 4
ER  - 
TY  - JOUR
A1  - Schmid, Michael
A1  - Steinlein, Claus
T1  - Chromosome Banding in Amphibia. XXXIII. Demonstration of 5-Methylcytosine-Rich Heterochromatin in Anura
JF  - Cytogenetic and Genome Research
N2  - An experimental approach using monoclonal anti-5-methylcytosine (5-MeC) antibodies and indirect immunofluorescence was elaborated for detecting 5-MeC-rich chromosome regions in anuran chromosomes. This technique was applied to mitotic metaphases of 6 neotropical frog species belonging to 6 genera and 4 families. The hypermethylation patterns were compared with a variety of banding patterns obtained by conventional banding techniques. The hypermethylated DNA sequences are species-specific and located exclusively in constitutive heterochromatin. They are found in centromeric, pericentromeric, telomeric, and interstitial positions of the chromosomes and adjacent to nucleolus organizer regions. 5-MeC-rich DNA sequences can be embedded both in AT- and GC-rich repetitive DNA. The experimental parameters that have major influence on the reproducibility and quality of the anti-5-MeC antibody labeling are discussed.
KW  - Anura
KW  - heterochromatin
KW  - hypermethylated DNA
KW  - immunofluorescence
KW  - 5-Methylcytosine
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-199022
SN  - 1424-8581
SN  - 1424-859X
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 148
IS  - 1
ER  - 
TY  - JOUR
A1  - Schneider, Eberhard
A1  - El Hajj, Nady
A1  - Müller, Fabian
A1  - Navarro, Bianca
A1  - Haaf, Thomas
T1  - Epigenetic Dysregulation in the Prefrontal Cortex of Suicide Completers
JF  - Cytogenetic and Genome Research
N2  - The epigenome is thought to mediate between genes and the environment, particularly in response to adverse life experiences. Similar to other psychiatric diseases, the suicide liability of an individual appears to be influenced by many genetic factors of small effect size as well as by environmental stressors. To identify epigenetic marks associated with suicide, which is considered the endpoint of complex gene-environment interactions, we compared the cortex DNA methylation patterns of 6 suicide completers versus 6 non-psychiatric sudden-death controls, using Illumina 450K methylation arrays. Consistent with a multifactorial disease model, we found DNA methylation changes in a large number of genes, but no changes with large effects reaching genome-wide significance. Global methylation of all analyzed CpG sites was significantly (0.25 percentage point) lower in suicide than in control brains, whereas the vast majority (97%) of the top 1,000 differentially methylated regions (DMRs) were higher methylated (0.6 percentage point) in suicide brains. Annotation analysis of the top 1,000 DMRs revealed an enrichment of differentially methylated promoters in functional categories associated with transcription and expression in the brain. In addition, we performed a comprehensive literature research to identify suicide genes that have been replicated in independent genetic association, brain methylation and/or expression studies. Although, in general, there was no significant overlap between different published data sets or between our top 1,000 DMRs and published data sets, our methylation screen strengthens a number of candidate genes (APLP2, BDNF, HTR1A, NUAK1, PHACTR3, MSMP, SLC6A4, SYN2, and SYNE2) and supports a role for epigenetics in the pathophysiology of suicide.
KW  - Cortex
KW  - DNA methylation
KW  - Suicidal behavior
KW  - Transcription regulation
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-199032
SN  - 1424-8581
SN  - 1424-859X
VL  - 146
IS  - 1
ER  - 
TY  - JOUR
A1  - Schmid, Michael
A1  - Steinlein, Claus
A1  - Haaf, Thomas
A1  - Mijares-Urrutia, Abraham
T1  - Nascent ZW Sex Chromosomes in Thecadactylus rapicauda (Reptilia, Squamata, Phyllodactylidae)
JF  - Cytogenetic and Genome Research
N2  - The chromosomes of the turnip-tailed gecko Thecadactylus rapicauda from the Falcón State in northern Venezuela were examined by means of conventional staining, a variety of banding techniques and in situ hybridization with an 18S + 28S rDNA probe. In female specimens, C-banding analyses detected a cryptic W sex chromosome-associated interstitial heterochromatic segment which is absent in the Z sex chromosome. These ZW sex chromosomes are considered to be in a nascent stage of morphological differentiation and are absent in T. rapicauda collected in Guatemala. The amount, location and fluorochrome affinities of constitutive heterochromatin, the position of the nucleolus organizer region, and the genome sizes of female and male individuals were determined. The previously published cytogenetic data on T. rapicauda are discussed.
KW  - ZW sex chromosomes
KW  - Gecko
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-199041
SN  - 1424-8581
SN  - 1424-859X
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 143
IS  - 4
ER  - 
TY  - JOUR
A1  - Bura, Thomas
A1  - Beaupré, Serge
A1  - Légaré, Marc-André
A1  - Ibraikulov, Olzhas A.
A1  - Leclerc, Nicolas
A1  - Leclerc, Mario
T1  - Theoretical calculations for highly selective Direct Heteroarylation Polymerization: new nitrile-substituted Dithienyl-Diketopyrrolopyrrole-based polymers
JF  - Molecules
N2  - Direct Heteroarylation Polymerization (DHAP) is becoming a valuable alternative to classical polymerization methods being used to synthesize π-conjugated polymers for organic electronics applications. In previous work, we showed that theoretical calculations on activation energy (Ea) of the C–H bonds were helpful to rationalize and predict the selectivity of the DHAP. For readers’ convenience, we have gathered in this work all our previous theoretical calculations on Ea and performed new ones. Those theoretical calculations cover now most of the widely utilized electron-rich and electron-poor moieties studied in organic electronics like dithienyl-diketopyrrolopyrrole (DT-DPP) derivatives. Theoretical calculations reported herein show strong modulation of the Ea of C–H bond on DT-DPP when a bromine atom or strong electron withdrawing groups (such as fluorine or nitrile) are added to the thienyl moiety. Based on those theoretical calculations, new cyanated dithienyl-diketopyrrolopyrrole (CNDT-DPP) monomers and copolymers were prepared by DHAP and their electro-optical properties were compared with their non-fluorinated and fluorinated analogues.
KW  - DHAP
KW  - selectivity
KW  - theoretical calculations
KW  - conjugated polymers
KW  - organic electronics
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-197648
SN  - 1420-3049
VL  - 23
IS  - 9
ER  - 
TY  - JOUR
A1  - Papenfort, Kai
A1  - Vogel, Jörg
T1  - Small RNA functions in carbon metabolism and virulence of enteric pathogens
JF  - Frontiers in Cellular and Infection Microbiology
N2  - Enteric pathogens often cycle between virulent and saprophytic lifestyles. To endure these frequent changes in nutrient availability and composition bacteria possess an arsenal of regulatory and metabolic genes allowing rapid adaptation and high flexibility. While numerous proteins have been characterized with regard to metabolic control in pathogenic bacteria, small non-coding RNAs have emerged as additional regulators of metabolism. Recent advances in sequencing technology have vastly increased the number of candidate regulatory RNAs and several of them have been found to act at the interface of bacterial metabolism and virulence factor expression. Importantly, studying these riboregulators has not only provided insight into their metabolic control functions but also revealed new mechanisms of post-transcriptional gene control. This review will focus on the recent advances in this area of host-microbe interaction and discuss how regulatory small RNAs may help coordinate metabolism and virulence of enteric pathogens.
KW  - sRNA
KW  - carbon metabolism
KW  - Hfq
KW  - CsrA
KW  - virulence
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-197520
SN  - 2235-2988
VL  - 4
IS  - 91
ER  - 
TY  - JOUR
A1  - Jungwirth, Gerhard
A1  - Yu, Tao
A1  - Moustafa, Mahmoud
A1  - Rapp, Carmen
A1  - Warta, Rolf
A1  - Jungk, Christine
A1  - Sahm, Felix
A1  - Dettling, Steffen
A1  - Zweckberger, Klaus
A1  - Lamszus, Katrin
A1  - Senft, Christian
A1  - Loehr, Mario
A1  - Keßler, Almuth F.
A1  - Ketter, Ralf
A1  - Westphal, Manfred
A1  - Debus, Juergen
A1  - von Deimling, Andreas
A1  - Simon, Matthias
A1  - Unterberg, Andreas
A1  - Abdollahi, Amir
A1  - Herold-Mende, Christel
T1  - Identification of KIF11 as a Novel Target in Meningioma
JF  - Cancers
N2  - Kinesins play an important role in many physiological functions including intracellular vesicle transport and mitosis. The emerging role of kinesins in different cancers led us to investigate the expression and functional role of kinesins in meningioma. Therefore, we re-analyzed our previous microarray dataset of benign, atypical, and anaplastic meningiomas (n = 62) and got evidence for differential expression of five kinesins (KIFC1, KIF4A, KIF11, KIF14 and KIF20A). Further validation in an extended study sample (n = 208) revealed a significant upregulation of these genes in WHO°I to °III meningiomas (WHO°I n = 61, WHO°II n = 88, and WHO°III n = 59), which was most pronounced in clinically more aggressive tumors of the same WHO grade. Immunohistochemical staining confirmed a WHO grade-associated upregulated protein expression in meningioma tissues. Furthermore, high mRNA expression levels of KIFC1, KIF11, KIF14 and KIF20A were associated with shorter progression-free survival. On a functional level, knockdown of kinesins in Ben-Men-1 cells and in the newly established anaplastic meningioma cell line NCH93 resulted in a significantly inhibited tumor cell proliferation upon siRNA-mediated downregulation of KIF11 in both cell lines by up to 95% and 71%, respectively. Taken together, in this study we were able to identify the prognostic and functional role of several kinesin family members of which KIF11 exhibits the most promising properties as a novel prognostic marker and therapeutic target, which may offer new treatment options for aggressive meningiomas.
KW  - meningioma
KW  - KIF
KW  - kinesin
KW  - KIF11
KW  - NCH93
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-197402
SN  - 2072-6694
VL  - 11
IS  - 4
ER  - 
TY  - JOUR
A1  - Lamatsch, D. K.
A1  - Trifonov, V.
A1  - Schories, S.
A1  - Epplen, J. T.
A1  - Schmid, M.
A1  - Schartl, M.
T1  - Isolation of a Cancer-Associated Microchromosome in the Sperm-Dependent Parthenogen Poecilia formosa
JF  - Cytogenetic and Genome Research
N2  - In the asexual all-female fish species Poecilia formosa, the Amazon molly, supernumerary chromosomes have frequently been found in both laboratory-reared and wild-caught individuals. While wild-caught individuals with B chromosomes are phenotypically indifferent from conspecifics, individuals carrying B chromosomes from recent introgression events in the laboratory show phenotypic changes. Former analyses showed that the expression of a pigment cell locus is associated with the presence of these B chromosomes. In addition, they contain a so far unidentified locus that confers a higher susceptibility to tumor formation in the presence of pigmentation pattern. Isolation by microdissection and hybridization to metaphase chromosomes revealed that they contain one or several sequences with similarity to a highly repetitive pericentromeric and subtelomeric sequence in A chromosomes. Isolation of one particular sequence by AFLP showed that the B chromosomes contain at least 1 copy of an A-chromosomal region which is highly conserved in the whole genus Poecilia, i.e. more than 5 million years old. We propose it to be a single copy sequence.
KW  - paternal introgression
KW  - AFLP
KW  - asexual reproduction
KW  - B chromosomes
KW  - gynogenesis
KW  - microdissection
KW  - telomeres
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196785
SN  - 1424-8581
SN  - 1424-859X
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 135
IS  - 2
ER  - 
TY  - JOUR
A1  - Dengler, Julius
A1  - Maldaner, Nicolai
A1  - Gläsker, Sven
A1  - Endres, Matthias
A1  - Wagner, Martin
A1  - Malzahn, Uwe
A1  - Heuschmann, Peter U.
A1  - Vajkoczy, Peter
T1  - Outcome of Surgical or Endovascular Treatment of Giant Intracranial Aneurysms, with Emphasis on Age, Aneurysm Location, and Unruptured Aneuryms - A Systematic Review and Meta-Analysis
JF  - Cerebrovascular Diseases
N2  - Background: Designing treatment strategies for unruptured giant intracranial aneurysms (GIA) is difficult as evidence of large clinical trials is lacking. We examined the outcome following surgical or endovascular GIA treatment focusing on patient age, GIA location and unruptured GIA. Methods: Medline and Embase were searched for studies reporting on GIA treatment outcome published after January 2000. We calculated the proportion of good outcome (PGO) for all included GIA and for unruptured GIA by meta-analysis using a random effects model. Results: We included 54 studies containing 64 study populations with 1,269 GIA at a median follow-up time (FU-T) of 26.4 months (95% CI 10.8-42.0). PGO was 80.9% (77.4-84.4) in the analysis of all GIA compared to 81.2% (75.3-86.1) in the separate analysis of unruptured GIA. For each year added to patient age, PGO decreased by 0.8%, both for all GIA and unruptured GIA. For all GIA, surgical treatment resulted in a PGO of 80.3% (95% CI 76.0-84.6) compared to 84.2% (78.5-89.8, p = 0.27) after endovascular treatment. In unruptured GIA, PGO was 79.7% (95% CI 71.5-87.8) after surgical treatment and 84.9% (79.1-90.7, p = 0.54) after endovascular treatment. PGO was lower in high quality studies and in studies presenting aggregate instead of individual patient data. In unruptured GIA, the OR for good treatment outcome was 5.2 (95% CI 2.0-13.0) at the internal carotid artery compared to 0.1 (0.1-0.3, p < 0.1) in the posterior circulation. Patient sex, FU-T and prevalence of ruptured GIA were not associated with PGO. Conclusions: We found that the chances of good outcome after surgical or endovascular GIA treatment mainly depend on patient age and aneurysm location rather than on the type of treatment conducted. Our analysis may inform future research on GIA.
KW  - surgical aneurysm treatment
KW  - giant intracranial aneurysm
KW  - endovascular treatment
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196792
SN  - 1015-9770
SN  - 1421-9786
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 41
IS  - 3-4
ER  - 
TY  - JOUR
A1  - Schneider, Eberhard
A1  - El Hajj, Nady
A1  - Haaf, Thomas
T1  - Epigenetic Information from Ancient DNA Provides New Insights into Human Evolution
BT  - Commentary on Gokhman D et al. (2014): Reconstructing the DNA 
Methylation Maps of the Neanderthal and the Denisovan. Science 344:523–527
JF  - Brain, Behavior and Evolution
N2  - No abstract available.
KW  - human evolution
KW  - Neanderthal
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196800
SN  - 0006-8977
SN  - 1421-9743
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 84
IS  - 3
ER  - 
TY  - JOUR
A1  - Stieb, Sara Mae
A1  - Kelber, Christina
A1  - Wehner, Rüdiger
A1  - Rössler, Wolfgang
T1  - Antennal-Lobe Organization in Desert Ants of the Genus Cataglyphis
JF  - Brain, Behavior and Evolution
N2  - Desert ants of the genus Cataglyphis possess remarkable visual navigation capabilities. Although Cataglyphis species lack a trail pheromone system, Cataglyphis fortis employs olfactory cues for detecting nest and food sites. To investigate potential adaptations in primary olfactory centers of the brain of C. fortis, we analyzed olfactory glomeruli (odor processing units) in their antennal lobes and compared them to glomeruli in different Cataglyphis species. Using confocal imaging and 3D reconstruction, we analyzed the number, size and spatial arrangement of olfactory glomeruli in C. fortis, C.albicans, C.bicolor, C.rubra, and C.noda. Workers of all Cataglyphis species have smaller numbers of glomeruli (198–249) compared to those previously found in olfactory-guided ants. Analyses in 2 species of Formica – a genus closely related to Cataglyphis – revealed substantially higher numbers of olfactory glomeruli (c. 370), which is likely to reflect the importance of olfaction in these wood ant species. Comparisons between Cataglyphis species revealed 2 special features in C. fortis. First, with c. 198 C. fortis has the lowest number of glomeruli compared to all other species. Second, a conspicuously enlarged glomerulus is located close to the antennal nerve entrance. Males of C. fortis possess a significantly smaller number of glomeruli (c. 150) compared to female workers and queens. A prominent male-specific macroglomerulus likely to be involved in sex pheromone communication occupies a position different from that of the enlarged glomerulus in females. The behavioral significance of the enlarged glomerulus in female workers remains elusive. The fact that C. fortis inhabits microhabitats (salt pans) that are avoided by all other Cataglyphis species suggests that extreme ecological conditions may not only have resulted in adaptations of visual capabilities, but also in specializations of the olfactory system.
KW  - olfactory glomeruli
KW  - plasticity
KW  - ant
KW  - antennal lobe
KW  - glomerulus
KW  - insects
KW  - interspecific comparison
KW  - macroglomerulus
KW  - olfaction
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196815
SN  - 0006-8977
SN  - 1421-9743
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 77
IS  - 3
ER  - 
TY  - JOUR
A1  - Schraven, Sebastian P.
A1  - Dalhoff, Ernst
A1  - Wildenstein, Daniela
A1  - Hagen, Rudolf
A1  - Gummer, Anthony W.
A1  - Mlynski, Robert
T1  - Alternative Fixation of an Active Middle Ear Implant at the Short Incus Process
JF  - Audiology and Neurotology
N2  - Introduction: Since 1996, the preferred approach for positioning the active middle-ear implant Vibrant Soundbridge© is a mastoidectomy and a posterior tympanotomy. With this device, placement of the floating mass transducer (FMT) on the long incus process is the standard method for treatment of mild-to-severe sensorineural hearing loss in the case of normal middle-ear anatomy. The aim of this study was to determine the vibrational effectiveness of FMT placement at the short incus process. Materials and Methods: An extended antrotomy and a posterior tympanotomy were performed in 5 fresh human temporal bones. As a control for normal middle-ear function, the tympanic membrane was stimulated acoustically and the vibration of the stapes footplate and the round-window (RW) membrane were (sequentially) measured by laser Doppler vibrometry. Vibration responses for coupling of an FMT to the long incus process (standard coupling) were compared to those for coupling to the short incus process. Results: Apart from narrow frequency bands near 3 and 9 kHz for the stapes footplate and RW membrane, respectively, the velocity responses presented no significant differences between standard coupling of the FMT and coupling to the short incus process. Conclusion: Coupling the FMT to the short incus process may be a viable alternative in cases where the surgical approach is limited to an extended antrotomy. A reliable technique for attachment to the short incus process has yet to be developed.
KW  - middle-ear surgery
KW  - active middle-ear implant
KW  - floating mass transducer
KW  - incus
KW  - Laser Doppler vibrometer
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196823
SN  - 1420-3030
SN  - 1421-9700
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 19
IS  - 1
ER  - 
TY  - JOUR
A1  - de Zeeuw, Dick
A1  - Akizawa, Tadao
A1  - Agarwal, Rajiv
A1  - Audhya, Paul
A1  - Bakris, George L.
A1  - Chin, Melanie
A1  - Krauth, Melissa
A1  - Lambers Heerspink, Hiddo J.
A1  - Meyer, Colin J.
A1  - McMurray, John J.
A1  - Parving, Hans-Henrik
A1  - Pergola, Pablo E.
A1  - Remuzzi, Giuseppe
A1  - Toto, Robert D.
A1  - Vaziri, Nosratola D.
A1  - Wanner, Christoph
A1  - Warnock, David G.
A1  - Wittes, Janet
A1  - Chertow, Glenn M.
T1  - Rationale and Trial Design of Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes: The Occurrence of Renal Events (BEACON)
JF  - American Journal of Nephrology
N2  - Background: Chronic kidney disease (CKD) associated with type 2 diabetes mellitus constitutes a global epidemic complicated by considerable renal and cardiovascular morbidity and mortality, despite the provision of inhibitors of the renin-angiotensin-aldosterone system (RAAS). Bardoxolone methyl, a synthetic triterpenoid that reduces oxidative stress and inflammation through Nrf2 activation and inhibition of NF-κB was previously shown to increase estimated glomerular filtration rate (eGFR) in patients with CKD associated with type 2 diabetes mellitus. To date, no antioxidant or anti-inflammatory therapy has proved successful at slowing the progression of CKD. Methods: Herein, we describe the design of Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes: the Occurrence of Renal Events (BEACON) trial, a multinational, multicenter, double-blind, randomized, placebo-controlled Phase 3 trial designed to determine whether long-term administration of bardoxolone methyl (on a background of standard therapy, including RAAS inhibitors) safely reduces renal and cardiac morbidity and mortality. Results: The primary composite endpoint is time-to-first occurrence of either end-stage renal disease or cardiovascular death. Secondary endpoints include the change in eGFR and time to occurrence of cardiovascular events. Conclusion: BEACON will be the first event-driven trial to evaluate the effect of an oral antioxidant and anti-inflammatory drug in advanced CKD.
KW  - clinical trial
KW  - diabetes mellitus
KW  - glomerular filtration rate
KW  - trial design
KW  - bardoxolone methyl
KW  - Nrf2
KW  - end-stage renal disease
KW  - cardiovascular death
KW  - chronic kidney disease
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196832
SN  - 0250-8095
SN  - 1421-9670
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 37
IS  - 3
ER  - 
TY  - JOUR
A1  - Mayr, Stefan
A1  - Kuenzer, Claudia
A1  - Gessner, Ursula
A1  - Klein, Igor
A1  - Rutzinger, Martin
T1  - Validation of earth observation time-series: a review for large-area and temporally dense land surface products
JF  - Remote Sensing
N2  - Large-area remote sensing time-series offer unique features for the extensive investigation of our environment. Since various error sources in the acquisition chain of datasets exist, only properly validated results can be of value for research and downstream decision processes. This review presents an overview of validation approaches concerning temporally dense time-series of land surface geo-information products that cover the continental to global scale. Categorization according to utilized validation data revealed that product intercomparisons and comparison to reference data are the conventional validation methods. The reviewed studies are mainly based on optical sensors and orientated towards global coverage, with vegetation-related variables as the focus. Trends indicate an increase in remote sensing-based studies that feature long-term datasets of land surface variables. The hereby corresponding validation efforts show only minor methodological diversification in the past two decades. To sustain comprehensive and standardized validation efforts, the provision of spatiotemporally dense validation data in order to estimate actual differences between measurement and the true state has to be maintained. The promotion of novel approaches can, on the other hand, prove beneficial for various downstream applications, although typically only theoretical uncertainties are provided.
KW  - accuracy
KW  - error estimation
KW  - global
KW  - intercomparison
KW  - remote sensing
KW  - uncertainty
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-193202
SN  - 2072-4292
VL  - 11
IS  - 22
ER  - 
TY  - JOUR
A1  - Grebinyk, Anna
A1  - Prylutska, Svitlana
A1  - Buchelnikov, Anatoliy
A1  - Tverdokhleb, Nina
A1  - Grebinyk, Sergii
A1  - Evstigneev, Maxim
A1  - Matyshevska, Olga
A1  - Cherepanov, Vsevolod
A1  - Prylutskyy, Yuriy
A1  - Yashchuk, Valeriy
A1  - Naumovets, Anton
A1  - Ritter, Uwe
A1  - Dandekar, Thomas
A1  - Frohme, Marcus
T1  - C60 fullerene as an effective nanoplatform of alkaloid Berberine delivery into leukemic cells
JF  - Pharmaceutics
N2  - A herbal alkaloid Berberine (Ber), used for centuries in Ayurvedic, Chinese, Middle-Eastern, and native American folk medicines, is nowadays proved to function as a safe anticancer agent. Yet, its poor water solubility, stability, and bioavailability hinder clinical application. In this study, we have explored a nanosized carbon nanoparticle—C60 fullerene (C60)—for optimized Ber delivery into leukemic cells. Water dispersions of noncovalent C60-Ber nanocomplexes in the 1:2, 1:1, and 2:1 molar ratios were prepared. UV–Vis spectroscopy, dynamic light scattering (DLS), and atomic force microscopy (AFM) evidenced a complexation of the Ber cation with the negatively charged C60 molecule. The computer simulation showed that π-stacking dominates in Ber and C\(_{60}\) binding in an aqueous solution. Complexation with C\(_{60}\) was found to promote Ber intracellular uptake. By increasing C\(_{60}\) concentration, the C\(_{60}\)-Ber nanocomplexes exhibited higher antiproliferative potential towards CCRF-CEM cells, in accordance with the following order: free Ber < 1:2 < 1:1 < 2:1 (the most toxic). The activation of caspase 3/7 and accumulation in the sub-G1 phase of CCRF-CEM cells treated with C\(_{60}\)-Ber nanocomplexes evidenced apoptosis induction. Thus, this study indicates that the fast and easy noncovalent complexation of alkaloid Ber with C\(_{60}\) improved its in vitro efficiency against cancer cells.
KW  - C60 fullerene
KW  - Berberine
KW  - noncovalent nanocomplex
KW  - UV–Vis
KW  - DLS and AFM measurements
KW  - drug release
KW  - leukemic cells
KW  - uptake
KW  - cytotoxicity
KW  - apoptosis
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-193216
SN  - 1999-4923
VL  - 11
IS  - 11
ER  - 
TY  - JOUR
A1  - Teichmann, Christoph
T1  - Corporate Groups within the Legal Framework of the European Union: The Group-Related Aspects of the SUP Proposal and the EU Freedom of Establishment
JF  - European Company and Financial Law Review
N2  - No abstract available.
KW  - EU
KW  - corporate groups
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-194513
SN  - 1613-2556
SN  - 1613-2548
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 12
IS  - 2
SP  - 202
EP  - 229
ER  - 
TY  - JOUR
A1  - Brinktrine, Ralf
T1  - Konkurrentenstreitverfahren im Beamtenrecht
JF  - JURA - Juristische Ausbildung
N2  - Kein Abstract verfügbar.
KW  - Konkurrentenstreitverfahren
KW  - Beamtenrecht
KW  - Klausur
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-194866
SN  - 1612-7021
SN  - 0170-1452
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 37
IS  - 11
ER  - 
TY  - JOUR
A1  - Nord, Ilona
T1  - Wolfhard Schweiker, Prinzip Inklusion. Grundlagen einer interdisziplinären Metatheorie in religionspädagogischer Perspektive. Göttingen: Vandenhoeck & Ruprecht 2017.
JF  - Zeitschrift für Pädagogik und Theologie
N2  - Kein Abstract verfügbar.
KW  - Rezension
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-194874
SN  - 2366-7796
SN  - 1437-7160
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 69
IS  - 3
ER  - 
TY  - JOUR
A1  - Li, Shan
A1  - Li, Xin
A1  - Link, Roman
A1  - Li, Ren
A1  - Deng, Liping
A1  - Schuldt, Bernhard
A1  - Jiang, Xiaomei
A1  - Zhao, Rongjun
A1  - Zheng, Jingming
A1  - Li, Shuang
A1  - Yin, Yafang
T1  - Influence of cambial age and axial height on the spatial patterns of xylem traits in Catalpa bungei, a ring-porous tree species native to China
JF  - Forests
N2  - Studying how cambial age and axial height affects wood anatomical traits may improve our understanding of xylem hydraulics, heartwood formation and axial growth. Radial strips were collected from six different heights (0–11.3 m) along the main trunk of three Manchurian catalpa (Catalpa bungei) trees, yielding 88 samples. In total, thirteen wood anatomical vessel and fiber traits were observed usinglight microscopy (LM) and scanning electron microscopy (SEM), and linear models were used to analyse the combined effect of axial height, cambial age and their interaction. Vessel diameter differed by about one order of magnitude between early- and latewood, and increased significantly with both cambial age and axial height in latewood, while it was positively affected by cambial age and independent of height in earlywood. Vertical position further had a positive effect on earlywood vessel density, and negative effects on fibre wall thickness, wall thickness to diameter ratio and length. Cambial age had positive effects on the pit membrane diameter and vessel element length, while the annual diameter growth decreased with both cambial age and axial position. In contrast, early- and latewood fiber diameter were unaffected by both cambial age and axial height. We further observed an increasing amount of tyloses from sapwood to heartwood, accompanied by an increase of warty layers and amorphous deposits on cell walls, bordered pit membranes and pit apertures. This study highlights the significant effects of cambial age and vertical position on xylem anatomical traits, and confirms earlier work that cautions to take into account xylem spatial position when interpreting wood anatomical structures, and thus, xylem hydraulic functioning.
KW  - wood anatomy
KW  - vertical and radial variation
KW  - earlywood
KW  - latewood
KW  - growth ring width
KW  - tyloses
KW  - pit membrane diameter
KW  - vessel lumen diameter
KW  - fibre length
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196297
SN  - 1999-4907
VL  - 10
IS  - 8
ER  - 
TY  - JOUR
A1  - Camacho, J.P.M.
A1  - Schmid, M.
A1  - Cabrero, J.
T1  - B Chromosomes and Sex in Animals
JF  - Sexual Development
N2  - Supernumerary (B) chromosomes are dispensable elements found in many eukaryote genomes in addition to standard (A) chromosomes. In many respects, B chromosomes resemble sex chromosomes, so that a common ancestry for them has frequently been suggested. For instance, B chromosomes in grasshoppers, and other insects, show a pycnotic cycle of condensation-decondensation during meiosis remarkably similar to that of the X chromosome. In some cases, B chromosome size is even very similar to that of the X chromosome. These resemblances have led to suggest the X as the B ancestor in many cases. In addition, sex chromosome origin from B chromosomes has also been suggested. In this article, we review the existing evidence for both evolutionary pathways, as well as sex differences for B frequency at adult and embryo progeny levels, B chromosome effects or B chromosome transmission. In addition, we review cases found in the literature showing sex-ratio distortion associated with B chromosome presence, the most extreme case being the paternal sex ratio (PSR) chromosomes in some Hymenoptera. We finally analyse the possibility of B chromosome regularisation within the host genome and, as a consequence of it, whether B chromosomes can become regular members of the host genome.
KW  - A chromosomes
KW  - B chromosomes
KW  - sex ratio
KW  - X chromosome
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196321
SN  - 1661-5425
SN  - 1661-5433
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 5
IS  - 3
ER  - 
TY  - JOUR
A1  - Kühn, Heike
A1  - Schön, Franz
A1  - Edelmann, Karola
A1  - Brill, Stefan
A1  - Müller, Joachim
T1  - The Development of Lateralization Abilities in Children with Bilateral Cochlear Implants
JF  - ORL
N2  - Objectives: The purpose of this study was to investigate the development of lateralization skills in children who received bilateral cochlear implants (CIs) in sequential operations. Methods: The lateralization skills of 9 children with a mean age of 4.1 years at the first surgery and 5.5 years at the second surgery were assessed at 3 time intervals. Children were assessed with a 3-loudspeaker setup (front, left and right) at 0.9 years (interval I) and 1.6 years (interval II) after the second implantation, and after 5.3 years of bilateral implant use (interval III) with a 9-loudspeaker setup in the frontal horizontal plane between -90° and 90° azimuth. Results: With bilateral implants, a significant decrease in lateralization error was noted between test interval I (45.0°) and II (23.3°), with a subsequent significant decrease at test interval III (4.7°). Unilateral performance with the CI did not improve significantly between the first 2 intervals; however, there was a bias of responses towards the unilateral side by test interval III. Conclusions: The lateralization abilities of children with bilateral CIs develop in a relatively short period of time (1-2 years) after the second implant. Children appear to be able to acquire binaural skills after bilateral cochlear implantation.
KW  - localization
KW  - bilateral cochlear implant
KW  - children
KW  - MED-EL cochlear implant
KW  - lateralization
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196375
SN  - 0301-1569
SN  - 1423-0275
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 75
IS  - 2
ER  - 
TY  - JOUR
A1  - Kolominsky-Rabas, Peter L.
A1  - Wiedmann, Silke
A1  - Weingärtner, Michael
A1  - Liman, Thomas G.
A1  - Endres, Matthias
A1  - Schwab, Stefan
A1  - Buchfelder, Michael
A1  - Heuschmann, Peter U.
T1  - Time Trends in Incidence of Pathological and Etiological Stroke Subtypes during 16 Years: The Erlangen Stroke Project
JF  - Neuroepidemiology
N2  - Background: Population-based data, which continuously monitors time trends in stroke epidemiology are limited. We investigated the incidence of pathological and etiological stroke subtypes over a 16 year time period. Methods: Data were collected within the Erlangen Stroke Project (ESPro), a prospective, population-based stroke register in Germany covering a total study population of 105,164 inhabitants (2010). Etiology of ischemic stroke was classified according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria. Results: Between January 1995 and December 2010, 3,243 patients with first-ever stroke were documented. The median age was 75 and 55% were females. The total stroke incidence decreased over the 16 year study period in men (Incidence Rate Ratio 1995-1996 vs. 2009-2010 (IRR) 0.78; 95% CI 0.58-0.90) but not in women. Among stroke subtypes, a decrease in ischemic stroke incidence (IRR 0.73; 95% CI 0.57-0.93) and of large artery atherosclerotic stroke (IRR 0.27; 95% CI 0.12-0.59) was found in men and an increase of stroke due to small artery occlusion in women (IRR 2.33; 95% CI 1.39-3.90). Conclusions: Variations in time trends of pathological and etiological stroke subtypes were found between men and women that might be linked to gender differences in the development of major vascular risk factors in the study population.
KW  - stroke
KW  - epidemiology
KW  - incidence
KW  - time trends
KW  - register
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196503
SN  - 0251-5350
SN  - 1423-0208
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 44
IS  - 1
ER  - 
TY  - JOUR
A1  - Schneider, Andreas
A1  - Gutjahr-Lengsfeld, Lena
A1  - Ritz, Eberhard
A1  - Scharnagl, Hubert
A1  - Gelbrich, Götz
A1  - Pilz, Stefan
A1  - Macdougall, Iain C.
A1  - Wanner, Christoph
A1  - Drechsler, Christiane
T1  - Longitudinal Assessments of Erythropoietin-Stimulating Agent Responsiveness and the Association with Specific Clinical Outcomes in Dialysis Patients
JF  - Nephron Clinical Practice
N2  - Background: Dose requirements of erythropoietin-stimulating agents (ESAs) can vary considerably over time and may be associated with cardiovascular outcomes. We aimed to longitudinally assess ESA responsiveness over time and to investigate its association with specific clinical end points in a time-dependent approach. Methods: The German Diabetes and Dialysis study (4D study) included 1,255 diabetic dialysis patients, of whom 1,161 were receiving ESA treatment. In those patients, the erythropoietin resistance index (ERI) was assessed every 6 months during a median follow-up of 4 years. The association between the ERI and cardiovascular end points was analyzed by time-dependent Cox regression analyses with repeated ERI measures. Results: Patients had a mean age of 66 ± 8.2 years; 53% were male. During follow-up, a total of 495 patients died, of whom 136 died of sudden death and 102 of infectious death. The adjusted and time-dependent risk for sudden death was increased by 19% per 5-unit increase in the ERI (hazard ratio, HR = 1.19, 95% confidence interval, CI = 1.07-1.33). Similarly, mortality increased by 25% (HR = 1.25, 95% CI = 1.18-1.32) and infectious death increased by 27% (HR = 1.27, 95% CI = 1.13-1.42). Further analysis revealed that lower 25-hydroxyvitamin D levels were associated with lower ESA responsiveness (p = 0.046). Conclusions: In diabetic dialysis patients, we observed that time-varying erythropoietin resistance is associated with sudden death, infectious complications and all-cause mortality. Low 25-hydroxyvitamin D levels may contribute to a lower ESA responsiveness.
KW  - dialysis
KW  - erythropoietin
KW  - diabetes
KW  - epidemiology
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196511
SN  - 1660-2110
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 128
IS  - 1-2
ER  - 
TY  - JOUR
A1  - Poot, Martin
A1  - Haaf, Thomas
T1  - Mechanisms of Origin, Phenotypic Effects and Diagnostic Implications of Complex Chromosome Rearrangements
JF  - Molecular Syndromology
N2  - Complex chromosome rearrangements (CCRs) are currently defined as structural genome variations that involve more than 2 chromosome breaks and result in exchanges of chromosomal segments. They are thought to be extremely rare, but their detection rate is rising because of improvements in molecular cytogenetic technology. Their population frequency is also underestimated, since many CCRs may not elicit a phenotypic effect. CCRs may be the result of fork stalling and template switching, microhomology-mediated break-induced repair, breakage-fusion-bridge cycles, or chromothripsis. Patients with chromosomal instability syndromes show elevated rates of CCRs due to impaired DNA double-strand break responses during meiosis. Therefore, the putative functions of the proteins encoded by ATM, BLM, WRN, ATR, MRE11, NBS1, and RAD51 in preventing CCRs are discussed. CCRs may exert a pathogenic effect by either (1) gene dosage-dependent mechanisms, e.g. haploinsufficiency, (2) mechanisms based on disruption of the genomic architecture, such that genes, parts of genes or regulatory elements are truncated, fused or relocated and thus their interactions disturbed - these mechanisms will predominantly affect gene expression - or (3) mixed mutation mechanisms in which a CCR on one chromosome is combined with a different type of mutation on the other chromosome. Such inferred mechanisms of pathogenicity need corroboration by mRNA sequencing. Also, future studies with in vitro models, such as inducible pluripotent stem cells from patients with CCRs, and transgenic model organisms should substantiate current inferences regarding putative pathogenic effects of CCRs. The ramifications of the growing body of information on CCRs for clinical and experimental genetics and future treatment modalities are briefly illustrated with 2 cases, one of which suggests KDM4C(JMJD2C) as a novel candidate gene for mental retardation.
KW  - triplosufficiency
KW  - complex chromosome rearrangements
KW  - DNA double-strand break
KW  - haploinsufficiency
KW  - mixed mutation mechanisms
KW  - structural genome variations
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196524
SN  - 1661-8769
SN  - 1661-8777
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 6
IS  - 3
ER  - 
TY  - JOUR
A1  - Heinrich, T.
A1  - Nanda, I.
A1  - Rehn, M.
A1  - Zollner, U.
A1  - Frieauff, E.
A1  - Wirbelauer, J.
A1  - Grimm, T.
A1  - Schmid, M.
T1  - Live-Born Trisomy 22: Patient Report and Review
JF  - Molecular Syndromology
N2  - Trisomy 22 is a common trisomy in spontaneous abortions. In contrast, live-born trisomy 22 is rarely seen due to severe organ malformations associated with this condition. Here, we report on a male infant with complete, non-mosaic trisomy 22 born at 35 + 5 weeks via caesarean section. Peripheral blood lymphocytes and fibroblasts showed an additional chromosome 22 in all metaphases analyzed (47,XY,+22). In addition, array CGH confirmed complete trisomy 22. The patient’s clinical features included dolichocephalus, hypertelorism, flattened nasal bridge, dysplastic ears with preauricular sinuses and tags, medial cleft palate, anal atresia, and coronary hypospadias with scrotum bipartitum. Essential treatment was implemented in close coordination with the parents. The child died 29 days after birth due to respiratory insufficiency and deterioration of renal function. Our patient’s history complements other reports illustrating that children with complete trisomy 22 may survive until birth and beyond.
KW  - chromosomal abnormality
KW  - live-born
KW  - non-mosaic
KW  - trisomy 22
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196535
SN  - 1661-8769
SN  - 1661-8777
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 3
IS  - 6
ER  - 
TY  - JOUR
A1  - Almanzar, Giovanni
A1  - Klein, Matthias
A1  - Schmalzing, Marc
A1  - Hilligardt, Deborah
A1  - El Hajj, Nady
A1  - Kneitz, Hermann
A1  - Wild, Vanessa
A1  - Rosenwald, Andreas
A1  - Benoit, Sandrine
A1  - Hamm, Henning
A1  - Tony, Hans-Peter
A1  - Haaf, Thomas
A1  - Goebeler, Matthias
A1  - Prelog, Martina
T1  - Disease Manifestation and Inflammatory Activity as Modulators of Th17/Treg Balance and RORC/FoxP3 Methylation in Systemic Sclerosis
JF  - International Archives of Allergy and Immunology
N2  - Background: There is much evidence that T cells are strongly involved in the pathogenesis of localized and systemic forms of scleroderma (SSc). A dysbalance between FoxP3+ regulatory CD4+ T cells (Tregs) and inflammatory T-helper (Th) 17 cells has been suggested. Methods: The study aimed (1) to investigate the phenotypical and functional characteristics of Th17 and Tregs in SSc patients depending on disease manifestation (limited vs. diffuse cutaneous SSc, dcSSc) and activity, and (2) the transcriptional level and methylation status of Th17- and Treg-specific transcription factors. Results: There was a concurrent accumulation of circulating peripheral IL-17-producing CCR6+ Th cells and FoxP3+ Tregs in patients with dcSSc. At the transcriptional level, Th17- and Treg-associated transcription factors were elevated in SSc. A strong association with high circulating Th17 and Tregs was seen with early, active, and severe disease presentation. However, a diminished suppressive function on autologous lymphocytes was found in SSc-derived Tregs. Significant relative hypermethylation was seen at the gene level for RORC1 and RORC2 in SSc, particularly in patients with high inflammatory activity. Conclusions: Besides the high transcriptional activity of T cells, attributed to Treg or Th17 phenotype, in active SSc disease, Tregs may be insufficient to produce high amounts of IL-10 or to control proliferative activity of effector T cells in SSc. Our results suggest a high plasticity of Tregs strongly associated with the Th17 phenotype. Future directions may focus on enhancing Treg functions and stabilization of the Treg phenotype.
KW  - methylation
KW  - systemic sclerosis
KW  - suppression
KW  - Tregs
KW  - Th17
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196577
SN  - 1018-2438
SN  - 1423-0097
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 171
IS  - 2
ER  - 
TY  - JOUR
A1  - Matthies, Cordula
A1  - Brill, Stefan
A1  - Kaga, Kimitaka
A1  - Morita, Akio
A1  - Kumakawa, Kozo
A1  - Skarzynski, Henryk
A1  - Claassen, Andre
A1  - Hui, Yau
A1  - Chiong, Charlotte
A1  - Müller, Joachim
A1  - Behr, Robert
T1  - Auditory Brainstem Implantation Improves Speech Recognition in Neurofibromatosis Type II Patients
JF  - ORL
N2  - This prospective study aimed to determine speech understanding in neurofibromatosis type II (NF2) patients following implantation of a MED-EL COMBI 40+ auditory brainstem implant (ABI). Patients (n = 32) were enrolled postsurgically. Nonauditory side effects were evaluated at fitting and audiological performance was determined using the Sound Effects Recognition Test (SERT), Monosyllable-Trochee-Polysyllable (MTP) test and open-set sentence tests. Subjective benefits were determined by questionnaire. ABI activation was documented in 27 patients, 2 patients were too ill for testing and 3 patients were without any auditory perception. SERT and MTP outcomes under auditory-only conditions improved significantly between first fitting and 12-month follow-up. Open-set sentence recognition improved from 5% at first fitting to 37% after 12 months. The number of active electrodes had no significant effect on performance. All questionnaire respondents were ‘satisfied' to ‘very satisfied' with their ABI. An ABI is an effective treatment option in NF2 patients with the potential to provide open-set speech recognition and subjective benefits. To our knowledge, the data presented herein is exceptional in terms of the open-set speech perception achieved in NF2 patients.
KW  - acoustic neuroma
KW  - auditory brainstem implant
KW  - nonauditory side effects
KW  - open-set sentence recognition
KW  - subjective benefits
KW  - vestibular schwannoma
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196383
SN  - 0301-1569
SN  - 1423-0275
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 75
IS  - 5
ER  - 
TY  - JOUR
A1  - Müller, Joachim
A1  - Brill, Stefan
A1  - Hagen, Rudolf
A1  - Moeltner, Alexander
A1  - Brockmeier, Steffi-Johanna
A1  - Stark, Thomas
A1  - Helbig, Silke
A1  - Maurer, Jan
A1  - Zahnert, Thomas
A1  - Zierhofer, Clemens
A1  - Nopp, Peter
A1  - Anderson, Ilona
T1  - Clinical Trial Results with the MED-EL Fine Structure Processing Coding Strategy in Experienced Cochlear Implant Users
JF  - ORL
N2  - Objectives: To assess the subjective and objective performance of the new fine structure processing strategy (FSP) compared to the previous generation coding strategies CIS+ and HDCIS. Methods: Forty-six adults with a minimum of 6 months of cochlear implant experience were included. CIS+, HDCIS and FSP were compared in speech perception tests in noise, pitch scaling and questionnaires. The randomized tests were performed acutely (interval 1) and again after 3 months of FSP experience (interval 3). The subjective evaluation included questionnaire 1 at intervals 1 and 3, and questionnaire 2 at interval 2, 1 month after interval 1. Results: Comparison between FSP and CIS+ showed that FSP performed at least as well as CIS+ in all speech perception tests, and outperformed CIS+ in vowel and monosyllabic word discrimination. Comparison between FSP and HDCIS showed that both performed equally well in all speech perception tests. Pitch scaling showed that FSP performed at least as well as HDCIS. With FSP, sound quality was at least as good and often better than with HDCIS. Conclusions: Results indicate that FSP performs better than CIS+ in vowel and monosyllabic word understanding. Subjective evaluation demonstrates strong user preferences for FSP when listening to speech and music.
KW  - pitch
KW  - CIS+
KW  - OPUS
KW  - fine structure processing
KW  - cochlear implant
KW  - coding strategy
KW  - speech perception
KW  - music
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196396
SN  - 0301-1569
SN  - 1423-0275
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 74
IS  - 4
ER  - 
TY  - JOUR
A1  - Ono, Mitsuaki
A1  - Sonoyama, Wataru
A1  - Nema, Kazuki
A1  - Hara, Emilio Satoshi
A1  - Oida, Yasutaka
A1  - Pham, Hai Thanh
A1  - Yamamoto, Katushi
A1  - Hirota, Kazuo
A1  - Sugama, Kazushige
A1  - Sebald, Walter
A1  - Kuboki, Takuo
T1  - Regeneration of calvarial defects with Escherichia coli-derived rhBMP-2 adsorbed in PLGA membrane
JF  - Cells Tissues Organs
N2  - Objective: Escherichia coli-derived recombinant human bone morphogenetic protein-2 (E-BMP-2) has been shown to be as effective as mammalian cell-derived BMP-2. However, several in vitro and in vivo experiments are still necessary to validate the effectiveness of E-BMP-2 due to the difference in synthesis process, mainly related to protein nonglycosylation. The objective of this study was to investigate whether biodegradable polylactide-co-glycolide (PLGA) membrane is a suitable carrier for E-BMP-2 delivery for bone regeneration of critical-sized defects in rat calvaria. Materials and Methods: First, the osteoinductive effect of E-BMP-2 was confirmed in vitro in mouse bone marrow stromal cells by analysis of osteocalcin mRNA levels, and calcium deposition was detected by alizarin red staining. Before in vivo experiments, the release profile of E-BMP-2 from PLGA membranes was determined by ELISA. E-BMP-2 (0, 1, 5 and 10 μg/μl) was applied for ectopic and orthotopic bone formation and was analyzed by X-ray, micro-CT and histology. Results: Release-profile testing showed that PLGA membrane could retain 94% of the initially applied E-BMP-2. Ectopic bone formation assay revealed that combination of E-BMP-2/PLGA membrane strongly induced bone formation. Stronger osteoinductivity with complete repair of critical-sized defects was observed only with PLGA membranes adsorbed with 5 and 10 μg/μl of E-BMP-2, whereas no bone formation was observed in the groups that received no membrane or 0-μg/μl dose of E-BMP-2. Conclusion: PLGA membrane was shown to be a suitable carrier for sustained release of E-BMP-2, and the E-BMP-2/PLGA membrane combination was demonstrated to be efficient in bone regeneration in a model of critical-sized defects.
KW  - Escherichia coli-derived recombinant human bone morphogenetic protein-2
KW  - Bone regeneration
KW  - Polylactide-co-glycolide
KW  - Ectopic bone formation
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196680
SN  - 1422-6405
SN  - 1422-6421
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 198
IS  - 5
SP  - 367
EP  - 376
ER  - 
TY  - JOUR
A1  - Schmid, Michael
A1  - Steinlein, Claus
T1  - Chromosome Banding in Amphibia. XXXIV. Intrachromosomal Telomeric DNA Sequences in Anura
JF  - Cytogenetic and Genome Research
N2  - The mitotic chromosomes of 4 anuran species were examined by various classical banding techniques and by fluorescence in situ hybridization using a (TTAGGG)\(_n\) repeat. Large intrachromosomal telomeric sequences (ITSs) were demonstrated in differing numbers and chromosome locations. A detailed comparison of the present results with numerous published and unpublished data allowed a consistent classification of the various categories of large ITSs present in the genomes of anurans and other vertebrates. The classification takes into consideration the total numbers of large ITSs in the karyotypes, their chromosomal locations and their specific distribution patterns. A new category of large ITSs was recognized to exist in anuran species. It consists of large clusters of ITSs located in euchromatic chromosome segments, which is in clear contrast to the large ITSs in heterochromatic chromosome regions known in vertebrates. The origin of the different categories of large ITSs in heterochromatic and euchromatic chromosome regions, their mode of distribution in the karyotypes and evolutionary fixation in the genomes, as well as their cytological detection are discussed.
KW  - heterochromatin
KW  - intrachromosomal telomeric sequences
KW  - Anura
KW  - euchromatin
KW  - evolutionary fixation
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196693
SN  - 1424-8581
SN  - 1424-859X
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 148
IS  - 2-3
ER  - 
TY  - JOUR
A1  - Schmid, Michael
A1  - Steinlein, Claus
A1  - Lomb, Christian
A1  - Sperling, Karl
A1  - Neitzel, Heidemarie
T1  - 5-Methylcytosine-Rich Heterochromatin in the Indian Muntjac
JF  - Cytogenetic and Genome Research
N2  - Two 5-methylcytosine (5-MeC)-rich heterochromatic regions were demonstrated in metaphase chromosomes of the Indian muntjac by indirect immunofluorescence using a monoclonal anti-5-MeC antibody. The metaphases were obtained from diploid and triploid cell lines. A major region is located in the ‘neck' of the 3;X fusion chromosome and can be detected after denaturation of the chromosomal DNA with UV-light irradiation for 1 h. It is located exactly at the border of the X chromosome and the translocated autosome 3. A minor region is found in the centromeric region of the free autosome 3 after denaturing the chromosomal DNA for 3 h or longer. The structure and possible function of the major hypermethylated region as barrier against spreading of the X-inactivation process into the autosome 3 is discussed.
KW  - heterochromatin
KW  - immunofluorescence
KW  - Indian muntjac
KW  - 5-Methylcytosine
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196701
SN  - 1424-8581
SN  - 1424-859X
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 147
IS  - 4
ER  - 
TY  - JOUR
A1  - Schmid, Michael
A1  - Steinlein, Claus
A1  - Yano, Cassia F.
A1  - Cioffi, Marcelo B.
T1  - Hypermethylated Chromosome Regions in Nine Fish Species with Heteromorphic Sex Chromosomes
JF  - Cytogenetic and Genome Research
N2  - Sites and amounts of 5-methylcytosine (5-MeC)-rich chromosome regions were detected in the karyotypes of 9 Brazilian species of Characiformes fishes by indirect immunofluorescence using a monoclonal anti-5-MeC antibody. These species, belonging to the genera Leporinus, Triportheus and Hoplias, are characterized by highly differentiated and heteromorphic ZW and XY sex chromosomes. In all species, the hypermethylated regions are confined to constitutive heterochromatin. The number and chromosome locations of hypermethylated heterochromatic regions in the karyotypes are constant and species-specific. Generally, heterochromatic regions that are darkly stained by the C-banding technique are distinctly hypermethylated, but several of the brightly fluorescing hypermethylated regions merely exhibit moderate or faint C-banding. The ZW and XY sex chromosomes of all 9 analyzed species also show species-specific heterochromatin hypermethylation patterns. The analysis of 5-MeC-rich chromosome regions contributes valuable data for comparative cytogenetics of closely related species and highlights the dynamic process of differentiation operating in the repetitive DNA fraction of sex chromosomes.
KW  - heterochromatin
KW  - heteromorphic sex chromosomes
KW  - hypermethylation
KW  - immunofluorescence
KW  - 5-Methylcytosine
KW  - fish
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196710
SN  - 1424-8581
SN  - 1424-859X
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 147
IS  - 2-3
ER  - 
TY  - JOUR
A1  - Schmid, Michael
A1  - Steinlein, Claus
T1  - Chromosome Banding in Amphibia. XXXII. The Genus Xenopus (Anura, Pipidae)
JF  - Cytogenetic and Genome Research
N2  - Mitotic chromosomes of 16 species of the frog genus Xenopus were prepared from kidney and lung cell cultures. In the chromosomes of 7 species, high-resolution replication banding patterns could be induced by treating the cultures with 5-bromodeoxyuridine (BrdU) and deoxythymidine (dT) in succession, and in 6 of these species the BrdU/dT-banded chromosomes could be arranged into karyotypes. In the 3 species of the clade with 2n = 20 and 4n = 40 chromosomes (X. tropicalis, X. epitropicalis, X. new tetraploid 1), as well as in the 3 species with 4n = 36 chromosomes (X. laevis, X. borealis, X. muelleri), the BrdU/dT-banded karyotypes show a high degree of homoeology, though differences were detected between these groups. Translocations, inversions, insertions or sex-specific replication bands were not observed. Minor replication asynchronies found between chromosomes probably involve heterochromatic regions. BrdU/dT replication banding of Xenopus chromosomes provides the landmarks necessary for the exact physical mapping of genes and repetitive sequences. FISH with an X. laevis 5S rDNA probe detected multiple hybridization sites at or near the long-arm telomeric regions in most chromosomes of X. laevis and X. borealis, whereas in X. muelleri, the 5S rDNA sequences are located exclusively at the long-arm telomeres of a single chromosome pair. Staining with the AT base pair-specific fluorochrome quinacrine mustard revealed brightly fluorescing heterochromatic regions in the majority of X. borealis chromosomes which are absent in other Xenopus species.
KW  - X. laevis-type karyotype
KW  - X. tropicalis-type karyotype
KW  - BrdU/dT replication banding
KW  - chromosome staining
KW  - FISH
KW  - polyploidy
KW  - Xenopus
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196727
SN  - 1424-8581
SN  - 1424-859X
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 145
IS  - 3-4
ER  - 
TY  - JOUR
A1  - Schmid, Michael
A1  - Evans, Ben J.
A1  - Bogart, James P.
T1  - Polyploidy in Amphibia
JF  - Cytogenetic and Genome Research
N2  - This review summarizes the current status of the known extant genuine polyploid anuran and urodelan species, as well as spontaneously originated and/or experimentally produced amphibian polyploids. The mechanisms by which polyploids can originate, the meiotic pairing configurations, the diploidization processes operating in polyploid genomes, the phenomenon of hybridogenesis, and the relationship between polyploidization and sex chromosome evolution are discussed. The polyploid systems in some important amphibian taxa are described in more detail.
KW  - allopolyploidy
KW  - Anura
KW  - autopolyploidy
KW  - diploidization
KW  - hybridogenesis
KW  - polyploidization
KW  - sex chromosome evolution
KW  - Urodela
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196730
SN  - 1424-8581
SN  - 1424-859X
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 145
IS  - 3-4
ER  - 
TY  - JOUR
A1  - Matsuda, Yoichi
A1  - Uno, Yoshinobu
A1  - Kondo, Mariko
A1  - Gilchrist, Michael J.
A1  - Zorn, Aaron M.
A1  - Rokhsar, Daniel S.
A1  - Schmid, Michael
A1  - Taira, Masanori
T1  - A New Nomenclature of Xenopus laevis Chromosomes Based on the Phylogenetic Relationship to Silurana/Xenopus tropicalis
JF  - Cytogenetic and Genome Research
N2  - Xenopus laevis (XLA) is an allotetraploid species which appears to have undergone whole-genome duplication after the interspecific hybridization of 2 diploid species closely related to Silurana/Xenopus tropicalis (XTR). Previous cDNA fluorescence in situ hybridization (FISH) experiments have identified 9 sets of homoeologous chromosomes in X. laevis, in which 8 sets correspond to chromosomes 1-8 of X. tropicalis (XTR1-XTR8), and the last set corresponds to a fusion of XTR9 and XTR10. In addition, recent X. laevis genome sequencing and BAC-FISH experiments support this physiological relationship and show no gross chromosome translocation in the X. laevis karyotype. Therefore, for the benefit of both comparative cytogenetics and genome research, we here propose a new chromosome nomenclature for X. laevis based on the phylogenetic relationship and chromosome length, i.e. XLA1L, XLA1S, XLA2L, XLA2S, and so on, in which the numbering of XLA chromosomes corresponds to that in X. tropicalis and the postfixes ‘L' and ‘S' stand for ‘long' and ‘short' chromosomes in the homoeologous pairs, which can be distinguished cytologically by their relative size. The last chromosome set is named XLA9L and XLA9S, in which XLA9 corresponds to both XTR9 and XTR10, and hence, to emphasize the phylogenetic relationship to X. tropicalis, XLA9_10L and XLA9_10S are also used as synonyms.
KW  - BrdU replication banding pattern
KW  - homoeologous chromosomes
KW  - nomenclature
KW  - Xenopus laevis
KW  - Xenopus tropicalis
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196748
SN  - 1424-8581
SN  - 1424-859X
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 145
IS  - 3-4
ER  - 
TY  - JOUR
A1  - Schmid, Michael
A1  - Steinlein, Claus
A1  - Feichtinger, Wolfgang
A1  - Haaf, Thomas
A1  - Mijares-Urrutia, Abraham
A1  - Schargel, Walter E.
A1  - Hedges, S. Blair
T1  - Cytogenetic Studies on Gonatodes (Reptilia, Squamata, Sphaerodactylidae)
JF  - Cytogenetic and Genome Research
N2  - Mitotic and meiotic chromosomes of 5 species of the reptile genus Gonatodes are described by means of conventional staining, banding analyses and in situ hybridization using a synthetic telomeric DNA probe. The amount, location and fluorochrome affinities of constitutive heterochromatin, the number and positions of nucleolus organizer regions, and the patterns of telomeric DNA sequences were determined for most of the species. The karyotypes of G. falconensis and G. taniae from northern Venezuela are distinguished by their extraordinarily reduced diploid chromosome number of 2n = 16, which is the lowest value found so far in reptiles. In contrast to most other reptiles, both species have exclusively large biarmed (meta- and submetacentric) chromosomes. Comparison of the karyotypes of G. falconensis and G. taniae with those of other Gonatodes species indicates that the exceptional 2n = 16 karyotype originated by a series of 8 centric fusions. The karyotypes of G. falconensis and G. taniae are further characterized by the presence of considerable amounts of (TTAGGG)<sub>n</sub> telomeric sequences in the centromeric regions of all chromosomes. These are probably not only relics of the centric fusion events, but a component of the highly repetitive DNA in the constitutive heterochromatin of the chromosomes. The genome sizes of 4 Gonatodes species were determined using flow cytometry. For comparative purposes, all previously published cytogenetic data on Gonatodes and other sphaerodactylids are included and discussed.
KW  - banding analyses
KW  - FISH
KW  - geckos
KW  - karyotype evolution
KW  - meiotic chromosomes
KW  - mitotic chromosomes
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196753
SN  - 1424-8581
SN  - 1424-859X
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 144
IS  - 1
ER  - 
TY  - JOUR
A1  - Schmid, Michael
A1  - Steinlein, Claus
A1  - Feichtinger, Wolfgang
A1  - Bogart, James P.
T1  - Chromosome Banding in Amphibia. XXXI. The Neotropical Anuran Families Centrolenidae and Allophrynidae
JF  - Cytogenetic and Genome Research
N2  - The mitotic chromosomes of 11 species from the anuran families Centrolenidae and Allophrynidae were analyzed by means of conventional staining, banding techniques, and in situ hybridization. The amount, location, and fluorochrome affinities of constitutive heterochromatin, the number and positions of nucleolus organizer regions, and the patterns of telomeric DNA sequences were determined for most of the species. The karyotypes were found to be highly conserved with a low diploid chromosome number of 2n = 20 and morphologically similar chromosomes. The sister group relationship between the Centrolenidae and Allophrynidae (unranked taxon Allocentroleniae) is clearly corroborated by the cytogenetic data. The existence of heteromorphic XY♂/XX♀ sex chromosomes in an initial stage of morphological differentiation was confirmed in Vitreorana antisthenesi. The genome sizes of 4 centrolenid species were determined using flow cytometry. For completeness and for comparative purposes, all previously published cytogenetic data on centrolenids are included.
KW  - Allophrynidae
KW  - Anura
KW  - chromosome evolution
KW  - sex chromosomes
KW  - Centrolenidae
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196763
SN  - 1424-8581
SN  - 1424-859X
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 142
IS  - 4
ER  - 
TY  - JOUR
A1  - Focken, T.
A1  - Steinemann, D.
A1  - Skawran, B.
A1  - Hofmann, W.
A1  - Ahrens, P.
A1  - Arnold, N.
A1  - Kroll, P.
A1  - Kreipe, H.
A1  - Schlegelberger, B.
A1  - Gadzicki, D.
T1  - Human BRCA1-associated breast cancer: No increase in numerical chromosomal instability compared to sporadic tumors
JF  - Cytogenetic and Genome Research
N2  - BRCA1 is a major gatekeeper of genomic stability. Acting in multiple central processes like double-strand break repair, centrosome replication, and checkpoint control, BRCA1 participates in maintaining genomic integrity and protects the cell against genomic instability. Chromosomal instability (CIN) as part of genomic instability is an inherent characteristic of most solid tumors and is also involved in breast cancer development. In this study, we determined the extent of CIN in 32 breast cancer tumors of women with a BRCA1 germline mutation compared to 62 unselected breast cancers. We applied fluorescence in situ hybridization (FISH) with centromere-specific probes for the chromosomes 1, 7, 8, 10, 17, and X and locus-specific probes for 3q27 (BCL6), 5p15.2 (D5S23), 5q31 (EGR1), 10q23.3 (PTEN), and 14q32 (IGH@) on formalin-fixed paraffin-embedded tissue microarray sections. Our hypothesis of an increased level of CIN in BRCA1-associated breast cancer could not be confirmed by this approach. Surprisingly, we detected no significant difference in the extent of CIN in BRCA1-mutated versus sporadic tumors. The only exception was the CIN value for chromosome 1. Here, the extent of CIN was slightly higher in the group of sporadic tumors.
KW  - Hereditary breast cancer
KW  - BRCA1
KW  - Chromosomal instability
KW  - CIN
KW  - Fluorescence in situ hybridization
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196770
SN  - 1424-8581
SN  - 1424-859X
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 135
IS  - 2
SP  - 84
EP  - 92
ER  - 
TY  - JOUR
A1  - Hohmann, Cynthia
A1  - Pinart, Mariona
A1  - Tischer, Christina
A1  - Gehring, Ulrike
A1  - Heinrich, Joachim
A1  - Kull, Inger
A1  - Melén, Eric
A1  - Smit, Henriette A.
A1  - Torrent, Maties
A1  - Wijga, Alet H.
A1  - Wickman, Magnus
A1  - Bachert, Claus
A1  - Lødrup Carlsen, Karin C.
A1  - Carlsen, Kai-Håkon
A1  - Bindslev-Jensen, Carsten
A1  - Eller, Esben
A1  - Esplugues, Ana
A1  - Fantini, Maria Pia
A1  - Annesi-Maesano, Isabella
A1  - Momas, Isabelle
A1  - Porta, Daniela
A1  - Vassilaki, Maria
A1  - Waiblinger, Dagmar
A1  - Sunyer, Jordi
A1  - Antó, Josep M.
A1  - Bousquet, Jean
A1  - Keil, Thomas
T1  - The Development of the MeDALL Core Questionnaires for a Harmonized Follow-Up Assessment of Eleven European Birth Cohorts on Asthma and Allergies
JF  - International Archives of Allergy and Immunology
N2  - Background: Numerous birth cohorts have been initiated in the world over the past 30 years using heterogeneous methods to assess the incidence, course and risk factors of asthma and allergies. The aim of the present work is to provide the stepwise proceedings of the development and current version of the harmonized MeDALL-Core Questionnaire (MeDALL-CQ) used prospectively in 11 European birth cohorts. Methods: The harmonization of questions was accomplished in 4 steps: (i) collection of variables from 14 birth cohorts, (ii) consensus on questionnaire items, (iii) translation and back-translation of the harmonized English MeDALL-CQ into 8 other languages and (iv) implementation of the harmonized follow-up. Results: Three harmonized MeDALL-CQs (2 for parents of children aged 4-9 and 14-18, 1 for adolescents aged 14-18) were developed and used for a harmonized follow-up assessment of 11 European birth cohorts on asthma and allergies with over 13,000 children. Conclusions: The harmonized MeDALL follow-up produced more comparable data across different cohorts and countries in Europe and will offer the possibility to verify results of former cohort analyses. Thus, MeDALL can become the starting point to stringently plan, conduct and support future common asthma and allergy research initiatives in Europe.
KW  - harmonization
KW  - MeDALL
KW  - european birth cohorts
KW  - asthma
KW  - allergy
KW  - questionnaire assessment
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196594
SN  - 1018-2438
SN  - 1423-0097
VL  - 163
IS  - 3
ER  - 
TY  - JOUR
A1  - Prelog, Martina
T1  - Differential Approaches for Vaccination from Childhood to Old Age
JF  - Gerontology
N2  - Primary prevention strategies, such as vaccinations at the age extremes, in neonates and elderly individuals, demonstrate a challenge to health professionals and public health specialists. The aspects of the differentiation and maturation of the adaptive immune system, the functional implications of immunological immaturity or immunosenescence and its impact on vaccine immunogenicity and efficacy will be highlighted in this review. Several approaches have been undertaken to promote Th1 responses in neonates and to enhance immune functions in elderly, such as conjugation to carrier proteins, addition of adjuvants, concomitant vaccination with other vaccines, change in antigen concentrations or dose intervals or use of different administration routes. Also, early protection by maternal vaccination seems to be beneficial in neonates. However, it also appears necessary to think of other end points than antibody concentrations to assess vaccine efficacy in neonates or elderly, as also the cellular immune response may be impaired by the mechanisms of immaturity, underlying health conditions, immunosuppressive treatments or immunosenescence. Thus, lifespan vaccine programs should be implemented to all individuals on a population level not only to improve herd protection and to maintain protective antibody levels and immune memory, but also to cover all age groups, to protect unvaccinated elderly persons and to provide indirect protection for neonates and small infants.
KW  - immunosenescence
KW  - aging
KW  - T cells
KW  - B cells
KW  - immunization
KW  - vaccination
KW  - thymus
KW  - influenza
KW  - neonates
KW  - antibody
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196602
SN  - 0304-324X
SN  - 1423-0003
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 59
IS  - 3
ER  - 
TY  - JOUR
A1  - Vaiopoulos, Aristeidis G.
A1  - Kanakis, Meletios A.
A1  - Kapsimali, Violetta
A1  - Vaiopoulos, Georgios
A1  - Kaklamanis, Phedon G.
A1  - Zouboulis, Christos C.
T1  - Juvenile Adamantiades-Behçet disease
JF  - Dermatology
N2  - Adamantiades-Behçet disease (ABD) is a chronic, multisystemic, recurrent, inflammatory vascular disorder of unknown etiology. Patients with symptoms initially appearing at the age of 16 or less are considered as cases of juvenile-onset ABD (JABD). JABD is relatively rare compared to ABD of adults, and only case reports and case studies have been published regarding this subtype of the disease. Epidemiology, clinical features, diagnosis and treatment of JABD are discussed in this review.
KW  - Aphthae
KW  - Childhood
KW  - Epidemiological study
KW  - Genitoanal region
KW  - Adamantiades-Behçet disease
KW  - Behçet’s disease
KW  - Uveitis
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196616
SN  - 1018-8665
SN  - 1421-9832
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 232
IS  - 2
SP  - 129
EP  - 136
ER  - 
TY  - JOUR
A1  - Müller, P.A.
A1  - Bröcker, E.B.
A1  - Klinker, E.
A1  - Stoevesandt, J.
A1  - Benoit, S.
T1  - Adjuvant treatment of recalcitrant Bullous pemphigoid with immunoadsorption
JF  - Dermatology
N2  - Elimination of pathogenic autoantibodies by immunoadsorption (IA) has been described as an effective adjuvant treatment in severe bullous autoimmune diseases, especially in pemphigus. There is much less experience in the treatment of bullous pemphigoid (BP). BP was diagnosed in a 62-year-old Caucasian woman presenting a pruritic rash with multiple tense blisters. Standard treatments with topical and oral corticosteroids, steroid-sparing agents including dapsone, azathioprine, mycophenolate mofetil (MMF) and intravenous immunoglobulins were ineffective or had to be discontinued due to adverse events. An immediate clinical response could be achieved by two treatment cycles of adjuvant protein A immunoadsorption (PA-IA) in addition to continued treatment with MMF (2 g/day) and prednisolone (1 mg/kg/day). Tolerance was excellent. Clinical improvement remained stable after discontinuation of IA and went along with sustained reduction of circulating autoantibodies. Our data demonstrate that PA-IA might be a safe and effective adjuvant treatment in severe and recalcitrant BP.
KW  - Bullous pemphigoid
KW  - Immunoadsorption
KW  - Immunoapheresis
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196620
SN  - 1018-8665
SN  - 1421-9832
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 224
IS  - 3
SP  - 224
EP  - 227
ER  - 
TY  - JOUR
A1  - Grundmeier, Natalie
A1  - Hamm, Henning
A1  - Weissbrich, Benedikt
A1  - Lang, Sabrina Christine
A1  - Bröcker, Eva-Bettina
A1  - Kerstan, Andreas
T1  - High-risk human papillomavirus infection in Bowen’s disease of the nail unit: report of three cases and review of the literature
JF  - Dermatology
N2  - Background: Bowen’s disease (BD) of the nail unit is associated with human papillomavirus (HPV) infection. Objective: This study aimed to investigate the frequency of high-risk HPV infection, gender, age and digital distribution in this condition. 
Methods: Biopsy specimens of 3 consecutive cases with periungual BD were investigated for the presence of HPV DNA by in situ hybridization and by polymerase chain reaction (PCR). Furthermore, 74 cases of ungual BD conducted with HPV genotyping as reported in the literature were reviewed. 
Results: PCR of biopsy specimens revealed in 2 cases infection with HPV-16 and in 1 case with HPV-73. Additionally, in 1 HPV-16-positive case HPV-31/33 was detected by in situ hybridization. In line, review of the literature demonstrated a clear association of HPV-positive BD with high-risk HPV types. Interestingly, age at diagnosis was significantly lower in women. Whereas in both genders the second to fourth fingers on both hands were commonly diseased, only in men the thumbs were also prominently affected. 
Conclusions: Infection with high-risk HPV types is common in BD of the nail unit suggesting the aetiological cause. Therefore, patients and partners should be closely followed up for digital and genital HPV-associated lesions.
KW  - Nail unit
KW  - Human papillomavirus
KW  - Bowen’s disease, periungual
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196638
SN  - 1018-8665
SN  - 1421-9832
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 223
IS  - 4
SP  - 293
EP  - 300
ER  - 
TY  - JOUR
A1  - Abdullahi, Sahra
A1  - Wessel, Birgit
A1  - Huber, Martin
A1  - Wendleder, Anna
A1  - Roth, Achim
A1  - Kuenzer, Claudia
T1  - Estimating penetration-related X-band InSAR elevation bias: a study over the Greenland ice sheet
JF  - Remote Sensing
N2  - Accelerating melt on the Greenland ice sheet leads to dramatic changes at a global scale. Especially in the last decades, not only the monitoring, but also the quantification of these changes has gained considerably in importance. In this context, Interferometric Synthetic Aperture Radar (InSAR) systems complement existing data sources by their capability to acquire 3D information at high spatial resolution over large areas independent of weather conditions and illumination. However, penetration of the SAR signals into the snow and ice surface leads to a bias in measured height, which has to be corrected to obtain accurate elevation data. Therefore, this study purposes an easy transferable pixel-based approach for X-band penetration-related elevation bias estimation based on single-pass interferometric coherence and backscatter intensity which was performed at two test sites on the Northern Greenland ice sheet. In particular, the penetration bias was estimated using a multiple linear regression model based on TanDEM-X InSAR data and IceBridge laser-altimeter measurements to correct TanDEM-X Digital Elevation Model (DEM) scenes. Validation efforts yielded good agreement between observations and estimations with a coefficient of determination of R\(^2\) = 68% and an RMSE of 0.68 m. Furthermore, the study demonstrates the benefits of X-band penetration bias estimation within the application context of ice sheet elevation change detection.
KW  - InSAR height
KW  - penetration bias
KW  - cryosphere
KW  - TanDEM-X
KW  - Greenland ice sheet
KW  - DEM
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-193902
SN  - 2072-4292
VL  - 11
IS  - 24
ER  - 
TY  - JOUR
A1  - Kraft, Stephan
T1  - Wider den „Hauffen junger Schnautzhahnen“ : Grimmelshausens Versuch, die Erinnerung an den Dreißigjährigen Krieg in der Gegenwart festzuhalten
JF  - Internationales Archiv für Sozialgeschichte der deutschen Literatur
N2  - This paper retraces the specific conception of the ‘present’ as manifested in Satyrischer Pilgram, Grimmelshausen’s first published work. In the face of progressively vanishing consciousness of the past terrors of the Thirty Years’ War, the Pilgram devises a program for bringing the experience of a whole generation to the present, thereby saving it for the future. Instead of delivering a general reflection on the nature of war, it suggests to narrate individually experienced “particularities.” It is crucial that all of these experiences are negative, not meant to prompt imitation, but instead rather to build and keep up a stronghold against attitudes and actions of the past.
KW  - Grimmelshausen
KW  - Dreißigjähriger Krieg
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-193938
SN  - 1865-9128
SN  - 0340-4528
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 42
IS  - 1
ER  - 
TY  - JOUR
A1  - Beck, Lukas
T1  - Die Reform des Verbraucherschutzrechts
JF  - JURA - Juristische Ausbildung
N2  - Kein Abstract verfügbar.
KW  - Verbraucherschutzrecht
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-193956
SN  - 1612-7021
SN  - 0170-1452
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 36
IS  - 7
SP  - 666
EP  - 677
ER  - 
TY  - JOUR
A1  - Teichmann, Christoph
T1  - Die Auslandsgesellschaft & Co.
JF  - Zeitschrift für Unternehmens- und Gesellschaftsrecht
N2  - Kein Abstract verfügbar.
KW  - Auslandsgesellschaft
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-193984
SN  - 1612-7048
SN  - 0340-2479
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 43
IS  - 2-3
SP  - 220
EP  - 251
ER  - 
TY  - JOUR
A1  - Osmers, Maria
T1  - Zwischen Vergemeinschaftung und Anarchie. Zur Konzeption und Wahrnehmung polisübergreifender Beziehungen in klassischer Zeit
JF  - Klio
N2  - Der Artikel fragt zunächst nach Konzepten, die in klassischer Zeit von Außenpolitik existierten. Überlegungen zu diesem Thema sind in den antiken philosophischen Schriften greifbar, wobei Vorstellungen von der Funktionsweise des Oikos und der Polis auf den griechischen Raum übertragen wurden. Ähnliche Kategorien, um polisübergreifende Beziehungen zu beschreiben, griff die politische Rhetorik auf. Bezogen sich antike Autoren jedoch in allgemeinen Abhandlungen auf die Außenpolitik, wurde der Krieg als bestimmendes Element identifiziert. Das theoretische Konzept von Außenpolitik konnte demnach für die Zeitgenossen in der Praxis wenig Wirkung entfalten. Ursachen hierfür waren sowohl die unsteten Verhältnisse des 4. Jahrhunderts als auch die konkrete Konzeption der Außenpolitik, da die Interaktion im griechischen Raum anders funktionierte als in kleineren sozialen Einheiten. Zudem wurden real existierende Mechanismen zur Befriedung von Hellas nur unzureichend in die Konzeption integriert.
N2  - This paper explores Classical Greek concepts of what today is understood as foreign policy. In philosophical treatises, the matter is mainly conceived by transferring the idea of how oikos and polis functioned onto the field of inter-state relations. Similar notions were employed by political rhetoric to describe interaction between poleis. Yet, whenever literature makes reference to foreign policy in more general considerations, warfare is identified as the decisive element. In practice, the theoretical concept of foreign policy therefore could not be brought to any considerable effect. The causes for this lay in the unsteady conditions of the 4th century as well as in the very concept itself, because the interaction in the Greek world in its  entirety worked differently from the interaction in smaller social units. Further, the existing modes of pacifying Hellas only played an insuffient part in the concept.
KW  - griechische Antike
KW  - klassische Zeit
KW  - polisübergreifende Beziehungen
KW  - antike Wahrnehmungsmuster
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-193997
SN  - 2192-7669
SN  - 0075-6334
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 97
IS  - 1
SP  - 32-58
ER  - 
TY  - JOUR
A1  - Weber, Christoph
A1  - Gräf, Stephan
T1  - Eine halb so schlimme Täuschung
JF  - JURA - Juristische Ausbildung
N2  - Kein Abstract verfügbar.
KW  - Examensklausur
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-195484
SN  - 1612-7021
SN  - 0170-1452
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 36
IS  - 1
ER  - 
TY  - JOUR
A1  - Kiesler, Reinhard
T1  - Anja Overbeck / Wolfgang Schweickard / Harald Völker (edd.), Lexikon, Varietät, Philologie: Romanistische Studien. Günter Holtus zum 65. Geburtstag, Berlin, De Gruyter, 2011, XLIV + 824 p.
JF  - Zeitschrift für romanische Philologie
N2  - Kein Abstract verfügbar.
KW  - Rezension
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-195505
SN  - 1865-9063
SN  - 0049-8661
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 130
IS  - 4
SP  - 1165
EP  - 1170
ER  - 
TY  - JOUR
A1  - Kraschl, Dominikus
T1  - Franz von Kutschera  über ungegenständliche Erfahrungen  und ihre (religions-)philosophische Bedeutung
JF  - Neue Zeitschrift für Systematische Theologie und Religionsphilosophie
N2  - Zusammenfassung
Der Beitrag diskutiert im Anschluss an Franz von Kutschera die (religions-)philosophische und theologische Bedeutung ungegenständlicher Erfahrungen. Es handelt sich um Erfahrungen, die sich nicht oder nur bedingt als Erfahrungen eines Subjekts von einem Objekt beschreiben lassen. Besonders in den Blick genommen wird die Relevanz ungegenständlicher Erfahrungen sowohl für die Semantik religiöser Rede als auch für die Epistemologie religiöser Überzeugungen. In diesem Zusammenhang wird argumentiert, dass die kognitive Relevanz dieser Erfahrungen davon abhängt, ob sie innerhalb eines weltanschaulichen Paradigmas einen Beitrag zu einem kohärenten und umfassenden Verständnis der uns begegnenden Wirklichkeit leisten.
KW  - Franz von Kutschera
KW  - ungegenständliche Erfahrungen
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-195533
SN  - 0028-3517
SN  - 1612-9520
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 56
IS  - 4
SP  - 422
EP  - 440
ER  - 
TY  - JOUR
A1  - Reber, Elisabeth
T1  - Constructing evidence at Prime Minister's Question Time: An analysis of the grammar, semantics and pragmatics of the verb see
JF  - Intercultural Pragmatics
N2  - Abstract
Constructing evidence constitutes a practice to establish the speaker's authority at Prime Minister's Question Time (PMQT), a weekly half-hour session in the British House of Commons. Here the verb see constitutes a resource for both the questioning Leader of the Opposition (LO) and Members of Parliament (MP) as well as for the responding Prime Minister (PM) to claim first-hand perceptual experience. This paper takes an integrated approach, offering a combined analysis of the grammatical formatting, semantics and pragmatics of the verb see in the context of evidential moves at PMQT. It shows how the verb see is functional in referring to the perceptual basis of a claim made and how its grammatical formatting is reflective of the contingencies of the local interactional context. The analysis is grounded in 32 sessions of PMQT (ca. 16 hrs of video-recordings). The results can be summarised as follows: 1) The evidential function of the verb is achieved through its context-specific grammatical formatting and semantics. 2) The reference to the perceptual basis of a claim evoked by see may co-occur with epistemic qualification and evaluative expressions. 3) The formatting of the verb may be indexical of the political relationship between the questioner and the responding PM.
KW  - parliamentary interaction
KW  - perception
KW  - evidentiality
KW  - epistemic modality
KW  - see
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-195549
SN  - 1613-365X
SN  - 1612-295X
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 11
IS  - 3
SP  - 357
EP  - 387
ER  - 
TY  - JOUR
A1  - Kiesler, Reinhard
T1  - Pour une typologie des phrases complexes
JF  - Zeitschrift für romanische Philologie
N2  - AbstractUne tradition grammaticale largement répandue distingue trois types de relations entre propositions, donc trois types de phrases complexes: les propositions juxtaposées, les propositions coordonnées et les phrases hypotaxiques. Riegel et al. (2009) ajoutent en outre les phrases avec incise ou incidente comme quatrième type. Les grammaires et traités décrivent les différentes sortes de coordination (copulative, disjonctive, adversative, causale et consécutive) et de subordination (complétive, relative et circonstancielle). Pourtant, jusqu’à présent il n’existe pas, à ce qu’il semble, de description plus détaillée, ni des divers degrés de l’hypotaxe et de la parataxe d’une part, ni des différentes combinaisons de structures hypotaxiques et parataxiques d’autre part. Le but de cet article est donc de proposer une typologie plus complète des phrases complexes sur la base d’un petit corpus de référence. Cette typologie distinguera, d’un côté, divers degrés de phrases parataxiques homogènes et de phrases parataxiques hétérogènes et, de l’autre côté, des phrases hypotaxiques simples et des phrases hypotaxiques multiples.
KW  - parataxe
KW  - hypotaxe
KW  - phrase complexe
KW  - relations entre propositions
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-195562
SN  - 1865-9063
SN  - 0049-8661
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 129
IS  - 3
SP  - 608
EP  - 628
ER  - 
TY  - JOUR
A1  - Beck, Lukas
T1  - Positive Publizität des Handelsregisters gem. § 15 Abs. 3 HGB
JF  - JURA - Juristische Ausbildung
N2  - Kein Abstract verfügbar.
KW  - Rechtsprechung
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-195229
SN  - 1612-7021
SN  - 0170-1452
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 36
IS  - 5
ER  - 
TY  - JOUR
A1  - Aurast, Anna
A1  - Gradl, Tobias
A1  - Pernes, Stefan
A1  - Pielström, Steffen
T1  - Big Data und Smart Data in den Geisteswissenschaften
JF  - Bibliothek Forschung und Praxis
N2  - Kein Abstract verfügbar.
KW  - Textanalyse
KW  - unstrukturierte Daten
KW  - Natural Language Processing
KW  - Text analysis
KW  - unstructured data
KW  - natural language processing
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-195237
SN  - 1865-7648
SN  - 0341-4183
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 40
IS  - 2
ER  - 
TY  - JOUR
A1  - Laubenthal, Klaus
T1  - Strafvollzug
JF  - Zeitschrift für die gesamte Strafrechtswissenschaft
N2  - Kein Abstract verfügbar.
KW  - Strafvollzug
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-195349
SN  - 1612-703X
SN  - 0084-5310
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 127
IS  - 4
ER  - 
TY  - JOUR
A1  - Dannecker, Christoph
T1  - Der nemo tenetur-Grundsatz – prozessuale Fundierung und Geltung für juristische Personen
JF  - Zeitschrift für die gesamte Strafrechtswissenschaft
N2  - Kein Abstract verfügbar.
KW  - nemo tenetur-Grundsatz
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-195368
SN  - 1612-703X
SN  - 0084-5310
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 127
IS  - 2
ER  - 
TY  - JOUR
A1  - Schmidt, Rainer F.
T1  - „Revanche pour Sedan“ – Frankreich und der Schlieffenplan. Militärische und bündnispolitische Vorbereitung des Ersten Weltkriegs
JF  - Historische Zeitschrift
N2  - In der mehr als einhundertjährigen Debatte über die Gründe und die Verantwortung für den Ausbruch des Ersten Weltkrieges blieb ein wesentlicher Faktor bislang unberücksichtigt: die französische Detailkenntnis des Schlieffenplans. Der Beitrag entwickelt die These, dass dieses Wissen um das seit 1913 alternativlose militärische Vorgehen des Deutschen Reiches sowie die sich hieraus ergebenden Handlungszwänge für Berlin zum Kompassbuch der Außen- und Militärpolitik Frankreichs vor dem Kriegsbeginn wurde. Als Ministerpräsident und als Staatspräsident verfolgte Poincaré eine Kriegsvorbereitungs- und Erpressungspolitik gegenüber Berlin. Sie sollte nicht nur die Sicherheit Frankreichs vor Deutschland verbürgen. Ihr Ziel und ihre Perspektive waren vielmehr die einer Revanche für 1870/71, um, analog zu Bismarcks Vorgehen in der „Hohenzollernkrise“, die Berliner Reichsleitung in eine Situation zu manövrieren, in der sich diese zur Flucht nach vorne in die Kriegsauslösung entschloss. Deshalb wurde die Entente Cordiale mit England zu einem de facto-Militärbündnis ausgebaut; deshalb agierte Poincaré als Geburtshelfer der Unterhandlungen für eine Marinekonvention zwischen London und Petersburg; und deshalb gab er der Pariser Balkanpolitik eine neue Ausrichtung, indem er die seit 1893/94 bestehende Beistandsautomatik gegenüber Rußland grundlegend modifizierte. Jetzt wurden die russischen Expansionsziele auf dem Balkan als handlungsleitendes Motiv der Pariser Politik adoptiert; jetzt wurde Petersburg angespornt, gegen Wien offensiv aufzutreten; jetzt bekamen die russischen Entscheidungsträger, anders als noch in der „bosnischen Annexionskrise“, die Versicherung uneingeschränkten französischen Beistands auf dem Balkan; und jetzt wurde mit Petersburg ein mit Anleihen unterfüttertes Kompensationsgeschäft abgeschlossen, das sich sowohl diplomatisch wie vor allem militärisch gegen Deutschland richtete und die Prämissen des Schlieffenplans zunehmend aushebelte. All diese Vorkehrungen dienten dazu, die Unzulänglichkeiten der eigenen militärstrategischen Aufstellung gemäß „Plan XVII“ auszubalancieren, die offene belgische Flanke abzudichten, die eminenten Bedenken der eigenen Generalität zu zerstreuen und Frankreich in einem Krieg an der Seite Russlands und Englands eine Siegchance zu verschaffen. Vor allem aber erfüllten sie den Zweck, Deutschland herauszufordern und unter enormen Handlungsdruck zu setzen. Die von Poincaré angeheizten Einkreisungsphobien in der deutschen Führungsspitze ebneten somit Berlin den Weg in die hochriskante und nicht beherrschbare Konfrontations- und Risikopolitik der „Julikrise“. Poincarés Kalkül erfüllt den Tatbestand einer indirekten Kriegsentfesselung.
KW  - Connectivity
KW  - World War I
KW  - Kriegspolitik
KW  - Kriegsvorbereitung
KW  - Entente Cordiale
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-195379
SN  - 2196-680X
SN  - 0018-2613
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 303
IS  - 2
ER  - 
TY  - JOUR
A1  - Soder, Lisa
T1  - An den Grenzen der Pragmatik
JF  - Zeitschrift für germanistische Linguistik
N2  - Kein Abstract verfügbar.
KW  - Arbeitsgemeinschaft Linguistische Pragmatik
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-195413
SN  - 1613-0626
SN  - 0301-3294
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 45
IS  - 3
ER  - 
TY  - JOUR
A1  - Shehata, Dahlia
T1  - Eine mannshohe Leier im altbabylonischen Ištar-Ritual aus Mari (FM 3, no. 2)
JF  - Altorientalische Forschungen
N2  - The Old Babylonian Ištar ritual from Mari (FM 3, no. 2) has been the focus of much discussion since its primary edition in 1938 by G. Dossin. This article offers a new analysis of the passage mentioning the balaĝ-deity Ninigizibara, which leads to identifying this balaĝ as a huge upright lyre as tall as a human played by two persons from both sides. Similar musical instruments are known from Anatolia and Egypt. Especially the Egyptian examples, which are attested only for the time of Echnaton, show striking parallels to the musical performance described in the Old Babylonian Ištar ritual. After discussing the possible background of cultural exchange, this article closes with a revaluation and new interpretation of the term balaĝ.
KW  - Musical instrument
KW  - lyre
KW  - Ištar ritual
KW  - balaĝ-deity
KW  - Ninigizibara
KW  - Echnaton
KW  - İnandık
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-195422
SN  - 2196-6761
SN  - 0232-8461
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 44
IS  - 1
ER  - 
TY  - JOUR
A1  - Essler, Holger
T1  - Phylenzahl und Phylenzyklus in Hermupolis und Oxyrhynchos
JF  - Archiv für Papyrusforschung und verwandte Gebiete
N2  - While the tribal cycles in Oxyrhynchos are fairly well attested from AD 206 until 271, no system has been proposed for other periods or other metropoleis. On the basis of recently published texts a first attempt is made to reconstruct the tribal cycles in Oxyrhynchus and Hermopolis for the later part of the 4th century.
KW  - Hermopolis
KW  - Oxyrhynchos
KW  - tribes
KW  - liturgy
KW  - administration
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-195465
SN  - 1867-1551
SN  - 0066-6459
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 62
IS  - 1
ER  - 
TY  - JOUR
A1  - Verma, Pramod Kumar
A1  - Steinbacher, Andreas
A1  - Schmiedel, Alexander
A1  - Nuernberger, Patrick
A1  - Brixner, Tobias
T1  - Excited-state intramolecular proton transfer of 2-acetylindan-1,3-dione studied by ultrafast absorption and fluorescence spectroscopy
JF  - Structural Dynamics
N2  - We employ transient absorption from the deep-UV to the visible region and fluorescence upconversion to investigate the photoinduced excited-state intramolecular proton-transfer dynamics in a biologically relevant drug molecule, 2-acetylindan-1,3-dione. The molecule is a ß-diketone which in the electronic ground state exists as exocyclic enol with an intramolecular H-bond. Upon electronic excitation at 300 nm, the first excited state of the exocyclic enol is initially populated, followed by ultrafast proton transfer (≈160 fs) to form the vibrationally hot endocyclic enol. Subsequently, solvent-induced vibrational relaxation takes place (≈10 ps) followed by decay (≈390 ps) to the corresponding ground state.
KW  - time resolved spectroscopy
KW  - ground states
KW  - fluorescence spectra
KW  - absorption spectra
KW  - ultraviolet light
KW  - hydrogen bonding
KW  - excited states
KW  - reaction mechanisms
KW  - fluorescence
KW  - solvents
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-181301
VL  - 3
ER  - 
TY  - JOUR
A1  - Gallo, Lorenzo
T1  - Nomenclatural adjustments and typifications in the genus Phedimus (Crassulaceae)
JF  - Forum Geobotanicum
N2  - This paper deals with the taxonomical position and the nomenclature of two taxa belonging to the genus Sedum (Crassulaceae), today treated as Phedimus, namely Sedum middendorffianum Maxim var. diffusum Praeger and Sedum oppositifolium Sims. The correct taxonomical application of names is based on the nomenclatural types designated here.
KW  - lectotype
KW  - neotype
KW  - Phedimus middendorffianus, var. diffusus
KW  - Phedimus spurius subsp. oppositifolius
KW  - Sedum oppositifolium
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-206347
UR  - http://www.forum-geobotanicum.net/articles/vol_9-2020/gallo-phedimus/gallo-phedimus.pdf
SN  - 1867-9315
VL  - 9
ER  - 
TY  - JOUR
A1  - Orouji, Elias
A1  - Peitsch, Wiebke K.
A1  - Orouji, Azadeh
A1  - Houben, Roland
A1  - Utikal, Jochen
T1  - Unique role of histone methyltransferase PRDM8 in the tumorigenesis of virus-negative Merkel cell carcinoma
JF  - Cancers
N2  - Merkel cell carcinoma (MCC) is a deadly skin cancer, and about 80% of its cases have been shown to harbor integrated Merkel polyomavirus in the tumor cell genome. Viral oncoproteins expressed in the tumor cells are considered as the oncogenic factors of these virus-positive Merkel cell carcinoma (VP-MCC). In contrast, the molecular pathogenesis of virus-negative MCC (VN-MCC) is less well understood. Using gene expression analysis of MCC cell lines, we found histone methyltransferase PRDM8 to be elevated in VN-MCC. This finding was confirmed by immunohistochemical analysis of MCC tumors, revealing that increased PRDM8 expression in VN-MCC is also associated with increased H3K9 methylation. CRISPR-mediated silencing of PRDM8 in MCC cells further supported the histone methylating role of this protein in VN-MCC. We also identified miR-20a-5p as a negative regulator of PRDM8. Taken together, our findings provide insights into the role of PRDM8 as a histone methyltransferase in VN-MCC tumorigenesis.
KW  - histone
KW  - histone methyltransferase PRDM8
KW  - chromatin regulator
KW  - EGR1
KW  - miRNA
KW  - MCV-negative
KW  - Merkel cell carcinoma
KW  - MCPyV
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-203815
SN  - 2072-6694
VL  - 12
IS  - 4
ER  - 
TY  - JOUR
A1  - Beer, Katharina
A1  - Schenk, Mariela
A1  - Helfrich-Förster, Charlotte
A1  - Holzschuh, Andrea
T1  - The circadian clock uses different environmental time cues to synchronize emergence and locomotion of the solitary bee Osmia bicornis
JF  - Scientific Reports
N2  - Life on earth adapted to the daily reoccurring changes in environment by evolving an endogenous circadian clock. Although the circadian clock has a crucial impact on survival and behavior of solitary bees, many aspects of solitary bee clock mechanisms remain unknown. Our study is the first to show that the circadian clock governs emergence in Osmia bicornis, a bee species which overwinters as adult inside its cocoon. Therefore, its eclosion from the pupal case is separated by an interjacent diapause from its emergence in spring. We show that this bee species synchronizes its emergence to the morning. The daily rhythms of emergence are triggered by temperature cycles but not by light cycles. In contrast to this, the bee’s daily rhythms in locomotion are synchronized by light cycles. Thus, we show that the circadian clock of O. bicornis is set by either temperature or light, depending on what activity is timed. Light is a valuable cue for setting the circadian clock when bees have left the nest. However, for pre-emerged bees, temperature is the most important cue, which may represent an evolutionary adaptation of the circadian system to the cavity-nesting life style of O. bicornis.
KW  - Behavioural ecology
KW  - Evolutionary developmental biology
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-202721
VL  - 9
ER  - 
TY  - JOUR
A1  - Maierhofer, Anna
A1  - Flunkert, Julia
A1  - Oshima, Junko
A1  - Martin, George M.
A1  - Poot, Martin
A1  - Nanda, Indrajit
A1  - Dittrich, Marcus
A1  - Müller, Tobias
A1  - Haaf, Thomas
T1  - Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes
JF  - Aging Cell
N2  - Werner Syndrome (WS) is an adult‐onset segmental progeroid syndrome. Bisulfite pyrosequencing of repetitive DNA families revealed comparable blood DNA methylation levels between classical (18 WRN‐mutant) or atypical WS (3 LMNA‐mutant and 3 POLD1‐mutant) patients and age‐ and sex‐matched controls. WS was not associated with either age‐related accelerated global losses of ALU, LINE1, and α‐satellite DNA methylations or gains of rDNA methylation. Single CpG methylation was analyzed with Infinium MethylationEPIC arrays. In a correspondence analysis, atypical WS samples clustered together with the controls and were clearly separated from classical WS, consistent with distinct epigenetic pathologies. In classical WS, we identified 659 differentially methylated regions (DMRs) comprising 3,656 CpG sites and 613 RefSeq genes. The top DMR was located in the HOXA4 promoter. Additional DMR genes included LMNA, POLD1, and 132 genes which have been reported to be differentially expressed in WRN‐mutant/depleted cells. DMRs were enriched in genes with molecular functions linked to transcription factor activity and sequence‐specific DNA binding to promoters transcribed by RNA polymerase II. We propose that transcriptional misregulation of downstream genes by the absence of WRN protein contributes to the variable premature aging phenotypes of WS. There were no CpG sites showing significant differences in DNA methylation changes with age between WS patients and controls. Genes with both WS‐ and age‐related methylation changes exhibited a constant offset of methylation between WRN‐mutant patients and controls across the entire analyzed age range. WS‐specific epigenetic signatures occur early in life and do not simply reflect an acceleration of normal epigenetic aging processes.
KW  - (classical and atypical) Werner syndrome
KW  - bisulfite pyrosequencing
KW  - methylation array
KW  - premature aging
KW  - segmental progeria
KW  - transcription deficiency
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-202733
VL  - 18
ER  - 
TY  - JOUR
A1  - Fayez, Shaimaa
A1  - Feineis, Doris
A1  - Aké Assi, Laurent
A1  - Seo, Ean-Jeong
A1  - Efferth, Thomas
A1  - Bringmann, Gerhard
T1  - Ancistrobreveines A–D and related dehydrogenated naphthylisoquinoline alkaloids with antiproliferative activities against leukemia cells, from the West African liana Ancistrocladus abbreviatus
JF  - RSC Advances
N2  - A unique series of six biaryl natural products displaying four different coupling types (5,10 , 7,10 , 7,80 , and 5,80) were isolated from the roots of the West African liana Ancistrocladus abbreviatus (Ancistrocladaceae). Although at first sight structurally diverse, these secondary metabolites all have in common that they belong to the rare group of naphthylisoquinoline alkaloids with a fully dehydrogenated isoquinoline portion. Among the African Ancistrocladus species, A. abbreviatus is so far only the second one that was found to produce compounds with such a molecular entity. Here, we report on four new representatives, named ancistrobreveines A–D (12–14, and 6). They were identified along with the two known alkaloids 6-O-methylhamateine (4) and entdioncophylleine A (10). The two latter naphthylisoquinolines had so far only been detected in Ancistrocladus species from Southeast Asia. All of these fully dehydrogenated alkaloids have in common being optically active despite the absence of stereogenic centers, due to the presence of the rotationally hindered biaryl axis as the only element of chirality. Except for ent-dioncophylleine A (10), which lacks an oxygen function at C-6, the ancistrobreveines A–D (12–14, and 6) and 6-O-methylhamateine (4) are 6-oxygenated alkaloids, and are, thus, typical ‘Ancistrocladaceae-type’ compounds. Ancistrobreveine C (14), is the first – and so far only – example of a 7,80-linked fully dehydrogenated naphthylisoquinoline discovered in nature that is configurationally stable at the biaryl axis. The stereostructures of the new alkaloids were established by spectroscopic (in particular HRESIMS, 1D and 2D NMR) and chiroptical (electronic circular dichroism) methods. Ancistrobreveine C (14) and 6-O-methylhamateine (4) exhibited strong antiproliferative activities against drug-sensitive acute lymphoblastic CCRF-CEM leukemia cells and their multidrugresistant subline, CEM/ADR5000.
KW  - chemistry
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-201686
VL  - 9
IS  - 28
ER  - 
TY  - JOUR
A1  - Trappe, Julian
A1  - Kneisel, Christof
T1  - Geophysical and sedimentological investigations of Peatlands for the assessment of lithology and subsurface water pathways
JF  - Geosciences
N2  - Peatlands located on slopes (herein called slope bogs) are typical landscape units in the Hunsrueck, a low mountain range in Southwestern Germany. The pathways of the water feeding the slope bogs have not yet been documented and analyzed. The identification of the different mechanisms allowing these peatlands to originate and survive requires a better understanding of the subsurface lithology and hydrogeology. Hence, we applied a multi-method approach to two case study sites in order to characterize the subsurface lithology and to image the variable spatio-temporal hydrological conditions. The combination of Electrical Resistivity Tomography (ERT) and an ERT-Monitoring and Ground Penetrating Radar (GPR), in conjunction with direct methods and data (borehole drilling and meteorological data), allowed us to gain deeper insights into the subsurface characteristics and dynamics of the peatlands and their catchment area. The precipitation influences the hydrology of the peatlands as well as the interflow in the subsurface. Especially, the geoelectrical monitoring data, in combination with the precipitation and temperature data, indicate that there are several forces driving the hydrology and hydrogeology of the peatlands. While the water content of the uppermost layers changes with the weather conditions, the bottom layer seems to be more stable and changes to a lesser extent. At the selected case study sites, small differences in subsurface properties can have a huge impact on the subsurface hydrogeology and the water paths. Based on the collected data, conceptual models have been deduced for the two case study sites.
KW  - peatland
KW  - slope bogs
KW  - geomorphology
KW  - subsurface hydrology
KW  - electrical resistivity tomography
KW  - ground penetrating radar
KW  - boreholes
KW  - Hunsrueck
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-201699
VL  - 9
IS  - 3
ER  - 
TY  - JOUR
A1  - Schuler, Michael
A1  - Murauer, Kathrin
A1  - Stangl, Stephanie
A1  - Grau, Anna
A1  - Gabriel, Katharina
A1  - Podger, Lauren
A1  - Heuschmann, Peter U.
A1  - Faller, Hermann
T1  - Pre-post changes in main outcomes of medical rehabilitation in Germany: protocol of a systematic review and meta-analysis of individual participant and aggregated data
JF  - BMJ Open
N2  - Introduction 
Multidisciplinary, complex rehabilitation interventions are an important part of the treatment of chronic diseases. However, little is known about the effectiveness of routine rehabilitation interventions within the German healthcare system. Due to the nature of the social insurance system in Germany, randomised controlled trials examining the effects of rehabilitation interventions are challenging to implement and scarcely accessible. Consequently, alternative pre-post designs can be employed to assess pre-post effects of medical rehabilitation programmes. We present a protocol of systematic review and meta-analysis methods to assess the pre-post effects of rehabilitation interventions in Germany.

Methods and analysis 
The respective study will be conducted within the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. A systematic literature review will be conducted to identify studies reporting the pre-post effects (start of intervention vs end of intervention or later) in German healthcare. Studies investigating the following disease groups will be included: orthopaedics, rheumatology, oncology, pulmonology, cardiology, endocrinology, gastroenterology and psychosomatics. The primary outcomes of interest are physical/mental quality of life, physical functioning and social participation for all disease groups as well as pain (orthopaedic and rheumatologic patients only), blood pressure (cardiac patients only), asthma control (patients with asthma only), dyspnoea (patients with chronic obstructive pulmonary disease only) and depression/anxiety (psychosomatic patients only). We will invite the principal investigators of the identified studies to provide additional individual patient data. We aim to perform the meta-analyses using individual patient data as well as aggregate data. We will examine the effects of both study-level and patient-level moderators by using a meta-regression method.

Ethics and dissemination 
Only studies that have received institutional approval from an ethics committee and present anonymised individual patient data will be included in the meta-analysis. The results will be presented in a peer-reviewed publication and at research conferences. A declaration of no objection by the ethics committee of the University of Würzburg is available (number 20180411 01).
KW  - medical rehabilitation
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-201929
VL  - 9
IS  - 5
ER  - 
TY  - JOUR
A1  - Mufusama, Jean-Pierre
A1  - Feineis, Doris
A1  - Mudogo, Virima
A1  - Kaiser, Marcel
A1  - Brun, Reto
A1  - Bringmann, Gerhard
T1  - Antiprotozoal dimeric naphthylisoquinolines, mbandakamines B\(_3\) and B\(_4\), and related 5,8′-coupled monomeric alkaloids, ikelacongolines A–D, from a Congolese Ancistrocladus liana
JF  - RSC Advances
N2  - From the leaves of a botanically and phytochemically as yet unexplored Ancistrocladus liana discovered in the rainforests of the Central region of the Democratic Republic of the Congo in the vicinity of the town of Ikela, six new naphthylisoquinoline alkaloids were isolated, viz., two constitutionally unsymmetric dimers, the mbandakamines B\(_3\) (3) and B\(_4\) (4), and four related 5,8′-linked monomeric alkaloids, named ikelacongolines A–D (5a, 5b, 6, and 7). The dimers 3 and 4 are structurally unusual quateraryls comprising two 5,8′-coupled monomers linked via a sterically strongly constrained 6′,1′′-connection between their naphthalene units. These compounds contain seven elements of chirality, four stereogenic centers and three consecutive chiral axes. They were identified along with two known related compounds, the mbandakamines A (1) and B\(_2\) (2), which had so far only been detected in two Ancistrocladus species indigenous to the Northwestern Congo Basin. In addition, five known monomeric alkaloids, previously found in related Central African Ancistrocladus species, were isolated from the here investigated Congolese liana, three of them belonging to the subclass of 5,8′-coupled naphthylisoquinoline alkaloids, whereas two compounds exhibited a less frequently occurring 7,8′-biaryl linkage. The stereostructures of the new alkaloids were established by spectroscopic (in particular HRESIMS, 1D and 2D NMR), chemical (oxidative degradation), and chiroptical (electronic circular dichroism) methods. The mbandakamines B\(_3\) (3) and B\(_4\) (4) displayed pronounced activities in vitro against the malaria parasite Plasmodium falciparum and the pathogen of African sleeping sickness, Trypanosoma brucei rhodesiense.
KW  - chemistry
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-201141
VL  - 9
IS  - 21
ER  - 
TY  - JOUR
A1  - Ebner, Katharina
A1  - Ostheimer, Jochen
A1  - Sautermeister, Jochen
T1  - The role of religious beliefs for the acceptance of xenotransplantation. Exploring dimensions of xenotransplantation in the field of hospital chaplaincy
JF  - Xenotransplantation
N2  - Background
The Changsha Communiqué (2008) calls for a greater account to be taken of the ethical aspects of xenotransplantation as well as of public perception. This also applies to the field of hospital chaplaincy. So far, there has been no empirical exploration of the assessment and acceptance of xenotransplantation by pastoral workers in German‐speaking countries. In view of the prospect of clinical trials, in‐depth research is both sensible and necessary, since both xeno‐ and allotransplantation can have far‐reaching consequences for patients, their relatives, and the social environment. In addition to the tasks of health monitoring, questions of the individual handling with and integration of a xenotransplant must also be considered. They can affect one's own identity and self‐image and thus also affect religious dimensions. Hence, they make a comprehensive range of accompaniment necessary.

Methods
This paper presents the first explorative results of a Dialogue Board with Christian, Jewish, and Muslim hospital chaplains. It explores pastoral challenges of xenotransplantation for the German‐speaking countries, in particular (a) self‐image and tasks of hospital pastoral care, (b) religious aspects of transplantation, and (c) religious aspects of xenotransplantation as anticipated by the hospital pastors.

Results
Depending on their religious background, hospital chaplains see different pastoral challenges when xenotransplantation reaches clinical stage. In particular, the effects on the identity and religious self‐image of those affected must be taken into account. Three desiderata or recommendations for action emerged from the Dialogue Board: (a) initial, advanced and further training for hospital pastoral workers, (b) contact points for patients, and (c) interreligious cooperation and a joint statement. All participants of the Dialogue Board emphasized the chances of xenotransplantation and expressed their hope that xenogenic transplants could save patients or improve the quality of their life substantially.

Conclusions
Xenotransplantation can affect the identity work of patients and relatives also in religious terms. In order to provide better pastoral and psychosocial support for these persons within the framework of the hospital, it is important to reflect on such challenges at an early stage and to develop concepts for pastoral further training and pastoral care in xenotransplantation.
KW  - Christianity
KW  - Dialogue Board
KW  - hospital chaplaincy
KW  - Islam
KW  - Judaism
KW  - pastoral care
KW  - theology
KW  - xenotransplantation
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-214114
VL  - 27
IS  - 4
ER  - 
TY  - JOUR
A1  - Karl, Franziska
A1  - Nandini Colaço, Maria B.
A1  - Schulte, Annemarie
A1  - Sommer, Claudia
A1  - Üçeyler, Nurcan
T1  - Affective and cognitive behavior is not altered by chronic constriction injury in B7-H1 deficient and wildtype mice
JF  - BMC Neuroscience
N2  - Background
Chronic neuropathic pain is often associated with anxiety, depressive symptoms, and cognitive impairment with relevant impact on patients` health related quality of life. To investigate the influence of a pro-inflammatory phenotype on affective and cognitive behavior under neuropathic pain conditions, we assessed mice deficient of the B7 homolog 1 (B7-H1), a major inhibitor of inflammatory response.

Results
Adult B7-H1 ko mice and wildtype littermates (WT) received a chronic constriction injury (CCI) of the sciatic nerve, and we assessed mechanical and thermal sensitivity at selected time points. Both genotypes developed mechanical (p < 0.001) and heat hypersensitivity (p < 0.01) 7, 14, and 20 days after surgery. We performed three tests for anxiety-like behavior: the light–dark box, the elevated plus maze, and the open field. As supported by the results of these tests for anxiety-like behavior, no relevant differences were found between genotypes after CCI. Depression-like behavior was assessed using the forced swim test. Also, CCI had no effect on depression like behavior. For cognitive behavior, we applied the Morris water maze for spatial learning and memory and the novel object recognition test for object recognition, long-, and short-term memory. Learning and memory did not differ in B7-H1 ko and WT mice after CCI.

Conclusions
Our study reveals that the impact of B7-H1 on affective-, depression-like- and learning-behavior, and memory performance might play a subordinate role in mice after nerve lesion.
KW  - B7-H1
KW  - Immune system
KW  - CCI
KW  - Anxiety
KW  - Cognitive behavior
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-200540
VL  - 20
ER  - 
TY  - JOUR
A1  - Mietrach, Nicole
A1  - Schlosser, Andreas
A1  - Geibel, Sebastian
T1  - An extracellular domain of the EsaA membrane component of the type VIIb secretion system: expression, purification and crystallization
JF  - Acta Crystallographica Section F
N2  - The membrane protein EsaA is a conserved component of the type VIIb secretion system. Limited proteolysis of purified EsaA from Staphylococcus aureus USA300 identified a stable 48 kDa fragment, which was mapped by fingerprint mass spectrometry to an uncharacterized extracellular segment of EsaA. Analysis by circular dichroism spectroscopy showed that this fragment folds into a single stable domain made of mostly α‐helices with a melting point of 34.5°C. Size‐exclusion chromatography combined with multi‐angle light scattering indicated the formation of a dimer of the purified extracellular domain. Octahedral crystals were grown in 0.2 M ammonium citrate tribasic pH 7.0, 16% PEG 3350 using the hanging‐drop vapor‐diffusion method. Diffraction data were analyzed to 4.0 Å resolution, showing that the crystals belonged to the enantiomorphic tetragonal space groups P41212 or P43212, with unit‐cell parameters a = 197.5, b = 197.5, c = 368.3 Å, α = β = γ = 90°.
KW  - ESAT‐6‐like secretion system
KW  - ESS
KW  - type VII secretion system
KW  - EsaA
KW  - extracellular domain
KW  - Staphylococcus aureus USA300
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-213681
VL  - 75
IS  - 12
ER  - 
TY  - JOUR
A1  - Münst, Bernhard
A1  - Thier, Marc Christian
A1  - Winnemöller, Dirk
A1  - Helfen, Martina
A1  - Thummer, Rajkumar P.
A1  - Edenhofer, Frank
T1  - Nanog induces suppression of senescence through downregulation of p27\(^{KIP1}\) expression
JF  - Journal of Cell Science
N2  - A comprehensive analysis of the molecular network of cellular factors establishing and maintaining pluripotency as well as self renewal of pluripotent stem cells is key for further progress in understanding basic stem cell biology. Nanog is necessary for the natural induction of pluripotency in early mammalian development but dispensable for both its maintenance and its artificial induction. To gain further insight into the molecular activity of Nanog, we analyzed the outcomes of Nanog gain-of-function in various cell models employing a recently developed biologically active recombinant cell-permeant protein, Nanog-TAT. We found that Nanog enhances the proliferation of both NIH 3T3 and primary fibroblast cells. Nanog transduction into primary fibroblasts results in suppression of senescence-associated beta-galactosidase activity. Investigation of cell cycle factors revealed that transient activation of Nanog correlates with consistent downregulation of the cell cycle inhibitor p27\(^{KIP1}\) (also known as CDKN1B). By performing chromatin immunoprecipitation analysis, we confirmed bona fide Nanog-binding sites upstream of the p27\(^{KIP1}\) gene, establishing a direct link between physical occupancy and functional regulation. Our data demonstrates that Nanog enhances proliferation of fibroblasts through transcriptional regulation of cell cycle inhibitor p27 gene.
KW  - Embryonic stem cell
KW  - Protein transduction
KW  - Pluripotency
KW  - Senescence
KW  - Cell reprogramming
KW  - p27(KIP1)
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-190761
VL  - 129
IS  - 5
ER  - 
TY  - JOUR
A1  - Greving, Sven
A1  - Richter, Tobias
T1  - Examining the testing effect in university teaching: retrievability and question format matter
JF  - Frontiers in Psychology
N2  - Review of learned material is crucial for the learning process. One approach that promises to increase the effectiveness of reviewing during learning is to answer questions about the learning content rather than restudying the material (testing effect). This effect is well established in lab experiments. However, existing research in educational contexts has often combined testing with additional didactical measures that hampers the interpretation of testing effects. We aimed to examine the testing effect in its pure form by implementing a minimal intervention design in a university lecture (N = 92). The last 10 min of each lecture session were used for reviewing the lecture content by either answering short-answer questions, multiple-choice questions, or reading summarizing statements about core lecture content. Three unannounced criterial tests measured the retention of learning content at different times (1, 12, and 23 weeks after the last lecture). A positive testing effect emerged for short-answer questions that targeted information that participants could retrieve from memory. This effect was independent of the time of test. The results indicated no testing effect for multiple-choice testing. These results suggest that short-answer testing but not multiple-choice testing may benefit learning in higher education contexts.
KW  - testing effect
KW  - university teaching
KW  - retrieval practice
KW  - question format
KW  - educational psychology
KW  - net testing effect
KW  - desirable difficulties
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-190802
SN  - 1664-1078
VL  - 9
ER  - 
TY  - JOUR
A1  - Ehnert, Ina
A1  - Parsa, Sepideh
A1  - Roper, Ian
A1  - Wagner, Marcus
A1  - Muller-Camen, Michael
T1  - Reporting on sustainability and HRM: a comparative study of sustainability reporting practices by the world's largest companies
JF  - International Journal of Human Resource Management
N2  - As a response to the growing public awareness on the importance of organisational contributions to sustainable development, there is an increased incentive for corporations to report on their sustainability activities. In parallel with this has been the development of Sustainable HRM' which embraces a growing body of practitioner and academic literature connecting the notions of corporate sustainability to HRM. The aim of this article is to analyse corporate sustainability reporting amongst the world's largest companies and to assess the HRM aspects of sustainability within these reports in comparison to environmental aspects of sustainable management and whether organisational attributes - principally country-of-origin - influences the reporting of such practices. A focus in this article is the extent to which the reporting of various aspects of sustainability may reflect dominant models of corporate governance in the country in which a company is headquartered. The findings suggest, first and against expectations, that the overall disclosure on HRM-related performance is not lower than that on environmental performance. Second, companies report more on their internal workforce compared to their external workforce. Finally, international differences, in particular those between companies headquartered in liberal market economies and coordinated market economies, are not as apparent as expected.
KW  - Human Resource Management
KW  - comparative HRM
KW  - global reporting initiative
KW  - sustainability reporting
KW  - Sustainable HRM
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-191141
VL  - 27
IS  - 1
ER  - 
TY  - JOUR
A1  - Daryaee, Fereidoon
A1  - Chang, Andrew
A1  - Schiebel, Johannes
A1  - Lu, Yang
A1  - Zhang, Zhuo
A1  - Kapilashrami, Kanishk
A1  - Walker, Stephen G.
A1  - Kisker, Caroline
A1  - Sotriffer, Christoph A.
A1  - Fisher, Stewart L.
A1  - Tonge, Peter J.
T1  - Correlating drug-target kinetics and in vivo pharmacodynamics: long residence time inhibitors of the FabI enoyl-ACP reductase
JF  - Chemical Science
N2  - Drug-target kinetics enable time-dependent changes in target engagement to be quantified as a function of drug concentration. When coupled to drug pharmacokinetics (PK), drug-target kinetics can thus be used to predict in vivo pharmacodynamics (PD). Previously we described a mechanistic PK/PD model that successfully predicted the antibacterial activity of an LpxC inhibitor in a model of Pseudomonas aeruginosa infection. In the present work we demonstrate that the same approach can be used to predict the in vivo activity of an enoyl-ACP reductase (FabI) inhibitor in a model of methicillin-resistant Staphylococcus aureus (MRSA) infection. This is significant because the LpxC inhibitors are cidal, whereas the FabI inhibitors are static. In addition P. aeruginosa is a Gram-negative organism whereas MRSA is Gram-positive. Thus this study supports the general applicability of our modeling approach across antibacterial space.
KW  - Staphylococcus aureus
KW  - antibacterial activity
KW  - LpxC inhibitors
KW  - enoyl-ACP reductase inhibitors
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-191218
VL  - 7
IS  - 9
ER  - 
TY  - JOUR
A1  - El Hajj, Nady
A1  - Dittrich, Marcus
A1  - Böck, Julia
A1  - Kraus, Theo F. J.
A1  - Nanda, Indrajit
A1  - Müller, Tobias
A1  - Seidmann, Larissa
A1  - Tralau, Tim
A1  - Galetzka, Danuta
A1  - Schneider, Eberhard
A1  - Haaf, Thomas
T1  - Epigenetic dysregulation in the developing Down syndrome cortex
JF  - Epigenetics
N2  - Using Illumina 450K arrays, 1.85% of all analyzed CpG sites were significantly hypermethylated and 0.31% hypomethylated in fetal Down syndrome (DS) cortex throughout the genome. The methylation changes on chromosome 21 appeared to be balanced between hypo- and hyper-methylation, whereas, consistent with prior reports, all other chromosomes showed 3-11times more hyper- than hypo-methylated sites. Reduced NRSF/REST expression due to upregulation of DYRK1A (on chromosome 21q22.13) and methylation of REST binding sites during early developmental stages may contribute to this genome-wide excess of hypermethylated sites. Upregulation of DNMT3L (on chromosome 21q22.4) could lead to de novo methylation in neuroprogenitors, which then persists in the fetal DS brain where DNMT3A and DNMT3B become downregulated. The vast majority of differentially methylated promoters and genes was hypermethylated in DS and located outside chromosome 21, including the protocadherin gamma (PCDHG) cluster on chromosome 5q31, which is crucial for neural circuit formation in the developing brain. Bisulfite pyrosequencing and targeted RNA sequencing showed that several genes of PCDHG subfamilies A and B are hypermethylated and transcriptionally downregulated in fetal DS cortex. Decreased PCDHG expression is expected to reduce dendrite arborization and growth in cortical neurons. Since constitutive hypermethylation of PCDHG and other genes affects multiple tissues, including blood, it may provide useful biomarkers for DS brain development and pharmacologic targets for therapeutic interventions.
KW  - trisomy 21
KW  - DNA methylation
KW  - Down syndrome
KW  - fetal brain development
KW  - frontal cortex
KW  - protocadherin gamma cluster
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-191239
VL  - 11
IS  - 8
ER  - 
TY  - JOUR
A1  - Pfister, Roland
A1  - Schwarz, Katharina A.
A1  - Janczyk, Markus
A1  - Dale, Rick
A1  - Freeman, Jonathan B.
T1  - Good things peak in pairs: a note on the bimodality coefficient
JF  - Frontiers in Psychology
N2  - A commentary on
Assessing bimodality to detect the presence of a dual cognitive process

by Freeman, J. B., and Dale, R. (2013). Behav. Res. Methods 45, 83–97. doi: 10.3758/s13428-012-0225-x
KW  - distribution analysis
KW  - bimodality
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-190413
SN  - 1664-1078
VL  - 4
ER  - 
TY  - JOUR
A1  - Foerster, Anna
A1  - Pfister, Roland
A1  - Schmidts, Constantin
A1  - Dignath, David
A1  - Kunde, Wilfried
T1  - Honesty saves time (and justifications)
JF  - Frontiers in Psychology
N2  - A commentary on
Honesty requires time (and lack of justifications)

by Shalvi, S., Eldar, O., and Bereby-Meyer, Y. (2012). Psychol. Sci. 23, 1264–1270. doi: 10.1177/0956797612443835
KW  - honesty
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-190451
SN  - 1664-1078
VL  - 4
ER  - 
TY  - JOUR
A1  - Meule, Adrian
A1  - Vögele, Claus
T1  - The psychology of eating
JF  - Frontiers in Psychology
N2  - No abstract available.
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-190460
SN  - 1664-1078
VL  - 4
ER  - 
TY  - JOUR
A1  - Meule, Adrian
T1  - Impulsivity and overeating: a closer look at the subscales of the Barratt Impulsiveness Scale
JF  - Frontiers in Psychology
N2  - No abstract available.
KW  - Impulsivity
KW  - Overeating
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-190497
SN  - 1664-1078
VL  - 4
ER  - 
TY  - JOUR
A1  - Bratengeier, Klaus
A1  - Holubyev, Kostyantyn
T1  - Anisotropy of dose contributions-an instrument to upgrade real time IMRT and VMAT adaptation?
JF  - Medical Physics
N2  - Purpose: 
To suggest a definition of dose deposition anisotropy for the purpose of ad hoc adaptation of intensity modulated arc therapy (IMRT) and volumetric arc therapy (VMAT), particularly in the vicinity of important organs at risk (OAR), also for large deformations. 

Methods: 
Beam's-eye-view (BEV) based fluence warping is a standard adaptation method with disadvantages for strongly varying OAR shapes. 2-Step-adaptation overcomes these difficulties by a deeper analysis of the 3D properties of adaptation processes, but requires separate arcs for every OAR to spare, which makes it impractical for cases with multiple OARs. The authors aim to extend the 2-Step method to arbitrary intensity modulated plan by analyzing the anisotropy of dose contributions. Anisotropy was defined as a second term of Fourier transformation of gantry angle dependent dose contributions. For a cylindrical planning target volume (PTV) surrounding an OAR of varying diameter, the anisotropy and the dose-normalized anisotropy were analyzed for several scenarios of optimized fluence distributions. 2-Step adaptation to decreasing and increasing OAR diameter was performed, and compared to a usual fluence based adaptation method. For two clinical cases, prostate and neck, the VMAT was generated and the behavior of anisotropy was qualitatively explored for deformed organs at risk. #

Results: 
Dose contribution anisotropy in the PTV peaks around nearby OARs. The thickness of the "anisotropy wall" around OAR increases for increasing OAR radius, as also does the width of 2-Step dose saturating fluence peak adjacent to the OAR K. Bratengeier et al., "A comparison between 2-Step IMRT and conventional IMRT planning," Radiother. Oncol. 84, 298-306 (2007)]. Different optimized beam fluence profiles resulted in comparable radial dependence of normalized anisotropy. As predicted, even for patient cases, anisotropy was inflated even more than increasing diameters of OAR. 

Conclusions: 
For cylindrically symmetric cases, the dose distribution anisotropy defined in the present work implicitly contains adaptation-relevant information about 3D relationships between PTV and OAR and degree of OAR sparing. For more complex realistic cases, it shows the predicted behavior qualitatively. The authors claim to have found a first component for advancing a 2-Step adaptation to a universal adaptation algorithm based on the BEV projection of the dose anisotropy. Further planning studies to explore the potential of anisotropy for adaptation algorithms using phantoms and clinical cases of differing complexity will follow.
KW  - modulated arc therapy
KW  - 2-step IMRT
KW  - radiation-therapy
KW  - online adaption
KW  - prostate-cancer
KW  - plans
KW  - IMAT
KW  - tracking
KW  - radiotherapy
KW  - adaption
KW  - IMRT
KW  - VMAT
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-186833
VL  - 43
IS  - 11
ER  - 
TY  - JOUR
A1  - Dotterweich, Julia
A1  - Schlegelmilch, Katrin
A1  - Keller, Alexander
A1  - Geyer, Beate
A1  - Schneider, Doris
A1  - Zeck, Sabine
A1  - Tower, Robert J. J.
A1  - Ebert, Regina
A1  - Jakob, Franz
A1  - Schütze, Norbert
T1  - Contact of myeloma cells induces a characteristic transcriptome signature in skeletal precursor cells-implications for myeloma bone disease
JF  - Bone
N2  - Physical interaction of skeletal precursors with multiple myeloma cells has been shown to suppress their osteogenic potential while favoring their tumor-promoting features. Although several transcriptome analyses of myeloma patient-derived mesenchymal stem cells have displayed differences compared to their healthy counterparts, these analyses insufficiently reflect the signatures mediated by tumor cell contact, vary due to different methodologies, and lack results in lineage-committed precursors. To determine tumor cell contact-mediated changes on skeletal precursors, we performed transcriptome analyses of mesenchymal stem cells and osteogenic precursor cells cultured in contact with the myeloma cell line INA-6. Comparative analyses confirmed dysregulation of genes which code for known disease-relevant factors and additionally revealed upregulation of genes that are associated with plasma cell homing, adhesion, osteoclastogenesis, and angiogenesis. Osteoclast-derived coupling factors, a dysregulated adipogenic potential, and an imbalance in favor of anti-anabolic factors may play a role in the hampered osteoblast differentiation potential of mesenchymal stem cells. Angiopoietin-Like 4 (ANGPTL4) was selected from a list of differentially expressed genes as a myeloma cell contact-dependent target in skeletal precursor cells which warranted further functional analyses. Adhesion assays with full-length ANGPTL4-coated plates revealed a potential role of this protein in INA6 cell attachment. This study expands knowledge of the myeloma cell contact-induced signature in the stromal compartment of myelomatous bones and thus offers potential targets that may allow detection and treatment of myeloma bone disease at an early stage.
KW  - marrow stromal cells
KW  - Endothelial growth-factor
KW  - precedes multiple-myeloma
KW  - monoclonial gammopathy
KW  - in-vitro
KW  - mesenchymal stem-cells
KW  - undetermined significance
KW  - angiogenic cytokines
KW  - peripheral-blood
KW  - gene-expression
KW  - Multiple myeloma
KW  - Bone disease
KW  - Angiopoietin-like 4
KW  - Gene expression profiling
KW  - Mesenchymal stem cells
KW  - Osteogenic precursor cells
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-186688
VL  - 93
ER  - 
TY  - JOUR
A1  - Scharaw, Sandra
A1  - Iskar, Murat
A1  - Ori, Alessandro
A1  - Boncompain, Gaelle
A1  - Laketa, Vibor
A1  - Poser, Ina
A1  - Lundberg, Emma
A1  - Perez, Franck
A1  - Beck, Martin
A1  - Bork, Peer
A1  - Pepperkok, Rainer
T1  - The endosomal transcriptional regulator RNF11 integrates degradation and transport of EGFR
JF  - Journal of Cell Biology
N2  - Stimulation of cells with epidermal growth factor (EGF) induces internalization and partial degradation of the EGF receptor (EGFR) by the endo-lysosomal pathway. For continuous cell functioning, EGFR plasma membrane levels are maintained by transporting newly synthesized EGFRs to the cell surface. The regulation of this process is largely unknown. In this study, we find that EGF stimulation specifically increases the transport efficiency of newly synthesized EGFRs from the endoplasmic reticulum to the plasma membrane. This coincides with an up-regulation of the inner coat protein complex II (COP II) components SEC23B, SEC24B, and SEC24D, which we show to be specifically required for EGFR transport. Up-regulation of these COP II components requires the transcriptional regulator RNF11, which localizes to early endosomes and appears additionally in the cell nucleus upon continuous EGF stimulation. Collectively, our work identifies a new regulatory mechanism that integrates the degradation and transport of EGFR in order to maintain its physiological levels at the plasma membrane.
KW  - Epidermal growth-factor
KW  - finger protein 11
KW  - receptor tyrosine kinases
KW  - early secretory pathway
KW  - breast-cancer
KW  - brefeldin-a
KW  - E3 ligase
KW  - trafficking
KW  - export
KW  - endoplasmic-reticulum
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-186731
VL  - 215
IS  - 4
ER  - 
TY  - JOUR
A1  - Dekant, Wolfgang
A1  - Bridges, James
T1  - Assessment of reproductive and developmental effects of DINP, DnHP and DCHP using quantitative weight of evidence
JF  - Regulatory Toxicology and Pharmacology
N2  - Quantitative weight of evidence (QWoE) methodology utilizes detailed scoring sheets to assess the quality/reliability of each publication on toxicity of a chemical and gives numerical scores for quality and observed toxicity. This QWoE-methodology was applied to the reproductive toxicity data on diisononylphthalate (DINP), di-n-hexylphthalate (DnHP), and dicyclohexylphthalate (DCHP) to determine if the scientific evidence for adverse effects meets the requirements for classification as reproductive toxicants. The scores for DINP were compared to those when applying the methodology DCHP and DnHP that have harmonized classifications. Based on the quality/reliability scores, application of the QWoE shows that the three databases are of similar quality; but effect scores differ widely. Application of QWoE to DINP studies resulted in an overall score well below the benchmark required to trigger classification. For DCHP, the QWoE also results in low scores. The high scores from the application of the QWoE methodology to the toxicological data for DnHP represent clear evidence for adverse effects and justify a classification of DnHP as category 1B for both development and fertility. The conclusions on classification based on the QWoE are well supported using a narrative assessment of consistency and biological plausibility.
KW  - n-hexyl phthalate
KW  - male rats
KW  - dicyclohexyl phthalate
KW  - Diisononyl phthalate
KW  - in-vivo
KW  - 2-Generation reproduction
KW  - testosterone production
KW  - sexual development
KW  - risk-assesment
KW  - fetal testis
KW  - weight of evidence
KW  - classification and labeling
KW  - reproductive and developmental toxicity
KW  - quantitative assessments
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-186750
VL  - 81
ER  -