Refine
Has Fulltext
- yes (2)
Is part of the Bibliography
- yes (2)
Document Type
- Journal article (2)
Language
- English (2)
Keywords
- ADHD (1)
- SLC2A3 (1)
- T-cadherin (1)
- cadherin-13 (CDH13) (1)
- dorsal raphe (1)
- induced pluripotent stem cells (1)
- neurodevelopment (1)
- prefrontal cortex (1)
- psychiatric disorders (1)
- radial glia (1)
Institute
- Institut für Anatomie und Zellbiologie (2) (remove)
Fibroblasts were isolated from a skin biopsy of a clinically diagnosed 51-year-old female attention-deficit/hyperactivity disorder (ADHD) patient carrying a duplication of SLC2A3, a gene encoding neuronal glucose transporter-3 (GLUT3). Patient fibroblasts were infected with Sendai virus, a single-stranded RNA virus, to generate transgene-free human induced pluripotent stem cells (iPSCs). SLC2A3-D2-iPSCs showed expression of pluripotency-associated markers, were able to differentiate into cells of the three germ layers in vitro and had a normal female karyotype. This in vitro cellular model can be used to study the role of risk genes in the pathogenesis of ADHD, in a patient-specific manner.