Refine
Has Fulltext
- yes (38)
Is part of the Bibliography
- yes (38)
Year of publication
Document Type
- Journal article (38)
Language
- English (38)
Keywords
- osteoporosis (4)
- hypophosphatasia (3)
- mechanotransduction (3)
- mineralization (3)
- sarcopenia (3)
- HPP (2)
- LMHFV (2)
- Mesenchymal stem cells (2)
- Multiple myeloma (2)
- TNAP (2)
- back pain (2)
- bone-mineral density (2)
- differentiation (2)
- exercise (2)
- fracture (2)
- fracture healing (2)
- in-vitro (2)
- inflammation (2)
- model (2)
- nervous system (2)
- oestrogen receptor signalling (2)
- stromal cells (2)
- teriparatide (2)
- tissue engineering (2)
- 2',7'-dichlorofluorescin (1)
- 3D printing (1)
- ALPL (1)
- Angiopoietin-like 4 (1)
- Bioreaktor (1)
- Bisphosphonates (1)
- Bone Mineral Density (1)
- Bone disease (1)
- Breast cancer cells (1)
- CCN1 (1)
- Caspase 3/7 activity (1)
- Cell viability, (1)
- EQ-5D (1)
- ER signaling (1)
- Endothelial growth-factor (1)
- Gene expression profiling (1)
- Hypophosphatasia (1)
- Mechanical strain (1)
- Medizin (1)
- Novobiocin (1)
- Osteogenic precursor cells (1)
- Probenecid (1)
- RT-PCR (1)
- Splicing (1)
- WNT pathway (1)
- WNT signaling pathway (1)
- WNT5A (1)
- Wnt (1)
- Wnt signalling (1)
- Wnt-signalling (1)
- Wnt/β-catenin signaling (1)
- additive manufacturing (1)
- age (1)
- age-related osteoporosis (1)
- aging (1)
- alendronate (1)
- alkaline phosphatase (1)
- alkaline-phosphatase (1)
- alpha (1)
- angiogenic cytokines (1)
- aseptic loosening (1)
- asfotase alfa (1)
- autologous chondrocyte implantation (1)
- autosomal-dominant osteopetrosis (1)
- biceps tendon (1)
- biodegradable polymers (1)
- biomarkers Myelomas (1)
- biomaterials – cells (1)
- bioreactor (1)
- bisphosphonates (1)
- bone (1)
- bone QCT (1)
- bone biology (1)
- bone formation (1)
- bone imaging (1)
- bone marrow (1)
- bone marrow lesion/edema (1)
- bone marrow stromal cells (1)
- bone mineral density (1)
- bone remodeling (1)
- bone tumour (1)
- cancer microenvironment (1)
- cardiovascular (1)
- cells (1)
- cellular signalling networks (1)
- click chemistry (1)
- colony-stimulating factor (1)
- community-dwelling (1)
- computer modelling (1)
- core depression (1)
- craniosynostosis (1)
- database (1)
- early stage (1)
- epidermal growth factor (1)
- expression (1)
- fluorescence microscopy (1)
- fluorescent dyes (1)
- gene (1)
- gene constructs (1)
- gene-expression (1)
- glycocalyx (1)
- growth factor (1)
- hMSC-TERT (1)
- health-related quality of life (1)
- high-bone-mass (1)
- homeostasis (1)
- human atherosclerotic lesions (1)
- hypovitaminosis D (1)
- impact (1)
- in situ guided tissue regeneration (1)
- in situ hybridization (1)
- in vitro (1)
- level mechanical vibrations (1)
- lines (1)
- malignancy (1)
- marrow stromal cells (1)
- mechanosensing (1)
- mechanosensitive reporter (1)
- men (1)
- mesenchymal cells (1)
- mesenchymal stem cell (1)
- mesenchymal stem cells (1)
- mesenchymal stem-cells (1)
- mesenchymal stromal cells (1)
- mesenchymal tissues (1)
- metaanalysis (1)
- metabolic glycoengineering (1)
- metabolic risk (1)
- metabolic syndrome (1)
- metabolism (1)
- microstructures (1)
- mineraliztion (1)
- modified monosaccharides (1)
- monoclonial gammopathy (1)
- morphogenetic protein (1)
- multiple myeloma Lesions (1)
- muscle (1)
- mutant mice (1)
- mutations (1)
- myeloma (1)
- myeloma cells (1)
- myokines (1)
- nanostructures (1)
- neurotransmission (1)
- nonspecific alkaline-phosphae (1)
- obesity (1)
- older people (1)
- osteoblastic cells (1)
- osteochondral allografts (1)
- osteoclasts (1)
- osteogenesis imperfecta (1)
- osteogenic differentiation (1)
- osteokines adaptation (1)
- osteomalacia (1)
- osteopenia (1)
- ovariectomized rats (1)
- ovariectomy (1)
- overview (1)
- oxidative stress (1)
- parathyroid-hormone (1)
- peripheral-blood (1)
- persistence (1)
- perspectives (1)
- precedes multiple-myeloma (1)
- prevalent fractures (1)
- progenitor cells (1)
- proliferation (1)
- promotes (1)
- quality of life (1)
- rare bone disease (1)
- receptor beta (1)
- receptor related protein (1)
- regenerative capacity (1)
- regenerative medicine (1)
- replacement therapy (1)
- replicative senescence (1)
- resistance exercise (1)
- responsiveness (1)
- rickets (1)
- scaffolds (1)
- segmental collapse (1)
- senescence (1)
- senescence‐associated secretory phenotype (1)
- serum amyloid A (1)
- sheep model (1)
- shoulder (1)
- signaling (1)
- skeletal overexpression (1)
- stem cells (1)
- teeth (1)
- tendon-derived stem cell (1)
- tissue (1)
- toll-like receptor (1)
- transcription factors (1)
- tumour malignancy (1)
- undetermined significance (1)
- vertebral fractures (1)
- vertebrate (1)
- vitamin D (1)
- vitamin D deficiency (1)
- vitamin-D-receptor (1)
- whole body vibration (1)
- whole-body electromyostimulation (1)
- whole-body vibration (1)
- zebrafish (1)
- zoledronic acid (1)
Institute
- Lehrstuhl für Orthopädie (38) (remove)
EU-Project number / Contract (GA) number
- 617989 (2)
- 241719 (1)
- 242175 (1)
- EU-1650-0006 (1)
This predefined analysis of the European Forsteo Observational Study (EFOS) aimed to describe clinical fracture incidence, back pain, and health-related quality of life (HRQoL) during 18 months of teriparatide treatment and 18 months post-teriparatide in the subgroup of 589 postmenopausal women with osteoporosis aged ≥75 years. Data on clinical fractures, back pain (visual analogue scale, VAS), and HRQoL (EQ-5D) were collected over 36 months. Fracture data were summarized in 6-month intervals and analyzed using logistic regression with repeated measures. A repeated-measures model analyzed changes from baseline in back pain VAS and EQ-VAS. During the 36-month observation period, 87 (14.8 %) women aged ≥75 years sustained a total of 111 new fractures: 37 (33.3 %) vertebral fractures and 74 (66.7 %) nonvertebral fractures. Adjusted odds of fracture was decreased by 80 % in the 30 to <36–month interval compared with the first 6-month interval (P < 0.009). Although the older subgroup had higher back pain scores and poorer HRQoL at baseline than the younger subgroup, both age groups showed significant reductions in back pain and improvements in HRQoL postbaseline. In conclusion, women aged ≥75 years with severe postmenopausal osteoporosis treated with teriparatide in normal clinical practice showed a reduced clinical fracture incidence by 30 months compared with baseline. An improvement in HRQoL and, possibly, an early and significant reduction in back pain were also observed, which lasted for at least 18 months after teriparatide discontinuation when patients were taking other osteoporosis medication. The results should be interpreted in the context of an uncontrolled observational study.