Covalent binding of ethinylestradiol and estrone to rat liver DNA in vivo

Please always quote using this URN: urn:nbn:de:bvb:20-opus-61162
  • Thecovalent bindingof [6,7-\(^3\)H]ethinylestradiol (EE)and [6,7-\(^3\)H]estrone (E) to liver DNA of 200 g female ratswas measured 8 h after the administration of 80 \(\mu\)g (9.2 mCi) estrogen by gavage. The binding is 1.5 for EE and 1.1 for E, expressedas binding to DNA/dose, in units of \(\mu\)mol hormonefmol DNA phosphate/mmole honnone/kg body wt. It is in the same order of magnitude as for benzene and about 10 000 tim es below the binding of typical liver carcinogens, such as aflatoxin B\(_1\) or N,N-dimethylnitrosamine.

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Metadaten
Author: W. Jaggi, Werner K. Lutz, C. Schlatter
URN:urn:nbn:de:bvb:20-opus-61162
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Pharmakologie und Toxikologie
Language:English
Year of Completion:1978
Source:Chemico-Biological Interactions (1978) 23, 1, 13-8.
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
GND Keyword:Toxikologie
Release Date:2012/01/27
Licence (German):License LogoDeutsches Urheberrecht