Study design of DIACORE (DIAbetes COhoRtE) - a cohort study of patients with diabetes mellitus type 2

Please always quote using this URN: urn:nbn:de:bvb:20-opus-122040
  • Background: Diabetes mellitus type 2 (DM2) is highly associated with increased risk for chronic kidney disease (CKD), end stage renal disease (ESRD) and cardiovascular morbidity. Epidemiological and genetic studies generate hypotheses for innovative strategies in DM2 management by unravelling novel mechanisms of diabetes complications, which is essential for future intervention trials. We have thus initiated the DIAbetes COhoRtE study (DIACORE). Methods: DIACORE is a prospective cohort study aiming to recruit 6000 patients of self-reportedBackground: Diabetes mellitus type 2 (DM2) is highly associated with increased risk for chronic kidney disease (CKD), end stage renal disease (ESRD) and cardiovascular morbidity. Epidemiological and genetic studies generate hypotheses for innovative strategies in DM2 management by unravelling novel mechanisms of diabetes complications, which is essential for future intervention trials. We have thus initiated the DIAbetes COhoRtE study (DIACORE). Methods: DIACORE is a prospective cohort study aiming to recruit 6000 patients of self-reported Caucasian ethnicity with prevalent DM2 for at least 10 years of follow-up. Study visits are performed in University-based recruiting clinics in Germany using standard operating procedures. All prevalent DM2 patients in outpatient clinics surrounding the recruiting centers are invited to participate. At baseline and at each 2-year follow-up examination, patients are subjected to a core phenotyping protocol. This includes a standardized online questionnaire and physical examination to determine incident micro-and macrovascular DM2 complications, malignancy and hospitalization, with a primary focus on renal events. Confirmatory outcome information is requested from patient records. Blood samples are obtained for a centrally analyzed standard laboratory panel and for biobanking of aliquots of serum, plasma, urine, mRNA and DNA for future scientific use. A subset of the cohort is subjected to extended phenotyping, e. g. sleep apnea screening, skin autofluorescence measurement, non-mydriatic retinal photography and non-invasive determination of arterial stiffness. Discussion: DIACORE will enable the prospective evaluation of factors involved in DM2 complication pathogenesis using high-throughput technologies in biosamples and genetic epidemiological studies.show moreshow less

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Metadaten
Author: Lena Dörhöfer, Alexander Lammert, Vera Krane, Mathias Gorski, Bernhard Banas, Christoph Wanner, Bernhard K. Krämer, Iris M. Heid, Carsten A. Böger
URN:urn:nbn:de:bvb:20-opus-122040
Document Type:Journal article
Faculties:Medizinische Fakultät / Medizinische Klinik und Poliklinik I
Language:English
Parent Title (English):BMC Medical Genetics
ISSN:1471-2350
Year of Completion:2013
Volume:14
Issue:25
Source:BMC Medical Genetics 2013, 14:25. doi:10.1186/1471-2350-14-25
DOI:https://doi.org/10.1186/1471-2350-14-25
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten
Tag:United States; blood-glucose control; cardiovascular disease; cardiovascular morbidity; chronic kidney-disease; diabetes complications; diabetes mellitus type 2; diabetic nephropathy; end stage renal disease; epidemiology; genetics; genome-wide association; glomerular-filtration-rate; replacement therapy; risk factors; serum creatinine; stage renal-disease
Release Date:2016/02/23
Contributing Corporation:DIACORE Study Group
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung