Refine
Has Fulltext
- yes (319)
Is part of the Bibliography
- yes (319)
Year of publication
Document Type
- Journal article (187)
- Doctoral Thesis (131)
- Review (1)
Keywords
- NFATc1 (15)
- apoptosis (14)
- NFAT (10)
- immunohistochemistry (10)
- lymphoma (10)
- Transkriptionsfaktor (9)
- Apoptose (8)
- B-Zell-Lymphom (8)
- CXCR4 (8)
- DLBCL (8)
- Non-Hodgkin-Lymphom (8)
- T-Lymphozyt (7)
- cancer (7)
- prognosis (7)
- Apoptosis (6)
- Lymphom (6)
- T cells (6)
- breast cancer (6)
- gene expression (6)
- glioblastoma (6)
- multiple myeloma (6)
- thymoma (6)
- thymus (6)
- B cells (5)
- Lymphome (5)
- Proliferation (5)
- astrocytoma (5)
- follicular lymphoma (5)
- glioblastoma multiforme (5)
- recurrence (5)
- therapy (5)
- Amplifikation (4)
- Autoaggressionskrankheit (4)
- EGFR (4)
- FISH (4)
- Fluoreszenz-in-situ-Hybridisierung (4)
- Follikuläres Lymphom (4)
- Immunhistochemie (4)
- Immuntherapie (4)
- Krebs <Medizin> (4)
- Microarray (4)
- NF-AT (4)
- Prognose (4)
- Thymom (4)
- Thymus (4)
- amplification (4)
- brain (4)
- chemokine receptor (4)
- expression (4)
- forensic neuropathology (4)
- gene regulation (4)
- mRNA (4)
- machine learning (4)
- metastasis (4)
- relapse (4)
- thymic carcinoma (4)
- transcription factors (4)
- B-Lymphozyten (3)
- Brustkrebs (3)
- CGH (3)
- EBV (3)
- Ependymom (3)
- Genexpression (3)
- Histopathologie (3)
- Hodgkin lymphoma (3)
- Immunglobulin M (3)
- Keimzentrum (3)
- Lymphknoten (3)
- Lymphoma (3)
- Lymphozyten (3)
- MALT1 (3)
- MYC (3)
- Malignes Lymphom (3)
- Medizin (3)
- Myasthenia gravis (3)
- NRF2 (3)
- PET/CT (3)
- Pathologie (3)
- T-cell lymphoma (3)
- adrenocortical carcinoma (3)
- biomarker (3)
- brain tumor (3)
- cerebrospinal fluid (3)
- comparative genomic hybridization (3)
- diffuse large B-cell lymphoma (3)
- flow cytometry (3)
- forensic neurotraumatology (3)
- germinal center (3)
- glioma (3)
- loss of heterozygosity (3)
- melanoma (3)
- monoclonal antibody (3)
- myasthenia gravis (3)
- neuronal differentiation (3)
- poor prognosis (3)
- positron emission tomography (3)
- protein (3)
- surgical oncology (3)
- AICD (2)
- ATF4 (2)
- Angeborene Immunität (2)
- Antigen (2)
- Antikörper (2)
- B-cell lymphoma (2)
- BCL6 (2)
- CD30 (2)
- CRISPR/Cas9 (2)
- CXCR2 (2)
- Colonkrebs (2)
- Cushing’s syndrome (2)
- Deletion (2)
- Differenzierung (2)
- EMT (2)
- Epidermaler Wachstumsfaktor-Rezeptor (2)
- Epstein-Barr-Virus (2)
- Expression (2)
- FFPE (2)
- FGFR (2)
- Glioblastoma (2)
- Graft-versus-leukemia (2)
- HNSCC (2)
- Hodgkin (2)
- Humorale Immunität (2)
- Immuncytochemie (2)
- Immunglobuline (2)
- Immunologie (2)
- Immunotherapy (2)
- Immunsystem (2)
- KEAP1 (2)
- Krebs (2)
- LOH (2)
- Lymphogranulomatose (2)
- MALT (2)
- MALT-Lymphom (2)
- MALT-lymphoma (2)
- MPS1 (2)
- Magenkarzinom (2)
- Magenkrebs (2)
- Mammakarzinom (2)
- Mantelzell-Lymphom (2)
- Mantle cell lymphoma (2)
- Maus (2)
- Methylation (2)
- Methylierung (2)
- Mikrosatellitenanalyse (2)
- Mikrosatelliteninstabilität (2)
- Molekularbiologie (2)
- Monoklonaler Antikörper (2)
- Multiple Myeloma (2)
- NAFLD (2)
- NASH (2)
- NHL (2)
- NSCLC (2)
- Nekrose (2)
- Neuroinflammation (2)
- Nfatc1 (2)
- Onkogen (2)
- PD-L1 (2)
- PET (2)
- PTCL (2)
- Plattenepithelcarcinom (2)
- Protein p53 (2)
- Rhabdomyosarcoma (2)
- SC-1 (2)
- Signaltransduktion (2)
- Speicheldrüse (2)
- T-Lymphozyten (2)
- T-Zell-Lymphome (2)
- T-Zellen (2)
- T-cell differentiation (2)
- TAF15 (2)
- TTK (2)
- Thymuskarzinome (2)
- Transkriptionsfaktoren (2)
- Tumor (2)
- Tumorimmunologie (2)
- Tumorsuppressorgen (2)
- USP28 (2)
- VEGF (2)
- alloreactive T cells (2)
- amplicon sequencing (2)
- angiogenesis (2)
- animal model (2)
- antigen (2)
- autoimmune disease (2)
- cancer stem cells (2)
- cancers and neoplasms (2)
- carcinomas (2)
- case report (2)
- cell staining (2)
- cell-cycle arrest (2)
- chemokine (2)
- chromosomal aberration (2)
- classification (2)
- cytotoxic T cells (2)
- development (2)
- discriminant analysis (2)
- endothelial cells (2)
- enzyme-linked immunoassays (2)
- ependymoma (2)
- extranodal (2)
- gastric carcinoma (2)
- gene (2)
- genetic aberrations (2)
- genetische Aberrationen (2)
- grade 3B (2)
- humoral immunity (2)
- imaging (2)
- immune response (2)
- immunohistochemistry techniques (2)
- immunotherapy (2)
- in vivo imaging (2)
- inflammation (2)
- innate immunity (2)
- keratinocytes (2)
- kidneys (2)
- low-grade glioma (2)
- lung cancer (2)
- malignant tumors (2)
- mantle cell lymphoma (2)
- messenger RNA (2)
- miRNA (2)
- mice (2)
- microenvironment (2)
- microsatellite instability (2)
- mitochondrial DNA (2)
- molecular diagnostics (2)
- molecular imaging (2)
- mouse models (2)
- mutation (2)
- mutations (2)
- natural immunity (2)
- natürliche Antikörper (2)
- natürliche Immunität (2)
- neuroinflammation (2)
- obesity (2)
- organoids (2)
- oxidative stress (2)
- p53 (2)
- pancreatic cancer (2)
- plasma cells (2)
- positron emission tomography/computed tomography (2)
- postnatal development (2)
- principal component analysis (2)
- proteomics (2)
- rat (2)
- receptor tyrosine kinases (2)
- regression analysis (2)
- regulatory T cells (2)
- senile lymphoproliferation (2)
- signal transduction (2)
- survival (2)
- targeted therapy (2)
- temozolomide (2)
- transcription (2)
- translocation (2)
- tumor immunology (2)
- tumor microenvironment (2)
- tumor suppressor gene (2)
- vestibular schwannoma (2)
- vitamin D (2)
- - (1)
- 16S-rRNA (1)
- 3D ex vivo models (1)
- 3D lung tumor tissue models (1)
- <sup>18</sup>F-FDG (1)
- <sup>68</sup>Ga-Pentixafor (1)
- AD-AID (1)
- ADAM9 (1)
- ADP-ribosylation toxins (1)
- AICDA (1)
- AID-ΔE4a (1)
- AIDS (1)
- AIRE (1)
- AKT-signaling (1)
- ALCL (1)
- ALK-1 (1)
- AMACR (1)
- APECED (1)
- ATF5 (1)
- ATG7 (1)
- ATM (1)
- Aberrationen (1)
- Activation (1)
- Activation induced cell death/AICD (1)
- Adamantiades-Behçet disease (1)
- Adult (1)
- Akute Ösophagusnekrose (1)
- Allogenic hematopoietic stem cell transplantation (1)
- Alpha therapy (1)
- Alter (1)
- Alzheimerkrankheit (1)
- Amplicon Sequencing (1)
- Anergy (1)
- Aneuploidie (1)
- Antibodies (1)
- Antigen CD30 (1)
- Antigen CD8 (1)
- Antiparanodal Autoantibodies (1)
- Aphthae (1)
- Apoptose-Resistenz (1)
- Apoptoseinduktion (1)
- Appendizitis (1)
- Autoantikörper (1)
- Autoimmune diseases (1)
- Autoimmunerkrankung (1)
- Autoimmungastritis (1)
- Autoimmunkrankheit (1)
- Autoimmunregulator (1)
- Autoregulation (1)
- B Lymphocytes (1)
- B cell lymphoma (1)
- B cell malignancies (1)
- B lymphocytes (1)
- B-Lymphozyt (1)
- B-Lymphozyt-Tumor (1)
- B-MYB (1)
- B-Zell Lymphome (1)
- B-Zell-Leukämie (1)
- B-Zell-Rezeptor (1)
- B-Zellen Differenzierung (1)
- B-cell Lymphome (1)
- B-cell differentiation (1)
- B-cells (1)
- B-lymphocytes (1)
- BAC-Konstrukt (1)
- BAC-construct (1)
- BARB-4 (1)
- BCL1 rearrangement (1)
- BCL1-Rearrangement (1)
- BCL2 (1)
- BIRC7 (1)
- BLIMP1 (1)
- BRMS1 (1)
- Barrett-Ösophagus (1)
- Bauchfellentzündung (1)
- Bauchspeicheldrüsenkrebs (1)
- Bcl-2-Gen (1)
- Bcl-2-gene (1)
- Behçet’s disease (1)
- Bevacizumab (1)
- Bioluminescence imaging (1)
- Biomarker (1)
- Bisphosphonate (1)
- Blasenkrebs (1)
- Blimp-1 (1)
- Blimp1 (1)
- Blinddarmentzündung (1)
- Bone chips (1)
- Bone marrow cells (1)
- Bone marrow transplantantation (1)
- Bone marrow transplantation (1)
- Braak (1)
- Breast-cancer (1)
- Bruton Tyrosine Kinase (1)
- Burkitt (1)
- B‐cell lymphoma (1)
- C-Myc (1)
- C/EBP (1)
- C/EBP-Beta (1)
- C/EBPβ (1)
- C3 (1)
- CABG-operation (1)
- CBP (1)
- CCR7 (1)
- CD 27 (1)
- CD-Marker (1)
- CD/metabolism (1)
- CD117 (1)
- CD133 (1)
- CD27 (1)
- CD274 (1)
- CD30-Rezeptor (1)
- CD319 (1)
- CD4+ (1)
- CD40 ligand (1)
- CD5-positive B-Lymphozyten (1)
- CD56 (1)
- CD8 (1)
- CD9 (1)
- CFR-1 (1)
- CHAC1 (1)
- CIITA (1)
- CK5 (1)
- COVID-19 (1)
- CRC (1)
- CRISPR-Cas9 (1)
- CRISPR/Cas-Methode (1)
- CS1 (1)
- CSF (1)
- CTL function (1)
- CTNNB1 (1)
- CX5461 (1)
- CXCL5 (1)
- CXCL8 (1)
- CXCR1 (1)
- CXCR4/SDF-1 (1)
- CXCR5 (1)
- CXCR7 (1)
- CYP24A1 (1)
- CYP2W1 (1)
- Calcineurin (1)
- Calcium (1)
- Cancer (1)
- Cancer genetics (1)
- Cancer treatment (1)
- Cancer/Testis Antigene (1)
- Cancer/Testis antigen (1)
- Candida (1)
- Carcinogenese (1)
- Cartilage Oligomeric Matrix Protein (1)
- Caspase 12 (1)
- Ccl2 (1)
- Chains (1)
- Checkpoint-Inhibitor (1)
- Chemokin (1)
- Chemokin CXCL10 (1)
- Chemokine (1)
- Chemokinrezeptor (1)
- Chemotherapy (1)
- Childhood (1)
- Chromosom 9 (1)
- Chromosome 18 (1)
- Chromosomenaberration (1)
- Cisplatin (1)
- Clonality (1)
- Clonality analysis (1)
- Cocktail (1)
- Cushings syndrome (1)
- Cushing’s disease (1)
- Cytogenetik (1)
- Cytotoxizität (1)
- DCIS (1)
- DCR1 (1)
- DEL(5Q) (1)
- DHAP (1)
- DLBCL multilobated (1)
- DLBCL multilobuliert (1)
- DLBL (1)
- DNA hypermethylation (1)
- DNA methylation (1)
- DNA-PK (1)
- DNS-Reparatur (1)
- DOTATOC (1)
- DT40 cells (1)
- DWI (1)
- Defined burkitts lymphoma (1)
- Delta Repertoire (1)
- Dendritic cells (1)
- Dendritische Zelle (1)
- Design (1)
- Diabetes mellitus (1)
- Diagnostik (1)
- Dickdarmkrebs (1)
- Differentielle Genexpression (1)
- Diffuse großzellige B-Zell Lymphome (1)
- Diffuses großzelliges B-Zell Lymphom (1)
- Diphosphonate (1)
- Durchflusszytometrie (1)
- E-Learning (1)
- E-cadherin (1)
- EAHP/SH bone marrow workshop (1)
- EATCL (1)
- EBER in situ hybridization (1)
- EGF (1)
- EL-4 (1)
- EL-4 Zellen (1)
- ERM proteins (1)
- ETL (1)
- EZH1 (1)
- EZH2 (1)
- Endothel (1)
- Enteropathie-Typ (1)
- Entzündung (1)
- Enzephalitis (1)
- Epidemiological study (1)
- Epigenese (1)
- Epigenetics (1)
- Epigenetik (1)
- Epitope (1)
- Epstein-Ba (1)
- Epstein-Barr virus (1)
- Ewing-Sarkom (1)
- Extrafollikuläre Aktivierung (1)
- Extraocular eye muscles (1)
- F-19 MRI (1)
- FADD (1)
- FARS1 (1)
- FDG PET/CT (1)
- FGF-pathway (1)
- FINCA (1)
- FL (1)
- FL3B (1)
- FLT-PET (1)
- FTIR spectroscopy (1)
- Factor receptor (1)
- Fas (1)
- Fibrin glue (1)
- Fluoreszenzaktivierter Zellsortierer (1)
- Forskolin (1)
- Frequency (1)
- Frühdiagnostik (1)
- Frühphase (1)
- GABP (1)
- GATA-3 (1)
- GFAP (1)
- GIST (1)
- GLP-1 (1)
- GRP78 (1)
- GSH (1)
- Gallium (1)
- Gen-Anordnung (1)
- Genamplifikation (1)
- Gene (1)
- Gene-expression (1)
- Genetik (1)
- Genitoanal region (1)
- Genome wide analysis (1)
- Genregulation (1)
- Gewebemicroarray (1)
- Gewebeverlust (1)
- Glioma stem cells (1)
- Glykosylierung (1)
- Grad 3B (1)
- Grading (1)
- Graft-versus-host-disease (1)
- GvHD (1)
- GvL (1)
- Gvhd (1)
- H. pylori Gastritis (1)
- H.pylori gastritis (1)
- H2O2 (1)
- H3K27me3 (1)
- HD (1)
- HER2 conversion (1)
- HER2 targeted therapy (1)
- HER2-low (1)
- HHV8 (1)
- HNSC (1)
- HPK1 (1)
- HSC (1)
- Hals-Nasen-Ohren-Heilkunde (1)
- Hals-Nasen-Ohren-Tumor (1)
- Hans algorithm (1)
- Harnblasenkarzinom (1)
- Hautlymphom (1)
- Head (1)
- Head and neck cancers (1)
- Heavy chain mutations (1)
- Helicobacter (1)
- Helicobacter pylori (1)
- Helicobacter-pylori-Infektion (1)
- High-resolution (1)
- Hirntumor (1)
- Histologie (1)
- Histone deacetylase inhibition (1)
- Histopathology (1)
- Hitzeschockprotein (1)
- Hodgkin-Lymphom (1)
- Hodgkin´s disease (1)
- Hsp90 (1)
- Human antibodies (1)
- Humane Antikörper (1)
- Hybridom (1)
- Hypercortisolism (1)
- Hypermutation (1)
- Hypopharynxkarzinom (1)
- IDH (1)
- IDH1/2 (1)
- IFN (1)
- IFN-γ (1)
- IGF1R (1)
- IGF2BP3 (1)
- IL-10 (1)
- IL-17 (1)
- IL-2 (1)
- IL-4 (1)
- IL-5 (1)
- IL2 (1)
- IMP3 (1)
- IR (1)
- IRF4 (1)
- Ibrutinib (1)
- IgG4 (1)
- IgM (1)
- IgM isotyp (1)
- Images (1)
- Immun-Checkpoint (1)
- Immunbiologie (1)
- Immunfluoreszenz (1)
- Immunhistologie (1)
- Immunisierung (1)
- Immunität <Medizin> (1)
- Immunmodulation (1)
- Immunology (1)
- Immunoreceptors (1)
- Immunosuppression (1)
- Immunphänotyp (1)
- Immunreaktion (1)
- Immunrezeptoren (1)
- In-vivo (1)
- Inflammation (1)
- Intestinal Intraepithelial Lymphocy (1)
- Intrakranielle Blutung (1)
- Involution (1)
- Iron-oxide (1)
- Irradiation (1)
- Isoformen (1)
- JNK (1)
- JUN (1)
- KIT (1)
- KRAS (1)
- KRAS biomarker signatures (1)
- Kaposi sarcoma (1)
- Keimzelltumor (1)
- Keimzentrumsreaktion (1)
- Keratine (1)
- Keratinozyt (1)
- Ki-67 (1)
- KiSS1 (1)
- Kidney cancer (1)
- Kiefernekrosen (1)
- Killerzelle (1)
- Kindesalter (1)
- Klarzellsarkom (1)
- Klassifikation (1)
- Klonale Evolution (1)
- Klonalitaetsanalysen (1)
- Klonalität (1)
- Knochenmetastase (1)
- Knochensialoprotein (1)
- Knock-out-Mäuse (1)
- Kolonkarzinom (1)
- Komparative Genomische Hybridisierung (1)
- Komparative genomische Hybridisierung (1)
- Krebstherapie (1)
- Kreuzreaktion (1)
- LESA (1)
- LGA (1)
- LITAF (1)
- LM-1 (1)
- Lagerungsmedium (1)
- Laminin (1)
- Langfristige Prognose (1)
- Larynxkarzinom (1)
- Lateral suboccipital craniectomy (1)
- Lesions (1)
- Leukoplakia (1)
- Leukoplakie (1)
- Lichen planus (1)
- Lichen ruber planus (1)
- Ligand (1)
- Lipom (1)
- Liposarkom (1)
- Lipotoxizität (1)
- Lokalisation (1)
- Low grade Astrocytoma (1)
- Lung-cancer (1)
- Lymph2Cx assay (1)
- Lymphadenitis (1)
- Lymphdrüse (1)
- Lymphocytes (1)
- Lymphomas (1)
- Lymphozyt (1)
- Lymphsystem (1)
- MAGE A3 (1)
- MAGE-A (1)
- MAGE-A-Antigene (1)
- MAGE-A-antigens (1)
- MALT lymphoma (1)
- MALT-Lymphome (1)
- MALT-Typ Lymphome (1)
- MALT-type lymphoma (1)
- MALT1-Gen (1)
- MALT1-gene (1)
- MAPK (1)
- MCL (1)
- MDS (1)
- MEF2D (1)
- MEK/ERK-signaling (1)
- MGMT (1)
- MGMT promoter methylation (1)
- MHC (1)
- MITF-low (1)
- MIZ1 (1)
- MMP2 (1)
- MMP9 (1)
- MTB (1)
- MTCH2 (1)
- MTX (1)
- Malignancies (1)
- Malt (1)
- Mantelzellen (1)
- Mantelzelllymphom (1)
- Marginal zone lymphomas (1)
- Marginalzonen-B-Zell-Lymphom (1)
- Marginalzonen-Lymphome (1)
- Masaoka (1)
- Maschinelles Lernen (1)
- Mediastinum (1)
- Medical research (1)
- Mensch (1)
- Merlin (1)
- Metastases (1)
- Mikroglia (1)
- Mikrosatelliten (1)
- Mikrosatelliten-Instabilität (1)
- Milz (1)
- Mismatch (1)
- Molecular pathogenesis (1)
- Molekulargenetik (1)
- Monoklonaler Antikrper (1)
- Morphometrie (1)
- Mukosa-assoziiertes lymphatisches Gewebe (1)
- Multigentests (1)
- Multiple Sklerose (1)
- Mundhöhlentumor (1)
- Muskelzelle (1)
- Mutation (1)
- MyD88 (1)
- Myasthenia gravi (1)
- Myb-MuvB (1)
- Myc (1)
- Myeloma cells (1)
- Myelomas (1)
- Mykose (1)
- Mysthenia Gravis (1)
- N-Glykosylierungsmotive (1)
- N-glycosylation sites (1)
- NEC (1)
- NET (1)
- NF-KAPPA-B (1)
- NF-\(\kappa\)B pathway (1)
- NF-κB (1)
- NFAT in EAE (1)
- NFATc (1)
- NFATc1 sumoylation (1)
- NFATc1/αA (1)
- NFATc3 (1)
- NFATs (1)
- NFE2L2 (1)
- NFkappaB (1)
- NGS (1)
- NHLRC2 (1)
- NIH-3T3 (1)
- NLPHL (1)
- NORM-1 (1)
- NR3C1 (1)
- NY-ESO 1 (1)
- Natürliche Killerzelle (1)
- Nebennierenrinde (1)
- Nebennierenrindenkrebs (1)
- Nestin (1)
- Neurodegeneration (1)
- Nicotinischer Acetylcholinrezeptor (1)
- Nierenzellcarcinom (1)
- Nodo-parandopathy (1)
- Non Hodgkin Lymphoma (1)
- Non Hodgkin Lymphome (1)
- Non-Hodgkin Lymphome (1)
- Non-Hodgkin-Lymphome (1)
- Nrf2 (1)
- Nuclear Factor of Activated T cells (NFAT) (1)
- Nuclear expression (1)
- Nur77 (1)
- OBF-1 OCA-B (1)
- OCT-1-deficient mice (1)
- Oncotype DX® (1)
- OncotypeDX (1)
- OncotypeDX\(^{®}\) (1)
- Oral Precancer (1)
- Oral mucosa (1)
- Oral squamous cell carcinoma (1)
- Organoids (1)
- Osteoarthrose (1)
- Osteogeneration (1)
- Osteopontin (1)
- PAI-1 (1)
- PAM-1 (1)
- PAT-LM1 (1)
- PAT-SM6 (1)
- PCDHGC3 (1)
- PCI-32765 (1)
- PD-1 (1)
- PI3K (1)
- PKA (1)
- PLAG1 rearrangement (1)
- POLKADOTS (1)
- PRDI-BF1 (1)
- PRRT (1)
- PTCL NOS (1)
- PTEN (1)
- Paraffin (1)
- Parkinson (1)
- Parkinsons disease (1)
- Parkinson’s disease (1)
- Particles (1)
- Pathohistologie (1)
- Pathway (1)
- Pentixafor (1)
- Phylogenetik (1)
- Phänotyp (1)
- Plaques und Tangels (1)
- Plasmozytom (1)
- Plattenepithelkarzinom (1)
- Polyadenylierung (1)
- Polymerase-Kettenreaktion (1)
- Positron emission tomography (1)
- Positronen-Emissions-Tomografie (1)
- Posttranskriptionelle Regulation (1)
- Pou2af1 (1)
- Primär kutane Marginalzonen-Lymphome (1)
- Primär kutanes Lymphom (1)
- Profiling (1)
- Prog (1)
- Prognosis (1)
- Proliferation index (1)
- Proliferationsindex (1)
- Promoter (1)
- Promotor (1)
- Promotor <Genetik> (1)
- Prophylaxe (1)
- Prostata-DNA-Datenbank (1)
- Prostatakarzinom (1)
- Protein-DNA-Interaktion (1)
- Protein-Protein-Interaktion (1)
- Präkanzerose (1)
- Präkanzerosen (1)
- R-CHOP (1)
- RCC (1)
- RNA Expression (1)
- RNA probe (1)
- RNA-Sequenzierung (1)
- RNAPOL1 (1)
- RNAScope (1)
- ROS (1)
- RPS27 (1)
- RYGB (1)
- Rac (1)
- Raf (1)
- Random Forest (1)
- Rats (1)
- Receptor-Tyrosine Kinases (1)
- Regulatorgen (1)
- Regulatory-cells (1)
- Reifung (1)
- Renal cell carcinoma (1)
- Restriktionsfragmentlängenpolymorphismus (1)
- Retroperitoneum (1)
- Retroviraler Gentransfer (1)
- Rezeptor-Expression (1)
- Rezeptor-Tyrosinkinasen (1)
- Rhabdomyosarkom (1)
- Rheumatoid arthritis (1)
- Rheumatoide Arthritis (1)
- Rho-GTPases (1)
- Ribosomale RNS (1)
- Richter's syndrome (1)
- Richter-Syndrom (1)
- Risiko (1)
- Risikofaktoren (1)
- Risk factors (1)
- Rituximab plus (1)
- Riutximab (1)
- Rotatorenmanschettensyndrom (1)
- S-Phase-Fraktion (1)
- S-phase fraction (1)
- SAM-6 (1)
- SARS-CoV-2 (1)
- SB332235 (1)
- SGN-35 (1)
- SHARP-Screening (1)
- SIV (1)
- SLC7A11 (1)
- SOAT1 (1)
- SSTR (1)
- STEAP-1 (1)
- Sarkom (1)
- Schleimhaut (1)
- Schleimhaut-Ulzera (1)
- Schütteltrauma (1)
- Senile Lymphoproliferation (1)
- Sequenzdaten (1)
- Skelettmuskulatur (1)
- Soft-tissue infection (1)
- Sox9 (1)
- Speicheldrüsenkrebs (1)
- Speiseröhre (1)
- SphK1 (1)
- Spinal dissemination (1)
- Spindle cell (1)
- Spleen (1)
- Sporadic Alzheimer’s disease (1)
- Sporadische Alzheimer-Demenz (1)
- Sprue (1)
- Squamous cell carcinoma (1)
- Staging (1)
- Stammzelltransplantation (1)
- Stanzbiopsie (1)
- Starry Sky (1)
- Sternberg-Riesenzelle (1)
- Sunitinib (1)
- Suppression (1)
- Surgery (1)
- Survival (1)
- Synovialmembran (1)
- Synovialsarkom (1)
- T Lymphocytes (1)
- T Zellen (1)
- T cell differentiation (1)
- T cell receptors (1)
- T helper cells (1)
- T lymphocyte (1)
- T(H)17 cells (1)
- T-Helfer Zellen (1)
- T-Lymphozyt info (1)
- T-Zell-Entwicklung (1)
- T-Zell-Lymphom (1)
- T-Zell-Marker (1)
- T-Zell-Reifung (1)
- T-Zell-Rezeptor (1)
- T-Zelldifferenzierung (1)
- T-cell non-Hodgkin's lymphomas (1)
- T-cell receptor (1)
- T-cell transfer (1)
- T-cells (1)
- T-follicular regulatory cell (1)
- T-lymphocytes (1)
- TAD-A (1)
- TCR signaling cascade (1)
- TGF-alpha (1)
- TP53 (1)
- TP53 mutations (1)
- T\(_{reg}\) and Foxp3 (1)
- Targeted Therapies (1)
- Targets (1)
- Telepathologie (1)
- Temozolomide (1)
- Th (1)
- Th17 (1)
- Therapie (1)
- Thomas (Arzt) (1)
- Thymocytes (1)
- Thymoma (1)
- Thymome (1)
- Thymopoese (1)
- Thymuskrankheit (1)
- Tissue-Microarray-Technik (1)
- Tlymphozyten (1)
- Tolerance (1)
- Toleranz <Biologie> (1)
- Tonsilla (1)
- Tracking (1)
- Transcription factors (1)
- Transcription-factor (1)
- Transkription <Genetik> (1)
- Transkriptionfaktoren (1)
- Transkriptionsfaktor NF-KappaB (1)
- Transkriptionsfaktor info (1)
- Translational research (1)
- Translokation (1)
- Translokation t(11;14)(q13;q32) (1)
- Translokation t(11;18) (1)
- Transplantat-Wirt-Reaktion (1)
- Transplantatabstoßung (1)
- Tregs (1)
- Trisomie (1)
- Tumor Microenvironment (1)
- Tumor Treating Fields (TTFields) (1)
- Tumor-necrosis-factor (1)
- Tumorantigen (1)
- Tumorimmunity (1)
- Tumorimmunität (1)
- Tumornephrektomie (1)
- Tumorprogression (1)
- Tumorzell-Migration (1)
- Tumour markers (1)
- Typ 1 Muskelfasern (1)
- Tyrosine kinase inhibition (1)
- UMAP (1)
- USP8 (1)
- USP9X (1)
- UV-Strahlung (1)
- Urothelkarzinom (1)
- Usage (1)
- Uveitis (1)
- VDR (1)
- VH-JgG Mutationen (1)
- Vascular endothelial Growth Factor (1)
- Venenlagerung (1)
- Verlust der Heterozygosität (1)
- Vielfalt (1)
- Virtual Microscopy (1)
- Virtuelle Mikroskopie (1)
- Vitamin-K-Mangel-Blutung (1)
- Vorhersage (1)
- WHO (1)
- WHO-Klassifikation (1)
- WNT signaling (1)
- WTAP (1)
- Waldeyer-Ring (1)
- Waldeyer´s ring (1)
- Waldeyer’s tonsillar ring (1)
- Wilms tumour (1)
- XIAP (1)
- YAP (1)
- Zellmigration (1)
- Zelltod (1)
- Zellzyklus (1)
- Zentroblastisches Lymphom (1)
- Zytokeratin (1)
- [18F]FDG-PET-CT (1)
- [18F]Fluorodeoxythymidine (1)
- [\(^{68}\)Ga] pentixafor (1)
- [\(^{68}\)Ga]Pentixafor (1)
- \(^{68}\)Ga-Pentixafor (1)
- abdominal lymph node metastases (1)
- aberrations (1)
- abnormalities (1)
- actin (1)
- actin filament (1)
- actin filaments (1)
- activation (1)
- acute esophageal necrosis (1)
- acute graft-versus host disease (1)
- acute graft-versus-host disease (1)
- acute lymphoblastic leukemia (1)
- acute lymphocytic leukaemia (1)
- acute myeloid leukaemia (1)
- acute myeloid leukemia (1)
- adenomas (1)
- adenosine kinase (1)
- adhesion (1)
- adrenal glands (1)
- adrenal tumor (1)
- adrenocortical (1)
- adrenocortical cancer (1)
- adrenocortical tissues (1)
- adrenocortical tumors (1)
- affinity (1)
- aggressive B‐cell lymphoma (1)
- allergy (1)
- allogenic stem cell transplantation (1)
- allografts (1)
- alternative splicing (1)
- aluminum granuloma (1)
- aminoacyl‐tRNA synthetases (1)
- amplifications (1)
- amyloidoma (1)
- amyloidosis (1)
- anaplasia (1)
- anaplastic large T-cell-lymphoma (1)
- anaplastic large cell lymphoma (1)
- anaplastic large cell lymphoma (ALCL) (1)
- anaplastic medulloblastoma (1)
- anaplastisch-großzellige T-Zell-Lymphome (1)
- aneuploidy (1)
- aneusomy (1)
- angeborenes Immunsystem (1)
- annecin-V (1)
- anti-CD30 drug conjugate (1)
- antibodies (1)
- antibody (1)
- antibody-mediated (1)
- antigen loss (1)
- antigens (1)
- antikörpervermittelt (1)
- antioxidant function (1)
- aortic adventitia (1)
- aortokoronarer Venenbypass (1)
- apoptosis, Myc (1)
- appendicitis (1)
- arteriovenous loop (1)
- atopic dermatitis (1)
- atrial natriuretic peptide (1)
- aurora kinase A polymorphism (1)
- aurorakinase B (1)
- autoantibodies (1)
- autoantibody (1)
- autoantigen (1)
- autoimmune regulator (1)
- autoimmunregulator (1)
- autoimmuns gastitis (1)
- autologous transplantation (1)
- autophagy (1)
- axonally transported proteins (1)
- azacitidine (1)
- b-cell lymphoma of the MALT type (1)
- b-cell lymphomas (1)
- b-cell receptor (1)
- bacterial toxins (1)
- behavior (1)
- benige tumor (1)
- binding (1)
- binding proteins (1)
- biofluid (1)
- bioinformatic clustering (1)
- biological sciences (1)
- biomarker prediction (1)
- biopsy (1)
- biosynthesis (1)
- bisphosphonate (1)
- blood–brain barrier (1)
- bone disease (1)
- bone marrow biopsy (1)
- bone marrow cells (1)
- bone marrow–spleen–liver large B‐cell lymphoma (1)
- bone metastases (1)
- bone metastasis (1)
- bone sialoprotein (1)
- boolean in silico models (1)
- botulinum C2 toxin (1)
- breast carcinoma (1)
- buparlisib (1)
- c-MYC (1)
- c-kit (1)
- c-myc (1)
- c/ebp (1)
- cAMP (1)
- calcium (1)
- cancer care (1)
- cancer detection (1)
- cancer diagnosis (1)
- cancer metabolism (1)
- cancer of unknown primary (CUP) (1)
- cancer therapy (1)
- cancer treatment (1)
- carcinogenesis (1)
- carcinoma (1)
- carcinoma metastases to pancreas (1)
- cardiac transplantation (1)
- cardiomyocyte proliferation (1)
- cartilage oligomeric matrix protein (1)
- caspase-3 (1)
- catenin (1)
- caveolin-1 (1)
- cell binding (1)
- cell cycle and cell division (1)
- cell death (1)
- cell of origin (1)
- cells (1)
- cellular uptake (1)
- centroblastic lymphoma of the multilobated subtype (1)
- cerebellum (1)
- cerebral cortex (1)
- cerebropulmonary disease (1)
- cetuximab (1)
- checkpoint inhibition (1)
- chemokine receptor-4 (1)
- chemokinereceptor (1)
- childhood (1)
- childhood interstitial lung disease (1)
- children (1)
- children´s interstitial lung disease (chILD) lipoid pneumonia (1)
- cholesterol pneumonia (1)
- cholesterol pneumonitis (1)
- chromatin (1)
- chromosome 18 (1)
- chromosome 9 (1)
- chromosomes (1)
- chronic lymphocytic leukemia (1)
- chronische B-Zell Leukaemie (1)
- chronophin (1)
- classical Hodgkin lymphoma (1)
- cleavage (1)
- clonal evolution (1)
- clonality (1)
- clostridium botulinum (1)
- coactivator OBF-1 (1)
- coated vesicles (1)
- cofilin (1)
- colorectal carcinoma (1)
- combined immunodeficiency (1)
- combined therapy (1)
- complement system (1)
- complex (1)
- confocal Raman imaging (1)
- consensus DNA (1)
- cross-priming (1)
- cross-reaction (1)
- cutaneous T-cell-lymphoma (1)
- cycle (1)
- cyclophsophamide (1)
- cyclosporine A (1)
- cytokeratin (1)
- cytotoxicity (1)
- damage (1)
- damage responses (1)
- deformation (1)
- deletions (1)
- diagnosis (1)
- diagnostics (1)
- diffuse large B-Cell lymphoma (1)
- diffuse large B‐cell lymphoma (1)
- disease (1)
- distinct (1)
- down regulation (1)
- drug abuse (1)
- drug resistance (1)
- drug therapy (1)
- eGFP (1)
- early (1)
- early breast cancer (1)
- early diagnosis (1)
- echocardiography (1)
- ectopic lymphoid follicle (1)
- egfr (1)
- ejection fraction (1)
- embryonic lethality (1)
- encephalitis (1)
- encephalitis lethargica (1)
- endothelium (1)
- enhancer (1)
- enteropathy-type (1)
- ependyoma (1)
- ephitelial cells (1)
- epigenetics (1)
- epithelial markers (1)
- epithelium (1)
- extrafollicular activation (1)
- extramedullary disease (1)
- features (1)
- ferroptosis (1)
- fetaler Acetylcholinrezeptor (1)
- fibroblast activation protein (1)
- fixation (1)
- fluorenscence (1)
- fluorescence in situ hybridisation (1)
- fluorescent-in -situ-hybridization (1)
- foetal typ acetylcholine receptor (1)
- follicular T helper cells (1)
- follicular lymphoma reactive germinal centers (1)
- follicular regulatory T cell (1)
- follikuläre Lymphome erhaltene reaktive Keimzentren (1)
- follikuläre regulatorische T-Zelle (1)
- follikulärer (1)
- forecasting (1)
- formalin (1)
- formalin-fixed (1)
- formalin-fixiert (1)
- functional characterization (1)
- fungal infection (1)
- gRNA-only (1)
- gastric bypass (1)
- gastrointestinal infections (1)
- gefitinib (1)
- genetic loci (1)
- genetics (1)
- genomic aberrations (1)
- germinal center formation (1)
- germline mutation (1)
- gesolin function (1)
- glioblastoma multiforme (GBM) (1)
- glucocorticoid excess (1)
- glutaminase inhibition (1)
- goldfish optic nerve (1)
- group 3 (1)
- growth (1)
- growth pattern (1)
- growth patterns (1)
- growth-associated protein (1)
- großzellige (1)
- gut–liver axis (1)
- head and neck (1)
- head and neck cancer (1)
- heart (1)
- heart failure (1)
- heatshockprotein (1)
- helicobacter (1)
- helicobacter pylori (1)
- helper T cells (1)
- helper T-cells (1)
- hematopoiesis (1)
- hematopoietic stem cells (1)
- hemophagocytosis (1)
- hepcidin (1)
- high numbers (1)
- high-dose chemotherapy (1)
- high-resolution analysis (1)
- high-risk Prostate Cancer (1)
- high‐grade B‐cell lymphoma (1)
- hippocampal stem cells (1)
- histopathology (1)
- hnRNP K (1)
- hormones (1)
- human (1)
- human antibodies (1)
- human brain (1)
- human cerebral endothelial cells (1)
- human genome (1)
- human monoclonal antibodies (1)
- human monoclonal antibody LM-1 (1)
- human monoclonal antibody PAM-1 (1)
- humane Antikörper (1)
- humane monoklonale Antikörper (1)
- humaner monoklonaler Antikörper LM-1 (1)
- humaner monoklonaler Antikörper PAM-1 (1)
- hybridization (1)
- hyper-IgM syndrome type 2 (HIGM2) (1)
- hypercortisolism (1)
- hypermutation (1)
- iiron transporter (1)
- immune cells (1)
- immune check inhibitor (1)
- immune checkpoint blockade (1)
- immune checkpoint inhibitor (ICI) (1)
- immune evasion (1)
- immune infiltration (1)
- immune system (1)
- immunhistochemical analysis of DLBCL (1)
- immunhistochemisch (1)
- immunhistochemische Analyse von DLBCL (1)
- immunity (1)
- immunocytochemistry (1)
- immunofuorescence double staining (1)
- immunoglobulin promoters (1)
- immunoglobuline (1)
- immunohistochemisty (1)
- immunohistological expression analysis (1)
- immunology and microbiology section (1)
- immunophenotype (1)
- immunotherapeutics (1)
- in silico analysis (1)
- in-situ-Hybridisierung (1)
- in-situ-hybridization (1)
- in-vitro (1)
- in-vivo (1)
- independent predictor (1)
- induction (1)
- induction of apoptosis (1)
- inflammation-induced tissue demage (1)
- innate Immunität (1)
- innate antibody (1)
- integrated stress response (1)
- integrin (1)
- interaction (1)
- interleukin-8 (1)
- interleukins (1)
- intestine (1)
- intracranial bleeding (1)
- intraosseous (1)
- intravascular large B‐cell lymphoma (1)
- invasion (1)
- involution (1)
- involvement (1)
- iron in parkinsonism (1)
- iron model (1)
- iron pathology (1)
- isoforms (1)
- karyotype (1)
- kidney cancer (1)
- kinase (1)
- kinases (1)
- kinetic mechanism (1)
- knock down (1)
- knock out mice (1)
- kolorektales Karzinom (1)
- komparative genomische Hybridisierung (1)
- kras (1)
- kras-Mutation (1)
- large cell transformation (1)
- latency type (1)
- lck (1)
- lesions (1)
- leukemia (1)
- lichen planus (1)
- lineage (1)
- lineage differentiation (1)
- lipid droplets (1)
- lipids (1)
- lipoblastoma (1)
- lipoid pneumonitis (1)
- lipotoxicity (1)
- liquid biopsy (1)
- liraglutide (1)
- livin (1)
- lung fibrosis (1)
- lymph node (1)
- lymph node stromal cells (1)
- lymph node transplantation (1)
- lymphatische Tumoren (1)
- lymphocyte (1)
- lymphocyte activation (1)
- lymphocyte differentiation (1)
- lymphocytes (1)
- lymphohistiocytosis (1)
- lymphoid aggregate (1)
- lymphoid hyperplasia (1)
- lymphoid-tissue (1)
- lymphoid-tissue lymphomas (1)
- lymphomas (1)
- mRNA expression (1)
- mTOR (1)
- major histocompatibility complex (1)
- malignancies (1)
- malt lymphoma (1)
- mammalian cells (1)
- mandible (1)
- mantel cell lymphoma (1)
- marcophages (1)
- marginal zone-B-cell-Lymphoma (1)
- marrow transplantation (1)
- mass cytometry (1)
- mast cells (1)
- mastocytosis (1)
- measles virus (1)
- mediastinum (1)
- medical research (1)
- medicine (1)
- membrane topology (1)
- membrane translocation (1)
- memory B cells (1)
- meningeal inflammation (1)
- mesenchymal markers (1)
- mesenteric lymph node (1)
- mesentery (1)
- messenger-RNA transport (1)
- metabolism (1)
- metagenomics (1)
- metastasis-associated in colon cancer 1 (MACC1) (1)
- methylation (1)
- miR-126 (1)
- miR-21 (1)
- microRNA-221 (1)
- microglia (1)
- microsatellite analysis (1)
- microsatellites (1)
- microvessel permeability (1)
- mikrobielle Diversität (1)
- mitochondriale DNA (1)
- mitochondriale DNA-Deletionen (1)
- mitosis (1)
- mitotane (1)
- mitotic genes (1)
- molecular marker (1)
- molecular subtypes (1)
- monoklonale Antikörper (1)
- monoklonaler Antikörper (1)
- morphometry (1)
- mouse model (1)
- mtDNA (1)
- mucosa-associated lymphatic tissue (1)
- mucosal ulcers (1)
- multifocal growth (1)
- multigene-array (1)
- multilobulierte centroblastische Lymphome (1)
- multiple Sclerosis immunomodulation Natalizumab (1)
- multiple sclerosis (1)
- multivariate Prognoseanalyse (1)
- multivariate data analysis (1)
- multi‐organ disease (1)
- murine homolog (1)
- mutant p53 (1)
- mutational targeting (1)
- myasthenia (1)
- mycosis fungoides (1)
- naive T-cell gene editing (1)
- natural IgG antibody (1)
- natural IgM antibodies (1)
- natural antibodies (1)
- natürliche IgM-Antikörper (1)
- natürlicher IgG-Antikörper (1)
- negative selection (1)
- nephroblastoma (1)
- nervous system (1)
- network (1)
- neurodegeneration (1)
- neurodegenerative disease (1)
- neuroendocrine tumor (1)
- neurogene Schädigung (1)
- neuromelanin (1)
- neuromucular disorders (1)
- neurooncology (1)
- neuropathology (1)
- neuroscience (1)
- neurotoxicity (1)
- neurovascular unit (1)
- neutral loss (1)
- next generation sequencing (1)
- niche (1)
- nicotinic acetylcholine receptor (1)
- nodal (1)
- nodal peripheral T-cell lymphoma (1)
- nodales peripheres T-Zell-Lymphom (1)
- nodular lymphcyte (1)
- non-GCB-Subtyp (1)
- non-GCB-like (1)
- non-Hodgkin lymphoma (1)
- non-hodgkin lymphoma (1)
- non-hodgkin-lymphoma (1)
- non-small cell lung cancer (1)
- noncoding RNAs (1)
- normal adrenal glands (1)
- notch signaling (1)
- nuclear DNA content (1)
- nukleare DNA-Inhalt (1)
- nur77 (1)
- obinutuzumab (1)
- octreotide (1)
- olfactory bulb (1)
- oncogene (1)
- organotypic hippocampal slice cultures (OHSC) (1)
- orthotopic xenograft (1)
- osteoarthritis (1)
- osteonecrosis of jaw (1)
- outcomes research (1)
- outreach (1)
- oxidativer Stress (1)
- p300 (1)
- p53 expression (1)
- p53-dependent apoptosis (1)
- p53-inducible regulator (1)
- pFADD (1)
- pan-RCC (1)
- panel sequencing (1)
- panel-sequencing (1)
- panniculitis (1)
- paraffin-eingebettet (1)
- paraffin-embedded (1)
- parathyroid carcinoma (1)
- parkinson’s disease (1)
- pathogenesis (1)
- pathohistology (1)
- pathology (1)
- pathway (1)
- patient access (1)
- patient survival (1)
- pediatric (1)
- pediatric lymphoma (1)
- pembrolizumab (1)
- peptide receptor radionuclide therapy (1)
- peptide tyrosine tyrosine (PYY) (1)
- peptide tyrosine tyrosine 3-36 (PYY\(_{3-36}\)) (1)
- peripheral T-cell (1)
- peripheral T-cell lymphoma (1)
- periphere T-Zell-Lymphome (1)
- phosphatase 2A (1)
- phospholipase A(2) (1)
- plasmablasts (1)
- pleural mesothelioma (1)
- polyadenylation (1)
- postencephalitic parkinsonism (1)
- posttranslational modification (1)
- posttranslationale Modifikation (1)
- potentiell therapeutisch relevante Proteine (1)
- precancerous lesions (1)
- precision oncology (1)
- prediction (1)
- primary bone marrow presentation (1)
- primary cell culture (1)
- primary cutaneous follicular B-cell lymphoma (1)
- primary cutaneous lymphoma (1)
- primary cutaneous marginal zone lymphomas (1)
- prognostic factor (1)
- prognostic factors (1)
- prognostic marker (1)
- prognostic value (1)
- progressive multiple sclerosis (1)
- proliferation (1)
- prophylaxis (1)
- prostate cancer (1)
- prostate carcinoma (1)
- prostate gland DNA – database (1)
- prostate gland cancer (1)
- protein and mRNA expression (1)
- proteins (1)
- pseudocarcinomatous hyperplasia (1)
- pseudolymphoma (1)
- psoas muscle (1)
- psoriasis (1)
- radiation (1)
- radiation-induced migration (1)
- radiotherapy (1)
- rag (1)
- raman spectroscopy (1)
- rare SNP (1)
- real world data (1)
- receptor expression (1)
- recurrence-free survival (1)
- refractory/relapsed lymphoma (1)
- regional development (1)
- regulatory T-cells (1)
- renal cancer (1)
- renal cell carcinoma (1)
- repeated surgery (1)
- resistance (1)
- resistance to apoptosis (1)
- restoration (1)
- retroperitoneal tumor (1)
- retroperitoneum (1)
- retroviral gene transfer (1)
- retroviral vector system (1)
- retrovirales Vektorsystem (1)
- reverse transcriptase-polymerase chain reaction (1)
- rhesus monkeys (1)
- rheumatoid arthritis (1)
- rheumatoiden Arthritis (1)
- ribosome (1)
- ribosyltransferase (1)
- risk (1)
- roquin (1)
- rotator-cuff injury (1)
- sFas (1)
- salivary gland (1)
- salivary gland neoplasia (1)
- salivary gland tumor (1)
- salivary gland tumors (1)
- salivary glands (1)
- sarcoma (1)
- scoring system (1)
- selective vulnerability (1)
- selektive Vulnerabilität (1)
- seminoma (1)
- senescence (1)
- senile Lymphoproliferation (1)
- serum (1)
- shaken baby syndrome (1)
- siv (1)
- slice culture (1)
- somatic hypermutation (1)
- somatic mutations (1)
- somatostatine (1)
- spinal-cord-injury (1)
- spleen (1)
- splice variant (1)
- sporadische Alzheimer-Demenz (1)
- squamous tumors (1)
- stem cell transplantation (1)
- stem-cells (1)
- stemness (1)
- stomach carcinoma (1)
- storage solution (1)
- stratification (1)
- subventricular zone (1)
- suppression (1)
- suppressor (1)
- surgery (1)
- surgical and invasive medical procedures (1)
- surgical treatment (1)
- systemic sclerosis (1)
- t cells (1)
- t(11;18)(q21;q21) (1)
- t(14;18)-negative follicular lymphoma (1)
- t(14;18)-negative follikuläre Lymphome (1)
- t-SNE (1)
- t-cell maturation (1)
- t-cell-lymphoma (1)
- target (1)
- target validation (1)
- targeted (1)
- targeted combination therapy (1)
- targeted sequencing (1)
- targeted therapies (1)
- tauopathy (1)
- telepathology (1)
- tetraspanin (1)
- tetraspanin protein (1)
- theranostics (1)
- therapeutic target (1)
- therapy response (1)
- thiol starvation (1)
- thymic epithelial tumor (1)
- thymitis (1)
- thymocytes (1)
- thymopoiesis (1)
- tissue preparation (1)
- tissuemicroarray (1)
- transcript (1)
- transcription factor FOXP1 (1)
- transcriptional repression (1)
- transcriptome (1)
- transcriptomic analysis (1)
- transformation (1)
- translocation t(11;14)(q13;q32) (1)
- translocation t(11;18) (1)
- transplantation (1)
- trastuzumab (1)
- trastuzumab deruxtecan (1)
- treg cells (1)
- triple-negative breast cancer (1)
- trisomy (1)
- tumor (1)
- tumor cell migration (1)
- tumor heterogeneity (1)
- tumor progression (1)
- tumor slice cultures (1)
- tumor specific antibody (1)
- tumor spheroids (1)
- tumor vaccination (1)
- tumor-vessel wall-interface model (1)
- tumorigenesis (1)
- tumormicroenvironment (1)
- tumors (1)
- tumorspecific (1)
- tumorspezifisch (1)
- tumorspezifische Antikörper (1)
- tumour heterogeneity (1)
- typ 1 muscle fibres (1)
- tyrosine kinase inhibitor (TKI) (1)
- uPA (1)
- ubiquitin (1)
- unspezifische Lymphadenitis (1)
- unsupervised clustering (1)
- up regulation (1)
- urinary bladder cancer (1)
- urothelial carcinoma (1)
- vascular wall stem and progenitor cells (1)
- vascularization model (1)
- vasculogenesis (1)
- vemurafenib (1)
- venetoclax (1)
- virus–iron interaction (1)
- visual clustering (1)
- vitamin D receptor (1)
- vitamin k deficiency bleeding (1)
- vitamin metabolism (1)
- von Economo (1)
- whole-exome sequencing (1)
- xxx (1)
- Östrogene (1)
- Überleben (1)
- Überlebenszeit (1)
- ɑ-Synuclein and iron (1)
- α-synuclein-specific T cells (1)
Institute
- Pathologisches Institut (319) (remove)
Schriftenreihe
Sonstige beteiligte Institutionen
- Center for Interdisciplinary Clinical Research, Würzburg University, Würzburg, Germany (1)
- Department of Paediatric Radiology, Institute of Diagnostic and Interventional Radiology, Josef-Schneider-Straße 2, Wuerzburg 97080, Germany (1)
- IZKF Nachwuchsgruppe Geweberegeneration für muskuloskelettale Erkrankungen (1)
- Lehrstuhl für Regeneration Muskuloskelettaler Gewebe (1)
- Muskuloskelettales Centrum Würzburg (MCW) (1)
The cystine/glutamate antiporter xCT is an important source of cysteine for cancer cells. Once taken up, cystine is reduced to cysteine and serves as a building block for the synthesis of glutathione, which efficiently protects cells from oxidative damage and prevents ferroptosis. As melanomas are particularly exposed to several sources of oxidative stress, we investigated the biological role of cysteine and glutathione supply by xCT in melanoma. xCT activity was abolished by genetic depletion in the Tyr::CreER; Braf\(^{CA}\); Pten\(^{lox/+}\) melanoma model and by acute cystine withdrawal in melanoma cell lines. Both interventions profoundly impacted melanoma glutathione levels, but they were surprisingly well tolerated by murine melanomas in vivo and by most human melanoma cell lines in vitro. RNA sequencing of human melanoma cells revealed a strong adaptive upregulation of NRF2 and ATF4 pathways, which orchestrated the compensatory upregulation of genes involved in antioxidant defence and de novo cysteine biosynthesis. In addition, the joint activation of ATF4 and NRF2 triggered a phenotypic switch characterized by a reduction of differentiation genes and induction of pro-invasive features, which was also observed after erastin treatment or the inhibition of glutathione synthesis. NRF2 alone was capable of inducing the phenotypic switch in a transient manner. Together, our data show that cystine or glutathione levels regulate the phenotypic plasticity of melanoma cells by elevating ATF4 and NRF2.