Refine
Has Fulltext
- yes (10)
Is part of the Bibliography
- yes (10)
Document Type
- Journal article (10)
Language
- English (10)
Keywords
- mitotane (2)
- ACTH (1)
- ALT (1)
- ATRX (1)
- Addisons disease (1)
- Adrenocortical Carcinoma (1)
- CRH stimulation test (1)
- CYP2B6 (1)
- CYP2W1 (1)
- Cushing's disease (1)
- Cushing’s syndrome (1)
- Graves disease (1)
- NOP10 (1)
- PPGL (1)
- SNP (1)
- TERT (1)
- adjuvant treatment (1)
- adrenal crisis (1)
- adrenal insufficiency (1)
- adrenal tumours (1)
- adrenocortical cancer (1)
- adrenocortical carcinoma (1)
- adrenocortical carcinoma (ACC) (1)
- adult patients (1)
- biomarker (1)
- circadian therapy (1)
- cortisol (1)
- diagnosis (1)
- ectopic (1)
- endogenous hypercortisolism (1)
- gene (1)
- glucocorticoid replacement regimens (1)
- haplotype (1)
- hashimotos-thyroiditis (1)
- high dose dexamethasone suppression test (1)
- hydrocortisone (1)
- hypopituitary patients (1)
- identical twins (1)
- liver resection (1)
- medicine (1)
- modified-release hydrocortisone (1)
- paraganglioma (1)
- pheochromocytoma (1)
- polyglandular autoimmune syndrome (1)
- polymorphism (1)
- population (1)
- predictive marker (1)
- premature mortality (1)
- prevalence (1)
- prognosis (1)
- prognostic biomarker (1)
- radiotherapy (RT) (1)
- recurrence (1)
- recurrence free survival (1)
- retrospective study (1)
- rheumatoid arthritis (1)
- short term (1)
- subjective health-status (1)
- survival analysis (1)
- susceptibility (1)
- telomeres (1)
- therapeutic management (1)
- timing (1)
Institute
- Medizinische Klinik und Poliklinik I (9)
- Comprehensive Cancer Center Mainfranken (4)
- Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) (2)
- Abteilung für Molekulare Innere Medizin (in der Medizinischen Klinik und Poliklinik II) (1)
- Klinik und Poliklinik für Strahlentherapie (1)
- Urologische Klinik und Poliklinik (1)
Context: Patients with primary adrenal insufficiency (PAI) or congenital adrenal hyperplasia (CAH) are at a high risk of adrenal crisis (AC). Glucocorticoid sensitivity is at least partially genetically determined by polymorphisms of the glucocorticoid receptor (GR).
Objectives: To determine if a number of intercurrent illnesses and AC are associated with the GR gene polymorphism \(Bcl\)I in patients with PAI and CAH.
Design and patients: This prospective, longitudinal study over 37.7 ± 10.1 months included 47 PAI and 25 CAH patients. During the study period, intercurrent illness episodes and AC were documented.
Results: The study period covered 223 patient years in which 21 AC occurred (9.4 AC/100 pat years). There were no significant differences between \(Bcl\)I polymorphisms (CC (n=29), CG (n=34) and GG (n=9)) regarding BMI, hydrocortisone equivalent daily dose and blood pressure. We did not find a difference in the number of intercurrent illnesses/patient year among \(Bcl\)I polymorphisms (CC (1.5±1.4/pat year), CG (1.2±1.2/pat year) and GG (1.6±2.2/pat year)). The occurrence of AC was not significantly different among the homozygous (GG) genotype (32.5 AC/100 pat years), the CC genotype (6.7 AC/100 pat years) and the CG genotype (4.9 AC/100 pat years). Concomitant hypothyroidism was the highest in the GG genotype group (5/9), compared to others (CC (11/29) and CG (11/34)).
Conclusions: Although sample sizes were relatively small and results should be interpreted with caution, this study suggests that the GR gene polymorphism \(Bcl\)I may not be associated with the frequencies of intercurrent illnesses and AC.