Filtern
Volltext vorhanden
- ja (18)
Gehört zur Bibliographie
- ja (18)
Dokumenttyp
Sprache
- Englisch (18)
Schlagworte
- breast cancer (4)
- CD39 (2)
- CD73 (2)
- Parkinson’s disease (2)
- T cells (2)
- adenosine (2)
- expression (2)
- immune escape (2)
- immune response (2)
- neurodegeneration (2)
- ovarian cancer (2)
- trastuzumab (2)
- ADCC (1)
- B7-H1 (1)
- Coronavirus Disease 2019 (1)
- HER2 conversion (1)
- HER2 targeted therapy (1)
- HER2-low (1)
- HLA-G gene (1)
- Hautkrebs (1)
- Krebs <Medizin> (1)
- PC-1 blockade (1)
- PD-1 (1)
- PD-L1 (1)
- Severe Acute Respiratory Syndrome Coronavirus 2 (1)
- T lymphocytes (1)
- acute respiratory distress syndrome (1)
- animal models (1)
- bioinformatics (1)
- biomarker (1)
- bioreactor culture (1)
- blastocysts (1)
- brain development (1)
- brain metastases (1)
- cancer microenvironment (1)
- cancer stem cell immunology (1)
- cancer stem cells (1)
- cell lung cancer (1)
- chlamydia trachomatis (1)
- combinatorial drug predictions (1)
- cytokines (1)
- disease (1)
- diseases of the nervous system (1)
- gene (1)
- growth differentiation factor 15 (1)
- histopathology (1)
- immunoresistance (1)
- immunosurveillance (1)
- immunotherapies (1)
- immunotherapy (1)
- in vitro (1)
- inflammation (1)
- inflammatory cascades (1)
- invasiveness (1)
- latency (1)
- lines (1)
- lung-cancer (1)
- mammography (1)
- melanoma (1)
- mhc molecules (1)
- miRNA (1)
- microarray (1)
- microglia (1)
- microna profiles (1)
- modular tumor tissue models (1)
- multiple sclerosis (1)
- nervous system (1)
- neuroimmunology (1)
- neuroinflammation (1)
- neurological disorders (1)
- peripheral blood (1)
- pertuzumab (1)
- safety (1)
- serum (1)
- signature (1)
- stem/progenitor cells (1)
- survival (1)
- trastuzumab deruxtecan (1)
- tumor (1)
- tumor associated macrophages (1)
- tumor dormancy (1)
- tumor immune escape (1)
- tumor immunology (1)
- tumor immunosurveillance (1)
- tumor size (1)
- tumor stem cells (1)
- tumor-infiltrating lymphocytes (1)
- tumor-propagating cells (1)
- tumour immunology (1)
- ultrasound (1)
- viral load (1)
- α-synuclein-specific T cells (1)
Institut
- Frauenklinik und Poliklinik (14)
- Institut für Virologie und Immunbiologie (4)
- Kinderklinik und Poliklinik (3)
- Klinik und Poliklinik für Anästhesiologie (ab 2004) (3)
- Neurologische Klinik und Poliklinik (3)
- Theodor-Boveri-Institut für Biowissenschaften (3)
- Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie (2)
- Medizinische Klinik und Poliklinik II (2)
- Pathologisches Institut (2)
- Institut für Hygiene und Mikrobiologie (1)
Cancer stem cell (CSC) biology and tumor immunology have shaped our understanding of tumorigenesis. However, we still do not fully understand why tumors can be contained but not eliminated by the immune system and whether rare CSCs are required for tumor propagation. Long latency or recurrence periods have been described for most tumors. Conceptually, this requires a subset of malignant cells which is capable of initiating tumors, but is neither eliminated by immune cells nor able to grow straight into overt tumors. These criteria would be fulfilled by CSCs. Stem cells are pluripotent, immune-privileged, and long-living, but depend on specialized niches. Thus, latent tumors may be maintained by a niche-constrained reservoir of long-living CSCs that are exempt from immunosurveillance while niche-independent and more immunogenic daughter cells are constantly eliminated. The small subpopulation of CSCs is often held responsible for tumor initiation, metastasis, and recurrence. Experimentally, this hypothesis was supported by the observation that only this subset can propagate tumors in non-obese diabetic/scid mice, which lack T and B cells. Yet, the concept was challenged when an unexpectedly large proportion of melanoma cells were found to be capable of seeding complex tumors in mice which further lack NK cells. Moreover, the link between stem cell-like properties and tumorigenicity was not sustained in these highly immunodeficient animals. In humans, however, tumor-propagating cells must also escape from immune-mediated destruction. The ability to persist and to initiate neoplastic growth in the presence of immunosurveillance - which would be lost in a maximally immunodeficient animal model - could hence be a decisive criterion for CSCs. Consequently, integrating scientific insight from stem cell biology and tumor immunology to build a new concept of "CSC immunology" may help to reconcile the outlined contradictions and to improve our understanding of tumorigenesis.