Protective effect of PAF-acether antagonist, BN 52021, in trichothecen toxicosis
Please always quote using this URN: urn:nbn:de:bvb:20-opus-63244
- Trichothecenes are mycotoxins which produce Iethai toxicosis in humans and animals, yet no adequate therapeutic regimen has been developed. This study provides evidence that the selective platelet activating factor (PAF) antagonist, BN 52021 (5-15 mg/kg i.v.) can prolong the survival of conscious rats exposed to a highly Iethai T -2 toxicosis. These data also suggest that P AF is an important mediator of this unique toxicosis.
| Author: | G. Feuerstein, P. Leader, Anna-Leena Sirén, P. Braquet |
|---|---|
| URN: | urn:nbn:de:bvb:20-opus-63244 |
| Document Type: | Journal article |
| Faculties: | Medizinische Fakultät / Neurochirurgische Klinik und Poliklinik |
| Language: | English |
| Year of Completion: | 1987 |
| Source: | In: Toxicology letters (1987) 38, 271-274. |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| GND Keyword: | Neurobiologie |
| Tag: | BN 52021; PAF-acether; T-2 toxin; mycotoxin; rat |
| Release Date: | 2012/08/07 |
| Licence (German): |  Deutsches Urheberrecht |