TY - CHAP A1 - Anders, F. A1 - Scholl, E. A1 - Schartl, Manfred T1 - Xiphophorus als Modell in der Krebsforschung N2 - No abstract available. KW - Schwertkärpfling KW - Krebsforschung KW - Modell Y1 - 1979 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-72752 ER - TY - GEN A1 - Schneider, Wolfgang T1 - Materialien zur deutschen Rechtschreibung : Textsammlung von Probearbeiten, Diktaten und Schulbüchern, alphabetische Indices, Frequenzranglisten, Konkordanzen N2 - Textsammlung von Probearbeiten, Diktaten und Schulbüchern, alphabetische Indices, Frequenzranglisten, Konkordanzen KW - Rechtschreibung Y1 - 1979 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-50571 N1 - gescannte Mikrofiches ER - TY - JOUR A1 - Krüger, Hans-Peter T1 - Zur Anwendungsindikation von nonparametrischen Prädiktionsverfahren N2 - No abstract available Y1 - 1979 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-40925 ER - TY - JOUR A1 - Krüger, Hans-Peter A1 - Lienert, Gustav A. A1 - Eye, Alexander von A1 - Gebert, Alfred T1 - Eine inferentielle nonparametrische Clusteranalyse mit Alternativdaten N2 - Am Konzept der Axialsymmetrie multivariater Daten wird eine Methode entwickelt, mit der statistisch Cluster aus gleich interkorrelierenden Variablen gebildet werden können. Es wird eine heuristische Vorgehensweise empfohlen, die nicht wie die übliche deskriptive Clusteranalyse willkürliche Entscheidungen über Abbruchkriterien u.ä. verlangt. Die vorgeschlagene Methode ist insbesondere zur mediandichotomierte kontinuierliche Variablen geeignet. Werden echte Alternativdaten verwendet, resultieren Cluster, die zusätzlich zur gleichen Interkorrelation Variablen mit gleicher Schwierigkeit aufweisen. Das Vorgehen wird an einem Beispiel illustriert. N2 - By means ofaxial symmetry testing of muItivariate data clusters may be defined statistically as equally intercorrelating variables (tests). A heuristic procedure is suggested which avoids arbitrary decisions as they are common in descriptive cluster analysis. The method is suitable for continuous variables dichotomized at their median.lf applied to genuine binary variables the cluster analysis results in clusters of variables having equal Yes-No proportions as well as equal interassociations. In order to illustrate their approach the authors give a numerical example. KW - Psychologie / Zeitschrift Y1 - 1979 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41606 ER - TY - JOUR A1 - Weinert, Franz E. A1 - Treiber, Bernhard A1 - Schneider, Wolfgang T1 - Educational psychology N2 - This is a report on the more recent developments and the present state of research into educational psychology in German speaking countries. Particular emphasis is given to research on: parental upbringing and its effects on child development; the examination of socialization effects within and across different scbool systems; studies on teaching-leaming processes and on social interaction in the classroom; the systematic promotion of the development of cognitive abilities and motives in students; and, finally, the design of improved instruments in methods of describing, explaining and predicting school success. Subsequently, the report will look into problems in tbe practical application of research findings in educational psychology. Finally, there follows a sbort discussion of various metatheoretical positions in educational psycbology in German speaking countries and their possible effects on the future development of the field. KW - Pädagogische Psychologie Y1 - 1979 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87234 ER - TY - CHAP A1 - Krüger, Hans-Peter T1 - Die Selbst- und Fremdbeurteilung als Resultante sozialer Erfahrung N2 - No abstract available KW - Selbsteinschätzung Y1 - 1979 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86039 ER - TY - JOUR A1 - Krüger, Hans-Peter T1 - Zum Problem der Bestimmung zweiseitiger Überschreitungswahrscheinlichkeiten beim exakten Vierfeldertest N2 - Drei Methoden zur Bestimmung zweiseitiger Überschreitungswahrscheinlichkeiten bei der exakten Prüfung von Vierfeldertafeln nach FISCHER-YATES werden diskutiert. An einem Beispiel wird aufgezeigt, daß diese Methoden zu verschiedenen Signifikanzentscheidungen führen können. Es werden Möglichkeiten aufgezeigt, wie diese Schwierigkeiten in der Praxis umgangen werden können. N2 - Three methods to determine two-sided exact probabilities in fourfold tables following FISCHER-YATES are discussed. An example illustrates that these methods may lead to different decisions. Same hints are given how these difficulties could be avoid ed in practical work. KW - Wahrscheinlichkeit KW - fourfold table Y1 - 1979 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-79816 ER - TY - JOUR A1 - Wilhelm, Gernot T1 - Ein neues Lamaštu-Amulett N2 - no Abstract available KW - Lamaštu-Amulett Y1 - 1979 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-103520 ER - TY - CHAP A1 - Ruhe, Ernstpeter T1 - Repetition und Integration: Strukturprobleme des 'Roman de Tristan en prose' N2 - No abstract available Y1 - 1979 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33610 ER - TY - CHAP A1 - Ruhe, Ernstpeter T1 - Thesen zum Ende der Gattungsgeschichte des höfischen Romans N2 - No abstract available Y1 - 1979 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33626 ER - TY - JOUR A1 - Werner, Helmut A1 - Kuehn, Alfred A1 - Burschka, Christian T1 - Strukturdynamische Organometall-Komplexe II: Synthese, Struktur und Dynamik der Komplexe C\(_5\)H\(_5\)M(2-R'C\(_3\)H\(_4\))PR\(_3\) (M = Pd, Pt) T1 - Structurally dynamic organometallic complexes II: Synthesis, structure, and dynamics of the complexes C\(_5\)H\(_5\)M(2-R'C\(_3\)H\(_4\))PR\(_3\) (M = Pd, Pt) N2 - No abstract available KW - Anorganische Chemie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-57853 ER - TY - JOUR A1 - Hoppe, J. A1 - Sebald, Walter T1 - Amino acid sequence of the proteolipid subunit of the proton-translocating ATPase complex from the thermophilic bacterium PS-3 N2 - No abstract available KW - Biochemie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62754 ER - TY - JOUR A1 - Hoppe, J. A1 - Schairer, H. U. A1 - Sebald, Walter T1 - The proteolipid of a mutant ATPase from Escherichia coli defective in H\(^+\)-conduction contains a glycine instead of the carbodiimide-reactive aspartyl residue N2 - No abstract available KW - Biochemie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62769 ER - TY - JOUR A1 - Hoppe, J. A1 - Schairer, HU A1 - Sebald, Walter T1 - Identification of amino-acid substitutions in the proteolipid subunit of the ATP synthase from dicyclohexylcarbodiimide-resistant mutants of Escherichia coli N2 - The amino acid sequence of the proteolipid subunit of the A TP synthase was analyzed in six mutant strains from Escherichia coli K 12, selected for their increased resistance towards the inhibitor N,N'-dicyclohexylcarbodiimide. All six inhibitor-resistant mutants were found to be altered at the same position of the proteolipid, namely at the isoleucine at residue 28. Two substitutions could be identified. In type I this residue was substituted by a valine resulting in a moderate decrease in sensitivity to dicyclohexylcarbodiimide. Type II contained a threonine residue at this position. Here a strong resistance was observed. These two amino acid substitutions did not influence functional properties of the ATPase complex. ATPase as well as A TP-dependent proton-translocating activities of mutant membranes were indistinguishable from the wild type. At elevated concentrations, dicyclohexylcarbodiimide still bound specifically to the aspartic acid at residue 61 of the mutant proteolipid as in the wild type, and thereby inhibited the activity of the ATPase complex. It is suggested that the residue 28 substituted in the resistant mutants interacts with dicyclohexylcarbodiimide during the reactions leading to the covalent attachment of the inhibitor to the aspartic acid at residue 61. This could indicate that these two residues are in close vicinity and would thus provide a first hint on the functional conformation of the proteolipid. Its polypeptide chain would have to fold back to bring together these two residues separated by a segment of 32 residues. KW - Biochemie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-47374 ER - TY - JOUR A1 - Burschka, Christian T1 - Kristallstruktur von NH\(_4\)CuS\(_4\) T1 - The crystal structure of NH\(_4\)CuS\(_4\) N2 - NH4CuS4 was prepared according to syntheses reported in the literature. Orthorhombic crystals could be grown (P21 21 21 , a = 5.249(1), b = 8.444(2), c = 12.782(2) A, Z = 4), the structure of which was solved from X-ray diffractometer data. (R = 0.031 for 767 obs. reflections). In the solid state (CuS4)- chelate rings are linked via additional Cu-S-bonds to form one-dimensional polymerie anions. KW - Chemie KW - Crystal Structure KW - Copper Polysulfides KW - Chain Polymers Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-46763 ER - TY - JOUR A1 - Sirén, Anna-Leena A1 - Karppanen, H. T1 - Influence of analgesic antipyretics on the central cardiovascular effects of clonidine in rats N2 - No abstract available KW - Prostaglandine Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-48640 ER - TY - JOUR A1 - Burschka, Christian A1 - Wieber, M. A1 - Ruedling, H. G. T1 - Alkylxanthogenato-diphenylbismutine N2 - No abstract available KW - Chemie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-46554 ER - TY - CHAP A1 - Hommers, Wilfried T1 - Information processing in children's choices among bets N2 - Children's information processing of risky choice alternatives was investigated in two studies without using verbal reports. In Study 1, the ability to integrate the probabilities and the payoffs of simple bets was examined using the rating scale methodology. Children's choices among three of those simple bets were recorded also. By cross-classifying the children's choice and rating behavior it was shown that a three-stage developmental hypothesis of decision making is not sufficient. A four-stage hypothesis is proposed. In Study 2, the influence of enlarging the presented number of alternatives from two to three and the influence of the similarity of the alternatives on children's choice probabilities was examined with those bets. Children's choice behavior was probabilistic and was influenced only by enlarging the presented number of alternatives. These results suggest that a Bayesian approach, based on two probabilistic choice models, should not be applied in order to analyze children's choice behavior. The functional measurement approach is, as was demonstrated in Study 1, a powerful implement to further the understanding of the development of decision making. KW - Kognitive Entwicklung / Informationsverarbeitung / Kind / Informationsintegration Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-44169 ER - TY - JOUR A1 - Kreft, Jürgen T1 - Reovirus-specific messenger ribonucleoprotein particles from Hela cells N2 - When reovirus-infected Hela cells are incubated at 43°C virus-specific messenger RNA is released ~rom the polysomes. It accumulates free in the cytoplasm as messenger ribonucleoprotem partIcles (mRNPs). The:e part~cles have a sedimentati~n rate of about 50S and a buoyant densIty m CsCI of 1.42 g/cm . ReovIrus mRNPs contam, beSIdes all three size classes of reovirus messenger RNA, the same spectrum of proteins found in the polysomal mRNPs from uninfected cells, plus t~o addi~ional pr?teins with molecular masses of 7000~ d and 110000 d, respectively. Electron mIcroscoPIc exammatlOn of the reovIrus mRNP fractIOn reveals specific Y-shaped structures wIth a total mean length ofO.5Ilm. KW - Hela Cells KW - Reovirus KW - Messenger Ribonucleoprotein Particles KW - mRNP-Proteins KW - Electron Microscopy Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-47028 ER - TY - JOUR A1 - Lutz, Werner K. A1 - Jaggi, W. A1 - Lüthy, J. A1 - Sagelsdorff, P. A1 - Schlatter, C. T1 - In vivo covalent binding of aflatoxin B\(_1\) and aflatoxin M\(_1\) to liver DNA of rat, mouse and pig N2 - [\(^{14}\)C] Aflatoxin B\(_1\) (AFB\(_1\)) was isolated from cultures of Aspergillus parasiticus grown on [1-\(^{114}\)C] sodium acetate. Covalent binding of AFB1 to liver DNA of rat and mouse was determined 6-8 h afteroral administration. The effectiveness of covalent binding, expressedas DNA binding per dose in the units of a 'Covalent Binding Index' (CBI), (\(\mu\)mol aflatoxin/mol DNA nucleotides)/(mmol aflatoxin/kg animal), was found to be 10 400 for rats and 240 for mice. These CBI partly explain the different susceptibility of the two species for the incidence of hepatic tumors. The corresponding values for pig liver DN A, 24 and 48 h after oral administration, were found to be as high as 19 100 and 13 300. DNA-binding has not so far been reported for this species although it could represent an appropriate animal model for studies where a human-like gastrointestinal tract physiology is desirable. Aflatoxin M \(_1\) ( AFM\(_1\)) is a metabolite found in the milk of cows that have been fed AFB\(_1\)-contaminated diet. [\(^{14}\)C] AFM\(_1\) was also found to be produced by cultures of A. parasiticus giving a yield of about 0.3% of the total aflatoxins. A test for covalent binding to rat liver DN A revealed a CBI of 2100 shoWing that AFM\(_1\) must also be regarded as a strong hepatocarcinogen. It is concluded that AFB\(_1\) contaminations should be avoided in dairy feed. KW - Toxikologie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61097 ER - TY - JOUR A1 - Jaggi, W. A1 - Lutz, Werner K. A1 - Lüthy, J. A1 - Zweifel, U. A1 - Schlatter, C. T1 - In vivo covalent binding of aflatoxin metabolites isolated from animal tissue to rat-liver DNA N2 - Ring-labelled [\(^{14}\)C)aflatoxin B\(_1\) (AFB\(_1\)), prepared by biosynthesis. or generally labelled [\(^3\)H]AFB\(_1\) was administered by oral gavage to young adult male rats. After 6 hr. the liver was removed and two fractions were isolated, namely macromolecules, which contamed about 3 % of the initial dose of AFB\(_1\) radioactivity. and water-soluble, low-molecular aftatoxin conjugates containing about0·2% of the administered radioactivity. These two fractions were administered orally to other rats in order to determine the potential of radioactive aftatoxin residues for covalent binding to DNA. Such binding can be used as an indicator for carcinogenic potency. Liver DNA was isolated 9-12 hr after admmistration of the aflatoxin derivatives and in no case was any radioactivity detected on the DNA. It can be deduced on the basis of the limit of detection of radioactivity on the DNA, that macromolecule bound AFB\(_1\) derivatives are at least 4000 times less active than AFB\(_1\) with respect to covalent binding to rat-liver DNA. and that the water-soluble conjugates are at least 100 times less potent than AFB, itself. It is concluded that the carcinogenic risk for humans who consume liver or meat. containing such aflatoxin residues is negligible when compared with the risk from intake of aftatoxins in other food items. KW - Toxikologie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61101 ER - TY - JOUR A1 - Viviani, A. A1 - Däniken, A. von A1 - Schlatter, C. A1 - Lutz, Werner K. T1 - Effect of selected induction of microsomal and nuclear aryl hydrocarbon monooxygenase and epoxide hydrolase as well as cytoplasmic glutathione S-epoxide transferase on the covalent binding of the carcinogen benzo(a)pyrene to rat liver DNA in vivo N2 - Groups of four adult male rats [ZUR:SIV -Z] were pretreated with corn oil (control; 2 ml/kg/day i. p. for 3 days), trans-stilbene-oxide (SO; 200 mg/kg/day i. p. for 2 days), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; 10 \(\mu\)g/kg i. p. once, 4 days before killing), phenobarbital (PB; 1 gjliter in the drinking water for 8 days), and dieldrin (20 mg/kg/day i. p. for 3 or 9 days). They received an injection of [G-\(^3\)H]benzo(a)pyrene (BaP, 31 \(\mu\)g/kg, 7.4. 10\(^9\) dpm/kg; i. v.) 16 h before killing. In the liver of each rat, five enzymatic activities and the covalent binding of BaP to DNA have been determined. The rnicrosomal aryl hydrocarbon monooxygenase activity (AHM) ranged frorn 75% of control (SO) to 356% (TCDD), the nuclear AHM from 63% (SO) to 333% (TCDD). Microsomal epoxide hydrolase activity (EH) was induced up to 238% (PB), nuclear EH ranged from 86% (TCDD) to 218% (PB). A different extent of induction was observed in the two compartments. Highest induction of glutathione S-epoxide transferase activity (GST) was found with PB (202%). The DNA binding of BaP was modulated within 79% (dieldrin, 9 days) and 238% of control (TCDD). An enzyme digest of control DNA was analysed by Sephadex LH-20 chromatography. Multiple linear regression analysis with all data expressedas o/o of control yielded the following equation: DNA Binding = 1.49 · Microsomal AHM- 1.07 · Nuclear AHM+ 0.33 · Microsomal EH- 0.52 · N uclear EH+ 0.11 · Cytoplasmic GST + 58.2. From this analysis it is concluded that (1) AHM located in the endoplasmic reticulum is most important in the formation of DNA-binding metabolites, (2) EH in the same compar.tment is not determinative in thls respect nor has it a protective effect, (3) both membrane-bound enzyme activities located in the nucleus may inactivate potential ultimate carcinogens, and ( 4) cytoplasmic GST probably cannot reduce DNA binding due to its subcellular localization. KW - Toxikologie KW - Carcinogen KW - Benzo(a)pyrene-DNA binding KW - Enzyme induction KW - Aryl hydrocarbon rnonooxygenase KW - Epoxide hydrolase KW - Glutathione Stransferase Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61114 ER - TY - JOUR A1 - Ackermann, J. A1 - Tacke, Reinhold A1 - Wannagat, U. A1 - Koke, U. A1 - Meyer, F. T1 - Sila-Analoga des Chlorphencyclans T1 - Sila Analogues of Chlorphencyclane N2 - Sila-Chlorphencyclan (8b), ein Sila-Analogon des Chlorphencyclans (8a), die Derivate 7 und 9, deren Ammoniumsalze 11, 12, 13 und 14b, das Hydrolyseprodukt 10 sowie die Vorstufen 3-6 wurden erstmalig dargestellt. Die neuen Verbindungen wurden in ihren chemischen und physikalischen Eigenschaften charakterisiert, ihre Struktur wurde sichergestellt. Chlorphencyclan, Sila-Chlorphencyclan und einige seiner Derivate wurden vergleichend pharmakologisch und toxikologisch untersucht. N2 - Silachlorphencyclane (8b), a sila analogue of chlorphencyclane (8a), the derivatives 7 and 9, their amrnonium salts 11, 12, 13 and 14b, the product of hydro Iysis 10, as weil as the precursors ~ were synthesized. The new compounds were characterized by their chemical and physical properties. The pharmacological and toxicological properties of chlorphencyclane, silachlorphencyclane and some derivatives were investigated. KW - Anorganische Chemie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63633 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Heeg, E. A1 - Berndt, B T1 - Sila-Analogon des Rythmols T1 - Sila Analogue of Rythmol N2 - Sila-Rythmol (llb), ein Sila-Analogon des Antiarrhythmieums Rythmol (lla), wurde erstmalig dargestellt. llb sowie die Vorstufen und Nebenprodukte 4, 5, 6, 7, 9b und lOb wurden in ihren physikalischen und chemischen Eigenschaften charakterisiert und in ihrer Struktur sichergestellt. Die pharmakologischen und toxikologischen Eigenschaften der Analoga lla und llb wurden vergleichend untersucht. N2 - Silarythmol (llb), a sila analogue of the antiarrhythmic rythmol (lla), was synthesized for the first time. llb as weil as the precursors and byproducts 4, 5, 6, 7, 9b, and lOb were characterized by their physical and chemical properties. The pharmacological and toxicological properties of the analogues lla and llb were also investigated. KW - Anorganische Chemie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63642 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Strecker, M. A1 - Sheldrick, W. S. A1 - Ernst, L. A1 - Heeg, E. A1 - Berndt, B. A1 - Knapstein, C.-M. A1 - Niedner, R. T1 - Sila-Pridinol und Pridinol: Darstellung und Eigenschaften sowie Strukturen im kristallinen und gelösten Zustand T1 - Sila-Pridinol and Pridinol: Preparation and Properties as weil as Structures ln the Solid Stateand in Solution N2 - Sila-Pridinol (2 b), ein Sila-Analogon des Anticholinergicums Pridinol (2a), wurde auf zwei verschiedenen Wegen dargestellt. Die Kristall- und Molekülstrukturen von 2 a und 2 b wurden röntgenstrukturanalytisch bestimmt. 2a bildet im festen Zustand intramolekulare Wasserstoffbrückenbindungen aus, während sich in kristallinem 2 b zentrosymmetrische, durch intermolekulare H-Brückenbindungen verknüpfte cyclische Dimere finden. IR- und \8^1\)H-NMR-spektroskopische sowie kryoskopische Untersuchungen ergaben Informationen über die Strukturen von 2a und 2 b in verschiedenen Lösungsmitteln. - Die pharmakologischen und toxikologischen Eigen" schaften von 2a und 2b wurden unter dem Gesichtspunkt bekannter Struktur-Wirkungs-Beziehungen vergleichend untersucht. 2 b erwies sich als ein etwa fünfmal so starkes Anticholincrgicum wie 2a. N2 - Sila"pridinol (2 b), a sila"analogue of the anticholinergic pridinol (2a). was prepared by two different routes. The crystal and molecular structures of 2 a and 2 b were determined by X-ray structural analyses. 2a forms intramolecular hydrogen bonds in the solid state, whereas centrosymrnetric cyclic dimers linked through intermolecular hydrogen bonds are observed for crystalline 2 b. IR- and \(^1\)H NMR spectroscopic as weil as cryoscopic studies yielded information ab out the structures of 2a and 2 bin different solvents. - The pharmacological and toxicological properties of2a and 2b were compared with one another on the basis ofknown structure-activity relationships. The anticholinergic properties of 2b were found tobe about five times as strong as those of 2a. KW - Anorganische Chemie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63654 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Zimonyi-Hegedüs, E. A1 - Strecker, M. A1 - Heeg, E. A1 - Berndt, B. A1 - Langner, R. T1 - Sila-Analogon des Tiemoniumiodids T1 - Sila-Analogue of Tiemonium Iodide N2 - Sila-Tiemoniumiodid (16b), ein Sila-Analogon des Anticholinergicums Tiemoniumiodid (16a), und das Sila-Analogon 14b der entsprechenden Tiemonium-Base 14a wurden erstmalig synthetisiert.14b und 16b sowie die Vorstufen 10-13 und 15 wurden in ihren physikalischen und chemischen Eigenschaften charakterisiert und in ihrer Struktur durch Elementaranalysen sowie \(^1\)H-NMR- und Massenspektren sichergestellt. Die spasmolytischen Eigenschaften der Paare 14a/14b und 16a/16b wurden am isolierten Meerschweinchendarm vergleichend untersucht. N2 - Silatiemonium iodide (16b), a sila-analogue of the anticholinergic tiemonium iodide (16a), and the siJa-analogue 14b of the corresponding free base 14a were synthesized for the first time. Compounds 14b and 16b as weil as their precursors 10-13 and 15 were characterized by their physical and chemical properties. Their structures were confirmed by elementary analyses, (^1\)H NMRand massspectroscopy. The spasmolytic properties of the pairs 14a/14b and 16a/16b were compared on the isolated guinea pig ileum. KW - Anorganische Chemie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63669 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Niedner, R. A1 - Frohnecke, J. A1 - Ernst, L. A1 - Sheldrick, W. S. T1 - Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, II T1 - Preparation and Properties of Silicon Compounds withPotential Curare-Like Activity, II N2 - Die potentiell curarewirksamen Silicium-Verbindungen Sa, Sc, Sd, Sg, Sh und 9a-9d wurden dargestellt. \(^1\)H-NMR-spektroskopische Untersuchungen ergaben Informationen über die Konformationen von 5 a- Sc in Lösung. Die Kristall- und Molekülstruktur von 5 c wurde röntgenstrukturanalytisch bestimmt. Die muskelrelaxierenden Eigenschaften von S a- 5 h und 9 a-9 d wurden vergleichend an der Maus (i.v., LD50-Werte) untersucht. Die ermittelten Struktur-WirkungsBeziehungen werden in Hinblick auf die unterschiedlichen kovalenten Radien des Kohlenstoffund Siliciumatoms und die hieraus resultierenden N ... N-Abstände diskutiert. N2 - 'The potential curare-like silicon compounds Sa, Sc, Sd, Sg, Sb, and 9a-9d were synthesized. \(^1\)H-NMR spectroscopic investigations provided information about the conformations of Sa-Sc in solution. The crystal and molecular structures 5 c were determined by X-ray structural analysis. The muscle relaxing properties of Sa-Sb and 9a-9d were investigated comparatively on mice (i. v., LD50 values). The observed structure-activity relationships are discussed with respect to the different covalent radii of the carbon and silicon atoms and the N ... N distances resulting therefrom. KW - Anorganische Chemie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63670 ER - TY - JOUR A1 - Leininger, H. A1 - Christl, Manfred T1 - Oxidationsreaktionen am Benzvalen: Ozonolyse, cis-Hydroxylierung, Epoxidation und Singulettsauerstoff-Addition N2 - No abstract available KW - Organische Chemie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-58088 ER - TY - JOUR A1 - Christl, Manfred A1 - Lang, R. A1 - Herbert, R. A1 - Freitag, G. T1 - Zusammenhang zwischen Orbitalcharakter und Reaktionsprodukt bei der Umsetzung von Benzvalen und Homobenzvalen mit Thiophenol N2 - No abstract available KW - Organische Chemie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-58065 ER - TY - JOUR A1 - Christl, Manfred A1 - Lang, R. A1 - Lechner, M. T1 - Tetra- und pentacyclische Tricyclo[4.1.0.0\(^{2,7}\)]hept-3-en-Derivate; Abfangprodukte des Tricyclo[4.1.0.0\(^{2,7}\)]hepta-3,4-diens N2 - No abstract available KW - Organische Chemie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-58078 ER - TY - GEN T1 - Jahresbericht 1979 T1 - Annual Report 1979 N2 - Die Entwicklung der Universitätsbibliothek Würzburg im Jahr 1979. N2 - Annual Report of the University Library of Würzburg, 1979. T3 - Jahresbericht der Universitätsbibliothek Würzburg - 1979 KW - Würzburg KW - Universitätsbibliothek KW - Bericht KW - Jahresbericht KW - Würzburg KW - University Library KW - Report KW - Annual Report KW - Wuerzburg KW - Wurzburg Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-42223 ER - TY - CHAP A1 - Krüger, Hans-Peter T1 - Selbst- und Fremdbeurteilung in Diagnostik und Psychotherapie N2 - No abstract available KW - Klinische Psychologie KW - Psychotherapie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-40964 ER - TY - CHAP A1 - Krüger, Hans-Peter A1 - Kohnen, Ralph T1 - Evaluierung gruppentherapeutischer Situationen durch physiologische Parameter und Selbsteinschätzungen N2 - No abstract available Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-40971 ER - TY - JOUR A1 - Krüger, Hans-Peter A1 - Lienert, Gustav A. T1 - Eine exakte nonparametrische Prüfung auf Kovariation zweier autokorrelierter Zeitreihen N2 - Häufig tritt in der psychologischen und psychiatrischen Forschung die Frage nach dem Zusammenhang zwischen zwei oder mehreren Zeitreihen auf. übliche Kovariationsmaße versagen dabei vor allem deshalb, weil sie nicht inferentiell ausgewertet werden können. An einem Beispiel aus der Pharmakopsychologie wird ein auf Pfanzagl (1963) zurückgehendes Verfahren vorgeschlagen, das es erlaubt, voraussetzungsfrei den Zusammenhang zwischen autokorrelierten Meßwertreihen zu prüfen. Als Unabhängigkeit zweier Zeitreihen wird definiert, daß zwischen ihnen bei Erhaltung der Autokorrelation kein höherer Zusammenhang besteht als nach dem Zufall zu erwarten. N2 - The problem of examining the relation between two or more series of successive observations occurs often in the psychologieal and psychiatrie research. The usual methods of measuring covariation cannot be employed here, particularly because they cannot be used to draw inferences. The present paper describes a new method to examine the relation between autocorrelated series of successive observations, without using any presuppositions. Two successive series are considered to be independent, when the relation between them is not higher than that expected by chance. The method described here is based upon a paper by Pfanzagl (1963), and is illustrated with the help of an example from the field of Pharmacopsychology. Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41049 ER - TY - JOUR A1 - Krüger, Hans-Peter A1 - Kohnen, Ralf A1 - Lienert, Gustav A. T1 - Lautstärke ungleich Lautheit: Wirkung von Psychopharmaka auf das Lärmerleben T1 - Sound Intensity unequal Loudness: Effect of Psychopharmacologic Agents on the Experience of Noise N2 - No abstract available Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41026 ER - TY - JOUR A1 - Krüger, Hans-Peter A1 - Kohnen, Ralf A1 - Lienert, Gustav A. T1 - Aufgabenvariation als Aktivationsparameter in Tranqualizer-Untersuchungen T1 - Choice of Performance Tasks as an Activation Parameter in Minor Tranquilizer Trials N2 - No abstract available Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41016 ER - TY - JOUR A1 - Burschka, Christian A1 - Leonhard, K. A1 - Werner, H. T1 - Basische Metalle. XIV. Synthese und Kristallstruktur von C\(_5\)H\(_5\)(PMe\(_3\))CoS\(_5\) : Ein neuer Metallapentathia-Heterocyclus T1 - Basic Metals. XIV. Synthesis and Crystal Structure of C\(_5\)H\(_5\)(PMe\(_3\))CoS\(_5\) : A New Metallapentathia Heterocycle N2 - Der Zweikernkomplex C\(_5\)H\(_5\)(PMe\(_3\))Co(\(\mu\)-CO)\(_2\)Mn(CO)C\(_5\)H\(_4\)Me (8) reagiert mit stöchiometrischen Mengen S\(_8\) in praktisch quantitativer Ausbeute zu C\(_5\)H\(_5\)(PMe\(_3\))CoS\(_5\) (4). Der Koba.ltapentathia-Heterocyclus 4 ist ebenfalls aus C\(_5\)H\(_5\)(PMe\(_3\))Co(h\(^2\)-CS\(_2\)) (5) und S\(_8\) zugänglich. 4 kristallisiert monoklin mit den Gitterkonstanten a = 8,467(3) A, b = 12,128(4) A, c = 14,210(4) A und \(\beta\) = 102,20(2)°_ Die Sesselform des sechsgliedrigen CoS\(_5\)-Rings entspricht derjenigen in den bekannten Verbindungen (C\(_5\)H\(_5\))\(_2\)TiS\(_5\) und (C\(_5\)H\(_5\))\(_2\)VS\(_5\) , wobei in 4 der Cyclopentadienylligand die axiale und die Trimethylphosphingruppe die ä.quatoriale Position einnehmen. N2 - The dinuclear complex C\(_5\)H\(_5\)(PMe\(_3\))Co(\(\mu\)-CO)\(_2\)Mn(CO)C\(_5\)H\(_4\)Me (8) reaots with stoichiometric amounts of S\(_8\) to form C\(_5\)H\(_5\)(PMe\(_3\))CoS\(_5\) (4) in practica.lly quantitative yields. The cobalt. apentathia heterocycle 4 is a.lso obtained by the reaction of C\(_5\)H\(_5\)(PMe\(_3\))Co(h\(^2\)-CS\(_2\)) (5) with S\(_8\), Cry. stals of 4 are monoclinic with a = 8.467(3) A, b = 12.128(4) A, c = 14.210(4) A and \(\beta\) = 102.20(2)°. The chair form of the six·membered CoS\(_5\) ringcorresponds to that of the compounds (C\(_5\)H\(_5\))\(_2\)TiS\(_5\) and (C\(_5\)H\(_5\))\(_2\)VS\(_5\) In 4, the cyclopentadienyl ligand occupies the axial and the trimethylphosphine group the equatorial position. KW - Chemie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31407 ER - TY - JOUR A1 - Burschka, Christian T1 - CsCu\(_4\)S\(_3\) und CsCu\(_3\)S\(_2\) : Sulfide mit tetraedrisch und linear koordiniertem Kupfer T1 - CsCu\(_4\)S\(_3\) and CsCu\(_3\)S\(_2\): Sulfides with Copper in Tetrahedral and Linear Coordination N2 - No abstract available KW - Chemie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31366 ER - TY - JOUR A1 - Scheer, Ulrich A1 - Sommerville, John A1 - Müller, Ulrike T1 - DNA is assembled into globular supranucleosomal chromatin structures by nuclear contents of amphibian oocytes N2 - The assembly of DNA into nucleosomal and supranucleosomal chromatin structures has been studied (i) by injection of circular DNA molecules (plasmids) into nuclei of Pleurodeles waltlii oocytes; and (ii) by in vitro incubation of plasmid molecules with the supernatant fraction from oocyte nuclei of Pleurodeles and Xenopus laevis, followed by purification of nucleoprotein structures formed with sucrose gradient centrifugation. [n both types of experiments , spread preparations of the newly assembled and transcriptionally inactive chromatin , examined by electron microscopy , show dense globular higher order (supranucleosomal) packing forms. Under partially relaxing (low salt) preparation conditions granular chromatin subunits of about 30 nm diameter can be seen either as widely spaced particles or in closely packed aggregates. The transcriptionally inactive endogenous chromatin of chromomeres of lampbrush chromosomes is arranged in similar higher order chromatin units. A correlation is found between the sizes of the DN A molecule probes used and the numbers of nucleosomes and higher order globules in the assembled chromatin structures. After prolonged dispersion in low salt buffers , these globular chromatin units unfold into chains of7-12 nucleosomes. The results support the concept that chromatin is arranged , under physiological ion concentrations as they are present in the nucleus , in supranucleosomal units of globular morphology. Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-39671 ER - TY - CHAP A1 - Wilhelm, Gernot T1 - Die Fortsetzungstafel eines Briefes aus Kamid el-Loz (KL 72 : 600) N2 - No abstract available KW - Archäologie KW - Bronzezeit KW - Tempel KW - Ausgrabungen Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-78079 ER - TY - CHAP A1 - Wilhelm, Gernot T1 - Ein Gefäßfragment mit alphabetischer Keilinschrift N2 - No abstract available KW - Archäologie KW - Bronzezeit KW - Ausgrabungen KW - Tempel KW - Funde Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-78068 ER - TY - JOUR A1 - Schneider, Wolfgang T1 - Kausalmodelle in der Pädagogischen Psychologie - Ergänzende Analysen zu zwei einschlägigen Untersuchungen N2 - In the present secondary analysis the results of studies by Simons et al. (1975) and Schwarzer (1979) were critically reanalyzed. The central point of the reanalysis concerned the test of the causal models used, especially the question, if the technique of path analysis was correctly applied. Whereas some modifications seemed necessary in both srudies, there was no reason to question their main results. KW - Pädagogische Psychologie KW - Kausalmodell Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87249 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Bentlagem, A. A1 - Towart, R. A1 - Meyer, H. A1 - Bossert, F. A1 - Vater, W. A1 - Stoepe, K. T1 - Sila-Analoga von Nifedipin-ähnlichen 4-Aryl-2.6-dimethyl-1.4-dihydropyridin-3.5-dicarbonsäure-dialkylestern, I N2 - no abstract available KW - Chemie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-82430 ER - TY - JOUR A1 - Wilhelm, Gernot T1 - Der Komitativ des Urartäischen N2 - No abstract available KW - Minoische Kultur KW - Mykenische Kultur KW - Ägäische Kultur KW - Anatolische Sprachen Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-82771 ER - TY - BOOK A1 - Wolf, Norbert Richard A1 - Domröse, Gerd A1 - Liebel, Hermann T1 - List Sprachbuch 5 N2 - No abstract available KW - Deutschunterricht KW - Lehrmittel Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41637 ER - TY - CHAP A1 - Franke, Werner W. A1 - Scheer, Ulrich A1 - Zentgraf, Hanswalter A1 - Trendelenburg, Michael F. A1 - Müller, U. A1 - Krohne, G. A1 - Spring, H. T1 - Organization of transcribed and nontranscribed chromatin N2 - No abstract available KW - Tumor / Zellteilung Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-40656 ER - TY - JOUR A1 - Scheer, Ulrich T1 - Structural organization of spacer chromatin between transcribed ribosomal RNA genes in amphibian oocytes N2 - Transcribed nucleolar chomatin, including the spacer regions interspersed between the rRNA genes, is different from the bulk of nontranscribed chromatin in that the DNA of these regions appears to be in an extended (B) conformation when examined by electron microscopy. The possibility that this may reflect artificial unfolding of nucleosomes during incubation in very low salt buffers as routinely used in such spread preparations has been examined by studying the influence of various ion concentrations on nucleolar chromatin structure. Amplified nucleolar chromatin of amphibian oocytes (Xenopus laevis, Pleurodeles waltlii, Triturus cristatus) was spread in various concentrations of NaCl (range 0 to 20 mM). Below 1 mM salt spacer chromatin frequently revealed a variable number of irregularly shaped beads, whereas above this concentration the chromatin axis appeared uniformly smooth. At all salt concentrations studied, however, the length distribution of spacer and gene regions was identical. Preparations fixed with glutaraldehyde instead of formaldehyde, or unftxed preparations, were indistinguishable in this respect. The observations indicate that (i) rDNA spacer regions are not compacted into nucleosomal particles and into supranucleosomal structures when visualized at chromatin stabilizing salt concentrations (e.g., 20 mM NaCl), and (ii) spacer DNA is covered by a uniform layer of proteins of unknown nature which, at very low salt concentrations (below 1 mM NaCl), can artificially give rise to the appearance of small granular particles of approximately nucleosome-like sizes. These particles, however, are different from nucleosomes in that they do not foreshorten the associated spacer DNA. The data support the concept of an altered nucleohistone conformation not only in transcribed chromatin but also in the vicinity of transcriptional events. KW - Cytologie KW - Chromatin structure KW - rDNA KW - amphibian oocytes Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41057 ER - TY - JOUR A1 - von Jagow, Gerhard A1 - Sebald, Walter T1 - b-Type cytochromes N2 - No abstract available KW - Biochemie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-47383 ER - TY - JOUR A1 - Sebald, Walter A1 - Machleidt, Werner A1 - Wachter, Elmar T1 - N,N'-dicyclohexylcarbodiimide binds specifically to a single glutamyl residue of the proteolipid subunit of the mitochondrial adenosinetriphosphatases from Neurospora crassa and Saccharomyces cerevisiae N2 - T~e N,N'-dicrclohexylcarbodiimide-binding proteolipid subumt of the mitochondrial adenosinetriphosphatases (ATP phosphohydrolase, EC 3.6.1.3) of Neurosporacrassa and Saccharomyces cerevisiae were purified from mitochondria incubated with the radioactively labeled inhibitor. The specifically labeled subunit was cleaved with cyanogen bromide and N-bromosuccinimide, and the resultant fragments were separated by gel chromatography in the presence of 80% (vol/vol) formic acid. The N,N'-dicyclohexylcarbodiimide label was recovered in each organism exclusively in a 17-residue fragment. Further analysis by automated solid-phase Edman degrada.ti.on revealed tha~ the bound label was present at only one positIOn, correspondmg to a glutamyl residue. The NN'~ icyc~ohexyl~a~bodiiJ?1~de-'!l0dified glutamyl residue is the ~nly Id~ntIcal aCidic posItIon m both proteins and occurs in the middle of a hydrophobic sequence of about 25 residues. KW - Dicyclohexylcarbodiimid KW - Aminosäuren KW - inhibition of H+ translocation KW - amino acid sequence KW - automated solid-phase Edman degradation Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-47394 ER - TY - BOOK A1 - Koller, Erwin T1 - Totentanz: Versuch einer Textembeschreibung N2 - No abstract available KW - Deutsch KW - Totentanz KW - Literatur KW - Textsorte Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-47239 SN - 3-85124-077-4 N1 - Zugl. Innsbruck, Univ., Habilitationsschrift, 1980 ER - TY - BOOK A1 - Bach, Ulrich A1 - Wolff, Dieter T1 - Ausgewählte Bibliographie zur Psycholinguistik und Sprachpsychologie N2 - No abstract available KW - Psycholinguistik KW - Bibliographie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-47220 SN - 3-589-20757-4 ER - TY - CHAP A1 - Weinert, Franz E. A1 - Schneider, Wolfgang A1 - Treiber, Bernhard T1 - Bedingungsanalysen von (erwartungswidrigen) Schulleistungen N2 - No abstract available. KW - Schulleistung KW - Fähigkeit KW - Leistungsmotivation KW - Erwartungwidrigkeit Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87261 ER - TY - JOUR A1 - Treiber, Bernhard A1 - Schneider, Wolfgang T1 - Qualifizierende und varianzreduzierende Wirkungen von Schulklassenunterricht N2 - Schulklassenunterricht soll möglichst vielen Schülern ein möglichst hohes kognitives Leistungsniveau erreichen helfen. Nur wenige Unterrichtsstudien haben bisher jedoch zur Aufklärung jener Lehr-Lern-Bedingungen beigerragen, unter denen sich hohe qualifikatorische und varianzreduktive Wirkungen gleichzeitig erreichen lassen. Die vorliegende Studie greift dafür auf Merkmale einer adaptiv-remedialen Lehr-Lern-Organisation zurück und überprüft ihren Erklärungsgehalt im Mathematikunterricht von 58 fünften Hauptschulklassen. Zur systematischen Entwicklung komplexer Erklärungen und ihrer einzelfallartigen Beurteilung wird ein neu entwickeltes Programmsystem (HYPAG) angewandt. Es fühn zur Auswahl einer Annahmenstruktur, in der Instrumental- und Rahmenbedingungen von Schulklassenunterricht in Wechselwirkung stehen, für sich genommen aber nur mehr hinreichende und darin substiruierbare Bedingungen qualifizierender und varianzreduktiver Unterrichtseffekte sind. KW - Schulklasse KW - Unterricht KW - Wirkung Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87259 ER - TY - CHAP A1 - Hommers, Wilfried T1 - Recht und Psychologie - Ein wechselseitiges Verhältnis T1 - Juristic thought and psychology: A relation of interdependence N2 - Traditionally psychological research had assisted (de lege lata and de lege ferenda) jurisdiction, legislation, and law enforcement. However, the fol1owing three examp1es support the thesis that certain areas of psycho1ogica1 research gain new concepts and hypotheses by considering re1ated juristic thought. First, a developmenta1 study on the judgment about neg1igent damages suggested a three-step deve10pment of the evaluation of neg1igence. That threestep development wou1d contradict Heider's sequence of responsibi1ity levels. Second, a cognitive algebra approach to asses the chi1d's understanding of the duty to compensate the victim for his 1055 caused by a culpab1e actor suggested a two-step deve10pment of understanding that duty. The chi1d of the first deve10pment a1 step wou1d regard giving on1y half compensation of the 10ss as doing his duty to repair damages. Third, the concept of cul pa and the "Strafzumes sungs 1 ehre" in the German juri 5 ti c thought are d i scussed as key concepts for innovating psycho1ogica1 research on a moral algebra. Insofar juristic thought proved to assist psycho1ogica1 theory bui1ding what would make the relation of juristic thought and psycho1ogy a relation of interdependence. Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-43938 ER - TY - CHAP A1 - Krüger, Hans-Peter A1 - Wolfrum, Christine T1 - Die Homogenität von Interaktion als Skalierungskriterium N2 - No abstract available Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41288 ER - TY - JOUR A1 - Krüger, Hans-Peter A1 - Kohnen, Ralf T1 - Eine neue Methode zur Prüfung der Wirkung von Psychopharmaka - Die "Weltbeschreibung" N2 - Kompensation und das Problem der Zuggebbarkeit werden als die beiden wichtigsten Störquellen bei der Erfassung pharmakonbedingter Befindlichkeitsänderungen dargestellt. Gefördert werden diese Prozesse durch eine Zentrierung der Methode auf die Selbstbeobachtung. Es wird die Hypothese aufgestellt, daß die Selbstbeobachtung ersetzbar ist durch eine Beschreibung der "Welt draußen". Die Person kann sich nur in der Welt erleben - folglich werden Veränderungen dieses Erlebnis auch Veränderungen in der Beschreibung der Welt nach sich ziehen. Ausgehend von dieser Hypothese wird ein Experiment konzipiert, in dem die Vpn lediglich die experimentelle Situation und die am Experiment beteiligten anderen Vpn beschreiben, nicht aber sich selbst. Es kann gezeigt werden, daß mit den so gewonnenen Maßen eindeutige Wirkungen des eingesetzten Tranquilizers nachgewiesen werden können, ebenso eindeutige Dosis-Wirkungs-Beziehungen. Die Konsequenzen für eine pharmakopsychologische Methodik werden diskutiert. Zudem wird herausgehoben, daß Tranquilantien dann als positiv bewertet werden können, wenn sie die Reagibilität der Vpn auf die Situation erhöhen und durch eine Verringerung des allgemeinen Aktivierungsniveaus eine adäquate Verarbeitung angstinduzierender Situatonen ermöglichen. N2 - Compensation and readiness to admit drug effects are described as the most important modifying factors in assessing changes of mood that is due to psychotropic drugs. Both processes are advanced by a methodology which focuses on the selfobservation of the experimental subjects. The authors propose the hypothesis that seifreports may be replaced by a description of the "outside world". The human being is only able to experience itself within its concrete world; consequently, changes of its experience entail changes of the description of the world. On the basis of this hypothesis an experiment is conceived in which the subjects describe only the experimental situation and the other participating subjects, not themselves, however. The authors hold that the parameters emerging from this approach give evidence both of clear-cut tranquilizer-effects and stable drug-dosage-relationships. Consequences for pharmaco-psychological methodology are discussed. The authors accentuate that tranquilizers can be seen as having positive effects if they help to enhance the subject's reagibility to the situation and, by reducing the general activation level, enable the subject to cope with anxiety inducing situations. Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41566 ER - TY - JOUR A1 - Krüger, Hans-Peter A1 - Buchta, Herbert T1 - Nichtparametrischer Vergleich von Testprofilen und Verlaufskurven bei unabhängigen Stichproben N2 - Werden k Testwerte an zwei oder mehreren Stichproben von Pbn erhoben, stellt sich das Problem des Vergleichs von Testprofilen. Ähnliche Fragen treten auf, wenn statt k verschiedenen Testwerten ein Meßwert zu k Zeitpunkten an einem Pb erhoben wird. Zur Auswertung dieser Fragestellung wird ein Vorgehen nach dem WILCOXON-Rangsummentest vorgeschlagen, der es erlaubt (1) Unterschiede aller Art (2) Unterschiede in der Lage und (3) Unterschiede in der Form der Profile zu prüfen. Das Vorgehen wird an einem Beispiel aufgezeigt. Erweiterungen auf andere Fälle werden diskutiert. N2 - If kotest scores are collected in two or more sampies of subjects the problem of a comparison of test-proftles arises. Similar problems can be observed in those cases in which instead of k-different test-scores a test result of k-times is ascertained from a subjecL For purposes of interpretation an approach (Wi1coxon rank sum test) is suggested allowing the examination 01 1) differences of all kind, 2) differences of location and 3) differences of the forms of profIles. This approach is demonstrated by means of an example. Possibilities of applieating this approach in other eases are discussed. Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41513 ER - TY - JOUR A1 - Krüger, Hans-Peter T1 - Grundlagen und Probleme von Dimensionen in der Psychologie / Heinrich Wottawa N2 - Buchbesprechung von Grundlagen und Probleme von Dimensionen in der Psychologie / Heinrich Wottawa. - Meisenheim am Glan: Hain, 1979. - 122 S., ISBN: 3-445-01927-4. - (Psychologia universalis ; 40) KW - Dimension KW - Psychologie KW - Skalierung KW - Testtheorie KW - Faktorenanalyse KW - Rezension Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41546 ER - TY - JOUR A1 - Daut, Volker T1 - Die Entwicklung der Todesvorstellung bei Kindern und Jugendlichen N2 - No abstract available Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-36069 ER - TY - CHAP A1 - Clarke, AH A1 - Ellgring, Johann Heinrich A1 - Wagner, H. T1 - Situational effects on the syntax of speech and gaze behaviour in dyads N2 - A substantial literature exists on the coordination of speaking and looking behaviour and their significance as indicators for the production and reception of social information. Within this framework, the temporal organisation of such behaviour has been 'shown to reflect both the coordination within the individual and between participants in a situation. In this paper, it is proposed that observed behavioural sequences may be formally described by rules of syntax, thus implying the likelihood of structural organisation as opposed to, for example, linear time dependence between behavioural states. This being the case, differing sets of rules and grammars respectively can be expected for various social situations. Clinical interviews and discu~sions between couples on a topic of marital conflict were analysed, the on-off patterns of speech and gaze being taken as data. The resulting behavioural repertoire was regarded, in the sense of a formal grammar, as the terminal vocabulary. A set of rewriting rules was determined and their associated probabilities inferred. The situational conditions were found to be reflectedin the syntactic features of the grammatical model - the terminal vocabulary, the production rules and the production probabilities. KW - Psychologie KW - Social interaction KW - verbal and nonverbal communication KW - mathematical linguistics KW - grammar KW - rules of syntax KW - behavioural analysis Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-50316 ER - TY - CHAP A1 - Krüger, Hans-Peter A1 - Rausche, A. T1 - Die Prüfung von Verlaufskurven auf das Vorliegen von Trends über die exakte Verteilung von Spearman's S N2 - no abstract available KW - Psychologie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-79827 ER - TY - JOUR A1 - Krüger, Hans-Peter A1 - Kohnen, Ralf T1 - Wirkungen von Psychopharmaka auf das Lärmerleben N2 - In allgemeinpsychologischen Lärmexperimenten ist eine monotone Beziehung zwischen physikalischer Lautstärke und erlebter Lautheit bestens abgesichert. In der vorliegenden Arbeit wird gezeigt, daß diese Beziehung unter Medikationsbedingungen nicht gilt. In einem 3 X 3 X 2-faktoriellen Versuchsplan mit den Faktoren physikalische Lautstärke (weißes Rauschen in 76, 79 und 82 dB), Medikation (Tranquilizer, Plazebo, Stimulizer) und (niedere bzw. hohe) Ansprechbarkeit auf Medikamente beurteilten insgesamt 54 junge weibliche Versuchspersonen in sechs Durchgängen eine Serie von 12 gleichabständigen Lärmstufen von 58 bis 92 dB in bezug auf die erlebte Lautheit. Es war weder eine Hauptwirkung Physikalische Lautstärke noch Medikation aufgetreten, dafür differenzierte die Schichtungsvariable Ansprechbarkeit auf beiden Faktoren. Eine Interpretation der Ergebnisse sensu Eysencks Drogenpostulat und im Sinne einer Aktivierungstheorie wird vorgenommen. Als Konsequenz für pharmakopsychologisches Experimentieren wird die Forderung erhoben, die in das Experiment eingebrachten Unabhängigen Variablen in ihrer Wirkung auf das Erleben der Vpn zu kontrollieren (subjektive Repräsentation des experimentellen Angebotes). N2 - 54 young female subjects were required to report the experienced loudness of aseries of 12 white noises of 58 to 92 db, after having taken a tranquillizer, a placebo, or a stimulant, in a room with a white noise of 76, 79, or 82 db, respectively. The subjects were divided into two groups according to their sensitivity to drugs. The subjects being sensitive to drugs, expeiienced the loudness of the whole series of white noises, after having taken the tranquillizer, or in the room with a white noise of 76 or 79 db, respectively, as "high", and after having taken the stimulant, or in the room with a white noise of 82 db, as "low". On the contrary, the subjects being not sensitive to drugs, experienced the loudness of the whole series of white noises, after having taken the stimulant, or in the room with a white noise of 82 db, as "high", and after having taken the tranquillizer, or in the room with a white noise of 76 or 79 db, respectively, as "low". The results were discussed in the light of Eysenck's theory of drugeffects and of an activation theory. The results show the necessity of controlling the experienced intensity of loudness in pharmaco-psychological experiments. Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41305 SN - 0044-2712 ER - TY - JOUR A1 - Ellgring, Johann Heinrich A1 - Wagner, Helmut A1 - Clarke, Andrew H. T1 - Binäre Kodierung von Sprechen und Blicken: Validität, Reliabilität und ihre Abhängigkeit von der zeitlichen Auflösung N2 - Validität und Reliabilität der Sprechkodierung einer Beobachtergruppe wurden in Abhängigkeit von der zeitlichen Auflösung untersucht. Die Validität wurde anhand der Übereinstimmung der Beobachter mit einem automatischen Sprachdetektor berechnet. Die Reliabilitätswerte für die Kodierung von Sprechen und Blikken ergaben sich aus der Übereinstimmung der Beobachter untereinander. Im wesentlichen zeigten sich folgende Ergebnisse: 1. Die Validität/Reliabilität der Sprechkodierung ist eine monotone, nichtlineare Funktion der gewählten Auflösung. Die systematischen Fehler, die auf Latenz und Trägheit der menschlichen Beobachter zurückgehen, werden bei einer Auflösung von 400 msec nahezu vollständig unterdrückt. 2. Weder bei der Erfassung des Sprech- noch des Blickverhaltens lassen sich Anzeichen für Observer-Drift feststellen. Trainierte und untrainierte Beobachter unterscheiden sich nicht signifikant. 3. Die Kodierung des Sprechverhaltens ist geringfügig reliabler als die des Blickverhaltens. Dieser Unterschied kann in der Praxis vernachlässigt werden. N2 - The reliability of the binary coding of speech and gaze was examined as a function of the temporal resolution of measurement. The reliability was calculated as the agreement between human observers. In addition, the validity of the speech coding could be determined from the agreement between the human observers and an electronic speech detector. Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-43163 ER - TY - BOOK A1 - Schneider, Wolfgang T1 - Bedingungsanalysen des Rechtschreibens N2 - No abstract available. KW - Rechtschreibung KW - Leistungsdiagnostik KW - Kreativität KW - Legasthenie KW - Forschung KW - Schulleistung KW - Informationsverarbeitung KW - Theorie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87151 ER - TY - CHAP A1 - Ellgring, Johann Heinrich T1 - Video in der Verhaltenstherapie N2 - No abstract available Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-42048 ER - TY - CHAP A1 - Ellgring, Johann Heinrich A1 - Wagner, H. A1 - Clarke, AH T1 - Psychopathological states and their effects on speech and gaze behaviour N2 - Internal characteristics such as depressed mood, anxiety and general negative emotions are accompanied, particularly during depressive illness, by changes in observable behaviour. Accordingly, the following questions may be examined: are intra-individual changes in speech and gaze behaviour related to changes in the internal psychopathological state? Further, do these changes occur synchronously to changes in the state of subjective well-being? A longitudinal study was made on depressed patients. Their behaviour was observed during standardised interviews and diagnostic-therapeutic discussions held at regu~ lar intervals. Various speech and gaze parameters were examined with respect to their coordination and their relationship to the subjective state of well-being. Considerable variation was found in the temporal relationship amongst these variables. The results are discussed with respect to the relevance of speech parameters and the coordination of verbal and nonverbal behaviour as indicators of the psychopathological condition. KW - Psychologie KW - Social interaction KW - depression KW - verbal and nonverbal behaviour KW - speech KW - looking behaviour KW - dyadic interaction KW - single case study Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-50323 ER - TY - CHAP A1 - Ruhe, Ernstpeter T1 - Vorwort zu "De l´art de parler" N2 - No abstract available KW - Bernard Lamy KW - Reden Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-36784 ER - TY - JOUR A1 - Burschka, Christian A1 - Stroppel, Klaus A1 - Jutzi, Peter T1 - Die Struktur von μ-Dibromgermandiyl-bis(pentacarbonylwolfram)(W-W) N2 - No abstract available KW - Chemie Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31852 ER - TY - JOUR A1 - Sirén, Anna-Leena T1 - Central cardiovascular and thermal effects of prostacyclin in rats N2 - Prostacyclin (PGI2) induced a dose-dependent decrease in blood pressure with slight increases in heart rate and body temperature, when administered at the doses of 0.1-100 ~g into the lateral cerebral ventricle (i.c.v.) of the urethane-anaesthetised rat. When the same doses were administered intravenously, both the blood pressure and heart rate decreased. Central pretreatment wib~ sodiurn meclofenamate (1 mg/rat i.c.v.) antagonised the central hypotensive effect of PGI2 but i.c.v. pretreatrnent of the rats with indomethacin (1 mg/rat) failed to affect the PGI 2-induced hypotension. Central pretreatment with two histamine H2-receptor antagonists, cimetidine (500 ~g/rat i.c.v.) or metiamide (488 ~g/rat i.c.v.), antagonised the blood pressure lowering effect of 0.1 ~g dose of PGI2 but failed to affect the hypotension induced by higher PGI2 doses. Therefore the main central hypotensive effect of PGI2 seems not to be associated with the stimulation of histamine H2 -receptors in the brain. The hypotensive effect of i.c.v. administered PGI2 appears to be due to an action upon the central nervous system rather than to a leakage into the peripheral circulation. This assurnption is supported by the fact that sodiurn meclofenamate i.c.v. antagonised the effect of PGI 2. In addition, the chronotropic response to i.c.v. PGI2 was opposite to that induced by intravenous administration. The results also suggest that there may be differences in the mode of action between sodiurn meclofenamate and indomethacin. KW - Prostaglandine Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-47943 ER - TY - JOUR A1 - Jutzi, Peter A1 - Karl, Alfons A1 - Burschka, Christian T1 - Synthese, Reaktionen und Struktur von Tricarbonyl(1R,1R',2,3,4,5-Tetraphenyl-1-Germacyclopentadien) Eisen-Komplexen N2 - Die Tricarbonyl(germacy~lopentadien)eisen-Komplexe VI-X werden durch Umsetzung der Germacyclopentadiene I-V niit Fe(CO)\(_5\) dargestellt. In l,l-Dialkyl- und -Diaryl-l-gemiacyclopentadien-Komplexen kann die Ge-C( exo )-Bindung durch verschiedene Elementhaloge~de gespalten werden, wobei die I-Halogen-l-germacyclopentadien-Komplexe XII, XIII, XV-XVII gebildet werden. Eine Entkomplexierung des Komplexes XI tritt bei der Reaktion mit Me\(_3\)NO oder TiCl\(_4\) ein. Das Tricarbonyl(l-chlor-l-germacyclopentadien)eisen XII reagiert mit AgF, NaJ, NaOMe und LiAIH\(_4\) zu den Komplexen XIXXXII. Das German XXII kann mit CCl\(_4)\ in XII überführt werden. Die Tricarbonyleisen-Komplexe XI, XII, XVI, XVII und XIX reagieren photochemisch mit Trimethylphosphan zu den Dicarbonyl(trimethylphosphan)-Komplexen XXIII-XXVII. Die Kristallstruktur des Tricarbonyl(l-exo-fluor-1-endo-methyl-2,3,4,5-tetraphenyl-1-germacyclopentadien)eisen wird beschrieben. N2 - The tricarbonyl(germacyclopentadiene)iron complexes VI-X are synthesized by the reaction of the germacyclopentadienes I-V with Fe(CO)\(_5\). In l,l-dialkyl- and -diaryi-l-germacyclopentadiene complexes the Ge-C(exo) bond can be split by different element halides, whereby the I-halo-l-germacyclopentadiene complexes XII. XIII. XV-XVII are formed. Decomplexation takes place by the reaction of complex XI with Me\(_3\)NO or TiCl\(_4\). Tricarbonyl(l-chloro-1-germacyclopentadiene)iron (XII) reacts with AgF. NaI. NaOMe and LiAIH\(_4\) to the complexes XIX-XXII. The germane XXII can be transferred to XII with CCl\(_4)\. The tricarbonyliron complexes XI. XII. XVI. XVII and XIX react photochemicaIly with trimethylphosphane to the dicarbonyl(trimethylphosphane) complexes XXIII-XXVll. The crystal structure of tricarbonyl(1-exo-fluoro-l-endo-methyl-2,3,4,5-tetraphenyl-l-germacyclopentadiene) iron is described. KW - Chemie Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-46723 ER - TY - JOUR A1 - Wilhelm, Gernot T1 - Die Siegel des Königs Itḫi-teššup von Arrapḫa N2 - No abstract available KW - Orientalistik Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-51174 ER - TY - JOUR A1 - Deltz, E. A1 - Müller-Hermelink, HK A1 - Ulrichs, Karin A1 - Thiede, A. A1 - Müller-Ruchholtz, W. T1 - Development of graft-versus-host reaction in various target organs after small intestine transplantation N2 - The GVHRIL foHowing transplantation of small intestine are different from those found after bone marrow transplantation or spleen cell injections in that they show a remarka ble, significant prevalence of lesions within the intestinal mucosa. These findings are consistent with the observation that jntestinal lymphocytes newly formed in mesenteric lymph nodes predominantly home in on the intestine again.& The degree of histologic alteration within different tissues indicates that the graft and the host may survive the lesions of the lymphatic tissues, whereas the severe intestinal lesions following GVHR may easily cause death of the recipient. With regard to clinical sman bowel transplantation two statements can be made: (l) GVHRIL play a significant role in small bowel trans~ plantation. (2) To minimize their biologic importance, a selective elimination of the graft's Jymph nodes by irradiation or surgical resection should be considered in view of the remarkable difference between GVHRIL in lymph nodes and in the graft's intestinal wall itself. KW - Chirurgie Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45459 ER - TY - JOUR A1 - Däniken, A. von A1 - Friederich, U. A1 - Lutz, Werner K. A1 - Schlatter, C. T1 - Tests for mutagenicity in Salmonella and covalent binding to DNA and protein in the rat of the riot control agent o-chlorobenzylidene malononitrile (CS) N2 - The aim of this study was to determine whether o-chlorobenzylidene malononitrile ( CS) exhibits any genotoxic activity towards Salmonella or mammalian DNA in vivo. CS was synthesized with a [\(^{14}\)C]-label at the benzylic carbon atom. It was administered i. p. at a dose level of 13 mg/kg (1 mCi/kg) to young adult male rats. Liverand kidney DNA was isolated after 8, 25, and 75 h. The radioactivity was at (liver, 8 and 75 h) or below (all other samples) the limit of detection of 3 dpm. Therefore, a possible binding of CS to DNA is at least 10\(^5\) times lower than that of the strong hepatocarcinogen aflatoxin B1, and 4,000 times lower than that of vinyl chloride. In contrast to this lack of DNA binding, but in agreement with the chemical reactivity of CS, a binding to nuclear proteins could be detected with specific activities ranging between 50 and 121 dpm/mg for liver and between 3 and 41 dpm/mg for kidney. Protein binding could well be responsible for its pronounced cytotoxic effects. Cs was also tested in the Ames Salmonella/microsome assay. Strains TA 1535, TA 1537, TA 1538, TA 98, and TA 100 were used with or without pre-incubation. Only with strain TA 100 and only without pre-incubation, a doubling of the number of revertants was detectable at the highest dose Ievels used, 1,000 and 2,000 !lg CS per plate. With pre-incubation of TA 100 with CS, a slight increase of the number of revertants was seen at 100 and 500 !lg per plate, and a subsequent fall below control values at 1,000 J.tg. A check for the number of surviving bacteria revealed a strong bacteriotoxicity of the higher doses of es so that the calculated mutation frequencies, i.e., the oumber of revertants per number of surviving bacteria, increased with doses up to 500 !J.g. This toxicity could be counteracted in part by the addition of increasing amounts of rat liver microsomes. In the view of these results, and taking into account the rare and low exposure of man, it is concluded that CS will not create a risk for the induction of point mutations or of carcinogenic processes mediated by DNA binding. KW - Toxikologie KW - o-Chlorobenzylidene malononitrile KW - Riot control agents KW - DNA Binding KW - Salmonella/microsome assay KW - Carcinogens KW - Mutagens Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61073 ER - TY - JOUR A1 - Däniken, A. von A1 - Lutz, Werner K. A1 - Schlatter, C. T1 - Lack of covalent binding to rat liver DNA of the hypolipidemic drugs clofibrate and fenofibrate N2 - \(^{14}\)C-Labelled clofibric acid and fenofibric acid were administered p.o. to 200 g male and female rats. After 10 h, liver nuclear DNA and protein were isolated and the radioactivity was determined. Binding to protein was clearly measurable whereas no binding to DNA could be detected from any drug. A comparison of the Iimit of detection of such DNA binding with well-known chemical carcinogens revealed that the known hepatocarcinogenicity of clofibrate cannot be based upon an initiating, DNA damaging, mode of action but must be due to other, nongenotoxic, mechanisms such as peroxisome proliferation, hepatomegaly, or cytotoxicity due to protein binding. The risk assessment in man and the interpretation of the carcinogenicity data for rodents are discussed. KW - Toxikologie Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61087 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Strecker, M. A1 - Niedner, R. T1 - Cholinesterase-hemmende Organophosphorsäureester und ihre Sila-Analoga T1 - Organophosphates with Anticholinesterase Activity and their Sila-Analogues N2 - Die Organophosphorsäureester la-4a und ihre Sila-Analoga lb-4b des Typs R\(^1\)R\(^2\)P(O)( p-OC\(_6\)H\(_4\)ElMe\(_3\)) (EI = C, Si) wurden synthetisiert. Die Kohlenstoff-Verbindungen 1 a- 4a zeigen hinsichtlich ihrer Anticholinesterase-Aktivität die gleichen Struktur-Wirkungs-Beziehungen wie die Silicium-Verbindungen 1 b- 4 b. Letztere sind jeweils wirksamer als die entsprechenden C-Analoga. N2 - The organophosphates la-4a and their sila-analogues lb-4b of the type R\(^1\)R\(^2\)P(O)( p-OC\(_6\)H\(_4\)ElMe\(_3\) (El = C, Si) were synthesized. With regard to their anticholinesterase activity, the carbon compounds ta- 4a exhibit the same structure-activity relationships as the silicon compounds 1 b- 4b. The latter are more activ than the corresponding C-analogues. KW - Anorganische Chemie Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63689 ER - TY - JOUR A1 - Wiese, D. A1 - Tacke, Reinhold A1 - Wannagat, U. T1 - 9,9-Dimethyl-10-(3-dimethylaminopropyl)-9-silaacridan, ein Sila-Analogon des Dimetacrins, und strukturverwandte Verbindungen T1 - 9,9-Dimethyl-10-(3-dimethylaminopropyl)-9-silaacridane,a Sila-Analogue of Dimetacrine, and Structurally Related Compounds N2 - Das Sila-Dimetacrin (3a), ein Sila-Analogon des Psychopharmakons Dimetacrin (2), und sein N,N-Diethylderivat 3 b sowie sein 3-Chlorderivat 3 c wurden, von den o-Halogenanilinen 4 a- c ausgehend, über die teilweise unbekannten Stufen 5 a- c bis 10a- d synthetisiert, in ihren Eigenschaften beschrieben und in ihrer Struktur über Elementaranalysen, \(^1\)H-NMR- und Massenspektren sichergestellt. Die Synthese des Zwischenproduktes Bis(2-bromphenyl)amin (9a) konnte optimiert werden. N2 - Sila-dimetacrine (Ja), a sila-analogue of the psychotropic drug dimetacrine (2), and its N,N-diethyl derivative 3 b as well as its 3-chloro derivative 3 c were synthesized from o-haloanilines 4 a- c via the - partially unknown - intermediates S a- c to 10 a- d. Their properties are described and their structure is confirmed by eiemental analysis, \(^1\)H-NMR, and mass spectroscopy. The preparation of the intermediate bis(2-bromophenyl)amine (9a) could be improved. KW - Anorganische Chemie Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63691 ER - TY - JOUR A1 - Christl, Manfred A1 - Brunn, E. T1 - Tetracyclo[4.1.0.0\(^{2,4}\).0\(^{3,5}\)]heptane aus 7,8-Diazatetracyclo[4.3.0.0\(^{2,4}\).0\(^{3,5}\)]non-7-enen N2 - No abstract available KW - Organische Chemie Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-58094 ER - TY - JOUR A1 - Heinsen, Helmut T1 - Regional differences in the distribution of lipofuscin in Purkinje cell perikarya : a quantitative Pigmentarchitectonic study of the Cerebellar Cortexof Senile Albino Rats N2 - The distribution of lipofuscin in the perikarya of Purkin je cells of vermal and hemispheric lobules has been determined quantitatively in 7 rats, 30-38 months old, by the point-counting method. On the basis of morphologically and statistically significant differences a pigmentarchitectonics of the cerebellar cortex is established. The Purkinje cells of lobule VIa (Larsell 1952) are extremely lipofuscin-rich. The Purkinje cells of the hemispheres, lobules V, Vlb + c and VII contain considerable amounts of a finely granular lipofuscin, the Purkinje cells of lobules I-III and VIII- IXa a globular type of lipofuscin. The Purkinje cells of sublobule XI d c and X are lipofuscin-poor cells. Three types of lipofuscin ha ve been identified in the light microscope. KW - Medizin KW - Lipofuscin KW - Purkinje cells KW - Pigmentarchitectonics KW - Senile rat Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-59904 ER - TY - JOUR A1 - Scheer, Ulrich A1 - Zentgraf, Hanswalter A1 - Sauer, Helmut W. T1 - Different chromatin structures in Physarum polycephalum: a special form of transcriptionally active chromatin devoid of nucleosomal particles N2 - Nonnucleolar chromatin from interphase nuclei of Physarum polycephalum plasmodia occurs in two different structural configurations as seen in electron microscopic spread preparations. While the majority of the chromatin is devoid of nascent ribonucleoprotein (RNP) fibrils and compacted into nucleosomal particles, a minor proportion (10- 20%) is organized differently and reveals a smooth contour. It is this form of smooth chromatin which is rich in transcription units (mean length: 1.36±0.21 11m). Only occasionally are solitary nascent RNP fibrils observed which are associated with beaded strands of chromatin. In transcribed smooth chromatin nucleosomal particles are not only absent from the transcription units but also from their nontranscribed flan king regions, indicating that this special structural aspect is not merely a direct consequence of the transcriptional process. The existence of ca. 10- 20% of Physarum chromatin in the smoothly contoured form is discussed in relation to reports of a preferential digestibility of a similar proportion of Physarum chromatin by DNAse I (Jalouzot et al. , 1980) and to the altered configuration of "peak A" chromatin subunits after micrococcal nuclease digestion (Johnson et al., 1978a, b). Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33148 ER - TY - JOUR A1 - König, Dorothea T1 - Wortindex zum Psalterium Sinaiticum / Maria Dumitrescu, Sinajskij Paterik N2 - Maria Dumitrescu, Sinajskij Paterik : Wortindex zum Psalterium Sinaiticum, Bucuresti, 1980 Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-38758 ER - TY - GEN T1 - Jahresbericht 1980 T1 - Annual Report 1980 N2 - Die Entwicklung der Universitätsbibliothek Würzburg im Jahr 1980. N2 - Annual Report of the University Library of Würzburg, 1980. T3 - Jahresbericht der Universitätsbibliothek Würzburg - 1980 KW - Würzburg KW - Universitätsbibliothek KW - Bericht KW - Jahresbericht KW - Würzburg KW - University Library KW - Report KW - Annual Report KW - Wuerzburg KW - Wurzburg Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-42232 ER - TY - JOUR A1 - Christl, Manfred A1 - Lanzendörfer, Ulrike A1 - Freund, Silke T1 - Olefinadditionen an 2,5-Diphenyl-1,3,4-oxadiazin-6-on N2 - No abstract available Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41525 N1 - Prof. Siegfried Hünig zum 60. Geburtstag gewidmet ER - TY - CHAP A1 - Krüger, Hans-Peter T1 - Nachuntersuchungen zur Ausbildung des Wollens N2 - Dükers Ergebnisse zur Wirkung von zwangsläufiger Arbeit bei wollensschwachen Vpn konnten wieder eingebracht werden. Die Variation des Versuchsgeräts ergab, daß das Gelingen dieser Untersuchungen wesentlich von der methodisch einzuführenden Unausweichlichkeit der Situation abhängt. Je weniger dies verwirklicht wird, desto geringer ist der Leistungsanstieg, um so mehr tritt die Person des Vls in den Vordergrund, um so schwerer fällt es den Vpn, die Leistungssteigerung der eigenen Person zu attribuieren. Ferner konnte gezeigt werden, daß das Schreiben von Achten in freier und zwangsläufiger Arbeit zumindest dieselbe Wirkung auf andere Leistungen hat wie das direkte üben dieser Leistungen. Offensichtlich wird mit dieser Methode eine zentrale Funktion der Leistung geübt. N2 - The effects of forced continuous activity on weak-willed slow learners, as shown by Düker, could be reproduced. Variation of the display apparatus cleared that the success of such tests essentially depends on the degree of inevitability imposed on the Ss by the situation. The less inevitable the situation, the lower becomes the increase in efficiency, the more the experimenter comes to the fore, and the harder it is on the Ss to attribute the increase to themselves. Moreover, the continuous writing of eights in free and in forced activity has at least the same bearing on other skills as practising these skills directly. Apparently, the method contributes to practising a central function of performance. Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-40995 ER - TY - JOUR A1 - Agranovsky, A. A. A1 - Dolya, V. V. A1 - Gorboulev, Valentin G. A1 - Kozlov, J. V. A1 - Atabekov, J. G. T1 - Aminoacylation of barley stripe mosaic virus RNA: polyadenylate-containing RNA has a 3'-terminal tyrosine-accepting structure N2 - Barley stripe mosaic virus (BSMV) RNA which was previously reported to contain poly(A) sequences (Agranovsky et al., 1978) can be specifically esterified with tyrosine in vitro in the presence of an aminoacyl-tRNA synthetase fraction from wheat embryos. All the three RNA components of the BSMV strain with a three-component genome (Norwich) and both RNA components of a two-component strain (Russian) can be tyrosylated. The poly(A)-containing (bound to oligo(dT)-cellulose) and poly(A)-deficient(not bound to oligo(dT)-cellulose) fractions of BSMV RNA display a similar amino acidaccepting ability. The nucleotide sequence which accepts tyrosine is coupled with the intact genomic polyadenylated BSMV RNA. The viral RNA isolated after sucrose density gradient centrifugation under drastic denaturing conditions retains its aminoacylating activity, which suggests that this activity is not due to the presence in a BSMV RNA preparation of a tyrosine tRNA associated with BSMV RNA. Inhibition of aminoacylation of the 3’-oxidized (treated with sodium metaperiodate) BSMV RNA suggests that the tyrosine-accepting structure is localized at the 3’ terminus of BSMV RNA molecules. It is shown that segments of different lengths obtained upon random fragmentation can be tyrosylated. The 3’-terminal (tyrosine-accepting) poly(A)+ segments can be isolated. The shortest segments of viral RNA capable of being aminoacylated [i.e., containing both tRNA-like structure and poly(A)] consists of approximately 150-200 nucleotides. The analysis of the oligonucleotides derived from individual BSMV RNA components labeled with 32P at the 3’ end revealed two types of 3’-terminal sequences different from poly(A). It is suggested that a poly(A) sequence is intercalated between a 3’-terminal tyrosineaccepting structure and the 5’-terminal portion of poly(A)+ BSMV RNA. Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-32566 ER - TY - JOUR A1 - Kozlov, J. V. A1 - Gorboulev, Valentin G. A1 - Kurmanova, A. G. A1 - Bayev, Alexander A. A1 - Shilov, A. A. A1 - Zhdanov, V. M. T1 - On the origin of the H1N1 (A/USSR/90/77) influenza virus N2 - The influenza virus H1N1 (the A/USSR/90/77 strain) that reappeared in 1977 after the H1N1 influenza viruses had disappeared from the human population, is compared with the A/FM/1/47 and the A/FW/1/50 influenza viruses by the method of oligonucleotide mapping of individual segments of the viral RNAs. Seven genes of the A/USSR/90/77 virus appear to be very similar to the corresponding genes of the A/FW/1/50 virus, whereas the gene coding for the M protein displays considerable homology to the corresponding gene of the A/FM/1/47 virus. The data demonstrate that the A/USSR/90/77 strain is a recombinant virus. KW - influenza virus ; virion RNA segments ; oligonucleotide mapping ; gene reassortment Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-32556 ER - TY - JOUR A1 - Scheer, Ulrich A1 - Sommerville, J. T1 - Structural organization of nascent transcripts and hnRNA molecules in amphibian oocytes N2 - Comparisons ofrelative lengths oflampbrush loops, nascent RNP transcripts and hnRNA molecules from oocytes of amphibia with different C-values show that there is an increasing trend in loop, and transcriptional unit, length with increase in genome size but no increasing trend with respect to RN A contour length.The formation of duplex regions and circles in RNP fibrils indicates that RNA processing may occur within the nascent fibrils. The hnRNA molecules from oocytes of the various amphibia readily form intermolecular duplex structures. These complementary sequences have a low kinetic complexity and are transcribed from highly repetitive sequences distributed throughout the genome. Their possible function is considered. Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-39765 ER - TY - JOUR A1 - Burschka, Christian A1 - Schenk, W. A. T1 - Die Kristallstruktur von Tetramethylammonium-Chloropentacarbonylwolframat T1 - Substituted Halocarbonyl Metallates of Chromium, Molybdenum, and Tungsten. IV. Crystal Structure of Tetramethylammonium Chloropentacarbonyltungstate N2 - Die Struktur von Tetramethylammoniumchloropentacarbonylwolframat wurde rontgenographisch aue Einkristalldaten bestimmt. Die Verbindung kristallisiert mit vier Formeleinheiten in del' monoklinen Elementarzelle (Raumgruppe P2Jc) folgender Dimensionen: a = 1111,3(4) pm, b = 1110,3(4) pm, c = 1204,1(3) pm, f3 = 99,63(3)°, V = 1464,8 . 106 pm' (R = 0,028). Das Anion besitzt annahernd C4v·Symmetrie mit d(W -C(ois» = 203 pm, d(WC( trans» = 197 pm, d(W-Cl) = 256,6 pm. Zwischen Kation undAnion treten keine ungewohnliche Kontakte auf. N2 - The structure of tetramethylam~onium chloropentacarbonyltungstate has been determined from single crystal X-ray data. The compound crystallizes with four formula units in the monoclinic unit cell (space group P21!c) of the dimensions a = 1111.3(4) pm, b = 1110.3(4) pm c = 120-1.1(3) pm, fJ = 99.63(3)°, V = 1464.8x 1()6 pm" (R = 0.028). The anion possesses approximately C!v symmetry with the principal interatomic distances d(W -C(cis» = 203 pm, d(WC( trans)) = 197pm dew -Cl) = 256.6 pm. No unusual contacts between cation and anion have been found. KW - Chemie Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31417 ER - TY - JOUR A1 - Albert, Bernhard A1 - Berning, Wilfried A1 - Burschka, Christian A1 - Hünig, Siegfried A1 - Martin, Hans-Dieter A1 - Prokschy, Frank, T1 - Transanulare Wechselwirkung des Azo-Chromophors inisodrinanalogen Systemen T1 - Transanular Interactions of the Azo Chromophore in Isodrin-type Systems N2 - No abstract available KW - Chemie Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31328 ER - TY - JOUR A1 - Christl, Manfred T1 - Benzvalen - Eigenschaften und Synthesepotential N2 - No abstract available Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-30041 ER - TY - JOUR A1 - Zentgraf, H. A1 - Müller, U. A1 - Scheer, Ulrich A1 - Franke, W. W. T1 - Evidence for the existence of globular units in the supranucleosomal organization of chromatin N2 - No abstract available Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-34123 ER - TY - JOUR A1 - Bona, Marion A1 - Scheer, Ulrich A1 - Bautz, Ekkehard K. F. T1 - Antibodies to RNA polymerase II (B) inhibit transcription in lampbrush chromosomes after microinjection into living amphibian oocytes N2 - Antibodies directed against RNA polymerase II (B) from Drosophila melanogaster were obtained from rabbit sera and, as monoclonal immunoglobulins, from mouse hybridomas and shown to cross-react with the amphibian enzyme protein. Localization by indirect immunofluorescence microscopy revealed the association of this enzyme with chromatin of interphase nuclei of amphibian cells and its absence in nucleoli. Purified immunoglobulins were microinjected in to nuclei ofliving vitellogenic oocytes of Ple1lrodeles waltlii and X enopus laevis and their effects on transcriptional processes were monitored by biochemical and light and electron microscopic stud ies. RNA polymerase II antibodies from rabbit sera caused a rapid and almost complete release of nascent transcripts from the chromatin axis of the loops of lampbrush chromosomes, followed by collapse of the loops and their retraction on the main chromosome axis. Monoclonal murine antibodies to the Iarge RNA polymerase II subunits also inhibited transcription in chromosome Ioops but appeared to inhibit initiation rather than elongation events. Activities of class land III RNA polymerases were not significantly affected by injection of antibodies to polymerase II, indicating immunological differences between the three RNA polymerases. The potential value of the in vitro test system described , as a very sensitive assay for detecting proteins involved in transcription in living cells, is discussed. 1 Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33128 ER - TY - JOUR A1 - Franke, Werner W. A1 - Scheer, Ulrich A1 - Krohne, Georg A1 - Jarasch, Ernst-Dieter T1 - The nuclear envelope and the architecture of the nuclear periphery N2 - No abstract available Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33108 ER - TY - JOUR A1 - Franke, Werner W. A1 - Kleinschmidt, Jürgen A. A1 - Spring, Herbert A1 - Krohne, Georg A1 - Grund, Christine A1 - Trendelenburg, Michael F. A1 - Stöhr, Michael A1 - Scheer, Ulrich T1 - A nucleolar skeleton of protein filaments demonstrated in amplified nucleoli of Xenopus laevis N2 - The amplified, extrachromosomal nucleoli of Xenopus oocytes contain a meshwork of -4-nm-thick filaments, which are densely coiled into higher-order fibrils of diameter 30-40 nm and are resistant to treatment with high- and low-salt concentrations, nucleases (DNase I, pancreatic RNase, micrococcal nuclease), sulfhydryl agents, and various nonionic detergents. This filamentous "skeleton" has been prepared from manually isolated nuclear contents and nucleoli as weil as from nucleoli isolated by fluorescence-activated particle sorting. The nucleolar skeletons are observed in light and electron microscopy and are characterized by ravels of filaments that are especially densely packed in the nucleolar cortex. DNA as weil as RNA are not constituents of this structure, and precursors to ribosomal RNAs are completely removed from the extraction-resistant filaments by treatment with high-salt buffer or RN ase. Fractions of isolated nucleolar skeletons show specific enrichment of an acidic major protein of 145,000 mol wt and an apparent pi value of -6.15, accompanied in some preparations by various amounts of minor proteins. The demonstration of this skeletal structure in "free" extrachromosomal nucleoli excludes the problem of contaminations by nonnucleolar material such as perinucleolar heterochromatin normally encountered in studies of nucleoli from somatic cells. It is suggested that this insoluble protein filament complex forms a skeleton specific to the nucleolus proper that is different from other extraction-resistant components of the nucleus such as matrix and lamina and is involved in the spatial organization of the nucleolar chromatin and its transcriptional products. In studies of the organization of the interphase nucleus, considerable progress has been made in the elucidation of the arrangement of chromatin components and transcriptional products. However, relatively little is known about the composition and function of another category of nuclear structures, the nonnucleoproteinaceous architectural components that are insoluble in solutions of low and high ionic strength, despite numerous studies dedicated to this problem. Such structures include (a) the nuclear envelope and its pore complexes (I, 15, 18, 23, 37, 41), (b) a peripheral layer of insoluble protein ("lamina"; I, 15, 22, 23, 59), (e) certain skeletal proteins related to the chromosome "scaffold" described by Laemmli and coworkers (see references 2 and 3), and (d) ill-defined tangles of fibrillar structures of the nuclear interior that are collectively described as residual "matrix" (6, 21 ; for reviews, see references THE JOURNAL OF CEll BrOlOGY . VOlUME 90 AUGUST 1981 289-299 © The RockefeIler University Press · 0021 -9525/ 81 / 08/ 0289/ 11 $1 .00 4 and 12). The latter, preparatively Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33130 ER - TY - JOUR A1 - Scheer, Ulrich T1 - Identification of a novel class of tandemly repeated genes transcribed on lampbrush chromosomes of Pleurodeles waltlii N2 - Electron microscope preparations of lampbrush chromosomes from oocytes of Pleurodeles waltl;; have revealed a new class of tandemly repeated genes. These genes are highly active, as judged by the close spacing of nascent transcripts. They occur in clusters of >100 copies and are transcribed in units containing roughly 940 base pairs of DNA that are separated by nontranscribed spacers of an estimated DNA content of 2,410 base pairs. The size and the pattern of arrangement of these transcription units can not be correlated with any of the repetitious genes so far described. Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33153 ER - TY - CHAP A1 - Krüger, Hans-Peter A1 - Kohnen, Ralph T1 - Kognitive, emotionale und physiologische Determinanten sozialer Zustände N2 - The psychological and physiological effects of a socially oriented sensitivity training were evaluated. It is shown that decreased physical distance as well as increased intimacy yields high activation, both in psychological measures (experienced stress) and in pulse frequences. One result (highly significant and replicated in other experiments) was paradoxical: when Ss had to caress the face of a heterosexual vis-a-vis, they reported high experienced stress, but pulse frequences dropped rapidely below the resting pulse. Some suggestions are made to explain these findings. The question arises whether an autonomic somatic process, induced by social Stimulation, but independent of the cognitive coping is responsible for these results. KW - Psychologie Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86055 ER - TY - JOUR A1 - Treiber, Bernhard A1 - Schneider, Wolfgang T1 - Schulisches Lernen im sozialökologischen Kontext N2 - No abstract available. KW - Lernen KW - Sozialökologie Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87271 ER - TY - CHAP A1 - Schartl, A. A1 - Schartl, Manfred A1 - Anders, F. T1 - Phenotypic conversion of malignant melanoma to benign melanoma and vice versa in Xiphophorus N2 - No abstract available. KW - Schwertkärpfling KW - Krebs Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86662 ER - TY - BOOK A1 - Wolf, Norbert Richard A1 - Domröse, Gerd A1 - Liebel, Hermann T1 - List Sprachbuch 6 [Hauptband] N2 - No abstract available KW - Deutschunterricht KW - Lehrmittel Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41688 ER - TY - BOOK A1 - Ante, Ulrich T1 - Politische Geographie T1 - Political geography N2 - No abstract available KW - Geopolitik KW - Einführung KW - Politische Geographie Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-36058 SN - 3-14-160278-6 ER - TY - JOUR A1 - Werner, S. A1 - Sebald, Werner T1 - Immunological techniques for studies on the biogenesis of mitochondrial membrane proteins N2 - no abstract available KW - Biochemie Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-82044 ER -