Refine
Has Fulltext
- yes (73)
Is part of the Bibliography
- yes (73)
Year of publication
Document Type
- Journal article (66)
- Preprint (4)
- Conference Proceeding (3)
Language
- English (73)
Keywords
- PET (17)
- prostate cancer (13)
- theranostics (13)
- PET/CT (10)
- Positronen-Emissions-Tomografie (10)
- positron emission tomography (10)
- CXCR4 (9)
- PSMA (9)
- molecular imaging (8)
- neuroendocrine tumor (8)
Institute
- Klinik und Poliklinik für Nuklearmedizin (70)
- Medizinische Klinik und Poliklinik II (16)
- Institut für diagnostische und interventionelle Radiologie (Institut für Röntgendiagnostik) (10)
- Urologische Klinik und Poliklinik (10)
- Medizinische Klinik und Poliklinik I (8)
- Pathologisches Institut (7)
- Deutsches Zentrum für Herzinsuffizienz (DZHI) (4)
- Comprehensive Cancer Center Mainfranken (3)
- Klinik und Poliklinik für Strahlentherapie (3)
- Neurochirurgische Klinik und Poliklinik (3)
Sonstige beteiligte Institutionen
C-X-C motif chemokine receptor 4 (CXCR4) and somatostatin receptors (SSTR) are overexpressed in gastro-entero-pancreatic neuroendocrine tumors (GEP-NET). In this study, we aimed to elucidate the feasibility of non-invasive CXCR4 positron emission tomography/computed tomography (PET/CT) imaging in GEP-NET patients using [\(^{68}\)Ga]Pentixafor in comparison to \(^{68}\)Ga-DOTA-D-Phe-Tyr3-octreotide ([\(^{68}\)Ga]DOTATOC) and \(^{18}\)F-fluorodeoxyglucose ([\(^{18}\)F]FDG). Twelve patients with histologically proven GEP-NET (3xG1, 4xG2, 5xG3) underwent [\(^{68}\)Ga]DOTATOC, [\(^{18}\)F]FDG, and [\(^{68}\)Ga]Pentixafor PET/CT for staging and planning of the therapeutic management. Scans were analyzed on a patient as well as on a lesion basis and compared to immunohistochemical staining patterns of CXCR4 and somatostatin receptors SSTR2a and SSTR5. [\(^{68}\)Ga]Pentixafor visualized tumor lesions in 6/12 subjects, whereas [\(^{18}\)F]FDG revealed sites of disease in 10/12 and [\(^{68}\)Ga]DOTATOC in 11/12 patients, respectively. Regarding sensitivity, SSTR-directed PET was the superior imaging modality in all G1 and G2 NET. CXCR4-directed PET was negative in all G1 NET. In contrast, 50% of G2 and 80% of G3 patients exhibited [\(^{68}\)Ga]Pentixafor-positive tumor lesions. Whereas CXCR4 seems to play only a limited role in detecting well-differentiated NET, increasing receptor expression could be non-invasively observed with increasing tumor grade. Thus, [\(^{68}\)Ga]Pentixafor PET/CT might serve as non-invasive read-out for evaluating the possibility of CXCR4-directed endoradiotherapy in advanced dedifferentiated SSTR-negative tumors.