Refine
Has Fulltext
- yes (25)
Is part of the Bibliography
- yes (25)
Year of publication
Document Type
- Journal article (25)
Language
- English (25)
Keywords
- magnesium phosphate cement (4)
- phytic acid (4)
- calcium phosphate (3)
- calcium phosphate cement (3)
- angiogenesis (2)
- baghdadite (2)
- bone (2)
- bone cement (2)
- bone replacement material (2)
- Blood-brain barrier (1)
- Breast-tumors (1)
- Brushite (1)
- Escherichia coli (1)
- Gene-expression (1)
- HEMA (1)
- Iron-uptake (1)
- MRI reporter (1)
- Mice (1)
- NLRP3 (1)
- Proteins (1)
- Salmonella-typhimurium (1)
- Sugar-transport (1)
- Therapy (1)
- ZIP (1)
- anisotropic porous structures (1)
- arteriovenous loop (1)
- arthritis (1)
- artificial bones (1)
- axial vascularization (1)
- balloon kyphoplasty (1)
- bending strength (1)
- bioceramic (1)
- biofabrication (1)
- bioinorganic (1)
- bioinspired interface (1)
- biomechanical evaluation (1)
- biomechanics (1)
- biomedical materials (1)
- bone adhesive (1)
- bone and cartilage tissue engineering (1)
- bone critical size defect (1)
- bone graft substitutes (1)
- brushite cement (1)
- calcaneus (1)
- calcium phosphate cements (1)
- calcium-magnesium phosphate cement (1)
- calcium-phosphate (1)
- carbon fiber reinforcement (1)
- cement (1)
- cement pastes (1)
- ceramics (1)
- collagen sponge (1)
- combination of physical vapor deposition and electrochemical etching (1)
- composite material (1)
- compressive strength (1)
- cryostructured scaffolds (1)
- cryostructuring (1)
- cyclic testing (1)
- damage tolerant cement (1)
- defined humanized test system (1)
- degradable implant (1)
- dicalcium phosphate cement (1)
- differentation (1)
- dihydrate cement (1)
- drillability (1)
- drillable bone cement (1)
- dual setting (1)
- dual setting system (1)
- expression (1)
- extrusion-based 3D printing (1)
- fiber reinforcement (1)
- fiber–matrix interaction (1)
- fixation (1)
- fracture (1)
- free radical polymerization (1)
- granules (1)
- growth (1)
- hydraulic reactivity (1)
- hydrogel (1)
- hydroxyapatite (1)
- implantation (1)
- implants (1)
- in vitro (1)
- inflammation (1)
- inflammatory response (1)
- inositol hexaphosphate (1)
- interface control (1)
- iron release (1)
- load to failure testing (1)
- mechanical activation (1)
- mechanical performance (1)
- mechanical properties (1)
- melt electrowriting (1)
- microfibres (1)
- mineralization (1)
- morphology controls (1)
- nanotopographical surfaces (1)
- osteoblasts (1)
- osteoporosis (1)
- phase conversion (1)
- platelets (1)
- polyacrylic acid (1)
- porosity (1)
- prefabricated granules (1)
- proliferation (1)
- radiopacity (1)
- rhBMP–2 (1)
- sanders (1)
- screw (1)
- setting reaction (1)
- signaling (1)
- silk fibroin scaffolds (1)
- synbones (1)
- synergistic reinforcement (1)
- systematic investigations (1)
- thrombin (1)
- thrombosis (1)
- tibial head depression fracture (1)
- unidirectional freezing (1)
- zinc (1)
- α-tricalcium phosphate (1)
Institute
- Abteilung für Funktionswerkstoffe der Medizin und der Zahnheilkunde (21)
- Klinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie (4)
- Klinik und Poliklinik für Unfall-, Hand-, Plastische und Wiederherstellungschirurgie (Chirurgische Klinik II) (4)
- Lehrstuhl für Tissue Engineering und Regenerative Medizin (2)
- Rudolf-Virchow-Zentrum (2)
- Institut für Experimentelle Biomedizin (1)
- Institut für Funktionsmaterialien und Biofabrikation (1)
- Institut für Molekulare Infektionsbiologie (1)
- Institut für diagnostische und interventionelle Radiologie (Institut für Röntgendiagnostik) (1)
- Lehrstuhl für Biochemie (1)
EU-Project number / Contract (GA) number
- 309962 (1)
In the treatment of bone non-unions, an alternative to bone autografts is the use of bone morphogenetic proteins (BMPs), e.g., BMP–2, BMP–7, with powerful osteoinductive and osteogenic properties. In clinical settings, these osteogenic factors are applied using absorbable collagen sponges for local controlled delivery. Major side effects of this strategy are derived from the supraphysiological doses of BMPs needed, which may induce ectopic bone formation, chronic inflammation, and excessive bone resorption. In order to increase the efficiency of the delivered BMPs, we designed cryostructured collagen scaffolds functionalized with hydroxyapatite, mimicking the structure of cortical bone (aligned porosity, anisotropic) or trabecular bone (random distributed porosity, isotropic). We hypothesize that an anisotropic structure would enhance the osteoconductive properties of the scaffolds by increasing the regenerative performance of the provided rhBMP–2. In vitro, both scaffolds presented similar mechanical properties, rhBMP–2 retention and delivery capacity, as well as scaffold degradation time. In vivo, anisotropic scaffolds demonstrated better bone regeneration capabilities in a rat femoral critical-size defect model by increasing the defect bridging. In conclusion, anisotropic cryostructured collagen scaffolds improve bone regeneration by increasing the efficiency of rhBMP–2 mediated bone healing.