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- ERP (12)
- Enzym (12)
- FRET (12)
- Fibrose (12)
- Fluorescence (12)
- Gen (12)
- Grundschule (12)
- Hirntumor (12)
- Immunotherapy (12)
- Kinderheilkunde (12)
- Klima (12)
- Klimawandel (12)
- Kohlenstoff-Nanoröhre (12)
- Komplikationen (12)
- Kulturwissenschaften (12)
- Kutikula (12)
- Lymphom (12)
- Magnetische Kernresonanz (12)
- Medienkompetenz (12)
- Metastase (12)
- Modell (12)
- Monitoring (12)
- NFAT (12)
- Nanostrukturiertes Material (12)
- Netzhaut (12)
- Nigeria (12)
- Non-Hodgkin-Lymphom (12)
- Onkogen (12)
- PCR (12)
- PRRT (12)
- Pharmakologie (12)
- Pilzkörper (12)
- Polytrauma (12)
- Quality of Experience (12)
- Quantenchemie (12)
- Rekonstruktion (12)
- Religion (12)
- Replikation (12)
- Rotatorenmanschette (12)
- Ruthenium (12)
- SMN (12)
- SNP (12)
- Schule (12)
- Siliciumorganische Verbindungen (12)
- Spracherwerb (12)
- Supraleitung (12)
- Toll-like-Rezeptoren (12)
- Tumor-Nekrose-Faktor <alpha> (12)
- Ubiquitin (12)
- Ultrakurzer Lichtimpuls (12)
- Validierung (12)
- Westafrika (12)
- Zelladhäsion (12)
- adhesion (12)
- antibody (12)
- blood–brain barrier (12)
- carbenes (12)
- catalysis (12)
- colorectal carcinoma (12)
- complications (12)
- database (12)
- dementia (12)
- drug delivery (12)
- dynamics (12)
- electronic properties and materials (12)
- emotions (12)
- endothelium (12)
- genome (12)
- genomics (12)
- head and neck cancer (12)
- heart rate (12)
- interaction (12)
- malignant hyperthermia (12)
- measles (12)
- mechanism (12)
- microarray (12)
- microbiome (12)
- molecular beam epitaxy (12)
- molecular biology (12)
- monoclonal antibodies (12)
- neuropathy (12)
- nuclear envelope (12)
- oncology (12)
- optimization (12)
- plasticity (12)
- pollen (12)
- pollination (12)
- polymers (12)
- rats (12)
- recombination (12)
- review (12)
- screening (12)
- synaptic plasticity (12)
- systematic review (12)
- thrombosis (12)
- tinnitus (12)
- topological insulator (12)
- total knee arthroplasty (12)
- trabeculectomy (12)
- tumor microenvironment (12)
- ultrasound (12)
- water oxidation (12)
- ++ (11)
- 3D (11)
- Alzheimer's disease (11)
- Alzheimer’s disease (11)
- Anorexia nervosa (11)
- Antigen CD8 (11)
- Arabidopsis (11)
- Atherosclerosis (11)
- B-Zelle (11)
- Bakterielle Infektion (11)
- Bioisosterie (11)
- Biosynthese (11)
- Bioverfügbarkeit (11)
- Blazar (11)
- Bruchpilot (11)
- CRISPR/Cas9 (11)
- Chromatin (11)
- Computertomografie (11)
- Dynamik (11)
- Elektronentransfer (11)
- Epidemiologie (11)
- Epidermaler Wachstumsfaktor-Rezeptor (11)
- Flavonoide (11)
- Fließverhalten (11)
- Fotovoltaik (11)
- Genom (11)
- Geschlecht (11)
- Handlungsorientierung (11)
- Hypoxie (11)
- Immuncytochemie (11)
- Immunology (11)
- Japankärpfling (11)
- Knochen (11)
- Knochenersatz (11)
- Kolorektales Karzinom (11)
- LASP1 (11)
- LPS (11)
- Laser (11)
- Längsschnittuntersuchung (11)
- MS (11)
- Mais (11)
- Mathematik (11)
- Megakaryozyt (11)
- Mensch-Maschine-Kommunikation (11)
- Mesenchymale Stammzellen (11)
- Mesenchymzelle (11)
- Model (11)
- Multiple Myeloma (11)
- Mutagenität (11)
- NIRS (11)
- Nanodiamant (11)
- Neuropathie (11)
- Niereninsuffizienz (11)
- Operation (11)
- Osteoinduktion (11)
- Parasit (11)
- Parathormon (11)
- Perylenbisimid (11)
- Phylogenie (11)
- Proteaseinhibitor (11)
- Proteasen (11)
- Psychotherapie (11)
- Pulmonale Hypertonie (11)
- Quality of life (11)
- Quanten-Hall-Effekt (11)
- Reperfusion (11)
- Risikofaktoren (11)
- Salmonella (11)
- Schizophrenia (11)
- Schlafapnoe (11)
- Schließzelle (11)
- Schultergelenk (11)
- Schädel-Hirn-Trauma (11)
- Silicate (11)
- Skala (11)
- Small RNA (11)
- Sprache (11)
- Squark (11)
- Stammzellen (11)
- Sterblichkeit (11)
- Symbiose (11)
- T cell (11)
- TWEAK (11)
- Training (11)
- Transplantat-Wirt-Reaktion (11)
- Tuberkelbakterium (11)
- USA (11)
- Vasodilatator-stimuliertes Phosphoprotein (11)
- Wahrnehmung (11)
- X-ray crystallography (11)
- Zebrabärbling (11)
- Zelltod (11)
- allergy (11)
- atrial fibrillation (11)
- biocompatibility (11)
- biofilm (11)
- cancer treatment (11)
- cell adhesion (11)
- clinical trial (11)
- cochlear implant (11)
- communication (11)
- coping (11)
- dosimetry (11)
- emotion regulation (11)
- fatigue (11)
- fear (11)
- fluorescence microscopy (11)
- glioblastoma multiforme (11)
- hydrogels (11)
- immunology (11)
- kinetics (11)
- lung (11)
- membrane proteins (11)
- microglia (11)
- molecular dynamics (11)
- molecular imaging (11)
- nervous system (11)
- neural networks (11)
- neuroendocrine tumor (11)
- next generation sequencing (11)
- oncolytic virus (11)
- periodontitis (11)
- phenotype (11)
- psychiatric disorders (11)
- randomized controlled trial (11)
- reactive oxygen species (11)
- relapse (11)
- signaling (11)
- tight junctions (11)
- transport (11)
- university (11)
- Alkohol (10)
- Antigen CD28 (10)
- BERA (10)
- BMP-2 (10)
- Bacteria (10)
- Bauchspeicheldrüsenkrebs (10)
- Beschichtung (10)
- Bildverarbeitung (10)
- Bioinformatics (10)
- Biokompatibilität (10)
- Borole (10)
- Cadherine (10)
- Calciumphosphate (10)
- Carbene (10)
- Children (10)
- Chronische Niereninsuffizienz (10)
- Churritisch (10)
- Cochlear-Implantat (10)
- Computational chemistry (10)
- Coronaviren (10)
- Covid-19 (10)
- Cyclo-GMP (10)
- Depressivität (10)
- Diamant (10)
- Digital Humanities (10)
- Dimerisierung (10)
- Dotierung (10)
- Echokardiographie (10)
- Eierstockkrebs (10)
- Elektrochemie (10)
- Elektronenkorrelation (10)
- Englisch (10)
- Enzyminhibitor (10)
- Erbkrankheit (10)
- Ereigniskorreliertes Potenzial (10)
- Erwachsener (10)
- Franken (10)
- Frau (10)
- Funktionalisierung <Chemie> (10)
- Funktionelle Kernspintomografie (10)
- Förderung (10)
- Geldpolitik (10)
- Glatter Krallenfrosch (10)
- Grenzfläche (10)
- HSM-Satztest (10)
- Herzmuskelzelle (10)
- Honigbiene (10)
- Hypophosphatasie (10)
- IL-4 (10)
- Immunfluoreszenz (10)
- Impfstoff (10)
- Induzierte pluripotente Stammzelle (10)
- Interleukin 4 (10)
- Interview (10)
- JNK (10)
- Klassifikation (10)
- Kleinsatellit (10)
- Kniegelenk (10)
- Kohlenstoff (10)
- Kommunikation (10)
- Komplikation (10)
- Kooperation (10)
- Kultur (10)
- LC-MS (10)
- Ladungstransfer (10)
- Ligand (10)
- Lokalisation (10)
- Magnesiumphosphate (10)
- Magnetismus (10)
- Mathematikunterricht (10)
- Mathematisches Modell (10)
- Medulloblastom (10)
- Metakognition (10)
- Metallocene (10)
- Methylphenidat (10)
- Mikrokerne (10)
- Musik (10)
- NAFLD (10)
- Nahrungserwerb (10)
- Nebennierenrindenkarzinom (10)
- Neolithikum (10)
- Neuropathischer Schmerz (10)
- Niger (10)
- Osteosynthese (10)
- PD-1 (10)
- PD-L1 (10)
- Pain (10)
- Panikstörung (10)
- Parodontitis (10)
- Pathogenität (10)
- Platelets (10)
- Plattenepithelkarzinom (10)
- Prevalence (10)
- Prostaglandine (10)
- Präfrontaler Cortex (10)
- Pädagogik (10)
- Qualitätskontrolle (10)
- RNA interference (10)
- RNA-seq (10)
- RNS-Spleißen (10)
- Radiotherapy (10)
- Remote Sensing (10)
- Rhodium (10)
- Rituximab (10)
- SAR (10)
- Schilddrüse (10)
- Sentinel-1 (10)
- Silaanaloga (10)
- Silber (10)
- Silicon (10)
- South Africa (10)
- Sprachverstehen (10)
- Staphylococcus (10)
- Starke Kopplung (10)
- Stickstoffmonoxid-Synthase (10)
- Stressreaktion (10)
- Stroke (10)
- Struktur (10)
- T-Lymphozyten (10)
- T-Lymphozyten-Rezeptor (10)
- Tagesrhythmus (10)
- Theologie (10)
- Totalsynthese (10)
- Toxizität (10)
- Transthorakale Echokardiographie (10)
- Treg (10)
- Trypanosomen (10)
- Verwaltungsrecht (10)
- Vitamin D (10)
- Vor- und Frühgeschichte (10)
- Vorschulkind (10)
- Wachstum (10)
- agriculture (10)
- aldosterone (10)
- amino acids (10)
- antimicrobial resistance (10)
- bariatric surgery (10)
- bioinformatics (10)
- biosynthesis (10)
- body size (10)
- boranes (10)
- cancer therapy (10)
- chemokines (10)
- chronic heart failure (10)
- circadian rhythms (10)
- cognitive impairment (10)
- collagen (10)
- comparison (10)
- complex (10)
- coronary artery disease (10)
- cortisol (10)
- decision-making (10)
- density functional calculations (10)
- eNOS (10)
- education (10)
- gene therapy (10)
- genome-wide association (10)
- glioma (10)
- global change (10)
- glycine receptor (10)
- human behaviour (10)
- immunomodulation (10)
- induced pluripotent stem cells (10)
- injury (10)
- insect (10)
- knockout (10)
- leaf-cutting ants (10)
- leukemia (10)
- lymph nodes (10)
- mapping (10)
- membrane potential (10)
- motivation (10)
- near-infrared spectroscopy (10)
- neuroscience (10)
- oncolytic virotherapy (10)
- oxidativer Stress (10)
- quality assurance (10)
- quantification (10)
- regulatorische T-Zellen (10)
- remodeling (10)
- senescence (10)
- silicon (10)
- social interaction (10)
- stem cell transplantation (10)
- subthalamic nucleus (10)
- synapse (10)
- tDCS (10)
- transcriptomics (10)
- tumors (10)
- vaccination (10)
- vertigo (10)
- walking (10)
- Östrogene (10)
- 3 (9)
- Adenosin (9)
- Adenosine receptors (9)
- Affekt (9)
- Afrika (9)
- Alps (9)
- Analyse (9)
- Angeregter Zustand (9)
- Anxiety (9)
- Aorta (9)
- Aortenstenose (9)
- Autophagie (9)
- Beyond Standard Model (9)
- Biotransformation (9)
- Bordetella pertussis (9)
- Borylierung (9)
- Boğazkale (9)
- Butyrat (9)
- CT (9)
- Carcinogenese (9)
- Catalysis (9)
- Chiralität <Chemie> (9)
- Cloud Computing (9)
- Deep learning (9)
- Dendritic cells (9)
- Diagnose (9)
- Diborane (9)
- Diskursanalyse (9)
- Dünndarm (9)
- Einzelphotonenemission (9)
- Elektroencephalographie (9)
- Elektronenmikroskopie (9)
- Elektronenstruktur (9)
- Elementarteilchenphysik (9)
- Epithel (9)
- Ernährung (9)
- Experimentelle Psychologie (9)
- Extremwertstatistik (9)
- Familie (9)
- Fanconi Anämie (9)
- Fettgewebe (9)
- Fibroblastenwachstumsfaktor (9)
- Fibromyalgie (9)
- Finite-Elemente-Methode (9)
- Frühgeborene (9)
- GIS (9)
- Geistigbehindertenpädagogik (9)
- Gentherapie (9)
- Geoinformationssystem (9)
- Geruchswahrnehmung (9)
- Glioblastoma (9)
- Google Earth Engine (9)
- Grammatik (9)
- Haut (9)
- Herzmuskelkrankheit (9)
- Hethiter (9)
- Hyaluronsäure (9)
- Immunisierung (9)
- Impulsivität (9)
- Innovation (9)
- Instrumentelle Analytik (9)
- Integrine (9)
- Iran (9)
- Isolierung <Chemie> (9)
- Jugendliche (9)
- Juvenile chronische Arthritis (9)
- Kapillarelektrophorese (9)
- Knorpel (9)
- Konflikt (9)
- Koordinationslehre (9)
- Korpus <Linguistik> (9)
- LC-MS/MS (9)
- Landsat (9)
- Leber (9)
- Linguistik (9)
- Löslichkeit (9)
- MAPK (9)
- Macrophage (9)
- Magnetische Resonanz (9)
- Mehrfachbindung (9)
- Mehrsprachigkeit (9)
- Messenger-RNS (9)
- Mice (9)
- Molekulare Erkennung (9)
- Monozyt (9)
- Morphologie (9)
- Mukoviszidose (9)
- Myokardprotektion (9)
- NO (9)
- NSCLC (9)
- Nebennierenrindenkrebs (9)
- Neuroinflammation (9)
- Nierentransplantation (9)
- Oberfläche (9)
- Oberflächenphysik (9)
- Optoelektronik (9)
- Pathogenese (9)
- Persönlichkeit (9)
- Pharmakotherapie (9)
- Photolumineszenzspektroskopie (9)
- Physiologie (9)
- Plasmamembran (9)
- Protein (9)
- Pseudomonas syringae (9)
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- Quantenmechanik (9)
- Rechenzentrum (9)
- Rechtsvergleich (9)
- Regeneration (9)
- Regionalentwicklung (9)
- Revision (9)
- Sarkoidose (9)
- Satellit (9)
- Schmalwand <Arabidopsis> (9)
- Schwindel (9)
- Schüttgut (9)
- Spin-Bahn-Wechselwirkung (9)
- Squaraine (9)
- Stathmin (9)
- Stereoselektive Synthese (9)
- Supply Chain Management (9)
- Syntax (9)
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- Südafrika (9)
- TDM (9)
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- Transplantat (9)
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- Trypanosoma (9)
- Tumorantigen (9)
- Vakuole (9)
- Vergleich (9)
- Visuelle Aufmerksamkeit (9)
- Wurzel (9)
- Zellkern (9)
- Zentralnervensystem (9)
- Zinkselenid (9)
- actin cytoskeleton (9)
- adolescence (9)
- aggregation (9)
- amyotrophic lateral sclerosis (9)
- antennal lobe (9)
- anxiety disorders (9)
- aromaticity (9)
- astrocytes (9)
- biomechanics (9)
- blood brain barrier (9)
- bone cement (9)
- bone marrow (9)
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- cardiovascular disease (9)
- cell culture (9)
- cell migration (9)
- cell wall (9)
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- cerebrospinal fluid (9)
- chromatin (9)
- computed tomography (9)
- coronary heart disease (9)
- cuticular hydrocarbons (9)
- cystic fibrosis (9)
- cytotoxic T cells (9)
- decision making (9)
- dendritische Zellen (9)
- dialysis (9)
- dispersal (9)
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- electron microscopy (9)
- electrophysiology (9)
- energy (9)
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- hip (9)
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- hydrogel (9)
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- macrophage (9)
- major depression (9)
- mechanotransduction (9)
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- metapopulation (9)
- methylation (9)
- mitosis (9)
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- prognostic factors (9)
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- reveals (9)
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- systematic uncertainty (9)
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- Übersetzung (9)
- ATLAS (8)
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- Adhärenz (8)
- Aggregat <Chemie> (8)
- Akt (8)
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- Asymmetrische Synthese (8)
- Auge (8)
- Autoaggressionskrankheit (8)
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- Darm (8)
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- Degradation (8)
- Demenz (8)
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- Diborene (8)
- ELISA (8)
- ERK (8)
- Elektronenspin (8)
- Elektronenspinresonanz (8)
- Emotionsregulation (8)
- Endothelzellen (8)
- Engagement (8)
- Erbrechen (8)
- Europa (8)
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- Exziton-Polariton (8)
- Fachdidaktik (8)
- Femtosekundenbereich (8)
- Fibroblasten (8)
- Fitness (8)
- Fluoreszenzspektroskopie (8)
- Forschung (8)
- Fußball (8)
- GABA (8)
- Gammastrahlung (8)
- Gedächtnisleistung (8)
- Genotoxicity (8)
- Geschlechtsunterschied (8)
- Gewebe (8)
- Gliom (8)
- Graphen (8)
- HPLC-MS (8)
- Habichtskraut (8)
- Haemophilus influenzae (8)
- Harnwegsinfektion (8)
- Hernie (8)
- Hochbegabung (8)
- Hubbard-Modell (8)
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- Hüftgelenk (8)
- IL-10 (8)
- Immunantwort (8)
- In vivo (8)
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- Komposit <Zahnmedizin> (8)
- Kondo-Effekt (8)
- Korrelation (8)
- Kreuzband (8)
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- Myokarditis (8)
- N-heterocyclic carbenes (8)
- Nachsorge (8)
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- Parton distributions (8)
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- Peptide (8)
- Periphere arterielle Verschlusskrankheit (8)
- Permeabilität (8)
- Pharmakodynamik (8)
- Photodissoziation (8)
- Photovoltaik (8)
- Platin (8)
- Pollen (8)
- Polycyclische Aromaten (8)
- Protein p53 (8)
- Protein-Tyrosin-Kinasen (8)
- Proteinbindung (8)
- Protonen-NMR-Spektroskopie (8)
- Präkonditionierung (8)
- Psychische Störung (8)
- Pump-Probe-Technik (8)
- Quantendynamik (8)
- Quelle (8)
- Quran (8)
- RNA sequencing (8)
- Radikal <Chemie> (8)
- Raf <Biochemie> (8)
- Raf-Kinasen (8)
- Raman spectroscopy (8)
- Rastertunnelmikroskop (8)
- Rechenzentrum Universität Würzburg (8)
- Rechnungslegung (8)
- Regenerative Medizin (8)
- Rekombination (8)
- Retroviren (8)
- Ringöffnungspolymerisation (8)
- Roman (8)
- Röntgen-Photoelektronenspektroskopie (8)
- Salmonella typhimurium (8)
- Schmerzforschung (8)
- Schwämme (8)
- Semimagnetischer Halbleiter (8)
- Siliciumcarbid (8)
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- MTUS1 (4)
- Macrophages (4)
- Magnetoelektronik (4)
- Magnetohydrodynamik (4)
- Magnetpartikelbildgebung (4)
- Maisstärke (4)
- Malignes Lymphom (4)
- Mammographie (4)
- Massenmedien (4)
- Mechanismus (4)
- Medaka (4)
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- Melodie (4)
- Meningococci (4)
- Mensch-Maschine-Interaktion (4)
- Menschenrechte (4)
- Mergers and Acquisitions (4)
- Mesenchymale Stammzelle (4)
- Mesopotamien (4)
- Metabolisches Syndrom (4)
- Metabolit (4)
- Metallkomplexe (4)
- Metallosupramolekulare Chemie (4)
- Metamorphose <Geologie> (4)
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- Mexiko (4)
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- Mikroarray (4)
- Mikrodialyse (4)
- Mikropartikel (4)
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- Mitotane (4)
- Mittelohr (4)
- Mixed Reality (4)
- Mixed-Methods (4)
- Miz1 (4)
- Mobilität (4)
- Modeling (4)
- Modelling (4)
- Models (4)
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- Myasthenia gravis (4)
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- Myelin (4)
- Mykobakterien (4)
- Mykose (4)
- Mäuse (4)
- NAD (4)
- NET (4)
- NF-kappa-B (4)
- NF-κB (4)
- NFkB (4)
- NFkappaB (4)
- NGF (4)
- NGS (4)
- NMDA-Rezeptor (4)
- NSSI (4)
- NT-proBNP (4)
- NaV1.9 (4)
- Naphthylisochinolin-Alkaloide (4)
- Natur (4)
- Natural products (4)
- Nausea (4)
- Navigation (4)
- Nebenniereninsuffizienz (4)
- Nebenwirkung (4)
- Nebenwirkungen (4)
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- Nervennetz (4)
- Nestbau (4)
- Netzwerkanalyse (4)
- Neugeborenenhörscreening (4)
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- Neuromelanin (4)
- Neurons (4)
- Neurospora crassa (4)
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- Neutrophiler Granulozyt (4)
- Nibelungenlied (4)
- Nichtglatte Optimierung (4)
- Nickelverbindungen (4)
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- Nonlinear Dynamics (4)
- Numerisches Modell (4)
- Oberflächenzustand (4)
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- Oncostatin M (4)
- Online-Handel (4)
- Onlinehandel (4)
- OpenSpaceAlps (4)
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- Osteoinduction (4)
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- Overlay-Netz (4)
- Oxidative Stress (4)
- Oxidative stress (4)
- PAK (4)
- PBMC (4)
- PEG (4)
- PER (4)
- PI3K (4)
- PKA (4)
- PSA (4)
- PSMA-RADS (4)
- PTCA (4)
- PTCDA (4)
- PTEN (4)
- PTH (4)
- Paläoklima (4)
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- Pe (4)
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- Phenomenology (4)
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- Phobie (4)
- Phosphatidylinositolkinase <Phosphatidylinositol-3-Kinase> (4)
- Phosphoglykolatphosphatase (4)
- Phospholipide (4)
- Phosphor (4)
- Photorezeptor (4)
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- Pleuraempyem (4)
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- Polyethylenglykole (4)
- Pontryagin maximum principle (4)
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- Prescriptive Analytics (4)
- Priming (4)
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- Protein-Protein-Interaktion (4)
- Proteinfaltung (4)
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- Proteinkinase B (4)
- Proteinsynthese (4)
- Proteintyrosinphosphatase (4)
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- Pyrrolizidinalkaloide (4)
- QSAR (4)
- QoE (4)
- Quadrocopter (4)
- Quality of Life (4)
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- Quantum information (4)
- RCT (4)
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- Register (4)
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- Ruthenium complexes (4)
- Röntgen-Kleinwinkelstreuung (4)
- Röntgendiffraktometrie (4)
- SAS <Programm> (4)
- SLC2A3 (4)
- SOAT1 (4)
- SOX9 (4)
- SPRED2 (4)
- SQH method (4)
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- Sahara (4)
- Sahel (4)
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- Sap47 (4)
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- Schaf (4)
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- Schüler (4)
- Score (4)
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- Simulator (4)
- Sintern (4)
- SnRK1 (4)
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- Spessart (4)
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- Sprachverständnistest (4)
- Staatliche Museen zu Berlin. Antikensammlung (4)
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- System (4)
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- Validität (4)
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- Viren (4)
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- Wellenpaket (4)
- Wide-gap-Halbleiter (4)
- William (4)
- Williams, Raymond (4)
- Wirbelsäulenverletzung (4)
- Wirkmechanismus (4)
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- Wissenschaftssprache (4)
- Wissensrepräsentation (4)
- Wittig-Reaktion (4)
- Wnt (4)
- Wnt-Proteine (4)
- Wolfgang Amadeus (4)
- Wolframkomplexe (4)
- XML (4)
- Xmrk (4)
- Yoga (4)
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- Zahnimplantat (4)
- Zeitaufgelöste Spektroskopie (4)
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- affect (4)
- age-related macular degeneration (4)
- agency (4)
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- alkaline phosphatase (4)
- allogene Stammzelltransplantation (4)
- allogeneic hematopoietic stem cell transplantation (4)
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- amyotrophic-lateral-sclerosis (4)
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- antibacterial (4)
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- arthropods (4)
- associative learning (4)
- athletes (4)
- atopic dermatitis (4)
- attention-deficit/hyperactivity disorder (ADHD) (4)
- attentional bias (4)
- auditory pathway (4)
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- bone adhesive (4)
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- borylenes (4)
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- bridging (4)
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- care (4)
- cell-cycle arrest (4)
- cervical dystonia (4)
- characterization (4)
- chemotaxis (4)
- chiral separation (4)
- chlamydia trachomatis (4)
- chondrogenesis (4)
- chondrogenic differentiation (4)
- cirrhosis (4)
- cluster analysis (4)
- cochlea (4)
- colon (4)
- colony-stimulating factor (4)
- combination therapy (4)
- comparative genomic hybridization (4)
- compensation (4)
- complement system (4)
- complication (4)
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- consciousness (4)
- consortium (4)
- context (4)
- convolutional neural network (4)
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- cooperation (4)
- copy number variation (4)
- corneal confocal microscopy (4)
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- critical care (4)
- crosstalk (4)
- crowdsensing (4)
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- definition (4)
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- diboration (4)
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- diffusion tensor imaging (4)
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- polymerization (4)
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- psychische Belastung (4)
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- punishment (4)
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Die Vögel der Azoren
(1971)
Während einer viermonatigen Reise zu allen neun Azoreninseln wurde der gesamte Brutvogelbestand dieses Archipels untersucht. Die Befunde sind in einer detaillierten Artenliste zusammengefaßt, ergänzt durch ökologische und brutbiologische Anmerkungen. Zahlreiche Beobachtungen lassen vermuten, daß vor allem Stieglitz und Kanarienvogel tägliche und auch jahreszeitlich bedingte interinsulare Flüge unternehmen. Die Lautäußerungen sechs verschiedener Vogel arten sind in Klangspektrogrammen dargestellt. Ein mathematischer Ansatz zeigt, daß sich die Anzahl der auf einer bestimmten Insel brütenden Landvogelarten umgekehrt proportional zur Entfernung zum europäischen Festland und proportional zum Logarithmus naturalis der Inselfläche verhält. Die abgeleitete Formel läßt sich prinzipiell auch auf andere Atlantikinseln anwenden, die weitgehend vom Festland isoliert sind.
No abstract available
The observed impurity induced far-infrared absorption in CsCl : Rb\(^+\) and CsCl : K\(^+\) is compared with a calculated density of acoustic phonon states in CsCl. The absorption due to CsCl : Rb\(^+\) displays a minimum between the acoustic and optic phonon bands. A narrow line is observed in CsCl: K\(^+\) at 85.8 cm\(^{-1}\) which falls in this quasi-phonon gap.
Das Rechtsinstitut der Culpa in contrahendo (Cic) wurde von der deutschen Rechtswissenschaft und Rechtsprechung entwickelt, um die vertraglichen Haftungsnormen einschl. der Schutzpflichten für Leib und Eigentum auf den vor-vertraglichen Bereich zu erstrecken. Diese Erstreckung ist für die genannten Schutzpflichten weder dogmatisch begründbar noch praktisch notwendig. Die funktionell für den Schutz des allgemeinen Erhaltungsinteresses zuständige Deliktsordnung reicht hier völlig aus. Der auf den vor-vertraglichen Bereich erstreckte Schutzbereich des Schuldvertrags ist durch dessen Funktion als rechtliches Instrument des Güter- und Leistungsaustauschs bestimmt und erfasst nicht das Interesse an der Integrität der gegenüber jedermann geschützten Rechtsgüter, insbes. an der Unversehrtheit von Person und Eigentum. Personen- und Sachschäden sind für das vor-vertragliche Verhandlungsschuldverhältnis ebenso wenig normrelevant wie für das Zielvertragsverhältnis. Der Schutzbereich des Cic-Schuldverhältnisses ist daher auf Verhalten zu beschränken, das Bezug zu dem konkret intendierten Leistungsverhältnis (Zielvertrag) aufweist.
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A small fraction of HeLa cells within an exponentially growing culture showed cisternal differentiations, such as cytoplasmic as well as intranuclear annulate lamellae and special smooth surfaced endoplasmic reticulum aggregates with a typical "Cotte de maillet" appearance. Additionally, clusters of dense granules were observed in the cytoplasm which were often associated with polysomes and strongly resembled the so-called "heavy bodies" known in particular in diverse oocytes. The functional meaning of these structures is discussed. Moreover, it is deduced from the ultrastructural identity of the pore complexes in the nuclear envelope and the cytoplasmic and intranuclear annulate lamellae that the pore complex material with its highly ordered arrangement is not a structure characteristic for nucleocytoplasmically migrating material, but rather is a general structural expression of a tight binding of ribonucleoprotein (RNP) to cisternal membranes. The pore complexes are thought of as representing sites of a RNP-storage. A similar functioning is hypothesized for the "heavy body"like aggregates. To the current hypotheses on the formation of annulate lamellae and the nuclear envelope, which are based on the concept of membrane continuities and constancies, the alternative view of a self assembly mechanism of membrane constituents on nucleoprotein structures is added.
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Different pool sizes of the precursor polypeptides of cytochrome oxidase from Neurospora crassa.
(1972)
Pulse-labelling experiments with growing Neurospora crassa revealed that the polypeptides composing the protein moiety of a cytochrome oxidase preparation are derived from at least four independent pools of precursor polypeptides. The pool sizes range from 2 ° f 0 to 25 °/0 of the amount of the corresponding polypeptide present in cytochrome oxidase. The smallest pool is assigned to a polypeptide of mitochondrial origm. Serial pools were found for one of the polypeptides.
Cytochrome oxidasewas prepared from Neurospora crassa by chromatography on oleyl polymethacrylic acid resin and separated into seven polypeptides by polyacrylamide gel electrophoresis in the presence of sodium dodecylsulfate. Incorporation oflabelled amino acids into the single polypeptideswas investigated after a pulse labelling in the absence and presence of chloramphenicol, and afterwashing out the inhibitor. Chloramphenicol (4 mg/ml) inhibited amino acid incorporation into all polypeptides 90-95%• while labeHing of the whole membrane protein was inhibited only 30%• Mter washing out the inhibitor and further growth of the cells. the four smaller polypeptides were highly labelled, whereas the other polypeptides showed only a. small increase in radioactivity. It is concluded that the four small-sized polypeptides of cytochrome oxidase are synthesized but not integrated into the functional enzyme under the action of chloramphenicol.
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Zum hurritischen Lexikon I
(1972)
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The 130 chemical shifts were determined of the carbons in 12 cycloheptanes, 21 cycloheptanols, and 8 cycloheptanones. In some cyc1oheptanols and cyc1oheptanones, the assignments have been obtained unambiguously by the synthesis of deuterated derivatives and the use of paramagnetic-shift reagents. Substituent effects for the different types of groups have been calculated. The most informative data about the cyc10heptane conformations were provided by the relatively well understood I' effects. The results are generally in,good agreement with predictions based on the twist-chair form, which has been predicted by Hendrickson to be the most stable conformation. Pairs of cis-trans isomers are found to have rather characteristic differences in their 130 spectra. This fact was used to assign the resonances found for cis-trans mixtures of methyl-substituted cyc1oheptanols to specific isomers.
The occurrence of stacked annulate tamellae is documented for a plant cell system, namely for pollen mother cells and developing pollen grains of Canna generalis. Their structural subarchiteeture and relationship to endoplasmie reticulum (ER) and nuclear envelope cisternae is described in detail. The results demonstrate structural homology between plant and animal annulate lamellae and are compatible with, though do not prove, the view that annulate lamcllar cisternae may originate as a degenerative form of endoplasmic retieulum.
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Structural details of the dictyosomal pores in several plant cell types are described from tangential and cross sections of Golgi cisternae. Frequency distributions of the sizes of such Golgi pores are given and compared with the corresponding values of nuclear pores in the same cells. Golgi pore inner diameters are less homogeneously distributed and can be as small as 100 A or less. They are not simply cisterna I holes, but are often associated with centrally located electron dense granules or rods and with inner pore filaments. This organization, which is very common in dictyosomal pores in plant and animal cells, has some similarities with the structural architecture of nuclear envelope and annulate lamellar pore complexes. The particulate material associated with the dictyosomal pores shows spatial and structural relationship to cytoplasmic ribosomes. Possible modes of Golgi pore formation and some consequences of these observations for interpretation of nuclear pore structures are discussed.
Electron opaque cross-bridge structures span the inter- and intracisternal spaces and provide membrane-to-membrane connections between adjacent cisternae of dictyosomes of pollen tubes of Clivia and Lilium. Additionally, the classic intercisternal rods, characteristic of intercisternal regions near the maturing face of dictyosomes, are connected with the adjacent membranes through similar cross-bridge elements. We suggest that these structural links are responsible for maintaining the flattened appearance of the central parts of Golgi apparatus cisternae as well as for the coherence of cisternae within the stack. Observations on other plant (e.g. microsporocytes of Canna) and animal cells (e.g. rodent liver and hepatoma cells, newt spermatocytes) show that such an array of membrane cross-links is a universal feature of Golgi apparatus architecture. The cross-bridges appear as part of the complex "zone of exclusion" which surrounds dictyosomes, entire Golgi apparatus and Golgi apparatus equivalents in a variety of cell types.
In order to investigate the chemical composition of the nuclear pore complexes isolated nuclei from mature Xenopus laevis oocytes were manually fractioned into nucleo· plasmic aggregates and the nuclear envelopes. The whole isolation procedure takes no more than 60- 90 sec, and the pore complexes of the isolated envelopes are well preserved as demonstrated by electron microscopy. Minor nucleoplasmic and cytoplasmic contaminations associated with the isolated nuclear envelopes were determined with electron microscopic morphometry and were found to be quantitatively negligible as far as their mass and nucleic acid content is concerned. The RNA content of the fractions was determined by direct phosphorus analysis after differential alkaline hydrolysis. Approximately 9% of the total nuclear RNA of the mature Xenopus egg was found to be attached to the nuclear envelope. The nonmembranous elements of one pore complex contain 0.41 X 10- 16 g RNA. This value agrees well with the content estimated from morphometric data. The RNA package density in the pore complexes (270 X 10- 15 g/fJ-3) is compared with the nucleolar, nucleoplasmic and cytoplasmic RNA concentration and is discussed in context with the importance of the pore complexes for the nucleo-cytoplasmic transport of RNA-containing macromolecules. Additionally, the results of the chemical analyses as well as of the 3H-actinomycin D autoradiography and of the nucleoprotein staining method of Bernhard (1969) speak against the occurence of considerable amounts of DNA in the nuclear pore complex structures.
New resonant-mode infrared absorption lines have been observed in NaCl with high concentrations of fluorine impurities. The quadratic concentration dependence of the strength of these lines indicates that they are due to pairs of fluorine impurities. At the resonant frequencies, the motion of some host ions appears to be as important as the motion of the impurities themselves.
Scorpions, living in North African semideserts are - in spite of disrupting experimental interferences - able to maintain a certain direction in their natural environment in the dark on a plane surface. Under comparable laboratory conditions, excluding the possibility of light or gravity orientation, they can orient themselves if a directed air current passes over the "arena." In most cases the scorpions do not run necessarily with or against the wind, but rather maintain constant angles to the air current for anywhere from minutes to many hours. They are running anemomenotactically (ref. 1). Under identical conditions many species of beetles also orient themselves to air currents (refs. 2 to 4). The main problems to be solved in the study of anemomenotactic orientation are: (1) Which physical qualities of the air current have an influence on the anemomenotaxis? (2) With which sense organs do beetles and scorpions perceive wind directions? (3) Which physiological mechanism is the basis of anemomenotactic orientation? (4) What is the biological significance of anemomenotaxis in beetles and scorpions? With respect to these problems, more study has been done on beetles than on scorpions. Therefore, due to lack of space, I shall discuss mainly some of the results obtained in experiments with dung beetles (Geotrupes silvaticus, G. ,Stercorarius, G. armifrons, G. niger, Scarabaeus variolosus) and tenebrionid beetles (Tenebrio molitor, Pimelia grossa, P. tenuicomis, Scaurus dubius).
Thin section electron microscopy of Actinomycin D treated Tetrahymena cells and amphibian oocytes (Xenopus laevis, Triturus aZpestris) reveal no reduction in the central granules in the nuclear pore complexes. Possible reasons for the diversity between these results and earlier observations using negatively stained isolated nuclear envelopes from the same objects are discussed. The results clearly show that the presence of central granules within the nuclear pores does neither depend on nuclear RNA synthesis nor does indicate nucleocytoplasmic RNA transport. This conclusion leads to a reconsideration of the nature of the central granule. The functioning of the central granule of the nuclear pore complexes is further discussed in connection with recent studies on the ultrastructure of various types of cisternal pores.
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In einem Lemexperiment beurteilten 10 Vpn als Empfiinger die Blicksignale einer Person, die als Sender fungierte. Die Diskriminierungsleistung der Empfanger verbesserte sich als Folge von feedback-Informationen. Die verbesserte Leistung war unabhangig von der Sehscharfe und korrelierte nicht mit Extraversion und Neurotizismus. Fur Zielpunkte des Blicks, die weiter vom Gesicht entfemt waren, war die Leistung am Anfang schlechter und die Leistungsverbesserung ausgepragter. Die Ergebnisse werden im Hinblick auf eine gro6ere Genauigkeit bei der Beobachtung der Variablen 'Blick-Verhalten' diskutiert, was fUr Untersuchungen liber non-verbales Verhalten wichtig ist. FUr Beobachter werden Trainings-Programme vorgeschlagen, bei denen RUckmeldungen liber die tatsachliche Blickrichtung des Senders vermittelt werden konnen. Resume Au cours d'une experience sur l'apprentissage, 10 sujets se comportant comme des recepteurs ont juge les signaux du regard d'un envoyeur. En fournissant de la retroaction quant a la vraie direction du regard on a obtenu un apprentissage dans le sens d'une amelioration de la performance discriminatoire: l'amelioration etait independante de l'acuite visuelle des recepteurs et n'6tait pas correlative a l'extraversion ou au caractere nevrose des sujets. Au debut la performance etait plus mediocre et le progres dans l'apprentissage meilleur dans le cas des points de fixation qui etaient les plus eloignes du visage. On discute des resultats en vue d'ameliorer la precision des observateurs sur la variable 'comportement du regard' important dans les etudes sur la communication nonverbale. On propose un entralnement prealable des observateurs, entrainement qui permet une retroaction explicite quant a la vraie direction du regard.
Cytochrome oxidase isolated from N eurospora crassa was resolved into seven protein eomponents by eleetrophoresis in polyaerylamide gels eontaining sodium dodeeylsulfate. The apparent molecular weights were determined tobe 41000, 28500, 21000, 16000, 14000, 11500 and 10000 for the eomponents 1, 2, 3, 4, 5, 6, and 7, respectively. The components 1, 2 and 3 are synthesized on mitochondrial ribosomes as shown by the incorporation of radioactive amino aeids in the presenee of cyeloheximide. Amino-acidanalysis of the isolated components 1, 2 and 3 revealed a high content of apolar amino acids and a low eontent of basic amino aeids compared to an average amino-aeid eomposition of components 4-7. Components 1, 2 and 3 eontribute 27.9°/0, 18°/0 and 14.2°/0 to the whole eytoehrome oxidase protein. This was calculated from the contributions of the single eomponents to the totalleueine eontent of the enzyme and the leueine eontents (nmol leueine per mg protein) of the single eomponents as determined by amino-aeid analysis. Equimolar relations of the components 1, 2 and 3 are found by dividing the amounts of protein by their apparent molecular weights. A stoichiometry of 1:1:1 results assuming a minimal molecular weight of 150000 for the whole cytochrome oxidase protein. On the basis of the heme a content a molecular weight of about 70000 per heme group was determined, using an absorption coeffieient L1e605 (redueed minus oxidized) of 12 mM-1 cm-1• It is concluded that the smallest structural unit of eytochrome oxidase contains two heme groups.
A cytochrome b preparation from Neurospora crassa mitochondria is found to consist of three polypeptides (apparent molecular weight 10 000, 11 000 and 32 000), a cytochrome aa3 preparation of six to seven polypeptides (apparent molecular weight 8 000, 11 000, 13 000, 18 000, 28 000 and 36 000). Selective incorporation of radioactive amino acids by eilher mitochondrial protein synthesis when the cytoplasmic one is blocked or by the cytoplasmic protein synthesis, when the mitochondrial one is blocked, indicates that one cytochrome b polypeptide (mw 32 000) and one to three cytochrome aa3 polypeptides (mw 36 000, 28 000 and 18 000) are mitochondrial translation products, the other cytochrome b and cytochrome aa3 polypeptides cytoplasmic translation products. The delayed appearance of labeling in the cytochrome b and cytochrome aa3 polypeptides compared to the average cell protein after a pulse of <~H leueine revealed that these polypeptides are derived from separate pools of precursor polypeptides. The pool sizes range from 2 p. cent to 25 p. cent of the amount of the corresponding polypeptide present in the cytochromes. The 32 000 molecular weight polypeptide of cytochrome band at least the 18 000 molecular weight polypeptide of cytochrome aa\(_3\) are mitochondrial translation products as well in the fungus Neurospora crassa as in the insect Locusta migratoria. So, despite the fact that the size of mitochondrial DNA and mitochondrial ribosomes is reduced in insects, the products have maintained their characteristics.
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Unter den Krebsen ist als größerer Gruppe allein den Landasseln (Oniscoidea) eine Eroberung des Festlandes gelungen. Ihre Anpassung an das Landleben blieb aber bislang recht mangelhaft, z. B. fehlt ein wirksamer Verdunstungsschutz. Wie zu erwarten, bewohnen daher die meisten Landasselarten feuchte Lebensstätten. Zu den wenigen Ausnahmen zählt die Wüstenassel Hemilepistus reaumuri, die nordafrikanische und kleinasiatische Halbwüsten - stellenweise auch echte Wüstengebiete - besiedelt. Es sind vor allem Verhaltensanpassungen, die den Wüstenasseln in diesen während vieler Monate trockenheißen Extrembiotopen nicht nur ein Oberleben erlauben, sondern sie darüber hinaus noch vielerorts zum erfolgreichsten Faunenelement machen.
Segregation of the nucleolar components is described in the differentiated nucleus of the generative cell in the growing Clivia and Lilium pollen tubes. This finding of a natural nucleolar segregation is discussed against the background of current views of the correlations of nucleolar morphology and transcriptional activity.
Electron microscopic spread preparations of oocyte nucleoli (lampbrush stage) of various amphibians are quantitatively evaluated and the length distributions of repeat-, matrix-, and spacer-units along the rRNA cistron containing axes are given. The correlation of the matrix unit data with the gel electrophoretic pattern of labelled nuclear RNA from the same oocytes is examined. The mean value of the matrix unit corresponds fairly well to a 2.6 million D peak of pre-rRNA but the distribution of both matrix units and labelled pre-rRNAs shows an asymmetrical heterogeneity indicating the existence of some larger primary transcription products of rDNA. Novel structural aspects are described in the spacer regions which suggest that transcription does also take place in DNP regions between the matrix units. A special "prelude piece" coding for approx. 0.5 million D of RNA is frequently visualized in the spacer segments at the beginning of a matrix unit. Possible artifacts resulting from the preparation, the relative congruence between the data obtained using both methods, and the functional meaning of the findings are discussed against the background of current concepts of structural organization and transcription products of nucleolar DNA.
The number of ribosomal RNA molecules which are transferred through an average nuclear pore complex per minute into the cytoplasm (nuclear pore flow rate, NPFR) during oocyte growth of Xenopus laevis is estimated. The NPFR calculations are based on determinations of the increase of cytoplasmic rRNA content during defined time intervals and of the total number of pore complexes in the respective oogenesis stages. In the mid-la mpbrush stage (500:"700 I'm oocyte diameter) the NPFR is maximal with 2.62 rRNA molecules/ pore/ minute. Then it decreases to zero at the end of oogenesis. The nucleocytoplasmic RNA f10w rates determined are compared with corresponding values of other cell types. The molecular weight of the rRNA precursor transcribed in the extrachromosomal nucleoli of Xenopus lampbrush stage oocytes is determined by acrylamide gel electrophoresis to be 2.5 x 10· daltons. From the temporal increase of cytoplasmic rRNA (3.8 I'g per oocyte in 38 days) and the known number of simultaneously growing precursor molecules in the nucleus the chain growth rate of the 40 S precursor RNA is estimated to be 34 nucleotides per second.
Cycloaddition an Benzvalen
(1973)
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Electron-opaque material is shown in the perinuclear cisternae of various cell types to connect the inner and outer nuclear membrane faces. Similar bridges were observed between the outer nuclear membrane and the outer mitochondrial membrane. The intracisternal bridges of the nuclear envelope appear to be important for the structural stability of the perinuclear cisterna. Stable structural linkage of mitochondria to the outer nuclear membrane might be relevant to the understanding of the characteristic juxtanuclear accumulation of mitochondria and also provide arguments for the discussions of certain biochemical activities found in nuclear and nuclear membrane fractions.
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Via reduction of benzvalene (1) with diirnine tricyclo[3.1.0.02•6]hexane is obtained in good yield. The procedure renders 3, which has already been synthesized by Lemal and Shim, accessible much easier and in larger quantities. IH and 13C n.m.r. spectroscopic data are discussed. Both the thermal and the AgBF4-catalyzed rearrangernent of 3 yield 1,3-cyclohexadiene (8). - The ozonolysis of 1 with subsequent LiAIH4-reduction results in cis-I,3- bis(hydroxyrnethyl)cyclobutane (13a).
Goldstandard in Nuzi
(1974)
Incubation of the colicinogenic Escherichia coli strain JC 411 (ColE1) at elevated temperatures (47-49°) leads to the accumulation of catenated molecules and replicative intermediates of this plasmid. Mature supercoiled OolE1 DNA molecules synthesized under these conditions have an increased number of tertiary turns as shown by electron microscopy. The monomeric tightly supercoiled molecules possess a slightly slower sedimentation rate and a higher binding capacity for ethidium bromide than supercoiJed monomers synthesized at lower temperatures. Recombination deficient mutants of E. coli recA, recB and recC, which carry the ColE1 plasmid, form about the same amount of catenated molecules at the elevated temperature as a rec+ strain. In addition, we have observed by electron microscopy a small percentage (.--.5% of the circular DNA molecules) of minicircular DNA molecules in all preparations of JC 411 (CoIE1). They are homogenous in size, with a molecular weight of 1.4 X 106 daltons. Addition of chloramphenicol to a culture of Proteus mirabilis (ColE1) leads to an increased amount of higher multiple circular oligomers and to a stimulated accumulation of catenated OolE1 DNA molecules of varying sizes. ColE1 DNA synthesis is more thermosensitive than chromosomal DNA replication in P. mirabili8. Plasmid replication stops completely at temperatures above 43°C.
Zum hurritischen Lexikon II
(1974)
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The structural organization of transcriptionally active DNA that contains cistrons for precursor molecules of ribosomal RNA is described in positively stained spread preparations from nuclei and nucleoli isolated from the green alga, Acetabularia mediterranea Lmx. These nuclei contain large aggregates of nucleolar subunits in which fibril-covered regions, the putative active cistrons for precursors of ribosomal RNA, alternate with fibril-free intercepts, the "spacers". The length distribution of the different intercepts of this DNA is given, and the pattern is compared with those shown in animal cell systems. The data are discussed in relation to problems of transcription and of amplification of ribosomal RNA genes.
The ultrastructure of th e growin g and ma turing primary nucleus of Acetabularia medite rranea and Acetabularia major has been studied with the use of various fi xation procedures. Particular interest has been focused on the deta ils of the nuclear periphery and the perinuclear region. It is demonstrated that early in nuclear grow th a characteristic perinucl ear structura l complex is formed which is, among the eukaryotic cells, unique to Acetabularia and re lated genera. This perinuclear system consists essentially of a) the nuclear envelope with a very hi gh pore frequency and various pore complex assoc iat ion s w ith granular and/or threadlike structures some of which are continuous with the nucleolus; b) an approx imate ly 100 nm thick intermediate zone densely filled with a filam entOus material and occasional sma ll membraneous structures from which the typical cytOplasmic and nuclear organe lles and particles are excl ud ed ; c) an adjacent Iacunar labyrinthum which is interrupted by many plasmatic junction channels between the intermed iate zone and the free cytOplasm; d) numerous dense perinuclear bodies in the juxtanuclear cytOplasm which a re especia lly frequent at the junction channels and reveal a composition of aggregated fibrillar and granul ar structures; e) very dense exclusively fibrill ar agg regates which occur either in assoc iation with t he perinuclear region of the lacunar labyrinthum or, somewhat further out, in the cytOplasmic strands between the bra nches of the lacun ar labyrinthum in the form of slender, characteristic rods or "sausages".
The present article had originally been conceived as a review on endomembranes, the plasma membrane, and the major product of membrane-bound activities, the cell wall material. However, limitations of space and the cascading number of pertinent literature articles made it necessary to confine this to one group of membranes and one type of cell wall components. Therefore, we shall begin our survey on the biochemical and cytological aspects of membranes by a review of the class of the pore complex bearing endomembranes, i.e. the nuclear envelope and the annulate lamellae (AL). Next year the membranes of the endoplasmic reticulum and the dictyosomes will be dealt with in conjunction with a discussion of the various intracellular vesicles, the tonoplast and the plasmalemma.
The preparation of Bi2Sea single crystals with low free carrier densities allowed an investigation of the lattice vibrations to be carried out from the reflectivity of cleavage planes at nearly normal incidence of the radiation (E ~ c). The experimental results ean be explained with two classical oscillators, whose eigenfrequencies oceur at 92 and 69.5 cm-I. The static dielectric constant was determined to be 100 ± 10 for E ~ c.
Primary (giant) nuclei of the green algae Acetabularia mediterranea and A. major were studied by light and electron microscopy using in situ fixed material as well as manually isolated nuclear components. In addition, cytochemical reactions of nuclear structures and biochemical determinations of nuclear and cytoplasmic RNA and of genome DNA content were performed. The data obtained and the structures observed are interpreted as demonstralions of transcriptional activities of different gene classes. The most prominent class is the nucleolar cistrons of precursors of ribosomal RNA which occur highly repeated in clusters in the form of regularly alternating intercepts on deoxyribonucleoprotein axes of transcribed rDNA, the fibril-covered matrix units, and the fibril-free "spacer" segments. A description and a classification of the various structural complexes which seem to represent transcriptional activities is given. Quantitative evaluations of these arrangements are presented. The morphology and the dimensions of such structures are compared with the RNA molecular weight determinations and with the corresponding data reported from various animal cell systems. It is suggested that the formation of the giant nucleus is correlated with, and probably due to, an enormous amplification of transcriptionally active rDNA and packing of the extrachromosomal copies into the large nucleolar aggregate bodies.
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Ausgehend von einigen Bedenken gegen die Verwendung von Wertungsfragen in der Soziometrie wird ein Verfahren vorgeschlagen, in dem konkretes Interaktionsverhalten (Sprechen und Ärgern) direkt skaliert wird. Der Zusammenhang zwischen direkter Skalierung, Bezugssystemtheorie und phänomenadäquater Verwendung von Skalen wird diskutiert. Jedes Gruppenmitglied (untersucht wurden Schulklassen) stuft seinen Kontakt zu jedem anderen ein. Daraus ergibt sich ein Sozioprofil, dessen Repräsentanz für das Sozialverhalten beispielhaft an Extremgruppen gezeigt wird. Es kann nachgewiesen werden, daß die bis jetzt unterstellte Trennung gemischtgeschlechtlicher Gruppen in zwei eingeschlechtliche Untergruppen ein methodenabhängiges Ergebnis der Wahlverfahren Morenoscher Prägung ist.
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Soluble mitochondrial ATPase (F1) isolated from Neurospora crassa is resolved by dodecylsulfate- gel electrophoresis into five polypeptide bands with apparent molecular weights of 59000, 55000, 36000, 15000 and 12000. At least nine further polypeptides remain associated with ATPase after disintegration of mitochondria with Triton X-100 as shown by the analysis of an immunoprecipitate obtained with antiserum to F 1 A TPase. Two of the associated polypeptides with apparent molecular weights of 19000 and 11000 are translated on mitochondrial ribosomes, as demonstrated by incorporation in vivo of radioactive leueine in the presence of specific inhibitors of mitochondrial (chloramphenicol) and extramitochondrial ( cycloheximide) protein synthesis. The appearance of mitochondrial translation products in the immunoprecipitated A TPase complex is inhibited by' cycloheximide. The same applies for some of the extramitochondrial translation products in the presence of chloramphenicol. This suggests that both types of polypeptides are necessary for the assembly of the A TPase complex.
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Sila-Analogues A 2, B 2 and C 2 of the drug mephenhydramine from the class of benzhydryl ethers were synthesized for the first time by the steps shown in scheme 1, and they and their precursors I-V characterized by their physical {table 1) and chemical properties, and their structures confirmed by NMR, n1ass and infrared spectroscopy (tables 3-5). Their physiological effects were investigated a.nd compared -with those of the parent carbon compounds (section 5).
Frühere Untersuchungen zum Entscheidungsverhalten von Kindern lassen zwei Interpretationen sogenannter lagebedingter Wahlen zu. Entscheidungen von 8- bis 14jährigen Schülern zeigten, daß sich lagebedingte Wahlen als orientiert am Erwartungsmaximum bezeichnen lassen. Die Beziehung zwischen Orientierung am Erwartungsmaximum und den Variablen Alter, Schulzugehörigkeit und Vorerfahrung erwies sich als positiv. Weiterhin konnte die Abhängigkeit der Wahlhäufigkeit des Erwartungsmaximums von der Hervorgehobenheit des Erwartungsmaximums nachgewiesen werden. Die Gültigkeit des objektiven Erwartungsmaximierungsmodells mußte aber wegen verschiedener Befunde eingeschränkt werden.
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Ziel der Untersuchung war, erste Informationen über die Verwendungsfähigkeit einer im amerikanischen Raum entwickelten Auswahlliste zur Messung des Spannungsbogens zu gewinnen. Dazu wurden mit 234 Jugendstrafgefangenen verschiedenen Alters die Verfahren Auswahlliste und Verhaltensprobe zur Erhebung des Spannungsbogens durchgeführt. Außerdem wurden Daten zum hypothetischen Sparverhalten der Vpn erhoben. Durch klassische und probabilistische Itemanalyse ergaben sich verschiedene Skalen aus der Auswahlliste, die alle in keiner Beziehung zum Alter und dem hypothetischen Sparverhalten standen. Verschiedene Nebenbefunde werden im Hinblick auf ihre Konsequenzen für die Verwendungsfähigkeit der Auswahlliste und auf Erklärungsmäglichkeiten diskutiert.
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