Complete loss of E-cadherin expression in a rare case of metastatic malignant meningioma: a case report
Please always quote using this URN: urn:nbn:de:bvb:20-opus-357996
- Background Hematogenous tumor spread of malignant meningiomas occurs very rarely but is associated with very poor prognosis. Case presentation We report an unusual case of a patient with a malignant meningioma who developed multiple metastases in bones, lungs and liver after initial complete resection of the primary tumor. After partial hepatic resection, specimens were histologically analyzed, and a complete loss of E-cadherin adhesion molecules was found. No oncogenic target mutations were found. The patient received a combination ofBackground Hematogenous tumor spread of malignant meningiomas occurs very rarely but is associated with very poor prognosis. Case presentation We report an unusual case of a patient with a malignant meningioma who developed multiple metastases in bones, lungs and liver after initial complete resection of the primary tumor. After partial hepatic resection, specimens were histologically analyzed, and a complete loss of E-cadherin adhesion molecules was found. No oncogenic target mutations were found. The patient received a combination of conventional radiotherapy and peptide receptor radionuclide therapy (PRRT). Due to aggressive tumor behavior and rapid spread of metastases, the patient deceased after initiation of treatment. Conclusions E-cadherin downregulation is associated with a higher probability of tumor invasion and distant metastasis formation in malignant meningioma. Up to now, the efficacy of systemic therapy, including PRRT, is very limited in malignant meningioma patients.…
Author: | Dominik Lisowski, Philipp E. Hartrampf, Natalie Hasenauer, Vera Nickl, Camelia-Maria Monoranu, Jörg Tamihardja |
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URN: | urn:nbn:de:bvb:20-opus-357996 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Neurochirurgische Klinik und Poliklinik |
Medizinische Fakultät / Klinik und Poliklinik für Nuklearmedizin | |
Medizinische Fakultät / Klinik und Poliklinik für Strahlentherapie | |
Medizinische Fakultät / Pathologisches Institut | |
Language: | English |
Parent Title (English): | BMC Neurology |
Year of Completion: | 2023 |
Volume: | 23 |
Article Number: | 398 |
Source: | BMC Neurology (2023) 23:398. https://doi.org/10.1186/s12883-023-03450-w |
DOI: | https://doi.org/10.1186/s12883-023-03450-w |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | E-cadherin; beta-catenin; meningioma; peptide receptor radionuclide therapy (PRRT); radiotherapy |
Release Date: | 2024/05/21 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |