Refine
Has Fulltext
- yes (10)
Is part of the Bibliography
- yes (10) (remove)
Document Type
- Journal article (10)
Language
- English (10)
Keywords
- tissue engineering (3)
- MSCs (2)
- breast cancer (2)
- chondrocytes (2)
- osteoarthritis (2)
- Bone marrow (1)
- Cartilage regeneration (1)
- Elderly patients (1)
- Hip joint (1)
- Joint capsule (1)
- Ligamentum capitis femoris (1)
- Lower extremity reconstruction (1)
- Osteoarthritis (1)
- Pedicled perforator flap (1)
- Propeller flap (1)
- Staphylococcus aureus / drug effects (1)
- Tissue engineering (1)
- Vancomycin / administration & dosage (1)
- Vancomycin / chemistry (1)
- Vancomycin / pharmacology (1)
- anti-bacterial agents / administration & dosage (1)
- anti-bacterial agents / chemistry (1)
- anti-bacterial agents / pharmacology (1)
- biocompatible Materials (1)
- bone colonization (1)
- bone metastasis (1)
- bone tumour (1)
- bone wires (1)
- calcium phosphate (1)
- cartilage regeneration (1)
- cell-based therapies (1)
- cellular origin (1)
- chondrogenic differentiation (1)
- defects (1)
- differentiation capacity (1)
- drug liberation (1)
- endochondral ossification (1)
- hMSCs (1)
- human prostate-cancer (1)
- humanized bone models (1)
- humanized xenograft model (1)
- hypovitaminosis D (1)
- implant positioning (1)
- in vitro (1)
- in vivo (1)
- knee axis (1)
- knee joint (1)
- knee osteoarthritis (1)
- malignancy (1)
- materials testing (1)
- melt electrospinning (1)
- morphogenetic protein (1)
- mouse model (1)
- osteoprogenitor cells (1)
- osteotropism (1)
- patient-specific knee arthroplasty (1)
- prostheses and implants (1)
- repair (1)
- scaffolds (1)
- skeletal metastases (1)
- stem cells (1)
- stem-cell niche (1)
- stimulation (1)
- sutures (1)
- therapy (1)
- total knee replacement (1)
- toxicity (1)
- trabecular bone (1)
- tranexamic acid (1)
- transplantation (1)
- tumour malignancy (1)
- vitamin D (1)
- vitamin D deficiency (1)
- β1 integrin (1)
Institute
- Lehrstuhl für Orthopädie (10) (remove)
Sonstige beteiligte Institutionen
In vitro evaluation of antibacterial efficacy of vancomycin-loaded suture tapes and cerclage wires
(2021)
Usage of implants containing antibiotic agents has been a common strategy to prevent implant related infections in orthopedic surgery. Unfortunately, most implants with microbial repellent properties are characterized by accessibility limitations during daily clinical practice. Aim of this in vitro study was to investigate whether suture tapes and cerclage wires, which were treated with vancomycin, show a sustainable antibacterial activity. For this purpose, we used 24 stainless steel wire cerclages and 24 ultra-high molecular weight polyethylene and polyester suture tape test bodies. The test bodies were incubated for 30 min. in 100 mg/ml vancomycin solution or equivalent volumes of 0.9% NaCl. After measuring the initial solution uptake of the test bodies, antibacterial efficacy via agar diffusion test with Staphylococcus aureus and vancomycin elution tests were performed 1, 2, 3, and 6 days after incubation. Vancomycin-loaded tapes as well as vancomycin-loaded cerclage wires demonstrated increased bacterial growth inhibition when compared to NaCl-treated controls. Vancomycin-loaded tapes showed an additional twofold and eightfold increase of bacterial growth inhibition compared to vancomycin-loaded wires at day 1 and 2, respectively. Elution tests at day 1 revealed high levels of vancomycin concentration in vancomycin loaded tapes and wires. Additionally, the concentration in vancomycin loaded tapes was 14-fold higher when compared to vancomycin loaded wires. Incubating suture tapes and cerclage wires in vancomycin solution showed a good short-term antibacterial activity compared to controls. Considering the ease of vancomycin application on suture tapes or wires, our method could represent an attractive therapeutic strategy in biofilm prevention in orthopedic surgery.