Refine
Year of publication
- 2019 (487) (remove)
Document Type
- Journal article (487) (remove)
Language
- English (487) (remove)
Keywords
- apoptosis (8)
- inflammation (7)
- boron (6)
- cancer (5)
- children (5)
- ischemic stroke (5)
- DNA methylation (4)
- cancer therapy (4)
- deep brain stimulation (4)
- infection (4)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (81)
- Medizinische Klinik und Poliklinik II (32)
- Physikalisches Institut (30)
- Neurologische Klinik und Poliklinik (25)
- Institut für Psychologie (23)
- Institut für Anorganische Chemie (19)
- Rudolf-Virchow-Zentrum (19)
- Institut für Geographie und Geologie (18)
- Institut für Hygiene und Mikrobiologie (18)
- Medizinische Klinik und Poliklinik I (18)
Sonstige beteiligte Institutionen
- Department of Hematology and Oncology, Sana Hospital Hof, Hof, Germany (1)
- Department of Laboratory Medicine and Medicine Huddinge, Karolinska Institutet and University Hospital, Stockholm, Sweden (1)
- Department of Medicine A, University Hospital of Münster, Münster, Germany (1)
- IZKF Nachwuchsgruppe Geweberegeneration für muskuloskelettale Erkrankungen (1)
- Interdisciplinary Center for Clinical Research (1)
- Johns Hopkins School of Medicine (1)
- University of Bari Medical School, Bari, Italy (1)
Animals must slow or halt locomotion to integrate sensory inputs or to change direction. In Caenorhabditis elegans, the GABAergic and peptidergic neuron RIS mediates developmentally timed quiescence. Here, we show RIS functions additionally as a locomotion stop neuron. RIS optogenetic stimulation caused acute and persistent inhibition of locomotion and pharyngeal pumping, phenotypes requiring FLP-11 neuropeptides and GABA. RIS photoactivation allows the animal to maintain its body posture by sustaining muscle tone, yet inactivating motor neuron oscillatory activity. During locomotion, RIS axonal Ca2+ signals revealed functional compartmentalization: Activity in the nerve ring process correlated with locomotion stop, while activity in a branch correlated with induced reversals. GABA was required to induce, and FLP-11 neuropeptides were required to sustain locomotion stop. RIS attenuates neuronal activity and inhibits movement, possibly enabling sensory integration and decision making, and exemplifies dual use of one cell across development in a compact nervous system.