Refine
Has Fulltext
- yes (6)
Is part of the Bibliography
- yes (6)
Document Type
- Journal article (6)
Language
- English (6)
Keywords
- ischemic stroke (2)
- Barthel-Index (1)
- Germany (1)
- acute ischemic stroke (1)
- atherosclerosis (1)
- biomarker (1)
- biomarkers (1)
- blood (1)
- blood coagulability (1)
- bullous pemphigoid (1)
- cardiovascular disease (1)
- cerebrovascular diseases (1)
- chronic cerebrovascular disease (1)
- comorbid diseases (1)
- demography (1)
- dependency (1)
- factor XI (1)
- factor XII (1)
- hospital medical complications (1)
- increased risk (1)
- mice impact (1)
- platelets (1)
- polymorphisms inflammation (1)
- predictors (1)
- quality indicators (1)
- quality of health care (1)
- quality-of-care (1)
- rankin scale (1)
- reliability (1)
- risk-factors (1)
- sex addiction (1)
- stroke (1)
- stroke register (1)
- stroke unit care (1)
- term mortality (1)
- trial (1)
- von Willebrand factor (1)
Institute
- Institut für Klinische Epidemiologie und Biometrie (5)
- Neurologische Klinik und Poliklinik (3)
- Medizinische Klinik und Poliklinik I (2)
- Abteilung für Molekulare Innere Medizin (in der Medizinischen Klinik und Poliklinik II) (1)
- Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie (1)
- Rudolf-Virchow-Zentrum (1)
EU-Project number / Contract (GA) number
- 223153 (1)
Background and objectives
Bullous pemphigoid (BP) is associated with neuropsychiatric disorders. Other comorbid diseases are discussed controversially. We evaluated the prevalence of comorbidity in BP patients in a representative area of Germany.
Patients and methods
Medical files of all BP patients treated at the Department of Dermatology, University Hospital Würzburg, Germany, between June 2002 and May 2013 were retrospectively reviewed. Bullous pemphigoid was diagnosed based on established criteria. For each patient, two controls were individually matched. Records were evaluated for age, sex, laboratory values, concomitant medication and comorbidity. Conditional logistic regression, multivariable regression analysis and complex regression models were performed to compare results.
Results
300 BP patients were identified and compared to 583 controls. Bullous pemphigoid was associated with neuropsychiatric disorders as well as laboratory abnormalities including leukocytosis and eosinophilia. Importantly, a highly significant association of BP with anemia (OR 2.127; 95 % CI 1.532–2.953) and renal impairment (OR 2.218; 95 % CI 1.643–2.993) was identified. No association was found with malignancy and arterial hypertension.
Conclusions
Our data revealed an increased frequency of anemia and renal impairment in BP patients. In accordance with previous studies the strong association for neuropsychiatric disorders was confirmed (p < 0.0005).