Refine
Has Fulltext
- yes (3)
Is part of the Bibliography
- yes (3)
Document Type
- Journal article (3)
Keywords
- muscarinic antagonists (2)
- (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium chloride/pharmacology (1)
- (Hydroxymethyl)diphenyl(piperidinoalkyl)silanes (1)
- Sila-difenidol (1)
- Sila-pridinol (1)
- acetylcholine (1)
- animals (1)
- antihypertensive agents / pharmacology (1)
- antimuscarinic and papaverine-like activity (1)
- aorta, abdominal / drug effects (1)
Institute
In the course of systematic investigations on sila-substituted parasympatholytics the diphenyl(2-aminoethoxymethyl)silanols 3b and 4b (and its carbon analogue 4a) were synthesized and characterized by their physical and chemical properties. In the solid state 4a and 4b form strong O-H---N hydrogen bonds, which are intramolecular (4a) and intermolecular (4b), respectively. 4a and 4b were found to be weak antimuscarinic agents (4b >4a) and strong papaverine-like spasmolytics (4a ≈4b).