Refine
Has Fulltext
- yes (17)
Is part of the Bibliography
- yes (17)
Document Type
- Journal article (17)
Keywords
- schizophrenia (7)
- Schizophrenie (6)
- Leonhard classification (4)
- Psychiatrie (4)
- Leonhard-Klassifikation (3)
- Medizin (3)
- Schizophrenia (3)
- P300 (2)
- Psychopathologie (2)
- psychopathology (2)
- "Familiär-sporadisch"- Konzept (1)
- 1p13.3 (1)
- 1q21 (1)
- 7q11.2 (1)
- Affective psychoses (1)
- Ankyrin (1)
- Association study (1)
- B 37 CAG repeat locus (1)
- Brain mappins (1)
- Brain trauma (1)
- Demyelination (1)
- Demyelinisierung (1)
- Early infant catatonia (1)
- Event-related potentials (1)
- Familial/sporadic concept (1)
- Frühkindliche Katatonie (1)
- Frühkindlicher Hirnschaden (1)
- Gemeindepsychiatrie (1)
- Hirninfarkt (1)
- Hyperintense Marklagerläsionen (1)
- Hyperintense white matter lesions (1)
- Iife threatening catatonic syndrome (1)
- Klinische Psychiatrie (1)
- Kontusion (1)
- Laterality (1)
- Leonhard cIassification (1)
- Leukoaraiose (1)
- Leukoaraiosis (1)
- MRI (1)
- MRT (1)
- Malignant neuroleptic syndrome (1)
- Malignes neuroleptisches Syndrom (1)
- Maternal infections (1)
- Neurologie (1)
- Neuropsychiatrie (1)
- P300 topography (1)
- Perinatal brain damage (1)
- Periventricular hyperintensities (1)
- Periventrikuläre Hyperintensitäten (1)
- Poststroke depression (1)
- Pregnancy (1)
- Psychologie (1)
- Psychopathology (1)
- Schwangerschaft (1)
- Schwangerschaftsinfektion (1)
- Secondary affective disorder (1)
- akut lebensbedrohlich katatones Syndrom (1)
- association (1)
- autism spectrum disorder (1)
- chromosome 12 (1)
- classification (1)
- copy number variants (1)
- cycloid psychoses (1)
- cycloid psychosis (1)
- developmental delay (1)
- disorder (1)
- electroeneephalography (1)
- endogenous psychoses (1)
- environment (1)
- evoked potentials (1)
- famiIiaI ·sporadic concept (1)
- familial-sporadic concept (1)
- family (1)
- follow-up (1)
- gene (1)
- genetic risk factor (1)
- genetics (1)
- glutamate (1)
- glycine (1)
- interstitial duplications (1)
- lethai catatonia (1)
- maternal infection (1)
- microarrays (1)
- microdeletion (1)
- monopolar depressive disorders (1)
- monopolare endogene Depression (1)
- neuroplasticity (1)
- obstetric complications (1)
- organische affektive Störungen (1)
- parental origin (1)
- periodic catatonia (1)
- perniziöse Katatonie (1)
- perspectives (1)
- polymorphisms (1)
- pregnancy (1)
- spectrum disorders (1)
- tryptophan (1)
- validity (1)
- zykloide Psychose (1)
With the introduction of new genetic techniques such as genome-wide array comparative genomic hybridization, studies on the putative genetic etiology of schizophrenia have focused on the detection of copy number variants (CNVs), ie, microdeletions and/or microduplications, that are estimated to be present in up to 3% of patients with schizophrenia. In this study, out of a sample of 100 patients with psychotic disorders, 80 were investigated by array for the presence of CNVs. The assessment of the severity of psychiatric symptoms was performed using standardized instruments and ICD-10 was applied for diagnostic classification. In three patients, a submicroscopic CNV was demonstrated, one with a loss in 1q21.1 and two with a gain in 1p13.3 and 7q11.2, respectively. The association between these or other CNVs and schizophrenia or schizophrenia-like psychoses and their clinical implications still remain equivocal. While the CNV affected genes may enhance the vulnerability for psychiatric disorders via effects on neuronal architecture, these insights have not resulted in major changes in clinical practice as yet. Therefore, genome-wide array analysis should presently be restricted to those patients in whom psychotic symptoms are paired with other signs, particularly dysmorphisms and intellectual impairment.