Refine
Has Fulltext
- yes (22)
Is part of the Bibliography
- yes (22)
Year of publication
- 2018 (22) (remove)
Document Type
- Journal article (14)
- Doctoral Thesis (8)
Keywords
- psychology (3)
- Fahrerverhalten (2)
- Sozialpsychologie (2)
- Textverstehen (2)
- Verkehrspsychologie (2)
- anxiety (2)
- ADAS (1)
- Affekt (1)
- Automation (1)
- Automatisiertes Fahren (1)
- Autonomes Fahrzeug (1)
- Concealed Information Test (1)
- DNA methylation (1)
- EEG (1)
- Epistemic Competences (1)
- Epistemische Kompetenzen (1)
- Evaluation (1)
- Experiment / Sozialpsychologie (1)
- Fahrerablenkung (1)
- Fahrerassistenzsystem (1)
- Fremdscham (1)
- Fremdschämen (1)
- Förderung (1)
- Gehirn-Computer-Schnittstelle (1)
- Haptische Feedback-Technologie (1)
- Higher Education (1)
- Human behaviour (1)
- Informationsverarbeitung (1)
- Intervention (1)
- Kompetenzen im Hochschulsektor (1)
- Lenkeingriffe (1)
- Locked-in-Syndrom (1)
- Mensch-Maschine-Interaktion (1)
- Mensch-Maschine-Kommunikation (1)
- Motion detection (1)
- Motivation (1)
- Motivationspsychologie (1)
- Notausweichassistenz (1)
- P300 (1)
- Peinlichkeit (1)
- Phonologische Bewusstheit (1)
- Progressive Relaxation (1)
- Propositional processing (1)
- Propositionale Verarbeitung (1)
- Psychologie (1)
- Qualität der Programmimplementierung (1)
- Reaktionszeit (1)
- Regulatorischer Fokus (1)
- Regulatory focus (1)
- Semantic cognition (1)
- Semantische Verarbeitung (1)
- Sensorimotor Rhythms (1)
- Social neuroscience (1)
- Student (1)
- Tastwahrnehmung (1)
- Verhalten (1)
- Verhaltensmodell (1)
- Wirksamkeit (1)
- Wissenschaftliche Literatur (1)
- Zwei-Prozess-Modell (1)
- acrophobia (1)
- adaptive role (1)
- affect (1)
- alcohol (1)
- altruism (1)
- altruistic compensation (1)
- altruistic punishment (1)
- anger (1)
- arousal (1)
- attention bias (1)
- automated driving (1)
- career self-management (1)
- careers (1)
- children (1)
- cognitive balance (1)
- cognitive dissonance (1)
- coherence (1)
- decision making (1)
- desirable difficulties (1)
- driver behavior (1)
- driver behavior model (1)
- driver distraction (1)
- drug regulation (1)
- educational psychology (1)
- emergency steering and evasion assistant (1)
- emotion (1)
- emotion regulation (1)
- epigenetics (1)
- extinction (1)
- eye tracking (1)
- eyetracking (1)
- fear behavior (1)
- group change (1)
- history (1)
- human behaviour (1)
- human learning (1)
- human-automation interaction (1)
- identity integration (1)
- immersion (1)
- implementation fidelity (1)
- implicit motives (1)
- intergroup bias (1)
- learning (1)
- locus coeruleus (1)
- major depression (1)
- mental representation (1)
- monoamine oxidase A (1)
- mood induction (1)
- net testing effect (1)
- networking (1)
- norepinephrine (1)
- null hypothesis testing (1)
- p-value (1)
- phonological awareness (1)
- picture comprehension (1)
- predictor analysis (1)
- prejudice (1)
- presence (1)
- psychologists (1)
- psychometrics (1)
- question format (1)
- reaction time (1)
- recategorization (1)
- retrieval practice (1)
- salivary alpha-amylase (1)
- scientists (1)
- significance testing (1)
- social capital (1)
- social identification (1)
- social interaction (1)
- statistical significance (1)
- supervisors (1)
- tVNS (1)
- testing effect (1)
- text comprehension (1)
- trainer effects (1)
- university teaching (1)
- valence (1)
- virtual reality (1)
- visual complexity (1)
- visuomotor coordination (1)
- work behavior (1)
Institute
- Institut für Psychologie (22) (remove)
Sonstige beteiligte Institutionen
- BMBF (1)
- Opel Automobile GmbH (1)
EU-Project number / Contract (GA) number
- 823881 (1)
Epigenetic mechanisms have been proposed to mediate fear extinction in animal models. Here, MAOA methylation was analyzed via direct sequencing of sodium bisulfite-treated DNA extracted from blood cells before and after a 2-week exposure therapy in a sample of n = 28 female patients with acrophobia as well as in n = 28 matched healthy female controls. Clinical response was measured using the Acrophobia Questionnaire and the Attitude Towards Heights Questionnaire. The functional relevance of altered MAOA methylation was investigated by luciferase-based reporter gene assays. MAOA methylation was found to be significantly decreased in patients with acrophobia compared with healthy controls. Furthermore, MAOA methylation levels were shown to significantly increase after treatment and correlate with treatment response as reflected by decreasing Acrophobia Questionnaire/Attitude Towards Heights Questionnaire scores. Functional analyses revealed decreased reporter gene activity in presence of methylated compared with unmethylated pCpGfree_MAOA reporter gene vector constructs. The present proof-of-concept psychotherapy-epigenetic study for the first time suggests functional MAOA methylation changes as a potential epigenetic correlate of treatment response in acrophobia and fosters further investigation into the notion of epigenetic mechanisms underlying fear extinction.