Refine
Has Fulltext
- yes (132)
Is part of the Bibliography
- yes (132)
Year of publication
Document Type
- Journal article (118)
- Conference Proceeding (9)
- Book article / Book chapter (5)
Keywords
- Physiologische Chemie (43)
- Schwertkärpfling (18)
- Xiphophorus (5)
- evolution (5)
- melanoma (5)
- Gen (4)
- Krebs <Medizin> (4)
- Onkogen (4)
- Tumor (4)
- medaka (4)
- Lebendgebärende Zahnkarpfen (3)
- Protein-Tyrosin-Kinasen (3)
- genome (3)
- meiosis (3)
- sex chromosomes (3)
- transcriptome (3)
- Biologie (2)
- DM-domain gene (2)
- DNS (2)
- Entstehung (2)
- Fingerprint-Verfahren (2)
- Fische (2)
- In vivo (2)
- Japankärpfling (2)
- Melanom (2)
- Umweltfaktor (2)
- Y chromosome (2)
- cancer (2)
- developmental biology (2)
- fish (2)
- fish model (2)
- gametogenesis (2)
- gene expression (2)
- genome annotation (2)
- genomics (2)
- microRNA (2)
- parthenogenesis (2)
- piRNA (2)
- preexisting bias (2)
- recombination (2)
- reproductive success (2)
- sequence alignment (2)
- sex determination (2)
- sex differentiation (2)
- sexual selection (2)
- synaptonemal complex (2)
- testis (2)
- transposable elements (2)
- zebrafish (2)
- 5-methylcytosine (1)
- Acipenser baerii (1)
- Amazon Molly (1)
- Annotation (1)
- Aulonocara (1)
- BMP signaling (1)
- Biology (1)
- Buntbarsche (1)
- Carcinogenese (1)
- Cell-line (1)
- Co-option (1)
- Coahuila (1)
- CrossQuery (1)
- Cynoglossus semilaevis (1)
- DMRT1 (1)
- DNA fingerprinting (1)
- DNA-binding proteins (1)
- Danio-rerio (1)
- Dmrt1bY (1)
- Drosophila melanogaster (1)
- Egfr (1)
- Embryo (1)
- Embryonalentwicklung (1)
- Enhancer (1)
- Epidermaler Wachstumsfaktor-Rezeptor (1)
- Eukaryoten (1)
- Fish (1)
- Freeze-etching (1)
- Gene expression analysis (1)
- Genetik (1)
- Genome (1)
- Genome assembly (1)
- Genome comparison (1)
- Genomics (1)
- Gentransfer (1)
- Germline (1)
- Gewebe (1)
- Goldbrasse (1)
- Human (1)
- Humangenetik (1)
- In vitro (1)
- Isoenzym (1)
- Jmjd6 (1)
- Karyotyp (1)
- Konservierung (1)
- Krebsforschung (1)
- Latimeria menadoensis (1)
- Ligand <Biochemie> (1)
- Male intromittent organ (1)
- Malignant melanoma (1)
- Mc4r (1)
- Medaka - Genetransfer - Transient expression - DNA fate - Fish developmental biology (1)
- Medizin (1)
- Megalobrama amblycephala (1)
- Melanoma (1)
- Messenger-RNS (1)
- Microarray data (1)
- Modell (1)
- Molekularbiologie (1)
- NGS (1)
- Nervenzelle (1)
- Niedere Wirbeltiere (1)
- Njassasee (1)
- PCR (1)
- PI3K (1)
- Pain (1)
- Perugia-Kärpfling (1)
- Physiologie (1)
- Pigmentmuster (1)
- Poecilia (Teleostei: Poeciliidae) (1)
- Poeciliid fish (1)
- Promotor (1)
- Protoonkogen (1)
- Protopterus annectens (1)
- RAS (1)
- RNA-SEQ data (1)
- RNA-Seq (1)
- RNA-seq transcriptome (1)
- RT -PCR (1)
- RTK (1)
- Recombinant DNA ; Growth hormone gene ; PCR; Silver carp ; Fish (1)
- Recombinant DNA ; polymerase chain reaction ; metallothionein gene ; rainbow trout ; fish (1)
- SGNH hydrolase (1)
- SMAD signaling (1)
- SOX9 (1)
- Schwertkräpfling (1)
- Sex chromosome (1)
- Sex determination (1)
- Sexual development and function (1)
- Single nucleotide change (1)
- Somatotropin (1)
- Sox5 (1)
- Sparus aurata (1)
- Spongilla lacustris (1)
- Sprouting angiogenesis (1)
- Squalius alburnoides (1)
- Synaptische Vesikel (1)
- Synaptophysin (1)
- Süßwasserpolypen (1)
- Transcription (1)
- Transcriptomic (1)
- Transgene Tiere (1)
- Transmission electron microscopy (1)
- Transposable element (1)
- Tumorzelle (1)
- Ultrastruktur (1)
- Veracruz <Stadt> (1)
- Wachstum (1)
- X. couchianus (1)
- X. hellerii (1)
- Xiphophorus fish (1)
- Y chromosome degeneration (1)
- Zebrafish (1)
- achiasmatic (1)
- acipenserid minisatellite (1)
- adaptive evolution (1)
- adaptive radiation (1)
- all-fish genes (1)
- amphimixis (1)
- androgen-induced masculinization (1)
- apomixis (1)
- automixis (1)
- beetle horns (1)
- cancer genomics (1)
- cancer models (1)
- cell fusion (1)
- cell proliferation (1)
- cellline transfection (1)
- chain reaction (1)
- chemotherapy resistance (1)
- chimera formation (1)
- chimeric RTKs (1)
- coloration (1)
- comparative genomics (1)
- contributes (1)
- copy-number alteration (1)
- crossing-over (1)
- crosstalk (1)
- cultures (1)
- determination locus (1)
- determining genes (1)
- deuterostomes (1)
- differentiation (1)
- dimorphic expression (1)
- divergent expression regulation (1)
- dmrt1 (1)
- drug selection (1)
- embryonic stem-cells (1)
- energy homeostasis (1)
- epidermal growth factor receptor (1)
- evolutionary biology (1)
- evolutionary genetics (1)
- evolutionary mutant model (1)
- exaptation (1)
- expression (1)
- expression analysis (1)
- factor acetylhydrolase activity (1)
- fishes Xiphophorus (1)
- gene (1)
- gene duplications (1)
- gene prediction (1)
- gene regulatory network evolution (1)
- generation (1)
- genetic markers (1)
- genetic oscillators (1)
- genome assembly (1)
- genome cells (1)
- genomic analysis (1)
- genomic organization (1)
- genus Xiphophorus (1)
- gonadal development (1)
- gonopodium (1)
- growth (1)
- growth hormone gene (1)
- gut microflora (1)
- gynogeaesls (1)
- gynogenesis (1)
- helitron (1)
- herbivorous diet (1)
- heterochromatin (1)
- heterogamety (1)
- human genomics (1)
- hybrid origin (1)
- hybridogenesis (1)
- in-vitro (1)
- intermuscular bone (1)
- introgressive hybridization (1)
- key innovation (1)
- kinase inhibitors (1)
- knockout (1)
- likelihood approach (1)
- linkage map (1)
- luciferase (1)
- lungfish (1)
- male size polymorphism (1)
- male-specific traits (1)
- malignant tumors (1)
- master sex-determining gene (1)
- medaka fish (1)
- medakafish oryzias latipes (1)
- melanogenesis (1)
- metastatic melanoma (1)
- miR-146a (1)
- miR-193a (1)
- mini-exon (1)
- mitochondrial DNA (1)
- mitochondrial genome (1)
- molecular biology (1)
- molecular mechanisms (1)
- molecular phylogeny (1)
- monodelphis domestica (1)
- mouse (1)
- mouse testis differentiation (1)
- mullerian hormone AMH (1)
- natural variation (1)
- oogenesis (1)
- oreochromis niloticus (1)
- oryzias latipes (1)
- oryzias-latipes (1)
- ovary (1)
- paralogs (1)
- parten-offspring conflict (1)
- pigment pattern (1)
- platelet activation factor (1)
- platyfish (1)
- pluripotency (1)
- poeciliid fishes (1)
- poeciliidae (1)
- polymerase (1)
- polyploidy (1)
- pp6oc-src (1)
- puberty (1)
- ras (1)
- receptor tyrosine kinase (1)
- regulatory regions (1)
- reproductive character displacement (1)
- retinoic acid (1)
- retrotransposons (1)
- rolling-circle transposons (1)
- sarcopterygian fish (1)
- satellite DNA (1)
- sex chromosome evolution (1)
- sex combs (1)
- sex linked pigmentation pattern (1)
- sex-determining gene (1)
- sex-determining region (1)
- sexual antagonistic genes (1)
- sexual conflict (1)
- sexually antagonistic genes (1)
- simple repeat sequences (1)
- simple repetitive sequences (1)
- size polymorpbism (1)
- small RNA-sequencing (1)
- sodal domlnance (1)
- species diversification (1)
- spermatogenesis (1)
- squalius alburnoides (1)
- stage III (1)
- sturgeon (1)
- sturgeon karyotype (1)
- swordtails (1)
- tandem repeats (1)
- teleost fish (1)
- teleost fishes (1)
- teleost flsh (1)
- teleostei (1)
- testosterone (1)
- topminnow (1)
- transcriptional rewiring (1)
- transgenic fish (1)
- transplantation (1)
- transposition (1)
- tree selection (1)
- variant detection (1)
- vertebrates (1)
- whole genome (1)
- whole genome duplication (1)
- whole genome duplications (1)
- whole-genome duplication (1)
- whole-genome sequencing (1)
- xiphophorus maculatus (1)
Institute
MicroRNAs play a crucial role in eukaryotic gene regulation. For a long time, only little was known about microRNA-based gene regulatory mechanisms in polyploid animal genomes due to difficulties of polyploid genome assembly. However, in recent years, several polyploid genomes of fish, amphibian, and even invertebrate species have been sequenced and assembled. Here we investigated several key microRNA-associated genes in the recently sequenced sterlet (Acipenser ruthenus) genome, whose lineage has undergone a whole genome duplication around 180 MYA. We show that two paralogs of drosha, dgcr8, xpo1, and xpo5 as well as most ago genes have been retained after the acipenserid-specific whole genome duplication, while ago1 and ago3 genes have lost one paralog. While most diploid vertebrates possess only a single copy of dicer1, we strikingly found four paralogs of this gene in the sterlet genome, derived from a tandem segmental duplication that occurred prior to the last whole genome duplication. ago1,3,4 and exportins1,5 look to be prone to additional segment duplications producing up to four-five paralog copies in ray-finned fishes. We demonstrate for the first time exon microsatellite amplification in the acipenserid drosha2 gene, resulting in a highly variable protein product, which may indicate sub- or neofunctionalization. Paralogous copies of most microRNA metabolism genes exhibit different expression profiles in various tissues and remain functional despite the rediploidization process. Subfunctionalization of microRNA processing gene paralogs may be beneficial for different pathways of microRNA metabolism. Genetic variability of microRNA processing genes may represent a substrate for natural selection, and, by increasing genetic plasticity, could facilitate adaptations to changing environments.