Refine
Has Fulltext
- yes (6)
Is part of the Bibliography
- yes (6)
Document Type
- Journal article (6)
Language
- English (6)
Keywords
- Bordetella pertussis (2)
- SARS-CoV-2 (2)
- acetylsalicylic acid (1)
- adenylate cyclase toxin (1)
- airway epithelia (1)
- anthocyanin (1)
- antiviral activity (1)
- aspirin (1)
- astaxanthin (1)
- bilberry (1)
- black currant (1)
- bone morphogenetic protein 2 (BMP2) (1)
- bone regeneration (1)
- ciliostasis (1)
- covalent coupling (1)
- herpesvirus (1)
- human airway mucosa tissue models (1)
- human nasal epithelial cells (1)
- human tracheo-bronchial epithelial cells (1)
- measels virus (1)
- precision-cut lung slices (1)
- salicylic acid (1)
- subcutaneous animal model (1)
- tight junction (1)
- tissue model (1)
- tracheal cytotoxin (1)
- viral epidemiology (1)
- viral infection (1)
Institute
- Lehrstuhl für Tissue Engineering und Regenerative Medizin (6)
- Institut für Virologie und Immunbiologie (3)
- Theodor-Boveri-Institut für Biowissenschaften (2)
- Institut für Organische Chemie (1)
- Julius-von-Sachs-Institut für Biowissenschaften (1)
- Klinik und Poliklinik für Hals-, Nasen- und Ohrenkrankheiten, plastische und ästhetische Operationen (1)
EU-Project number / Contract (GA) number
- 607051 (1)
Background
Anthocyanin-containing plant extracts and carotenoids, such as astaxanthin, have been well-known for their antiviral and anti-inflammatory activity, respectively. We hypothesised that a mixture of Ribes nigrum L. (Grossulariaceae) (common name black currant (BC)) and Vaccinium myrtillus L. (Ericaceae) (common name bilberry (BL)) extracts (BC/BL) with standardised anthocyanin content as well as single plant extracts interfered with the replication of Measles virus and Herpesviruses in vitro.
Methods
We treated cell cultures with BC/BL or defined single plant extracts, purified anthocyanins and astaxanthin in different concentrations and subsequently infected the cultures with the Measles virus (wild-type or vaccine strain Edmonston), Herpesvirus 1 or 8, or murine Cytomegalovirus. Then, we analysed the number of infected cells and viral infectivity and compared the data to non-treated controls.
Results
The BC/BL extract inhibited wild-type Measles virus replication, syncytia formation and cell-to-cell spread. This suppression was dependent on the wild-type virus-receptor-interaction since the Measles vaccine strain was unaffected by BC/BL treatment. Furthermore, the evidence was provided that the delphinidin-3-rutinoside chloride, a component of BC/BL, and purified astaxanthin, were effective anti-Measles virus compounds. Human Herpesvirus 1 and murine Cytomegalovirus replication was inhibited by BC/BL, single bilberry or black currant extracts, and the BC/BL component delphinidin-3-glucoside chloride. Additionally, we observed that BC/BL seemed to act synergistically with aciclovir. Moreover, BC/BL, the single bilberry and black currant extracts, and the BC/BL components delphinidin-3-glucoside chloride, cyanidin-3-glucoside, delphinidin-3-rutinoside chloride, and petunidin-3-galactoside inhibited human Herpesvirus 8 replication.
Conclusions
Our data indicate that Measles viruses and Herpesviruses are differentially susceptible to a specific BC/BL mixture, single plant extracts, purified anthocyanins and astaxanthin. These compounds might be used in the prevention of viral diseases and in addition to direct-acting antivirals, such as aciclovir.