Refine
Is part of the Bibliography
- yes (407)
Year of publication
Document Type
- Journal article (228)
- Doctoral Thesis (156)
- Book article / Book chapter (14)
- Conference Proceeding (6)
- Review (2)
- Preprint (1)
Keywords
- Toxikologie (121)
- DNA damage (18)
- Oxidativer Stress (16)
- micronuclei (13)
- oxidative stress (13)
- Adenosinrezeptor (12)
- DNS-Schädigung (12)
- genotoxicity (12)
- Fluoreszenz-Resonanz-Energie-Transfer (10)
- GPCR (10)
Author
- Lutz, Werner K. (80)
- Klotz, Karl-Norbert (52)
- Stopper, Helga (40)
- Schlatter, C. (31)
- Lohse, Martin J. (19)
- Lohse, M. J. (18)
- Schwabe, U. (17)
- Mally, Angela (11)
- Schwabe, Ulrich (11)
- Lorenz, Kristina (10)
- Schiffmann, D. (9)
- Shephard, S. E. (9)
- Jesaitis, A. J. (8)
- Sagelsdorff, P. (8)
- Hintzsche, Henning (7)
- Calebiro, Davide (6)
- Othman, Eman M. (6)
- Streckfuss-Bömeke, Katrin (6)
- Vittori, S. (6)
- Zimmermann, U. (6)
- Bankoglu, Ezgi Eyluel (5)
- Cantoreggi, S. (5)
- Cristalli, G. (5)
- Grifantini, M. (5)
- Hupp, Sabrina (5)
- Jaggi, W. (5)
- Jahns, Roland (5)
- Maiellaro, Isabella (5)
- Schupp, Nicole (5)
- Caviezel, M. (4)
- Dandekar, Thomas (4)
- Dekant, Wolfgang (4)
- Däniken, A. von (4)
- Friederich, U. (4)
- Gohla, Antje (4)
- Iliev, Asparouh I. (4)
- Jeanclos, Elisabeth (4)
- Mitchell, Timothy J. (4)
- Rebs, Sabine (4)
- Ergün, Süleyman (3)
- Ertl, Georg (3)
- Förtsch, Christina (3)
- Hadamek, Kerstin (3)
- Heidland, August (3)
- Higuchi, Takahiro (3)
- Hoffmann, Carsten (3)
- Hommers, Leif (3)
- Kayvanpour, Elham (3)
- Kirchner, S. (3)
- Ma, Jiangtao (3)
- Meier, I. (3)
- Nikolaev, Viacheslav O. (3)
- Reimann, Hauke (3)
- Schindelin, Hermann (3)
- Schlatter, J. (3)
- Sedaghat-Hamedani, Farbod (3)
- Sossalla, Samuel (3)
- Viviani, A. (3)
- Wippel, Carolin (3)
- Adaku Chilaka, Cynthia (2)
- Annibale, Paolo (2)
- Arend, L. J. (2)
- Asan, Esther (2)
- Awad, Eman (2)
- Bathe-Peters, Marc (2)
- Bathon, Kerstin (2)
- Boivin-Jahns, Valérie (2)
- Bommakanti, R. K. (2)
- Brand, Susanne (2)
- Bünemann, Moritz (2)
- Büsser, M. T. (2)
- Caspary, W. J. (2)
- Chilaka, Cynthia A. (2)
- Cubero, A. (2)
- Dybkova, Nataliya (2)
- Eckert, I. (2)
- Eisenbrand, Gerhard (2)
- Epe, B. (2)
- Epe, Bernd (2)
- Fassnacht, Martin (2)
- Fathy, Moustafa (2)
- Federico, Stephanie (2)
- Fischer, W. H. (2)
- Frantz, Stefan (2)
- Frey, Norbert (2)
- Grilli, S. (2)
- Haas, Jan (2)
- Hartmann, Nico (2)
- Hasenfuß, Gerd (2)
- Hegi, M. E. (2)
- Hengstler, Jan G. (2)
- Hentschel, Ute (2)
- Huber, K. W. (2)
- Humpf, Hans-Ulrich (2)
- Jahns, Valerie (2)
- Jarzina, Sebastian (2)
- Jauch, A. (2)
- Jonas, René (2)
- Kachler, Sonja (2)
- Keller, Angelika (2)
- Klaunig, James E. (2)
- Klenk, Johann Christoph (2)
- Klotz, K.-N. (2)
- Kodandaraman, Geema (2)
- Körber, C. (2)
- Lüthy, J. (2)
- Maier, P. (2)
- Mandel, Philipp (2)
- Marko, Doris (2)
- Maurer, Jana (2)
- Maurer, K. (2)
- Maurer, Wiebke (2)
- Meder, Benjamin (2)
- Metzler, M. (2)
- Neuenschwander, Martin (2)
- Nordbeck, Peter (2)
- Obidiegwu, Jude E. (2)
- Parodi, S. (2)
- Pott, Lutz (2)
- Queisser, Nina (2)
- Reddington, M. (2)
- Reiser, Pia (2)
- Ronchi, Cristina L. (2)
- Sbiera, Silviu (2)
- Schanbacher, Constanze (2)
- Schihada, Hannes (2)
- Schönfelder, Gilbert (2)
- Segerer, Gabriela (2)
- Seier, Kerstin (2)
- Seyfried, Florian (2)
- Siemsen, D. W. (2)
- Simon, W. (2)
- Soliman, Alexander (2)
- Spalluto, Giampiero (2)
- Spencer, D. L. (2)
- Tawfik-Schlieper, H. (2)
- Ukena, D. (2)
- Vogl, Silvia (2)
- Wakabayashi, Hiroshi (2)
- Weigand, Isabel (2)
- Werner, Rudolf (2)
- Witzinger, Linda (2)
- Zechmeister, Christina (2)
- Zimnol, Anna (2)
- Zink, Christoph (2)
- Zundler, Matthias (2)
- von Kries, Jens Peter (2)
- Abdelmohsen, Usama R. (1)
- Abdelmohsen, Usama Ramadan (1)
- Abou-Elzahab, Mohamed M. (1)
- Abtew, Wosene G. (1)
- Accomazzo, Maria Rosa (1)
- Adam, W. (1)
- Adam, Waldemar (1)
- Adami, Hans-Olov (1)
- Adelhardt, Melanie (1)
- Aeschbach, A. P. (1)
- Agarwal, Shailesh R. (1)
- Ahrweiler, M. (1)
- Akin, Ibrahim (1)
- Al-Husseni, Isehaq (1)
- Al-Shukaili, Ahmed (1)
- AlRemeithi, Fatima A. (1)
- Ali, Badreldin H. (1)
- Ali, Nairveen (1)
- Alldrick, A. J. (1)
- Alpers, G. W. (1)
- Alwahsh, Mohammad (1)
- Amann, Kerstin (1)
- Ambrosio, Manuela (1)
- Amirtham, Damodarasamy D. (1)
- Amr, Ali (1)
- Angeloni, Cristina (1)
- Anton, Selma (1)
- Arend, Lois J. (1)
- Argyriou, Loukas (1)
- Arias-Loza, Paula (1)
- Arimany-Nardi, Cristina (1)
- Arnaudov, Theresa Irina (1)
- Arnold, Charlotte (1)
- Arnold, Charlotte Antonia (1)
- Arolt, V. (1)
- Atanda, Olusegun Oladimeji (1)
- Audet, Martin (1)
- Baba, Hideo A. (1)
- Babak, Maria V. (1)
- Bachmann, M. (1)
- Backs, J. (1)
- Baertsch, A. (1)
- Bahner, Udo (1)
- Balasubramanian, Srikkanth (1)
- Banach, Katrin (1)
- Bankoglu, Ezgi E. (1)
- Barbalace, Maria Cristina (1)
- Barile, Frank A. (1)
- Basali, Timo (1)
- Bauer, Benedikt (1)
- Bauer, Jochen (1)
- Bauer, Wolfgang R. (1)
- Baumann, C. (1)
- Baumann, Klaus (1)
- Bayer, Tanja (1)
- Beaufort, F. (1)
- Beck, Sebastian (1)
- Beegam, Sumyia (1)
- Behr, Björn (1)
- Beland, P. E. (1)
- Bellwon, Patricia (1)
- Bencurova, Elena (1)
- Benz, Roland (1)
- Berisha, Filip (1)
- Berlin, Christopher (1)
- Bermel, Christina Maria (1)
- Bernatík, Ondřej (1)
- Berry, Colin (1)
- Bertelsmann, Dietmar (1)
- Bertherat, Jérôme (1)
- Berthiller, Franz (1)
- Beuschlein, Felix (1)
- Beyersdorf, Niklas (1)
- Bieber, Daniela (1)
- Bieber, Michael (1)
- Biebermann, Heike (1)
- Binder, Lutz (1)
- Bischoff, Carolin (1)
- Bittner, Nataly (1)
- Blaauboer, Bas (1)
- Blankenburg, Robert (1)
- Bley, Thorsten (1)
- Bock, Andreas (1)
- Bocklitz, Thomas (1)
- Boege, Fritz (1)
- Bohl, Alexandra (1)
- Boivin, Valérie (1)
- Bokoch, G. M. (1)
- Bolt, Herrmann M. (1)
- Bommakanti, R. (1)
- Boobis, Alan (1)
- Boon, Andy (1)
- Borgert, Christopher (1)
- Borges, Fernanda (1)
- Borisch, Bettina (1)
- Bornhorst, Julia (1)
- Borozan, Sunčica (1)
- Bossle, Franz (1)
- Bothe, Sebastian (1)
- Boullay, Felix (1)
- Bouvier, Michel (1)
- Brack, Alexander (1)
- Brand, T. (1)
- Brand, Theresa (1)
- Brede, Anja (1)
- Brede, Marc (1)
- Breitenbach, Tim (1)
- Brenner, Marian (1)
- Bridges, James (1)
- Brink, Andreas (1)
- Brocker, E. (1)
- Bryja, Vítězslav (1)
- Brändle, E. (1)
- Brück, Wolfgang (1)
- Buccioni, Michela (1)
- Buchholz, Eric (1)
- Bunkowski, Stephanie (1)
- Burkard, Philipp (1)
- Busnelli, Marta (1)
- Buss, P. (1)
- Bätz, Julia (1)
- Börner, Sebastian (1)
- Bösch, R. (1)
- Böser, S. (1)
- Bücheler, Markus (1)
- Cacciari, Barbara (1)
- Cachorro, Eleder (1)
- Capra, Valérie (1)
- Caspary, W.J. (1)
- Cañizal, Maria Consuelo Alonso (1)
- Chahoud, Ibrahim (1)
- Chakraborty, Trinad (1)
- Chasan, Safak (1)
- Chen, Wen (1)
- Chen, Yu Zong (1)
- Cheng, Cheng (1)
- Cheong, Siew Lee (1)
- Cherpokova, Deya (1)
- Chilaka, Augusta Chinenye (1)
- Chilaka, Cynthia Adaku (1)
- Chini, Bice (1)
- Choh, V. (1)
- Christalli, G. (1)
- Christian, Gentzsch (1)
- Ciancetta, Antonella (1)
- Cirkel, Nanett Christin (1)
- Cirnu, Alexandra (1)
- Clancy, Colleen E. (1)
- Claßen, Alexandra (1)
- Colacci, A. (1)
- Curtaz, Carolin Julia (1)
- Dal Ben, Diego (1)
- Dalmazi, Guido Di (1)
- Dave, Zankruti (1)
- De Boni, U. (1)
- Debus, Jörg (1)
- Decker, Michael (1)
- Deckert, J. (1)
- Deckert, Jürgen (1)
- Degen, Gisela (1)
- Deger, A. (1)
- Deiß, Katharina (1)
- Dekant, Raphael (1)
- Delbanco, Evert H. (1)
- Deuber, R. (1)
- Di Fiore, Stefano (1)
- Diekmann, E. (1)
- Diel, Patrick (1)
- Dierks, Johann (1)
- Dietrich, D. R. (1)
- Dietrich, Daniel (1)
- Dimitrijević-Srećković, Vesna (1)
- Dimitriou, Ioanna Maria (1)
- Djelić, Ninoslav (1)
- Dobrev, D. (1)
- Dobrev, Dobromir (1)
- Domingo, Jose L. (1)
- Domschke, K. (1)
- Dorsch, Sandra (1)
- Dragsted, Lars (1)
- Drakopoulos, Antonios (1)
- Dratz, E. A. (1)
- Dudek, Jan (1)
- Duff, Henry J. (1)
- Dunitz, J. D. (1)
- Duraphe, Prashant (1)
- Dussort, P. (1)
- Dänicke, Sven (1)
- Eberl, Hanna (1)
- Ebersbach, Paul (1)
- Ebert, Franziska (1)
- Ebert, Regina (1)
- Edlund, Karolina (1)
- Edrada-Ebel, RuAngelie (1)
- Ehlermann, Philipp (1)
- Eisenbrand, G. (1)
- El-Armouche, A. (1)
- El-Armouche, Ali (1)
- El-Battrawy, Ibrahim (1)
- Eleuteri, A. (1)
- Elger, B. (1)
- Elkenani, Manar (1)
- Ellinger, Bernhard (1)
- Emami-Nemini, Alexander Darius (1)
- Eman, Maher Othman Sholkamy (1)
- Engel, Karl-Heinz (1)
- Engelhardt, Stefan (1)
- Engelmann, Daria (1)
- Enig, Bent (1)
- Eppli, Nenad (1)
- Erickson, R. W. (1)
- Erkizia, Itziar (1)
- Ertl, G. (1)
- Esers, Stefan (1)
- Fawzy, Michael Atef (1)
- Fazeli, Gholamreza (1)
- Fedorchenko, Oleg (1)
- Fehm, L. (1)
- Fekete, Agnes (1)
- Fernández-Llamazares, Ana Iris (1)
- Fette, Georg (1)
- Filizola, Marta (1)
- Fink, Kristin (1)
- Firneburg, Rebecca (1)
- Fischer, H. (1)
- Fischer, Thomas Horst (1)
- Foertsch, Christina (1)
- Fortsch, Christina (1)
- Franchetti, P. (1)
- Frank, HK (1)
- Frank, Monika (1)
- Frank, Sabrina (1)
- Frankenbach, Tina (1)
- Frantz, S. (1)
- Fratz, Stefanie (1)
- Freier, Erik (1)
- Frey, Anna (1)
- Friedrich, K. (1)
- Frölich, Nadine (1)
- Früh, P. U. (1)
- Fydrich, T. (1)
- Galli, Corrado L. (1)
- Gallion, Jonathan (1)
- Galés, Celine (1)
- Gao, Shiqiang (1)
- Garcia, Sergio B. (1)
- Gassenmaier, Tobias (1)
- Gaßner, Birgit (1)
- Geier, Andreas (1)
- Gensler, Daniel (1)
- Gerber, Johanna (1)
- Gerlach, A. (1)
- Gerstberger, R. (1)
- Gerull, Brenda (1)
- Gessler, Manfred (1)
- Gimpl, G. (1)
- Glaser, Markus (1)
- Glaser, Nina (1)
- Gloster, A. T. (1)
- Gläser, Katharina (1)
- Gmach, Philipp (1)
- Gmeiner, Peter (1)
- Godbole, Amod (1)
- Gonzales-Calero, G. (1)
- Gonzalez-Calero, G. (1)
- Gori, Gio Batta (1)
- Graf, U. (1)
- Graiff, Claudia (1)
- Granier, Sébastien (1)
- Gregor, Caroline (1)
- Greil, W. (1)
- Greim, Helmut (1)
- Gripentrog, J. (1)
- Gross, E. (1)
- Gross, Eva (1)
- Grotmeyer, Alexander (1)
- Grune, Tilman (1)
- Grunicke, H. (1)
- Gruse, Tamara (1)
- Guan, Chonglin (1)
- Gunz, D. (1)
- Guo, Shuxia (1)
- Gupta, R. C. (1)
- Guth, Sabine (1)
- Gybeľ, Tomáš (1)
- Gärttner, Carola (1)
- Gömöryová, Kristína (1)
- Günther, Helmut (1)
- Haake, Monika (1)
- Hadi, Naji Said Aboud (1)
- Hamm, A. O. (1)
- Hankir, Mohammed (1)
- Hanlon, Paul (1)
- Hannawacker, Annette (1)
- Hansen, Jens (1)
- Hanáková, Kateřina (1)
- Haraldsdóttir, Jóhanna (1)
- Harnoš, Jakub (1)
- Harttig, U. (1)
- Harvey, Robert D. (1)
- Havemann, K. (1)
- Hayakawa, Nobuyuki (1)
- Hegi, M.E. (1)
- Heijman, Jordi (1)
- Heindel, Jerrold J. (1)
- Heinlein, U-Ju (1)
- Heinz, Volker (1)
- Helbig-Lang, S. (1)
- Henle, Thomas (1)
- Hergenröder, Roland (1)
- Hering, Ilona (1)
- Hermanns, Heike M. (1)
- Herr, Deron Raymond (1)
- Herrmann, Martin J. (1)
- Herrmann, Sebastian (1)
- Herterich, Sabine (1)
- Heslop-Harrison, Pat (1)
- Heterich, Sabine (1)
- Heusch, G. (1)
- Hietel, B. (1)
- Hill, Michael J. (1)
- Hoffmann, Axel (1)
- Hoffmann, Dana (1)
- Hoffmann, Linda S (1)
- Hofmann, Ulrich (1)
- Holler, Cornelia (1)
- Holler, E. (1)
- Hollmann, Robert (1)
- Holm, Lars Erik (1)
- Hommers, L. G. (1)
- Honda, Hiroshi (1)
- Hoppe, Stefanie (1)
- Horn, Daniela (1)
- Howari, Fares M. (1)
- Hrelia, Silvana (1)
- Hu, Kai (1)
- Humrich, Jan (1)
- Häring, Martin (1)
- Hübner, Harald (1)
- Hümmert, Martin W. (1)
- Hünig, Thomas (1)
- Hüser, Jörg (1)
- Hüser, Stephanie (1)
- Ilin, Alexander (1)
- Iqbal, Jibran (1)
- Jahn, Daniel (1)
- Jakob, Franz (1)
- Jakobs, K. H. (1)
- Janevski, J. (1)
- Janz, Anna (1)
- Jarzina, Sebastian Oskar (1)
- Jastrow, Christian (1)
- Javadi, Mehrbod S. (1)
- Jobin, Marie-Lise (1)
- Jochmann, Svenja (1)
- Jones, H. (1)
- Joos, J. P. (1)
- Joost, Hans-Georg (1)
- Jurásek, Miroslav (1)
- Jäckh, R. (1)
- Jäger, Henry (1)
- Kacew, Sam (1)
- Kaestner, Alexandra (1)
- Kaestner, Alexandra Annika Nadine (1)
- Kahlert, Katrin (1)
- Kampfinger, Katja (1)
- Kampik, Daniel (1)
- Kannen Cardoso, Vinicius (1)
- Kannen, Vinicius (1)
- Kauk, Michael (1)
- Keil, R. (1)
- Keil, Roger (1)
- Keim, Yvonne (1)
- Keller, Thorsten (1)
- Kellert, Marco (1)
- Kelm, S. (1)
- Kerkau, Thomas (1)
- Kestler, Christian (1)
- Kieffer, Brigitte L. (1)
- Kimmel, Marek (1)
- Kipp, Anna P. (1)
- Kircher, Malte Tim (1)
- Kircher, T. (1)
- Kistner, Katrin (1)
- Kitte, Robert J. (1)
- Kittel, Robert J (1)
- Klaffke, Horst (1)
- Klapproth, Erik (1)
- Klehr, Johann (1)
- Kleihues, P. (1)
- Kleinbongard, P. (1)
- Kleine-Ostmann, Thomas (1)
- Kleinschnitz, Christoph (1)
- Klenk, Christoph (1)
- Klopocki, Eva (1)
- Klotz, Barbara (1)
- Knaus, Anne Elizabeth (1)
- Knierim, Maria (1)
- Knobloch, Gunnar (1)
- Knudsen, Ib (1)
- Koch, E. (1)
- Koch, R. (1)
- Kocoski, Vladimir (1)
- Koentgen, Frank (1)
- Koepsell, Hermann (1)
- Kohlhaas, Michael (1)
- Konrad, Charlotte (1)
- Kopp, Eva Katharina (1)
- Koschel, K. (1)
- Koszegi, Zsombor (1)
- Koussémou, Yéwa Bony Marthe (1)
- Kramer, M. (1)
- Kramer, Nynke I. (1)
- Kramer, Sofia (1)
- Krause, Tobias (1)
- Kravec, Marek (1)
- Kreutzmann, Moritz Paul (1)
- Kreye, V. A. W. (1)
- Kroiss, Matthias (1)
- Krotec, K. L. (1)
- Krude, Heiko (1)
- Krämer, H. (1)
- Kuenzel, Stephan R. (1)
- Kugler-Steigmeier, M. E. (1)
- Kuhn, Michaela (1)
- Kulling, Sabine E. (1)
- Kulmanov, Murat (1)
- Kumar, Jitender (1)
- Kämmerer, Susanne (1)
- Kämpf, Anne Kristina (1)
- Kärst, Uwe (1)
- Kühnel, A. (1)
- Kühnen, Peter (1)
- Lambertucci, Catia (1)
- Lampen, Alfonso (1)
- Lamprecht, Anna‐Karina (1)
- Lang, Isabell (1)
- Lang, K. (1)
- Lang, R. E. (1)
- Lang, T. (1)
- Langenhan, Tobias (1)
- Langer, Michael (1)
- Langhauser, Friederike (1)
- Lanoiselée, Yann (1)
- Lapa, Constantin (1)
- Larsen, Jens-Jorgen (1)
- Lauer, Martin (1)
- Lbik, Dawid (1)
- Le Gouill, Christian (1)
- LeVier, David G. (1)
- Lehr, H.-A. (1)
- Leitz, Michael R. (1)
- Lenz, Kerstin (1)
- Leskien, Miriam (1)
- Leyh, Annekathrin (1)
- Liao, Zhenxing (1)
- Lichtarge, Olivier (1)
- Liedtke, Daniel (1)
- Lim, Clarissa (1)
- Linden, Christian (1)
- Lindenborn Fotinos, J. (1)
- Lindenborn-Fotinos, J. (1)
- Link, Samuel (1)
- Liu, Dan (1)
- Lohse, Christian (1)
- Loo, Jason Siau Ee (1)
- Lorenz, K. (1)
- Lorenz, Nicole (1)
- Lorenzen, A. (1)
- Lossow, Kristina (1)
- Lotz, Arietta Lucia (1)
- Ludeke, B. I. (1)
- Lueken, U. (1)
- Lupp, Maria (1)
- Lutz, Roman W. (1)
- Lutz, WK (1)
- Lyga, Sandra (1)
- Lyons, Jessica B. (1)
- Maack, Christoph (1)
- Maier, Elke (1)
- Maimari, Theopisti (1)
- Makiol, Christian (1)
- Mambretti, Egle M. (1)
- Mangerich, Aswin (1)
- Marchan, Rosemarie (1)
- Marino, Kristen (1)
- Marinovich, M. (1)
- Marquardt, Hans (1)
- Martin, Maximilian (1)
- Martinez-Picado, Javier (1)
- Marucci, Gabriella (1)
- Marx, Almuth (1)
- Masi, Alessio (1)
- Mason, Fleur E. (1)
- Massotte, Dominique (1)
- Matos, Maria João (1)
- Maurel, Damien (1)
- Mauss, U. (1)
- Mayer, Stefanie (1)
- Mazzullo, M. (1)
- Meier, Friedegund (1)
- Meier-Bratschi, A. (1)
- Melichar, Volker O. (1)
- Mentrup, Birgit (1)
- Meral, Derya (1)
- Merkl, Martin (1)
- Merkle, Sabine (1)
- Merz, Cornelia (1)
- Messerer, Regina (1)
- Messmer, K. (1)
- Michel, Martin C. (1)
- Miller, Duncan C. (1)
- Minini, U. (1)
- Minuesa, Gerard (1)
- Mirilović, Milorad (1)
- Mohamed, Belal A. (1)
- Molling, K. (1)
- Montag [geb. Kukielka], Gracia Anna (1)
- Montag, Gracia (1)
- Moro, Sabrina (1)
- Moro, Stefano (1)
- Mueller, Martin J. (1)
- Möller, Jan (1)
- Möllmann, Dorothe (1)
- Mühle, Eva (1)
- Müller, E. (1)
- Müller, G. (1)
- Müller, Justus (1)
- Müller, Marion (1)
- Müller, Markus (1)
- Müller, Stephanie (1)
- Müntze, Jonas (1)
- Nagel, Georg (1)
- Naseem, Muhammad (1)
- Naseem, Muhammed (1)
- Nattel, S. (1)
- Nau, Roland (1)
- Nedvetsky, Pavel I. (1)
- Neil, G. A. (1)
- Nemec, Katarina (1)
- Nemmar, Abderrahim (1)
- Nerlich, Kai (1)
- Nersesyan, Armen (1)
- Nickel, Alexander (1)
- Nickel, Florian (1)
- Nieberler, Matthias (1)
- Nieswandt, Bernhard (1)
- Nikaido, Toshio (1)
- Nikolaev, Viacheslav (1)
- Nikolaev, Viacheslov O. (1)
- Nitsche, Michael A. (1)
- Nolte, D. (1)
- Nose, Naoko (1)
- Nwogha, Jeremiah S. (1)
- Nöthlings, Ute (1)
- O'Hagan, Sue (1)
- Obidiegwu, Jude Ejikeme (1)
- Oder, Daniel (1)
- Odersky, Andrea (1)
- Oelschlaeger, Tobias A. (1)
- Ohgaki, H. (1)
- Olson, Barbara A. (1)
- Olsson, R. A. (1)
- Ong, Wei-Yi (1)
- Oselebe, Happiness O. (1)
- Osler, Merete (1)
- Ott, I. (1)
- Ott, Ilka (1)
- Overvad, Kim (1)
- Padmanabhan, Vasantha (1)
- Paisdzior, Sarah (1)
- Pajović, Nevena (1)
- Palm, Dieter (1)
- Pané-Farré, C. A. (1)
- Papp, T. (1)
- Pastor-Anglada, Marçal (1)
- Pastorin, Giorgia (1)
- Pauli, P. (1)
- Paumgartten, Francisco J. R. (1)
- Pawlak, Matthias (1)
- Pechan, R. (1)
- Pelkonen, Olavi (1)
- Perenna, Alessandro (1)
- Perpiñá Viciano, Cristina (1)
- Pfleiderer, B. (1)
- Philipp, Melanie (1)
- Picard, Louis-Philippe (1)
- Plotzke, Kathy (1)
- Podschun, B. (1)
- Poetzsch, J. (1)
- Polak, Thomas (1)
- Pollinger, Thomas (1)
- Poot, M. (1)
- Prada-Gracia, Diego (1)
- Propping, Stefan (1)
- Provasi, Davide (1)
- Prömel, Simone (1)
- Pyerin, W. (1)
- Raab, A. (1)
- Raab, Annette (1)
- Rabes, H. M. (1)
- Rached, Eva Katharina (1)
- Radaszkiewicz, Tomasz Witold (1)
- Ramaiah, Danaboyina (1)
- Ramge, Vanessa Magali (1)
- Ramm, Susanne (1)
- Rapp, R. (1)
- Rauchschwalbe, Sonja (1)
- Raveendran, Muthurajan (1)
- Ravens, Ursula (1)
- Redenti, Sara (1)
- Reeh, Peter W. (1)
- Regensburger, Martina (1)
- Reif, A. (1)
- Reinders, Yvonne (1)
- Restorff, B. von (1)
- Rethwilm, Axel (1)
- Rice, Monica (1)
- Richter, C. (1)
- Richter, J. (1)
- Richter, Kurt (1)
- Riese, Thorsten (1)
- Rietjens, Ivonne M. C. M. (1)
- Rittner, Heike L. (1)
- Ritzel, G. (1)
- Rizk-Rabin, Marthe (1)
- Roman, Adriana (1)
- Romanos, M. (1)
- Rosner, Marsha Rich (1)
- Roth, Angelika (1)
- Rothemund, Sven (1)
- Rother, Tobias (1)
- Rovati, G. Enrico (1)
- Rubin, Beatrice (1)
- Ruzicka, T. (1)
- Ruzicka, Thomas (1)
- Rychlik, Michael (1)
- Ryneš, Jan (1)
- Röhrdanz, Elke (1)
- Rübeling, Karsten (1)
- Saadatmand, A. R. (1)
- Sabroe, Svend (1)
- Sadek, Mirna S. (1)
- Saha-Möller, C. R. (1)
- Saha-Möller, Chantu R. (1)
- Salinger, Tim (1)
- Salzer, Manfred J. (1)
- Sanner, Tore (1)
- Sauer, Markus (1)
- Sauter, M. (1)
- Savolainen, Kai (1)
- Saxena, Ambrish (1)
- Schad, Lothar R. (1)
- Schambony, Alexandra (1)
- Scheerer, Patrick (1)
- Schenzle, D. (1)
- Schewe, Victoria Kristina (1)
- Schickinger, Stefanie (1)
- Schiele, M. A. (1)
- Schierling, Simone (1)
- Schirren, C. G. (1)
- Schirrmacher, V. (1)
- Schlatter, Josef (1)
- Schlegel, Nicolas (1)
- Schlipp [verh.: Wölfel], Angela (1)
- Schlipp, Angela (1)
- Schlosser, Andreas (1)
- Schlötzer, Jan (1)
- Schmid, Evelyn (1)
- Schmid, Ursula (1)
- Schmidt, Doris (1)
- Schmidt, Harald H H W (1)
- Schmidt, Peter M (1)
- Schmidt, Tobias (1)
- Schmitt, Dominik (1)
- Schmitt, Johannes (1)
- Schmitz, Werner (1)
- Schmähl, D. (1)
- Schnabel, C. (1)
- Schneidereit, Jutta (1)
- Schnelle, Moritz (1)
- Schober, Tilmann (1)
- Scholz, Gabriele (1)
- Scholz, Nicole (1)
- Schott, Lea Marie (1)
- Schrader, Thorsten (1)
- Schreiber, R. E. (1)
- Schuele, Carolin (1)
- Schuler, Irina (1)
- Schuster, Paul Xaver (1)
- Schwab, M. (1)
- Schwerdtle, Tanja (1)
- Schwinn, Andreas (1)
- Schäfer, Florian (1)
- Schönberger, A. (1)
- Schönegge, Anne-Marie (1)
- Schöpe, Paul Curtis (1)
- Schütz, Claudia (1)
- Scialli, Anthony R. (1)
- Seidel, Albrecht (1)
- Seifried, Annegrit (1)
- Semmel, Britta Birgit (1)
- Sengstag, C. (1)
- Sevastiadis, Emmanouil (1)
- Shah, Ajay M. (1)
- Sickmann, Albert (1)
- Sieber, Maximilian (1)
- Silva Jr., Wilson A. (1)
- Simek, H. (1)
- Simon, Karoline (1)
- Singer, Cherie A. (1)
- Sorensen, Thorkild I. A. (1)
- Sotriffer, Christoph (1)
- Sounier, Rémy (1)
- Spiegel, Silvana (1)
- Spielman, William S. (1)
- Spielmann, W. S. (1)
- Spielmann, W.-S. (1)
- Spinaci, Andrea (1)
- Stadler, Richard (1)
- Stallaert, Wayne (1)
- Stanimirović, Zoran (1)
- Stasch, Johannes-Peter (1)
- Steber, R. (1)
- Steger, H. (1)
- Steinbronn, Nadine (1)
- Steinmetz, Lars M. (1)
- Stipp, Franzisca (1)
- Stolz, W. (1)
- Stransky, M. (1)
- Strasser, Ruth (1)
- Straube, B. (1)
- Strube, Michael (1)
- Ströhle, A. (1)
- Stumpf, Anette D. (1)
- Sturlese, Mattia (1)
- Störk, Stefan (1)
- Sumski, Anna Magdalena (1)
- Surjanto, Jessica (1)
- Swenberg, James (1)
- Sättele, Mathias (1)
- Taleh, Scharoch (1)
- Tan, Aaron (1)
- Taningher, M. (1)
- Tas, P. (1)
- Taverne, Femke J. (1)
- Tawfik-Schlieper, Hoda (1)
- Tayebati, Seyed Khosrow (1)
- Teeguarden, Justin (1)
- Teichert, Christina (1)
- Telugu, Narasimha (1)
- Testai, Emanuela (1)
- Thorling, Eivind B. (1)
- Tiedge, Oliver (1)
- Toischer, Karl (1)
- Tolley, J. O. (1)
- Tolstik, Elen (1)
- Tomancak, P. (1)
- Trantírek, Lukáš (1)
- Treutlein, Anna-Teresa (1)
- Triebel, Sven (1)
- Tripsianes, Konstantinos (1)
- Trösken, Eva-Regina (1)
- Tsatsakis, Aristides (1)
- Tschopp, Oliver (1)
- Ubaldi, Massimo (1)
- Ulrich, D. (1)
- Uriarte, Eugenio (1)
- Urlaub, Daniela (1)
- Vandenabeele, Sylvie (1)
- Vandenberg, Laura N. (1)
- Vanselow, Jens T. (1)
- Vazquez-Rodriguez, Saleta (1)
- Velic, I. (1)
- Venkatesan, Gopalakrishnan (1)
- Vermeulen, Nico P. (1)
- Vidal, Marie (1)
- Vieths, Stefan (1)
- Vietinghoff, Sibylle von (1)
- Vig, B. K. (1)
- Viktorinová, I. (1)
- Vilar, Santiago (1)
- Villmann, Carmen (1)
- Viviant, A. (1)
- Vlachakis, Dimitrios (1)
- Vogel, Rudi F. (1)
- Vogt, H. (1)
- Vogt-Moykopf, Ingolf (1)
- Volpini, R. (1)
- Volpini, Rosaria (1)
- Vukicevic, Vladimir (1)
- Vutuc, C. (1)
- Vácha, Robert (1)
- Waaga-Gasser, Anna Maria (1)
- Wagner, Michael (1)
- Wagner, Nicole (1)
- Wagner, Silvia (1)
- Wahrendorf, J. (1)
- Wajant, Harald (1)
- Walter, Christof (1)
- Walz, Katharina (1)
- Wandt, Viktoria K. (1)
- Wascher, Edmund (1)
- Waschke, Jens (1)
- Wassermann, Veronika (1)
- Watzl, Carsten (1)
- Weber, C. (1)
- Weber, H. (1)
- Weber, S. (1)
- Weber, U. (1)
- Wecker, E. (1)
- Weidemann, Frank (1)
- Werthmann, Ruth (1)
- Wild, D. (1)
- Wild, Vanessa (1)
- Wilde, Sabrina (1)
- Wilken, Anke (1)
- Wilkins, Angela D. (1)
- Winkelbeiner, Nicola (1)
- Winkler, F. K. (1)
- Winkler, Jana (1)
- Winkler, Michaela (1)
- Wipf, H. K. (1)
- Wirth, Manfred P. (1)
- Wittchen, H.-U. (1)
- Wittmann, A. (1)
- Wolf, C. (1)
- Wu, Jiaqing (1)
- Wu, Jingyan (1)
- Wölfel, Angela (1)
- Wörsdörfer, Philipp (1)
- Wück, Daniela Maria (1)
- Xu, Qiang (1)
- Yang, Pei-Chi (1)
- Yang, Y. (1)
- Yesilyurt-Gerhards, Dilan (1)
- Yoo, H. J. (1)
- Yuan-Chen, Natalia (1)
- Zabel, Ulrike (1)
- Zanette, Dalila L. (1)
- Zbinden, G. (1)
- Zdráhal, Zbynêk (1)
- Zeck, Sabine (1)
- Zhong, Rujia (1)
- Zhou, Xiaobo (1)
- Zhu, Chenchen (1)
- Ziebuhr, Wilma (1)
- Zimmer, F. J. (1)
- Zimmer, F.-J. (1)
- Zimmer, Franz-Josef (1)
- Zink [geb. Sondergeld], Thomas Gerd (1)
- Zitron, Edgar (1)
- Zweifel, U. (1)
- Zürn, Alexander (1)
- ter Meulen, Volker (1)
- van Calker, D. (1)
- van Thriel, Christoph (1)
- von Hayn, Kathrin (1)
- İşbilir, Ali (1)
Institute
- Institut für Pharmakologie und Toxikologie (407) (remove)
Sonstige beteiligte Institutionen
- Institut für Biopsychologie, Universität Dresden (1)
- Johns Hopkins School of Medicine (1)
- Johns Hopkins School of Medicine, Baltimore, MD, U.S. (1)
- Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V. (1)
- Max Delbrück Center for Molecular Medicine (1)
- Max-Delbrück-Center für molekulare Medizin, Berlin (1)
- Pharmakologie, Universität Bonn (1)
- Pharmazie, Universität Mailand (1)
- Universitätsklinikum Düsseldorf, Institut für Toxikologie (1)
Pyrrolizidine alkaloids (PAs) are secondary plant metabolites, which can be found as contaminant in various foods and herbal products. Several PAs can cause hepatotoxicity and liver cancer via damaging hepatic sinusoidal endothelial cells (HSECs) after hepatic metabolization. HSECs themselves do not express the required metabolic enzymes for activation of PAs. Here we applied a co-culture model to mimic the in vivo hepatic environment and to study PA-induced effects on not metabolically active neighbour cells. In this co-culture model, bioactivation of PA was enabled by metabolically capable human hepatoma cells HepG2, which excrete the toxic and mutagenic pyrrole metabolites. The human cervical epithelial HeLa cells tagged with H2B-GFP were utilized as non-metabolically active neighbours because they can be identified easily based on their green fluorescence in the co-culture. The PAs europine, riddelliine and lasiocarpine induced micronuclei in HepG2 cells, and in HeLa H2B-GFP cells co-cultured with HepG2 cells, but not in HeLa H2B-GFP cells cultured alone. Metabolic inhibition of cytochrome P450 enzymes with ketoconazole abrogated micronucleus formation. The efflux transporter inhibitors verapamil and benzbromarone reduced micronucleus formation in the co-culture model. Furthermore, mitotic disturbances as an additional genotoxic mechanism of action were observed in HepG2 cells and in HeLa H2B-GFP cells co-cultured with HepG2 cells, but not in HeLa H2B-GFP cells cultured alone. Overall, we were able to show that PAs were activated by HepG2 cells and the metabolites induced genomic damage in co-cultured HeLa cells.