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Myc coordinates transcription and translation to enhance transformation and suppress invasiveness
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-150373
- c‐Myc is one of the major human proto‐oncogenes and is often associated with tumor aggression and poor clinical outcome. Paradoxically, Myc was also reported as a suppressor of cell motility, invasiveness, and metastasis. Among the direct targets of Myc are many components of the protein synthesis machinery whose induction results in an overall increase in protein synthesis that empowers tumor cell growth. At present, it is largely unknown whether beyond the global enhancement of protein synthesis, Myc activation results in translationc‐Myc is one of the major human proto‐oncogenes and is often associated with tumor aggression and poor clinical outcome. Paradoxically, Myc was also reported as a suppressor of cell motility, invasiveness, and metastasis. Among the direct targets of Myc are many components of the protein synthesis machinery whose induction results in an overall increase in protein synthesis that empowers tumor cell growth. At present, it is largely unknown whether beyond the global enhancement of protein synthesis, Myc activation results in translation modulation of specific genes. Here, we measured Myc‐induced global changes in gene expression at the transcription, translation, and protein levels and uncovered extensive transcript‐specific regulation of protein translation. Particularly, we detected a broad coordination between regulation of transcription and translation upon modulation of Myc activity and showed the connection of these responses to mTOR signaling to enhance oncogenic transformation and to the TGFβ pathway to modulate cell migration and invasiveness. Our results elucidate novel facets of Myc‐induced cellular responses and provide a more comprehensive view of the consequences of its activation in cancer cells.…
Autor(en): | Ran Elkon, Fabricio Loayza-Puch, Gozde Korkmaz, Rui Lopes, Pieter C van Breugel, Onno B Bleijerveld, AF Maarten Altelaar, Elmar Wolf, Francesca Lorenzin, Martin Eilers, Reuven Agami |
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URN: | urn:nbn:de:bvb:20-opus-150373 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | EMBO reports |
Erscheinungsjahr: | 2015 |
Band / Jahrgang: | 16 |
Heft / Ausgabe: | 12 |
Seitenangabe: | 1723-1736 |
Originalveröffentlichung / Quelle: | EMBO reports (2015), Vol. 16, No. 12, 1723-1736. DOI: 10.15252/embr.201540717 |
DOI: | https://doi.org/10.15252/embr.201540717 |
PubMed-ID: | https://pubmed.ncbi.nlm.nih.gov/PMC4687422 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
Freie Schlagwort(e): | cancer; c‐Myc; metastasis; protein biosynthesis & quality control; transcription; transcriptional responses; transformation; translational regulation |
Datum der Freischaltung: | 24.01.2019 |
Lizenz (Deutsch): | CC BY-NC-ND: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell, Keine Bearbeitungen 4.0 International |