Filtern
Erscheinungsjahr
Dokumenttyp
Schlagworte
- Plattenepithelcarcinom (11)
- HNSCC (10)
- BMP (9)
- Osteoinduktion (9)
- head and neck cancer (6)
- Plattenepithelkarzinom (5)
- Transplantat (5)
- artificial intelligence (5)
- caloric restriction (5)
- osteoinduction (5)
- HGF (4)
- Knochen-Morphogenese-Proteine (4)
- Knochenregeneration (4)
- Krebs <Medizin> (4)
- Mundschleimhaut (4)
- Osteoinduction (4)
- cancer (4)
- mass spectrometry (4)
- methionine (4)
- BMP-2 (3)
- Bone regeneration (3)
- Cisplatin (3)
- Dysgnathie (3)
- Kephalometrie (3)
- Knochenersatz (3)
- Kraniometrie (3)
- LC/MS (3)
- Lippen-Kiefer-Gaumenspalte (3)
- Mund-Kiefer-Gesichts-Chirurgie (3)
- Mundhöhlenkarzinom (3)
- Mundhöhlenkrebs (3)
- Plasmozytom (3)
- Sprachentwicklung (3)
- Tissue Engineering (3)
- Tumor (3)
- Tumorantigen (3)
- apoptosis (3)
- deep learning (3)
- machine learning (3)
- methionine restriction (3)
- multiple myeloma (3)
- prediction (3)
- 3D-Pulverdruck (2)
- ARONJ (2)
- Apoptose (2)
- Augmentation (2)
- B cells (2)
- BMP variants (2)
- CBCT (2)
- Cephalometry (2)
- Craniosynostosis (2)
- Dünndarmtransplantat (2)
- EXKK (2)
- Entnahmemorbidität (2)
- Epidermaler Wachstumsfaktor-Rezeptor (2)
- Hepatozyten-Wachstumsfaktor (2)
- Immuncytochemie (2)
- Knochen (2)
- Knochennekrose (2)
- Kopf-Hals-Karzinom (2)
- Kraniosynostose (2)
- L929 (2)
- Lagerungsplagiozephalus (2)
- Laminin (2)
- MAGE-A (2)
- Massenspektrometrie (2)
- Medizin (2)
- Met (2)
- Methionin-Restriktion (2)
- Mund-Kiefer-Gesichtsbereich (2)
- Mundhöhle (2)
- Mundhöhlentumor (2)
- NFκB (2)
- Oberkiefer (2)
- Osteoblasten (2)
- Oxidativer Stress (2)
- PET (2)
- Radialislappen (2)
- Rezidiv (2)
- Skapulatransplantat (2)
- Tyrosinkinaseinhibitoren (2)
- Unterkiefer (2)
- Vascular endothelial Growth Factor (2)
- Volumentomographie (2)
- Zellkultur (2)
- amino acid (2)
- amino acid restriction (2)
- bone (2)
- cancer metabolism (2)
- classification (2)
- cleft lip and palate (2)
- donor-site morbidity (2)
- dysgnathia (2)
- free jejunal graft (2)
- gene expression (2)
- liquid chromatography/mass spectrometry (2)
- malocclusion (2)
- mandible (2)
- oral cavity (2)
- oral squamous cell carcinoma (2)
- orales Plattenepithelkarzinom (2)
- osteoblast (2)
- osteonecrosis of the jaw (2)
- osteoradionecrosis (2)
- oxidative stress (2)
- radial forearm flap (2)
- restriction (2)
- scaffold (2)
- survival (2)
- xx (2)
- Überleben (2)
- 2-DG (1)
- 2-deoxy-D-glucose (1)
- 3D (1)
- 3D Printing (1)
- 3D-Druck (1)
- 3D-Stereophotogrammetrie (1)
- 3d (1)
- 3d powder printing (1)
- 5-Fluorouracil (1)
- 5-Fluoruracil (1)
- AAA-Knochen (1)
- ABC-Transporter (1)
- AMPK (1)
- Adhäsivsystem (1)
- Adult (1)
- Afatinib (1)
- Agglomeration (1)
- American Association of Oral and Maxillofacial Surgeons (1)
- Ampicillin (1)
- Anpassung (1)
- Antibiotikatherapie (1)
- Apert (1)
- Apoptosis (1)
- Arbeitsgedächtnis (1)
- Autophagie (1)
- Autophagy (1)
- B cell receptors (1)
- BMP- Varianten (1)
- BMP-Mutanten (1)
- BMP-Varianten (1)
- BMP-mutants (1)
- BMP2 (1)
- BRONJ (1)
- BV6 (1)
- Bafilomycin (1)
- Basalmembran (1)
- Behandlungsdauer (1)
- Benzopyren (1)
- Biocompatible Materials (1)
- Biomarker (1)
- Birinapant (1)
- Bisphosphonat (1)
- Bleeding (1)
- Blei (1)
- Blutung (1)
- Bogengang <Anatomie> (1)
- Bogengangsdehiszenz (1)
- Bone graft (1)
- Bone morphogenetic protein (1)
- Bone-Lock-System (1)
- Brustkrebs (1)
- Bürstenbiopsie (1)
- CARE (1)
- CD40 (1)
- CD44 (1)
- COPD (1)
- CT (1)
- Calciumphosphate (1)
- Calciumphosphatzemente (1)
- Calibration (1)
- Carcinoma of oral cavity (1)
- Cephalometric (1)
- Cetuximab (1)
- Chemotherapie (1)
- Chloroquin (1)
- Clinical prediction rule (1)
- Co-culture (1)
- Collagen membrane (1)
- Composite Graft (1)
- Compound 3k (1)
- Computertomographie (1)
- Connective tissue (1)
- Cranio-Maxillo-Facial-Reconstructive (1)
- Crouzon (1)
- Cytostatikum (1)
- DASA-58 (1)
- Datenbank (1)
- Defektdeckung (1)
- Dehiszenz (1)
- Delaire (1)
- Dendritic cell tumor (1)
- Dental Practice (1)
- Dentale Implantate (1)
- Dentoalveolär (1)
- Digitale Computertomographie (1)
- Distraktionsosteogenese (1)
- Docetaxel (1)
- E-cadherin (1)
- Einfluss auf die Bisskraft (1)
- Emissions-Computertomographie (1)
- Entnahmedefekt (1)
- Entzündung (1)
- Epithese <Medizin> (1)
- Erlotinib (1)
- Expressionsprofile (1)
- False positive reactions (1)
- FasL (1)
- Felsenbein (1)
- Fernröntgenseitenbild (1)
- Fibroblasten (1)
- Foretinib (1)
- Formant (1)
- GBR (1)
- GDF-5 (1)
- GLUT1 (1)
- Gaumenplatte (1)
- Gaumenspalte (1)
- Gefitinib (1)
- Genioglossus Advancement (1)
- Gerinnungsstörung (1)
- Gesichtschirurgie (1)
- Gewebeklebung (1)
- Glucose (1)
- Glucosemetabolismus (1)
- Glukose-Restriktion (1)
- Glutamin (1)
- Glutamin-Restriktion (1)
- Grading (1)
- Grafton® (1)
- Growth (1)
- Hartgewebe-chirurgische Therapie (1)
- HeLa-Zelle (1)
- Head (1)
- Heilungsergebnisse (1)
- Häufigkeit (1)
- ICBM (1)
- Implantat (1)
- Implantat-gestützter Zahnersatz (1)
- Implantate (1)
- Implantatlager (1)
- Implizites Gedächtnis (1)
- In vitro (1)
- Infection control (1)
- Inflammation (1)
- Intracraniell volume (1)
- Intrakranielles Volumen (1)
- Intraorale Infektionen (1)
- Kaiserschnitt (1)
- Keratinocytes (1)
- Keratinozyt (1)
- Keratinozyten (1)
- Kiefer- (1)
- Kiefer- und Gesichtschirurgie (1)
- Kieferaugmentation (1)
- Kiefergelenk (1)
- Kiefergelenkendoprothese (1)
- Kiefergelenkrekonstruktion (1)
- Kiefergelenkresektion (1)
- Kiefergelenksersatz (1)
- Kieferhöhle (1)
- Kiefernekrose (1)
- Kieferosteonekrose (1)
- Kieferspalte (1)
- Klasse-V-Kavität (1)
- Knochenbildung (1)
- Knochenchirurgie (1)
- Knochendeformität (1)
- Knochenersatzmaterial (1)
- Knocheninfiltration (1)
- Knochenmineralisation (1)
- Knochentransplantation (1)
- Knochenzement (1)
- Kokultur (1)
- Kollagen (1)
- Kombinationstherapie (1)
- Komposit (1)
- Kopf-Hals-Tumore (1)
- Kopforthesentherapie (1)
- Koronarnahtsynostose (1)
- Kraniektomie (1)
- Kraniometrische Vermessung (1)
- Kraniostenose (1)
- LC-MS (1)
- LCL161 (1)
- LKGS (1)
- Lagerungsplagiocephalus (1)
- Lapatinib (1)
- Leukoplakie (1)
- Lichen ruber planus (1)
- Lippen-Kiefer-Gaumenspalten (1)
- Lippen-Kieferspalte (1)
- Lippenspalte (1)
- Lymphknotenausräumung (1)
- Lymphknotenmetastase (1)
- MAGE-A11 (1)
- MMP2 (1)
- MMP9 (1)
- MRONJ (1)
- Mandibular reconstruction (1)
- Maschinelles Lernen (1)
- Maxillo Mandibuläres Advancement (1)
- Mere-Exposure-Effekt (1)
- Methicillin-resistant staphylococcus aureus (1)
- Methionin (1)
- Mikrochirurgie (1)
- Modell-OP (1)
- Monetit (1)
- Multidrug-Resistenz (1)
- Multiples Myelom (1)
- Mund-Kiefer-Gesichtschirurgie (1)
- Mundh�hlentumor (1)
- N0- Carcinoma (1)
- N0- Karzinom (1)
- Nase (1)
- Neck dissection (1)
- Neck-Dissection (1)
- Neugeborenenschrei (1)
- Neugeborenes (1)
- NfkappaB (1)
- Nintedanib (1)
- Nuklearfaktor Kappa B (1)
- OHIP-49 (1)
- ONJ (1)
- OSAS (1)
- Obstruktives Schlaf-Apnoe-Syndrom (1)
- Operations-Planungsmodelle (1)
- Operative Therapie (1)
- Oral Mucosa (1)
- Oral Squamous cell carcinoma (1)
- Oral soft tissue infections (1)
- Orales Plattenepithelcarcinom (1)
- Orales Plattenepithelkarzinom (1)
- Oropharynx (1)
- Ossifikation (1)
- Osteoporose (1)
- Osteosynthese (1)
- PD-L1 (1)
- PET/CT (1)
- PKM2 (1)
- PLLA (1)
- PMMA (1)
- Paramedian Foreheadflap (1)
- Paramedianer Stirnlappen (1)
- Perforation (1)
- Perfusion (1)
- Phonologische Bewusstheit (1)
- Piezosurgery (1)
- Plastische Chirurgie (1)
- Plattenepithelarzinom (1)
- Poly(L-Lactid) (1)
- Polycyclische Aromaten (1)
- Polymilchsäure (1)
- Predicting (1)
- Predictive value of tests (1)
- Proliferationsfähigkeit (1)
- Prostatakrebs (1)
- Präzision von Organmodellen (1)
- Pseudarthrosen (1)
- RAF1 (1)
- Radialisflap (1)
- Randspalt (1)
- Rapamycin (1)
- Rapid Prototyping (1)
- Real time quantitative PCR (1)
- Referenzgen (1)
- Rekonstruktion (1)
- Resensibilisierung (1)
- Residualtumor (1)
- Resonanz (1)
- Revascularization (1)
- Rhabdomyosarcoma (1)
- Risikofaktor (1)
- Risikofaktoren (1)
- SCCHN (1)
- SHH (1)
- SLC-family (1)
- SWLS (1)
- Saethre-Chotzen (1)
- Sagittalnahtsynostose (1)
- Scaffold (1)
- Scapula (1)
- Scapula Transplant (1)
- Schaf (1)
- Schafmodell (1)
- Schallleitungsschwerhörigkeit (1)
- Schichttechnik (1)
- Schlafapnoe (1)
- Schreinanalyse (1)
- Schwermetall (1)
- Schädelnaht (1)
- Schädelsuturen (1)
- Selektive Laser-Sinterung (1)
- Sensitivität (1)
- Sirolimus (1)
- Skapula (1)
- Smac Mimetic (1)
- Smam-mimetics (1)
- Speicheldrüse (1)
- Speicheldrüsenkrankheit (1)
- Speicheldrüsenkrebs (1)
- Speicheldrüsenmalignom (1)
- Spermidine (1)
- Spezifität (1)
- Spindle cell (1)
- Spiral-Computertomographie (1)
- Spracherwerb (1)
- Sprechentwicklung (1)
- Squamous cell carcinoma (1)
- Standardwerte (1)
- Stereolithographie (1)
- Struvit (1)
- Sulbactam (1)
- Surgery (1)
- Suspension (1)
- Synergismus (1)
- Säugling (1)
- T4 (1)
- TGF-ß (1)
- TGF-ß1 (1)
- TMJ-endoprostheses (1)
- TNF (1)
- TNFα (1)
- TNM- Classification (1)
- TNM- Klassifikation (1)
- TNM-System (1)
- TPCA1 (1)
- TWEAK (1)
- TXNIP (1)
- TachoComb (1)
- TachoComb® H (1)
- Targeted therapy (1)
- Targetierung (1)
- Taxol (1)
- Temporomandibular Joint prostheses (1)
- Therapeutic results (1)
- Therapieergebnisse (1)
- Therapiegrundsätze Mund- (1)
- Titan (1)
- Titanium (1)
- Tracheotomie (1)
- Transplantatabstoßung (1)
- Transplantatentnahme (1)
- Transplantatlager (1)
- Trapezius-Osteomuskulokutaneous-Lappen (1)
- Treatment Time (1)
- Tumordatenbank (1)
- Tumordiagnostik (1)
- Tumorregister (1)
- Tumorstoffwechsel (1)
- Tuning (1)
- Tyrosine Kinase Inhibitors (1)
- UICC (1)
- Umstellungsosteotomie (1)
- Unterarm (1)
- Unterkieferrekonstruktion (1)
- Untersuchung <Medizin> (1)
- VAS (1)
- VEGF-Rezeptor 1 (1)
- VEGF-Rezeptor 2 (1)
- Verarbeitungsflüssigkeit (1)
- Volasertib (1)
- Vollhaut (1)
- Volumentomografie (1)
- Vorbestrahlung (1)
- Vorherbestimmung (1)
- Wachstum (1)
- Warburg effect (1)
- Weichgewebsschädigung (1)
- Weisheitszahnextraktion (1)
- Weltgesundheitsorganisation. Expert Committee on Prevention Methods and Programmes for Oral Diseases (1)
- Wortflüssigkeit (1)
- Würzburg / Klinik und Poliklinik für Mund- (1)
- X-ray (1)
- Zahnarztpraxis (1)
- Zahnextraktion (1)
- Zetapotential (1)
- Zometa (1)
- Zufriedenheitsanalyse (1)
- Zytoreduktion (1)
- aaa-bone (1)
- agar diffusion test (1)
- alveolar bone loss (1)
- alveolar crest augmentation (1)
- amino acid analogues (1)
- amino acid transporter (1)
- ampicillin (1)
- antagonist (1)
- antibiotic bone concentration (1)
- antibiotic resistance (1)
- antibiotics in oral surgery (1)
- antiresorptive drug-related osteonecrosis of the jaw (1)
- apparente Knochendichte (1)
- augmentation (1)
- autgenous bone graft (1)
- axial pattern flap (1)
- benzopyrene (1)
- beta-lactam (1)
- bone adhesive (1)
- bone loss (1)
- bone replacement material (1)
- bovine bone substitute (1)
- c-section (1)
- calcium (1)
- calcium-magnesium phosphate cement (1)
- cancer therapy (1)
- case report (1)
- cell binding (1)
- cell culture (1)
- cell cycle and cell division (1)
- cell metabolism (1)
- cell proliferation (1)
- cell vitality (1)
- cellular marker (1)
- cement (1)
- cement pastes (1)
- cisplatin (1)
- class V cavity (1)
- clp (1)
- complications (1)
- composite (1)
- computer-aided (1)
- contact inhibition (1)
- conventional or implant-supported prosthetic appliance (1)
- coronar suture (1)
- craniofacial orthodontics (1)
- craniometric (1)
- craniosynostosis (1)
- crystal structure (1)
- cysteine restriction (1)
- cysteine synthase inhibitor (1)
- dbm (1)
- deformational cranial asymmetry (1)
- deformational plagiocephaly (1)
- demineralisierter Knochen (1)
- dental implants (1)
- dentsitry (1)
- design (1)
- eNOS (1)
- edentulous (1)
- egfr (1)
- energy restriction (1)
- fibrin coated collagene (1)
- fibroblast activation protein (1)
- fibula (1)
- fluency (1)
- formant (1)
- free microsurgical transfer (1)
- free skin grafts (1)
- frequency (1)
- full-thickness skin graft (1)
- functional and aesthetic outcomes (1)
- gefäßgestieltes Transplantat (1)
- gingivitis (1)
- glucose restriction (1)
- glutamine (1)
- glycolysis (1)
- grading (1)
- graft (1)
- growth and differentiation factor 5 (1)
- guided bone regeneration (1)
- headsuture (1)
- helical-volume-computed-tomography (1)
- heterotop (1)
- hnscc (1)
- homocysteine (1)
- human oral mucosa (1)
- iNOS (1)
- immune therapy (1)
- immunhistchemistry (1)
- immunocytochemistry (1)
- implantation (1)
- in vivo Studie (1)
- in vivo study (1)
- infant (1)
- infant skull (1)
- infants with deformational plagiocephaly (DP) (1)
- inferior trapezius musculocutaneous flap (1)
- inferiore Trapeziuslappen (1)
- inflammation (1)
- influence on the bite force (1)
- inhibitor (1)
- intraosseous (1)
- ischemia (1)
- isolated (1)
- isoliert (1)
- jaw bone (1)
- konventioneller Zahnersatz (1)
- kras (1)
- kras-Mutation (1)
- language developement (1)
- lateral radiograph (1)
- lead (1)
- length of stay (1)
- ligand-receptor complex (1)
- linguistic development (1)
- low carb (1)
- low energy metabolism (1)
- low-intensity ultrasound (1)
- lymph node (1)
- magnesium phosphate cement (1)
- malignoma of the salivary glands (1)
- mandibular (1)
- mandibular host bed (1)
- manufacturing (CAD/CAM) (1)
- marginal adaptation (1)
- maxillo-facial surgery (1)
- maxillofacial surgery (1)
- mean maximum bite force (1)
- medication-related osteonecrosis of the jaw (1)
- melody (1)
- melt electrospinning writing (1)
- membrane receptor signaling (1)
- mere exposure effect (1)
- metabolism (1)
- metabolomics (1)
- microRNA (1)
- mikrochirurgisch reanastomosiert (1)
- mittlere Trapeziuslappen (1)
- mittlere maximale Bisskraft (1)
- model (1)
- molecular alterations (1)
- molecular imaging (1)
- molecular marker (1)
- morphological features (1)
- multicentric (1)
- necrotic cell death (1)
- neoadjuvant (1)
- newborn (1)
- newborn cry (1)
- niederenergetischer Ultraschall (1)
- non-union (1)
- object detection (1)
- operation planning models (1)
- operative planning (1)
- oral health (1)
- oral microbiome (1)
- oral potentially malignant disorders (1)
- oral-health-related quality of life (1)
- oro-antral communication (1)
- oro-antral fistula (1)
- oroantral fistula (1)
- oropharyngeal carcinoma (1)
- oropharyngeal squamous cell carcinoma (1)
- oropharynx (1)
- orthognatic surgery (1)
- osseus regeneration (1)
- osseus substitution (1)
- osteocutaneous (1)
- outcome (1)
- pN1 (1)
- partially edentulous (1)
- patientenspezifische Implantate (1)
- perforation (1)
- perfusion (1)
- perfusion culture (1)
- periimplant evaluation (1)
- periimplantäre Evaluation (1)
- periodontitis (1)
- periphere quantitative Computertomographie (1)
- phonological awareness (1)
- phosphate (1)
- physical examination (1)
- phytic acid (1)
- placement technique (1)
- planning (1)
- platelet-rich fibrin (1)
- poly(l-lactide) (1)
- polycaprolactone (1)
- polylactide (1)
- positional plagiocephaly (1)
- positionalskull deformities (1)
- postoperative complications (1)
- potential (1)
- precision of anatomical models (1)
- preespeech (1)
- prefabricated granules (1)
- premature (1)
- preoperative (1)
- progression-free survival (1)
- proliferation (1)
- prospective (1)
- prämatur (1)
- prämature Kraniosynostosen (1)
- pseudocarcinomatous hyperplasia (1)
- qCT (1)
- quality of life (1)
- radiochemotherapy (1)
- radiographic bone loss (1)
- radiotherapy (1)
- reconstruction (1)
- recurrence (1)
- resection (1)
- resonance (1)
- resorbable osteosynthesis (1)
- resorbierbare Osteosynthese (1)
- risk factors (1)
- risk factors and etiology (1)
- riskfactors (1)
- salivary gland (1)
- salivary gland lymph node (1)
- satisfaction with life (1)
- selecitve laser-sintering (1)
- semicircular canal dehiscence (1)
- sheep-model (1)
- signaling (1)
- smac mimetic (1)
- soft tissue injury (1)
- speech and language development (1)
- sprague dawley (1)
- squamous cell carcinoma (1)
- stereolithographie (1)
- struvite (1)
- subjective perception (1)
- superiore Trapeziuslappen (1)
- surgery (1)
- survival analysis (1)
- survival rates (1)
- syndromal (1)
- synergism (1)
- teeth extraction (1)
- teilbezahnt (1)
- third molar surgery (1)
- three-dimensional (1)
- three-dimensional imaging (1)
- tooth extraction (1)
- tracheotomy (1)
- transplant (1)
- treatment (1)
- treatment benefit (1)
- tumourdatabase (1)
- vWF (1)
- verbal short-term memory (1)
- vorsprachlich (1)
- zahnlos (1)
- zervikale Lymphknotenmetastasen (1)
- zeta (1)
- Überlebensanalyse (1)
- Überlebensraten (1)
Institut
- Klinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie (136) (entfernen)
Sonstige beteiligte Institutionen
Objective: This study aims to critically evaluate the effectiveness and accuracy of a time safing and cost-efficient open-source algorithm for in-house planning of mandibular reconstructions using the free osteocutaneous fibula graft. The evaluation focuses on quantifying anatomical accuracy and assessing the impact on ischemia time.
Methods: A pilot study was conducted, including patients who underwent in-house planned computer-aided design and manufacturing (CAD/CAM) of free fibula flaps between 2021 and 2023. Out of all patient cases, we included all with postoperative 3D imaging in the study. The study utilized open-source software tools for the planning step, and three-dimensional (3D) printing techniques. The Hausdorff distance and Dice coefficient metrics were used to evaluate the accuracy of the planning procedure.
Results: The study assessed eight patients (five males and three females, mean age 61.75 ± 3.69 years) with different diagnoses such as osteoradionecrosis and oral squamous cell carcinoma. The average ischemia time was 68.38 ± 27.95 min. For the evaluation of preoperative planning vs. the postoperative outcome, the mean Hausdorff Distance was 1.22 ± 0.40. The Dice Coefficients yielded a mean of 0.77 ± 0.07, suggesting a satisfactory concordance between the planned and postoperative states. Dice Coefficient and Hausdorff Distance revealed significant correlations with ischemia time (Spearman's rho = −0.810, p = 0.015 and Spearman's rho = 0.762, p = 0.028, respectively). Linear regression models adjusting for disease type further substantiated these findings.
Conclusions: The in-house planning algorithm not only achieved high anatomical accuracy, as reflected by the Dice Coefficients and Hausdorff Distance metrics, but this accuracy also exhibited a significant correlation with reduced ischemia time. This underlines the critical role of meticulous planning in surgical outcomes. Additionally, the algorithm's open-source nature renders it cost-efficient, easy to learn, and broadly applicable, offering promising avenues for enhancing both healthcare affordability and accessibility.