TY - JOUR
A1 - Viviani, A.
A1 - Lutz, Werner K.
T1 - Modulation of the binding of the carcinogen benzo(a)pyrene to rat liver DNA in vivo by selective induction of microsomal and nuclear aryl hydrocarbon hydroxylase activity
N2 - The lnfluence of mlcrosomal and nuclear aryl hydrocarbon hydroxylase (AHH) actlvlty on the covalent blndlng of [G·3H]benzo(a )pyrene to rat llver DNA was evaluated in viWJ. lnductlon of mlcrosomal AHH was obtalned alter phenobarbltal treatment (160% of control), whlch also lncreased DNA blndlng to 190%, but left the nuclear actlvlty unchanged. Nuclear AHH was lnduced wlth dleldrln (150%), and the blndlng was decreased to 75%, whereaa the mlcrosomal AHH was at control Ievei. The lncreaslng effect of mlcrosomal AHH lnductlon as weil as the decreaslng effect of nuclear AHH lnductlon on the blndlng was shown clearly when the data of the Individual rata were uaed to solve the equatlon Binding = e•(mlcroeomal AHH) + b•(nuclear AHH) + c Multiple linear regresslon analysls wlth the data from 10 anlmala reaulted ln positive valuea for a and c, a negative value for b, and a good multiple correlatlon coefflclent of r = 0.974. Pretreatment wlth 3-methylcholanthrene ln· duced mlcrosomal AHH to 380% of control and nuclear AHH to 590% and lncreased the blndlng' to 175,.-o. The blndlng was hlgher than predlcted by the formula found, probably because the lncreaslng lnfluence of lnduced mlcrosomal AHH overahadowed the decreaslng effect of the nuclear AHH. The study ahows clearly that the blndlng of a forelgn compound to DNA in viWJ Ia dependent not only on mlcrosomal enzyme actlvltles but also on nuclear actlvltles even lf the latter are conslderably lower than thoae of mlcrosomes.
KW - Toxikologie
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61150
ER -
TY - JOUR
A1 - Jaggi, W.
A1 - Lutz, Werner K.
A1 - Schlatter, C.
T1 - Covalent binding of ethinylestradiol and estrone to rat liver DNA in vivo
N2 - Thecovalent bindingof [6,7-\(^3\)H]ethinylestradiol (EE)and [6,7-\(^3\)H]estrone (E) to liver DNA of 200 g female ratswas measured 8 h after the administration of 80 \(\mu\)g (9.2 mCi) estrogen by gavage. The binding is 1.5 for EE and 1.1 for E, expressedas binding to DNA/dose, in units of \(\mu\)mol hormonefmol DNA phosphate/mmole honnone/kg body wt. It is in the same order of magnitude as for benzene and about 10 000 tim es below the binding of typical liver carcinogens, such as aflatoxin B\(_1\) or N,N-dimethylnitrosamine.
KW - Toxikologie
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61162
ER -
TY - JOUR
A1 - Lutz, Werner K.
A1 - Viviant, A.
A1 - Schlatter, C.
T1 - Nonlinear dose-response relationship for the binding of the carcinogen benzo(a)pyrene to rat liver DNA in vivo
N2 - Wlth radioactive compound of high specific activity, the binding of carcinogene to DNA can be measured wlth doses that are ineffective ln long-term studies. The binding of tritiated benzo(a )pyrene to liver DNA of adult male rats has been determined 50 hr after a singie l.p. injection of doses between 40 1'9/kg and 4 mg/kg. The doseresponse relationship is linear up to 1 mg/kg, shows a step towards 2 mg/kg, and gives a shallow linear slope above that value. The observed binding ranges from 1.7 to 180 nmoles benzo(a)pyrene per mole DNA phosphate. The nonlinearity could be due to an induction of metabolizing enzymes. The microsomal aryl hydrocarbon hydroxylase activity increases significantly 24 hr after a single dose of 4 mg/kg and 48 hr after doses of 2 and 4 mg/kg, but no induction Ia found with 1 mg/kg. The binding from an equimolar dose is 35 times lower than the one found on mouse skin DNA and 300 times lower than that of N,Ndlmethylnitrosamine in rat liver. A good correlatlon exiats to the respective tumor formation in long-term studles.
KW - Toxikologie
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61179
ER -
TY - JOUR
A1 - Viviani, A.
A1 - Lutz, Werner K.
A1 - Schlatter, C.
T1 - Time course of the induction of aryl hydrocarbon hydroxylase in rat liver nuclei and microsomes by phenobarbital, 3-methylcholanthrene, 2,3,7,8-tetrachloro-dibenzo-p-dioxin, dieldrin and other inducers
N2 - Aryl hydrocarbon hydroxylase (AHH) has been measured in male rat Jiver nucJei and microsomes after treatment of adult animals with various inducers for up to 14 days. After daily i.p. injections of 3-methylcholanthrene (MC, 20 mg/kg) the nuclear activity increased to a maximum of 600 per cent of the control activity after 4 days whereas the microsomal activity was 400 per cent of control at the same date. After 12 days, both activities equilibrated at 400 per cent. A similar time course was found after a single i.p. injection of 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD, 0.01 mg/kg) with an induction to .500 and 300 per cent for nuclei and microsomes, respectiveJy. after 2 days, and to 400 per cent for both after 12 days. PhenobarbitaJ (PB) was given continuously in the drinking water (I g/1) and induced the microsomal activity to 200 per cent after 8 days and 170 per cent after 14 days. The nuclear activity was only slightly induced to a constant Ievei of 130 per cent between day 8 and 14. Dieldrin did not significantly increase the microsomal activity after daiJy i.p. injections (20 mg/kg), but the nuclear activity raised to 200 per cent after 3 days and levelled down tocontrol valuesafter 12 days. Other inducers tested were benz[a)anthracene (BA), hexachlorobenzene (HCB} and 1,1.1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT). The induction pattern with BA was similar tothat of MC, a modeJ compound for the group of cytochrome P448 inducers. The induction by HCB and DDT resembled that by PB. a typical cytochrome P450 inducer.
KW - Toxikologie
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61182
ER -
TY - JOUR
A1 - Tacke, Reinhold
A1 - Niederer, Reinhold
T1 - Sila-Pharmaka, 9. Mitt. [1] Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, I
T1 - Sila-Drugs, 9th Communication [1] Preparation and Properties of Silicon Compounds with Potential Curare-Like Activity, I
JF - Zeitschrift für Naturforschung B
N2 - Organosilicon compounds 8, 9 and 10 with potential curare-like action and their precursors 0, 6 and 7 were synthesized for the first time. 0-10 were characterized by their physical and chemical properties, and their structures were confirmed by analyses, IH NMR and mass spectroscopy (only for 0-7). The pharmacological and toxicological data of 8, 9 and 10 are reported.
KW - curare-like activity
KW - toxicological properties
KW - pharmacological properties
KW - silicon compounds
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-128277
VL - 33
IS - 4
ER -
TY - GEN
T1 - Jahresbericht 1977
T1 - Annual Report 1977
N2 - Die Entwicklung der Universitätsbibliothek Würzburg im Jahr 1977.
N2 - Annual Report of the University Library of Würzburg, 1977.
T3 - Jahresbericht der Universitätsbibliothek Würzburg - 1977
KW - Würzburg
KW - Universitätsbibliothek
KW - Bericht
KW - Jahresbericht
KW - Würzburg
KW - University Library
KW - Report
KW - Annual Report
KW - Wuerzburg
KW - Wurzburg
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-42204
ER -
TY - JOUR
A1 - Franke, Werner W.
A1 - Scheer, Ulrich
T1 - Morphology of transcriptional units at different states of activity
N2 - The morphology of two forms of transcription ally active chromatin, the nucleoli and the loops of lampbrush chromosomes, has been examined after fixation in situ or after isolation and dispersion of the material in media of low ionic strengths, using a variety of electron microscopic preparation techniques (e.g. spread preparations with positive or negative staining or without any staining at all, with bright and dark field illumination, with autoradiography, after pretreatment of the chromatin with specific detergents such as Sarkosyl NL-30; transmission and scanning transmission electron microscopy of ultrathin sections). Nucleolar chromatin and chromosomes from oocytes of various amphibia and insects as well as from green algae of the family of the Dasycladaceae were studied in particular detail. The morphology of transcriptional units that are densely packed with lateral ribonucleoprotein fibrils, indicative of great transcriptional activity, was compared with that of chromatin of reduced lateral fibril density, including stages of drug-induced inhibition. The micrographs showed that under conditions which preserve the nucleosomal organization in condensed chromatin studied in parallel, nucleosomes are not recognized in transcriptionally active chromatin. This holds for the transcribed regions as well as for apparently untranscribed (i.e. fibril-free) regions interspersed between ('spacer') and/or adjacent to transcribed genes and for the fibril-free regions within transcriptional units of reduced fibril density. In addition, comparison oflengths of repeating units of isolated rDNA with those observed in spread nucleolar chromatin indicated that this DNA is not foreshortened and packed into nucleosomal structures. Granular particles which were observed, at irregular frequencies and in variable patterns, in some spacer regions, did not result in a proportional shortening of the spacer axis, and were found to be resistant to detergent treatment effective in removing most of the chromatin associated proteins including histones. Thus, these particles behave like RNA polymerases rather than nucleosomes. It is suggested that structural changes from nucleosomal packing to an extended form of DNA are involved in the transcriptional activation of chromatin.
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41363
ER -
TY - JOUR
A1 - Ellgring, Johann Heinrich
A1 - Asendorpf, Jens
T1 - Ein ost-westliches Theoriegefälle in der Sozialpsychologie? Eine empirische Notiz
N2 - Fünf Jahre nach der programmatischen Aufforderung von ISRAEL & TAJFEL (1972), mit dem Datensammeln aufzuhören und die theoretische Konfrontation zu suchen, stellt sich die Frage, ob der "Wind der Veränderung" (GRAUMANN, 1975) in der "Europäischen Sozialpsychologie" inzwischen kräftig geblasen hat. Uns interessierte speziell, wie sich heute das Verhältnis von Theorie zu Empirie und von Grundlagen zu Anwendungen einem wohl an Sozialpsychologie interessierten, nicht aber auf Sozialpsychologie spezialisierten deutschen Psychologen darstellt: Ändert sich dieses Verhältnis von "Ost nach West", d.h. von deutschsprachigen über nicht deutschsprachige "europäische" zu "amerikanischen" Veröffentlichungen? Ausserdem fragten wir, ob sich unterschiedliche thematische Sch werpunkte ausfindig machen lassen.
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41961
ER -
TY - JOUR
A1 - Heller, Dieter
A1 - Krüger, Hans-Peter
T1 - Die Sinnentnahme aus Texten in Abhängigkeit von der Schriftart
N2 - Texte in drei Schriftarten (Normalschrift, Großschrift und Kleinschrift) wurden 215 Kindern der 5. Jahrgangsstufe vorgelegt mit dem Ziel, die Leistung bei der Sinnentnahme zu vergleichen. Gleichzeitig wurden von den Vpn Urteile über die Ermüdung, die Anstrengung und die Schriftschwere abgegeben. Die schlechteste Sinnentnahme-Leistung trat auf bei Texten, die nur aus Großbuchstaben bestanden. Die Urteile der Vpn deckten sich mit den Leistungen bei der Sinnentnahme. Eine Aufteilung der Vpn nach Leistungsgruppen zeigte, daß gute Leser auf die Variation der Schrift in der Leistung wie in den Urteilen ausgeprägter reagierten.
N2 - Texts of three different types of writing (normal, capital, sm all print) were presented to 215 pupils of the 5th grade in order to compare the resulting understanding of the content. At the same time Ss rated fatigue, tension and difficulty of print. The lowest performance in understanding was caused by texts printed exclusively in capital letters. The 5s ratings were in line with their performance data. When 5s are divided up according to reading efficiency, good readers responded more distinctly to variations of print in their performance as weil as in their judgements.
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41004
ER -
TY - JOUR
A1 - Hommers, Wilfried
A1 - Steller, Max
A1 - Zienert, Hans-Joachim
T1 - Über die Verbesserung des Rollenspiels von jugendlichen Inhaftierten in sozialen Interaktionen durch Modellunterstütztes Rollenspiel
N2 - 15 jugendliche Inhaftierte einer Entlassungsabteilung nahmen an einem Modellunterstützten Rollentraining in schwierigen Situationen nach der Entlassung teil. Videoaufnahmen von nicht geübten Szenen wurden im Paarvergleich von Ratern auf die Besserung des Rollenspielverhaltens beurteilt. Die Ergebnisse sprechen für eine Verhaltensbesserung, die auf das Modellunterstützte Rollentraining zurückgeführt werden kann.
N2 - 15 incarcerated juvenile delinquents of a discharge department took part at a model-assisted role training of suitable behavior in difficult situations after discharge. In a pair comparison videorecords of not trained situations were judged by raters wit~l regard to improvement of subjects in role playing behavior. Results indicate a behavior improvement which can be attributed to the model-assisted role training.
KW - Kinderpsychologie
KW - Kinderpsychiatrie
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-43763
ER -
TY - JOUR
A1 - Hommers, Wilfried
A1 - Gloth, Ingola
T1 - Alternativenart, persönliche Glückszahl und magisch animistische Begründungen von Entscheidungen bei Risiko
N2 - Durch Variation des Konfliktgehalts zwischen zwei Alternativen und damit der Begründbarkeit von Entscheidungen sollte geprüft werden, ob das Auftreten magisch-animistischer Begründungen bei Schulkindern nur Begründungsschwierigkeiten anzeigt und nicht magisch-animistisches Denken. Mit Hilfe einer erfragten Glückszahl beim Würfeln sollte außerdem die Validität des magisch-animistisehen Gehalts von derartigen Begründungen untersucht werden. Es zeigte sich bei 61 11jährigen Vpn, daß magisch-animistisch klassifizierte Antworten mit dem Konfliktgehalt der Alternativen zusammenhingen und bei eine Glückszahl besitzenden Vpn, die diese in den Entscheidungen berücksichtigen, häufiger vorkommen als bei Vpn zweier Vergleichsgruppen.
N2 - By varying the conflict between two alternatives the difficulty to give s. th. as an adequate reason for one's decisions was manipulated. 61 subjects aged 11 were tested to show by that whether their magic-animistic reasons for decisions only indicate their inability in finding well-founded reasons or indicate vaIidely their magic-animistic thinking. By asking for the lucky pip of the child the validity of the magic-animistic content of such reasonings should be investigated too. The data showed that answers which are classifled as magic-animistic, are related to the conflict between the alternatives and are given more often by subjects who reported to have a lucky pip and who considered it in their decisions than by subjects of two control groups. Resume: Les auteurs se demandent si les expIications magico-ammlstes des ecoIiers revelent une difficulte a formuler des justifications rationnelles ou un mode de pensee reellement magico-animiste. En demandant aux enfants si et pourquoi ils ont un nombre-chance lorsgu'ils jouent avec un de a six points, les auteurs etudient la vaIidite du contenu magico- animiste des justifications enfantines. Dans un groupe d'enfants de 11 ans les reponses magico-animistes sont en relation a la fois avec le contenu conflictuel de la situation et avec la croyance a un nombre-chance personnel.
KW - Angewandte Psychologie
KW - Experimentelle Psychologie
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-43822
ER -
TY - JOUR
A1 - Scheer, Ulrich
T1 - Changes of nucleosome frequency in nucleolar and non-nucleolar chromatin as a function of transcription: an electron microscopic study
N2 - The morphology of nucleolar and non-nucleolar (Iampbrush chromosome loops) chromatin was studied in the electron microscope during states of reduced transcriptional activity in amphibian oocytes (Xenopus laevis, Triturus alpestris, T. cristatus). Reduced transcriptional activity was observed in maturing stages of oocyte development and after treatment with an inhibitor, actinomycin D. Strands of nucleolar chromatin appear smooth and thin, and contain only few, if any, nucleosomal particles in the transcribed units. This is true whether they are densely or only sparsely covered with lateral ribonucleoprotein fibrils. This smooth and non-nucleosomal character is also predominant in the interspersed, apparently nontranscribed rDNA spacer regions. During inactivation, however, nucleolar chromatin frequently and progressively assumes a beaded appearance in extended fibril-free-that is, apparently nontranscribed - regions. I n either fUll-grown 00- cytes or late after drug treatment, most of the nucleolar chromatin is no longer smooth and thin, but rather shows a beaded configuration indistinguishable from inactive non - nucleolar chromatin. In many chromatin strands, transitions of fibril-associated regions of smooth character into beaded regions wihout lateral fibrils are seen. Similarly, in the non-nucleolar chromatin of the retracting lampbrush chromosome loops, reduced transcriptional activity is correlated with a change from smooth to beaded morphology. Here, however, beaded regions are also commonly found interspersed between the more or less distant bases of the lateral fibrils, the putative transcriptional complexes. I n both sorts of chromatin, detergents (in particular Sarkosyl) that remove most of the chromatin proteins including histones from the DNA axis but leave the RNA polymerases of the transcriptional complexes attached were used to discriminate between polymerases and nucleosomal particles. The results suggest that nucleosomes are absent in heavily transcribed chromatin regions but are reformed after inactivation. In contrast to the findings with inactivated nucleolar genes, in lampbrush chromosome loops the beaded nucleosomal configuration appears to be assumed also in regions within transcriptional units that, perhaps temporarily, are not involved in transcription.
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-39750
ER -
TY - JOUR
A1 - Burschka, Christian
T1 - Intermolekulare Koordination bei zyklischen Esternder stibonigen und der thiostibonigen Säure
T1 - Intermolecular Coordination in Cyclic Esters of Stibonic Acid and Thiostibonic Acid
N2 - Die Struktur von EinkristalIen des 2-Methoxi-l,3, 2-benzodioxastibols und des 2-Methylthio-l, 3, 2-benzodithiastibols konnte über Röntgendiffraktometermessungen ermittelt werden. Die Verbindungen kristallisieren beide monoklin mit Elementarzellen, die jeweils 4 Formeleinheiten enthalten, sie sind jedoch nicht isomorph. Als Raumgruppe ergibt sich P21/n bzw. P21/c. Ungewöhnlich kurze intermolekulare Antimon-Chalkogen-Abstände lassen in der Struktur des Oxastibols koordinative Bindungen erkennen, die in dieser Stärke beim Thiastibol nicht auftreten.
N2 - The crystal structure of 2-methoxi-l,3,2-benzodioxastibole and of 2-methylthio- 1,3,2-benzodithiastibole was solved by X-ray diffraction methods. The compounds crystallize with monoclinic unit cells which contain 4 formula units each, they are, however, not isomorphou8. The space grol1p is P21/n and P21/c, respectively. Unusually short intermolecular antimony.-chalcogen distances revenl the existance of additional coordinative bonds within the structure of the oX3stiboJe which to such an extent cannot be observed within the corresponding thiastibole.
KW - Chemie
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31374
ER -
TY - CHAP
A1 - Franke, Werner W.
A1 - Zentgraf, Hanswalter
A1 - Scheer, Ulrich
T1 - Supranucleosomal and non-nucleosomal chromatin configurations
N2 - A significant contribution to the understanding of chromatin organization was the d iscovery of the nucleosome as a globular repeating unit of the package of DNA (Hewish and Burgoyne, 1973; Woodcock, 1973; Kornberg, 1974; Olins and Olins, 1974; for review see Oudet et al., 1978 a) . In accord with the original definition and in ag reement with most workers in this field of research we identify a nucleosome as a spheric alor slightly oblate gr anular particle 10-13 nm in diameter, containing about 200 base pairs of DNA and two of each of the four his tones H2a, H2b, H3 and H4. It is this structure in which the bulk of the nuclear chroma tin is organized in most eukaryotic cells, with the exception of the dinofl age llates (Rae and Steele, 1977; dinofl agellate DNA, however, c an be packed into nucleosoma l structures in vitro by addition of the appropriate amounts of histones;the same reference). Although it seems clear from the work reported that condensed and transcriptiona lly inactive chroma tin is contained in nucleosomes as the principle for first order p acking of DNA there are two important questions onto which we are focusing in the present study: ( i ) What is the higher order of p a cking present in - and perhaps typical-of - the condensed sta te of chromatin, and (ii) what is the specific form of arrangement of transcriptionally a ctive chromatin?
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-39447
ER -
TY - JOUR
A1 - Lutz, Werner K.
A1 - Schlatter, C.
T1 - A closed inhalation system for pharmacokinetic and metabolism studies of volatile compounds with small laboratory animals
N2 - In the inhalation system described an animal can be kept in the same atmosphere of a 2-liter desiccator for up to 24 h. The expired carbon dioxide is adsorbed with soda lime and the resulting reduced pressure is balanced by a supply of oxygen also used for the inflow of the chemical to be investigated. Urine and faeces can be collected ~eparately and the system allows a periodical control of the concentration of the chemical by sampling the air with needle and syringe.
KW - Toxikologie
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-80145
ER -
TY - JOUR
A1 - Christl, Manfred
A1 - Buchner, Wolfgang
T1 - 13C-NMR-Spektren von Tetracyclo[4.1.0.02,4.03,5]heptanen, Tetracyclo[5.1.0.02,4.03,5]octanen und Tricyclo[4.1.0.02,7]hept-3-enen. Ungewöhnliche beta- und gamma-Substituenteneffekte
N2 - No abstract available
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-30087
ER -
TY - JOUR
A1 - Rungger, M.
A1 - Crippa, M.
A1 - Trendelenburg, M. F.
A1 - Scheer, Ulrich
A1 - Franke, Werner W.
T1 - Visualization of rDNA spacer transcription in Xenopus oocytes treated with fluorouridine
N2 - Under the intluence of 5-tluoro-uridine, the ultrastructure of the rDNA transcription units in Xenopus oocytes is altered. Whereas part of the matrix units maintains anormal aspect or shows various degrees of inhibition, in a strong proportion of the transcription units the alternating pattern of matrix units and fibril-free spacer regions is no longer recognized. Transcriptional complexes are found along the entire DNP axis, including the regions of the spacers. These observations support biochemical data on transcription in rDNA spacer region.
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33082
ER -
TY - JOUR
A1 - Krohne, Georg
A1 - Franke, Werner W.
A1 - Scheer, Ulrich
T1 - The major polypeptides of the nuclear pore complex
N2 - Nuclear envelopes of maturing oocytes of various amphibia contain an unusually high number of pore complexes in very close packing. Consequently, nuclear envelopes , which can be manually isolated in great purity, provide a remarkable enrichment of nuclear pore complex material, relative to membranous and other interporous structures. When the polypeptides of nuclear envelopes isolated from oocytes of Xenopl/s la evis and Triturus alpestris are examined by gel electrophoresis, visualized either by staining with Coomassie blue or by radiotluorography after in vitro reaction with [3H]dansyl chloride , a characteristic pattern is obtained (10 major and 15 minor bands). This polypeptide pattern is radically different from that of the nuclear contents isolated from the same cell. Extraction of the nuclear envelope with high salt concentrations and moderateIy ac tive detergents such as Triton X- 100 results in the removal of membrane material but leaves most of the non-membranous structure of the pore complexes. The dry weight of the pore complex (about 0.2 femtograms) remains essentially unchanged during such extractions as measured by quantitative electron microscopy . The extracted preparations which are highly enriched in nuclear pore complex material contain only two major polypeptide components with apparent molecular weights of 150000 and 73000. Components of such an electrophoretic mobility are not present as major bands , if at all , in nuclear contents extracted in the same way. lt is concluded that these two polypeptides are the major constituent protein(s) of the oocyte nuclear pore complex and are specific for this structure. When nuclear envelopes are isolated from rat liver and extracted with high salt buffers and Triton X- 100 similar bands are predominant, but two additional major components of molecular weights of 78000 and 66000 are also recognized. When the rat liver nuclear membranes are further subfractionated material enriched in the 66000 molecular weight component can be separated from the membrane material, indicating that this is relatively loosely associated material , probably a part of the nuclear matrix . The results suggest that the nuclear pore complex is not only a characteristic ubiquitous structure but also contains similar, if not identical , skeletal proteins that are remarkably re sistant to drastic changes of ionic strength as weil as to treatments with detergents and thiol reagents.
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33078
ER -
TY - JOUR
A1 - Scheer, Ulrich
A1 - Zentgraf, Hanswalter
T1 - Nucleosomal and supranucleosomal organization of transcriptionally inactive rDNA circles in Dytiscus oocytes
N2 - Oocytes of the water beetle, Dytiscus marginalis, contain large amounts of rDNA most of which is present in the form of rings containing one or several pre-rRNA genes. Electron microscopy of spread preparations of vitellogenic oocytes has shown that the rDNA is extended in chromatin rings with transcribed pre- rRNA genes and is not packed into nucleosomes (Trendelenburg eta!. , 1976). When similar preparations are made from previtellogenic ooytes in which a large proportion of the nuc1eolar chromatin is transcriptionally inactive, a different morphological form of this chromatin is recognized. In contrast to the transcribed chromatin rings the inactive nucleolar chromatin circles show the characteristic beaded configuration, indicative of nucleosomal packing. Nuc1eosomal packing is also indicated by the comparison of the lengths of these chromatin rings with both iso lated rDNA circ1es and transcribed chromatin rings. In addition, these inactive nuc1eofilaments often appear to be compacted into globular higher order structures of diameters from 21 to 34nm, each composed of an aggregate of 6-9 nuc1eosomes. While the estimated reduction of the overall length of rDNA, as seen in our preparations, is, on the average, only 2.2 - 2.4 fold in the nuc1eosomal state it is 10- 13 fold when supranuc1eosomal globules are present. These data show that the extrachromosomal rDNA of these oocytes goes through a cycle of condensation and extensio n, as a function of the specific transcriptional activity, and that the beaded state described here is exc1usively found in the non-transcribed state.
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33188
ER -
TY - JOUR
A1 - Wilhelm, Gernot
T1 - Découvertes épigraphiques à Kāmid el-Lōz
N2 - No abstract available
KW - Geschichte
KW - Theologie
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-78183
ER -
TY - CHAP
A1 - Lutz, Werner K.
A1 - Schlatter, C.
T1 - Extrapolation of carcinogenicity data to low doses with a dose-response study of the binding of benzo(a)pyrene to rat liver DNA
N2 - The binding of tritiated benzo(a)pyrene (BP) to liver DNA of 25 adult male rats (SIV 50) has been determined 50 h after a single intraperitoneal injection of doses between 40 ug/kg and 4; mg/kg. The dose-response relations~ ip is linear up to i mg/kg, shows a sigmoid step towards 2 mg/kg and a shallow linear. slope above that value. TlJe 0 bserved bin ding ranges from 1.7 to 180 nmoles BP per mole DNA phosphate. The non-linearity between 1 and 2 mg/kg could be explained 0):1 the basis of an induction of metabolizing enzymes. A pure1y mathematical extrapolation of therumour incidence from a carcinogenic dose (1 x 40mg/kg for a 20% hepatoma incidence in newborn mice) to human exposure levels (aboilt 0.1 ug/kg per day) would never have followed a step like the on~ found in our experiments. Our dose-effect study therefore shows how carcinogenitity data could be extrapolated in a biologically founded way to low doses.
KW - Toxikologie
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-80157
ER -
TY - JOUR
A1 - Wilhelm, Gernot
T1 - Zur Rolle des Großgrundbesitzes in der hurritischen Gesellschft
N2 - No abstract available
KW - hurritische Gesellschft
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-82759
ER -
TY - JOUR
A1 - Weiss, H.
A1 - Sebald, Walter
T1 - Purification of cytochrome oxidase from Neurospora crassa and other sources
N2 - A chromatographic procedure 1 is described by means of which cytochrome oxidase has been purified from a variety of organisms including the fungus N eurospora crassa,2,3 the unicellular alga Po/ytoma mirum, 4 the insect Locusta migratoria ,5 the frog Xenopus muel/eri,4 and the mammal Rattus norwegicus. 4 This procedure can be used to equal effect for large-scale preparations, starting from grams of mitochondrial protein, or for small-scale preparations starting from milligrams. The cytochrome oxidase preparations from the different organisms are enzymically active. They show similar subunit compositions.
KW - Biochemie
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-82082
ER -
TY - CHAP
A1 - Franke, Werner W.
A1 - Scheer, Ulrich
A1 - Trendelenburg, Michael F.
A1 - Zentgraf, H.
A1 - Spring, H.
T1 - Morphology of transcriptionally active chromatin
N2 - Some decades ago it was noted by cytologists that within the interphase nucleus large portions of the transcriptionally ("genetically," in their terms) inactive chromosomal material are contained in aggregates of condensed chromatin, the "chromocenters," whereas transcriptionally active regions of chromosomes appear in a more dispersed form and are less intensely stained with DNA-directed staining procedures (Heitz 1929, 1932, 1956; Bauer 1933). The hypothesis that condensed chromatin is usually characterized by very low or no transcriptional activity, and that transcription occurs in loosely packed forms of chromatin (including, in most cells, the nucleolar chromatin) has received support from studies of ultrathin sections in the electron microscope and from the numerous attempts to separate transcriptionally active from inactive chromatin biochemically (for references, see Anderson et al. 1975; Berkowitz and Doty 1975; Krieg and Wells 1976; Rickwood and Birnie 1976; Gottesfeld 1977). Electron microscopic autoradiography has revealed that sites of RNA synthesis are enriched in dispersed chromatin regions located at the margins of condensed chromatin (Fakan and Bernhard 1971, 1973; Bouteille et al. 1974; Bachellerie et al. 1975) and are characterized by the occurrence of distinct granular and fibrillar ribonucleoprotein (RNP) structures, such as perichromatin granules and fibrils. The discovery that, in most eukaryotic nuclei, major parts of the chromatin are organized in the form of nucleosomes (Olins and Olins 1974; Kornberg 1974; Baldwin et al. 1975) has raised the question whether the same nucleosomal packing of DNA is also present in transcriptionally active chromatin strands. Recent detailed examination of the morphology of active and inactive chromatin involving a diversity of electron microscopic methods, particularly the spreading technique by Miller and coworkers (Miller and Beatty 1969; Miller and Bakken 1972), has indicated that the DNA of some actively transcribed regions is not packed into nucleosomal particles but is present in a rather extended form within a relatively thin (4-7 nm) chromatin fiber.
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41097
ER -
TY - JOUR
A1 - Schneider, Wolfgang
A1 - Springer, Adolf
T1 - Individualisierendes Rechtschreibtraining auf verhaltenstherapeutischer Basis
T1 - The effects of individualized instruction and contingeny management on the training of dyslexic children
N2 - 14 rechtschreibschwache Schüier des 4. und 5. Schuljahrs nahmen an einem fünfmonatigen Rechtschreib-Förderprogramm auf verhaltenstherapeutischer und instruktionspsychologischer Grundlage teil. Das Training bestand aus einem individualisierenden Verfahren unter Anwendung eines Münzverstärkungsprogramms. Gegenüber einer unbehandelten Kontrollgruppe zeigte sich für die Experimentalgruppe eine insgesamt deutliche Abnahme in der Fehlerhäufigkeit, die sich statistisch absichern ließ. Zusätzlich wird ein statistisches Verfahren vorgestellt, mit dem sich die Veränderung auf der Individualebene auf ihre Signifikanz hin überprüfen läßt.
N2 - 14 dyslexic fourth and fifth graders took part in a five months remedial training based upon the principles of behavior therapy and instructional psychology. Tue training included individualized instruction and the application of a token economy program. Data analysis showed a clear decrease in the number of errors made by the experimental group-as cornpared to the control group- that proved statistically significant. In addition, a statistical procedure for testing significance of change on the individual level is presented.
KW - Rechtschreibung
KW - Übung
KW - Verhaltenstherapie
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87220
ER -
TY - JOUR
A1 - Hommers, Wilfried
T1 - Multinomiale und Bayes-statistische konfigurale Klassifikation
T1 - Multi-nomial and Bayes-statistical configural classification
N2 - Ein Verfahren zur Klassifikation von Pbn aufgrund individueller Abweichung von der Annahme wiederholter multinornialer Zufallsereignisse und aufgrund individueller maximaler Likelihood der Zugehörigkeit zu einer bestimmten Gruppe wird nebst Modelltest dargelegt. Als Anwendungsbeispiel wird über die Ergebnisse bei zwei denkbaren Klassifikationen in verschiedenen Therapiemotivationsgruppen berichtet
N2 - The author suggests a method and a "model test" for the classification of subjects on grounds on individual deviation from the assumption of repeated multi-nomial chance encounters and on grounds of individual maximallikelihood of membership in a certain group. The author reports on the results reached with two conceivable classifications into different therapy-motivation groups. (L. Canders) französisch: L'auteur presente - avec test-modele - un procede permettant de c1asser les sujets selon leur tendance individuelle a s'ecarter de la croyance aux evenements fortuits multinomiques repetes et selon la likelihood maximale individuelle d'appartenance a un groupe precis. En guise d'application, on relate les resultats dans le cas de deux classifications possibles dans deux groupes differents de motivation therapeutique. (J. Chanel)
KW - Psychologie
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-43798
ER -
TY - JOUR
A1 - Hommers, Wilfried
A1 - Trempler, Volker
T1 - Zum Verhalten von Lernbehinderten in Zwei-Personen-Spielen
T1 - The behaviour of slow learners in games involving two people (Le comportement des handicapes a l'apprentissage dans des jeux a deux personnages)
N2 - Die Methode der Matrix-Spiele, die in sozialpsychologischen Untersuchungen zur Erfassung von Kooperativität und Kompetitivität verwendet wurde, sollte auf ihre Tragfähigkeit in der Lernbehinderten-Forschung geprüft werden. Es wird über eine Untersuchung berichtet, in der zwei Nicht-Nullsummenspiele und ein Nullsummenspiel mit 56 lernbehinderten und 40 Normalschüler-Vpn durchgeftihrt wurden. Der Vergleich von Wahlhäufigkeiten zwischen Lernbehinderten und Normalschülern zeigte einige Unterschiede, die auf Retardierungen im-Bereich der Kooperativität-Kompetitivität-Entwicklung hinwiesen. Die Diskussion der Ergebnisse unterstützt aber an Hand der Wahlbegründungen nicht eine sozialpsychologische, sondern eine risikobezogene Interpretation des Verhaltens der Vpn.
N2 - The matrix game method used in social psychological tests of cooperativity and competitivity was to be examined from the point of view of possible usefulness in research on slow learners. The report concerns a test on 56 slow learners and 40 normal pupils using 2 nonzero sum games and one zero sum game. The comparison of choice frequency between the slow learners and the normal pupils showed some differences which indicated retardation in the development of cooperativity and competitivity. The discussion of the results, however, supports-on the basis of the choice reasons- not a social psychological but a risk related interpretation of the behaviour of the people tested. Resume: La methode des jeux a matrice, employee dans les recherches psycho-sociologiques afin de mesurer le degre d'esprit cooperatif ct competitif, avait a etre contrölee quant a son utilite dans les recherches sur les handicapes a l'apprentissage. On relate des travaux au cours desquels 56 sujets handicapes et 40 ecoliers normaux se sont livres a deux jeux a somme non nulle et a un jeu a somme nulle. La comparaison des frequences de choix entre handicapes et normaux a revele quelques differenees indiquant des retards dans le seeteur du developpement de l'esprit eooperatif et competitif. Cependant, la diseussion des resultats eonfirme, au vu des raisons motivant les ehoix, une interpretation non psyeho-sociologique, mais liee a la notion de risque, du eomportement des sujets.
KW - Sonderpädagogik
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-43921
ER -
TY - JOUR
A1 - Wilhelm, Gernot
T1 - Ist das Elamische eine Ergativsprache?
N2 - No abstract available
KW - Iran
KW - Archäologie
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-82762
ER -
TY - CHAP
A1 - Clarke, A. H.
A1 - Ellgring, Johann Heinrich
T1 - Verfahren zur halbautomatischen Bearbeitung von Videoaufzeichnungen
N2 - No abstract available
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33750
ER -
TY - CHAP
A1 - Ellgring, Johann Heinrich
A1 - Clarke, A. H.
T1 - Verlaufsbeobachtungen anhand standardisierter Videoaufzeichnungen bei depressiven Patienten
N2 - No abstract available
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33744
ER -
TY - JOUR
A1 - Ellgring, Johann Heinrich
T1 - Comment to J. Rojahn: "Validity and reliability of data from naturalistic observational studies - problems and alternatives"
N2 - No abstract available
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-42520
ER -
TY - JOUR
A1 - Ruhe, Ernstpeter
T1 - Caliban als Dialektiker
N2 - No abstract available
Y1 - 1978
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-36850
ER -
TY - JOUR
A1 - Christl, Manfred
A1 - Herbert, R.
T1 - Unusual Carbon Shielding Effects of Cyclopropanes and Double Bonds in Strained Bicyclo[3.1.0]hexanes and Cyclopentenes
N2 - Carbon-13 shieldings and one-bond \(^{13}\)C-H coupling constants of bicydo[2.1.1]hexane, bicydo[2.l.l]hex- 2-ene, tricydo[3.1.1.0\(^{2.4}\)]heptane and benzvalene are presented and compared. to the data of related. compounds. H a bicydo[3.1.0]hexane system is part of a rigid skeleton, the cydopropane ring exerts spedfk: 'Y substituent eflects of two ldnds. In the case of the bicyclobexane boat form an upfield shift of the C-3 signal is observed and in tbe esse of the chair form a downfield shift of 15-20 ppm. Compared to the corresponding cydopentanes the double bond in strained cydopentenes causes downfield shifts of the C-4 absorption. 1bis eftect increases witb increasing strain, reaching 8 45.9 ppm maximum in benzvalene. Hence it is tbe only known bicydo[l.l.O]butane baving 8 reversed order of carbon shieldings. The downfield shifts are e:xplained by means of simple orbital interaction schemes.
KW - Organische Chemie
Y1 - 1979
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-58038
ER -
TY - JOUR
A1 - Sebald, Walter
A1 - Wachter, E.
A1 - Tzagoloff, A.
T1 - Identification of amino acid substitutions in the dicyclohexylcarbodiimide-binding subunit of the mitochondrial ATPase complex from oligomycin-resistant mutants of Saccharomyces cerevisiae
N2 - No abstract available
KW - Biochemie
Y1 - 1979
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62770
ER -
TY - JOUR
A1 - Michel, R.
A1 - Wachter, E.
A1 - Sebald, Walter
T1 - Synthesis of a larger precursor for the proteolipid subunit of the mitochondrial ATPase complex of Neurospora crassa in a cell-free wheat germ system
N2 - No abstract available
KW - Biochemie
Y1 - 1979
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62789
ER -
TY - JOUR
A1 - Sebald, Walter
A1 - Graf, T.
A1 - Lukins, H. B.
T1 - The dicyclohexylcarbodiimide-binding protein of the mitochondrial ATPase complex from Neurospora crassa and Saccharomyces cerevisiae. Identification and isolation
N2 - Incubation of mitochondria from Neuraspara crassa and Saccharomyces cerevisiae with the radioactive ATPase inhibitor [14C]dicyclohexylcarbodiimide results in the irreversible and rather specific labelling of a low-molecular-weight polypeptide. This dicyclohexylcarbodiimide-binding protein is identical with the smallest subunit (Mr 8000) of the mitochondrial ATPase complex, and it occurs as oligomer, probably as hexamer, in the enzyme protein. The dicyclohexylcarbodiimide-binding protein is extracted from whole mitochondria with neutral chloroformjmethanol both in the free and in the inhibitor-modified form. In Neuraspara and yeast, this extraction is highly selective and the protein is obtained in homogeneaus form when the mitochondria have been prewashed with certain organic solvents. The bound dicyclohexylcarbodiimide Iabel is enriched in the purified protein up to 50-fold compared to whole mitochondria. Based on the amino acid analysis, the dicyclohexylcarbodiimide-binding protein from Neurospora and yeast consists of at least 81 and 76 residues, respectively. The content of hydrophobic residues is extremely high. Histidine and tryptophan are absent. The N-terminal ~mino acid is tyrosine in Neuraspara and formylmethionine in yeast.
KW - Biochemie
Y1 - 1979
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62792
ER -
TY - JOUR
A1 - Karppanen, H.
A1 - Sirén, Anna-Leena
A1 - Eskeli-Kaivosoja, Alice
T1 - Central cardiovascular and thermal effects of Prostaglandin F2α in rats
N2 - Administration of PGF 2IX (0.2-6.4 J.lg) into the lateral cerebral ventricle (i.c.v.) induced dosedependent increases in blood pressure , heart rate and body temperature in urethane-anaesthetised rats, but had no effect on these parameters when the same dose range was administered intravenously. Peripheral pretreatment with sodium meclofenamate (50 mg/kg s.c.) sltifted all the dose-response curves for PGF 2IX (i.c.v.) to the left, but indomethacin (50 mg/kg s.c.) did not significantly affect those changes. Central pretreatment with sodiurn meclofenamate or indomethacin (1.25 mg per rat i.c.v.) failed to modify significantly the effects of centrally administered PGF 2IX' The results support previous suggestions that PGF 2IX may participate in the central control of the cardiovascular and thermoregulatory systems, and also suggest that there may be differences in the sites and/or modes of action between sodiurn meclofenamate and indomethacin.
KW - Prostaglandine
Y1 - 1979
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-47955
ER -
TY - JOUR
A1 - Burschka, Christian
T1 - Na\(_3\)Cu\(_4\)S\(_4\) - ein Thiocuprat mit verknüpften \(^1 _\infty\)[Cu\(_4\)S\(_4\)]-Ketten
N2 - No abstract available
KW - Chemie
Y1 - 1979
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-46828
ER -
TY - JOUR
A1 - Burschka, Christian
T1 - Zur Kristallstruktur der Thiocuprate K\(_3\)Cu\(_8\)S\(_6\) und Rb\(_3\)Cu\(_8\)S\(_6\)
N2 - No abstract available
KW - Chemie
Y1 - 1979
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-46819
ER -
TY - JOUR
A1 - Schmidt, M.
A1 - Bender, R.
A1 - Burschka, Christian
T1 - Additionsverbindungen zwischen Antimon(III)-Halogeniden und 1,4-Dithiacycloheptan
T1 - Addition Compounds between Antimony(III)-Halides and 1,4-Dithiacycloheptane
N2 - No abstract available
KW - Chemie
Y1 - 1979
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-46570
ER -
TY - JOUR
A1 - Kutateladze, T. V.
A1 - Axelrod, V. D.
A1 - Gorboulev, Valentin G.
A1 - Belzhelarskaya, S. N.
A1 - Vartikyan, R. V.
T1 - New procedure of high-voltage electrophoresis in polyacrylamide gel and its application to the sequencing of nucleic acids
N2 - Fractionation of nucleic acids and their fragments with polyacrylamide gel has been widely applied in sequencing of nucleic acids. Although the conditions of electrophoresis for this purpose have previously been suggested. we have found that polyacrylamide gel electrophoresis at 5000 V (100 V/cm) is possible and effective. An apparatus consisting of a horizontal thermostated plate is used to remove the heat which was formed during the electrophoretic process. The techniques for loading samples on the horizontal thin gel and the procedure for high-voltage gel electrophoresis are described and illustrated by the fractionation of the spleen phosphodiesterase partial digest of tRNA¥~1 as well as by the RNA synthesis by RNA polymerase from E. coli with poly[d(A- T)j as template in the presence of "terminator," 3'-O-methyluridine 5'-triphosphate. This same technique was used for electrophoresis of oligonucleotides on acetylcellulose and was incorporated into a two-dimensional system which was demonstrated by fingerprinting of the guanylo-RNase digest of tRNAT'P from baker's yeast. In the third part of the article a simple technique for the electric trapping of nucleic acids or their fragments from a slab gel on a DEAE-paper sheet is presented.
Y1 - 1979
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-46927
ER -
TY - JOUR
A1 - Burschka, Christian
A1 - Wieber, Markus
T1 - Eine pentagonal pyramidale Koordination des Bismuts. Kristallstruktur von Methylbismutbis(dietyldithiocarbonat)
T1 - A pentagonal pyramidal coordination of Bismut. Crystal structure of Methylbismuthbis(diethyldithiocar bamate)
N2 - The crystal structure of the title compound, recrystallized from ethanol, was solved by means of X-ray diffraction methods and could be refined to an R-value of 0.050 with 2126 reflections observed. In contrast to its behaviour in benzene solution, where the compound is monomerie, in the crystalline state dimerie units are formed by intermoleeular Bi-S-interactions. The bismuth atoms are coordinated in form of a slightly distorted pentagonal pyramid with the free electron pair presumably directed opposite the apical C-atom.
KW - Chemie
Y1 - 1979
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-46750
ER -
TY - JOUR
A1 - Wilhelm, Gernot
T1 - Die Hurriter : Archäologen suchen ihr verschollenes Reich
N2 - No abstract available
KW - Archäologie
Y1 - 1979
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-51130
ER -
TY - JOUR
A1 - Wilhelm, Gernot
A1 - Boese, Johannes
T1 - Aššur-dān I., Ninurta-apil-Ekur und die mittelassyrische Chronologie
N2 - No abstract available
KW - Alter Orient
KW - Naher Osten
Y1 - 1979
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-51147
ER -
TY - JOUR
A1 - Ulrichs, Karin
A1 - Kuhlencordt, KM
A1 - Müller-Ruchholtz, W.
T1 - Plating inhibition assay (PIA): a new test for cell mediated cytotoxicity
N2 - No abstract available
Y1 - 1979
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45443
ER -
TY - JOUR
A1 - Lutz, Werner K.
T1 - In vivo covalent binding of organic chemicals to DNA as a quantitative indicator in the process of chemical carcinogenesis
N2 - The covalent binding of chemical carcinogens to DNA of mammalian organs is expressed per unit dose, and a 'Covalent-Binding Index', CBI, is defined. CBI for various carcinogens span over 6 orders of magnitude. A similar range is observed for the carcinogenic potency in long-term bioassays on carcinogenicity. For the assessment of a risk from exposure to a carcinogen, the total DN A darnage can be estimated if the actual dose is also accounted for. A detailed description is given for planning and performing a DNA-binding assay. A complete literature survey on DNA binding in vivo (83 compounds) is given with a calculation of CBI, where possible, 153 compounds are listed where a covalent binding to any biological macromolecule has been shown in vivo or in vitro. Recent, so far unpublished findings with aflatoxin Mh macromolecule- bound aflatoxin Bh ·diethylstilbestrol, and 1,2-epithiobutyronitrile are included. A comparison of CBI for rat-liver DNA with hepatocarcinogenic potency reveals a surprisingly good quantitative correlation. Refinements for a DN A-binding assay are proposed. Possibilities and Iimitations in the use of D NA binding in chemical carcinogenesis are discussed extensively.
KW - Toxikologie
Y1 - 1979
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61122
ER -
TY - JOUR
A1 - Jaggi, W.
A1 - Lutz, Werner K.
A1 - Schlatter, C.
T1 - Comparative studies on the covalent binding of the carcinogen benzo(a)pyrene to DNA in various model systems
N2 - The covalent binding of tritiated benzo(a)pyrene (BP) to DNA has been determined in rat liver in vivo, in rat liver perfused in situ, after incubation of BP with liver single cells, with liver homogenate, with liver microsomes and DNA, with fibroblasts from a rat granulorna pouch, and with · 2 cell lines. Li ver single cells were found to be a valuable compromise between the rnost sensitive system (microsomal incubation of BP with DNA) and the biologically most relevant system (in vivo ).
KW - Toxikologie
Y1 - 1979
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61131
ER -
TY - JOUR
A1 - Steiling, L.
A1 - Tacke, Reinhold
A1 - Wannagat, U.
T1 - Diphenyl(3-piperidinopropyl)silanol, ein Sila-Analogon des Difenidols
T1 - Dipbenyl(3-piperidinopropyl)silanol, a Sila-Analogue of Difenidol
N2 - Diphenyl(3-piperidinopropyl)silanol (6b), ein Sila-Analogon des Arzneimittels Difenidol (6a), und dessen Methoiodid 7 wurden erstmals gemäß Schema 1 synthetisiert. - Die pharmakologischen und toxikologischen Eigenschaften der Analoga 6a und 6b wurden vergleichend untersucht.
N2 - Diphenyl(3-piperidinopropyl)silanol (6b), a sila-analogue of the drug difenidol (6a), and its methoiodide 7 were synthesized for the firsttime according to scheme 1. - The pharmacological and toxicological properties of the analogues 6a and 6b were investigated comparatively.
KW - Anorganische Chemie
Y1 - 1979
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63618
ER -
TY - JOUR
A1 - Ackermann, J.
A1 - Tacke, Reinhold
A1 - Wannagat, U.
A1 - Koke, U.
A1 - Meyer, F.
T1 - Derivate des 1-(4-Chlorphenyl)silacyclohexans mit 3-(Diethylamino)propyl- und 2-(Diethylamino)ethyl-Gruppierungen
T1 - Derivatives of 1-(4-Chlorophenyl)silacyclobexane with 3-(Diethylamino)propyl- and 2-(Diethylamino)etbyl Groups
N2 - Die Darstellung der Verbindungen 3a (sowie 3b) und 10, die sich vom 1-(4-Chlorphenyl)-1-(2~ diethylaminoethoxy)silacyclohexan (Sila-Chlorphencyclan, II a) ableiten, wird beschrieben. Die Verbindung 3 b wurde pharmakologisch und toxikologisch untersucht. Die biologischen Eigen· schaften von 3b wurden mit denen von Ila (sowie Chlorphencyclan) und seinem Hydrochiarid Ilb verglichen.
N2 - The preparation of the compounds 3a (and 3b) and 10, which derive from 1-(4-chlorophenyl)-1· (2-diethylaminoethoxy)silacyclohexane (sila-chlorophencyclane, II a). is described. Compound 3 b has been investigated pharmacologically and toxicologically. The biological properties of 3 b and those of ßa (and chlorophencyclane) and its hydrochloride Ilb are compared.
KW - Anorganische Chemie
Y1 - 1979
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63621
ER -
TY - JOUR
A1 - Tacke, Reinhold
A1 - Zimonyi-Hegedüs, E.
A1 - Wannagat, U.
T1 - Si-C-Spaltung in 2-Thienylsilanen durch sekundäre Amine
N2 - Die Umsetzung von Diphenyl-vinylsilan mit zyklischen sekundären Aminen (z.B. Morpholin) in Gegenwart der entsprechenden Lithium-amide führt zu einer Substitution des an Silicium gebundenen H-Atoms durch eine Aminogruppe und zu einer Addition des Amins an die Vinylgruppe. 2-Thienylphenyl- vinylsilan reagiert jedoch zusätzlich unter Spaltung der Si-e-Bindung und Aminosubstitution der 2-Thienylgruppe.
N2 - Treatment of diphenylvinylsilane with cyclic secondary amines (e.g. morpholine) in the presence of the corresponding Iithium amides leads to substitution of the SiH hydrogen atom by an amino group and to. addition of the amine to the vinyl group. A similar reaction observed in the case of 2-thienylphenylvinylsilane is accompanied by cleavage of the Si-e band and substitution of the 2-thienyl group by an amino group.
KW - Anorganische Chemie
Y1 - 1979
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63608
ER -