Refine
Has Fulltext
- yes (127)
Is part of the Bibliography
- yes (127)
Year of publication
Document Type
- Preprint (127) (remove)
Language
- English (104)
- German (19)
- French (2)
- Portuguese (2)
Keywords
- boron (20)
- Quran (8)
- diborenes (8)
- Koran (7)
- Text Mining (7)
- crystallization (6)
- carbenes (5)
- cosmology (5)
- qubit (5)
- Archäologie (4)
- Boron (4)
- Positronen-Emissions-Tomografie (4)
- XML (4)
- decoherence (4)
- Bayesian classifier (3)
- Germanen (3)
- Historische Aufnahme (3)
- PET (3)
- Softwarearchitektur (3)
- Textvergleich (3)
- Visualisierung (3)
- Vor- und Frühgeschichte (3)
- Wissensmanagement (3)
- diboranes (3)
- diborene (3)
- low-valent compounds (3)
- prostate cancer (3)
- 18F-DCFPyL (2)
- Arabismus (2)
- Barbaricum (2)
- Base text (2)
- CSS (2)
- Cascading Style Sheets (2)
- Content Management (2)
- DFT calculations (2)
- Diborane (2)
- Fluoreszenz (2)
- Gothenburg model (2)
- Knowledge Management (2)
- Late Antiquity (2)
- Maschinelles Lernen (2)
- Meta-model (2)
- N-heterocyclic carbenes (2)
- Nonadiabatic quantum dynamics (2)
- PSMA (2)
- PSMA-RADS (2)
- Portugiesisch (2)
- RADS (2)
- SSTR (2)
- Spätantike (2)
- Strahlungstransport (2)
- Supraleiter (2)
- Text mining (2)
- Textual alterations weighting system (2)
- Textual document collation (2)
- Visualization (2)
- Wortschatz (2)
- Wrapper <Programmierung> (2)
- Zeitrichtung (2)
- bond activation (2)
- borylation (2)
- borylene (2)
- complexity (2)
- diborynes (2)
- emergent time (2)
- evolution (2)
- low-valent main group chemistry (2)
- modified inflation (2)
- multiple bonding (2)
- phase transition (2)
- prostate-specific membrane antigen (2)
- protein folding (2)
- qubit interaction (2)
- time-resolved photoelectron spectroscopy (2)
- transition metal complex (2)
- 1,2-additions (1)
- 2Dimensionale Spektroskopie (1)
- 3D cultures (1)
- 68Ga-DOTANOC (1)
- 68Ga-DOTATATE (1)
- 68Ga-DOTATOC (1)
- AMP-activated protein kinase (AMPK) (1)
- Academia (1)
- Academia (Zeitschrift, Bad Honnef) (1)
- Addendum (1)
- Akkad (1)
- Analysis of RNA Modifications (1)
- Anfangsunterricht (1)
- Anorexia nervosa (1)
- Anzahl (1)
- Arabic (1)
- Arabisch (1)
- Aromaticity (1)
- Artus (1)
- Artusepik (1)
- Aussprache (1)
- Barbituric Acid Merocyanines (1)
- Bayes-Klassifikator (1)
- Bedeutung (1)
- Beige adipocytes (1)
- Beobachter (1)
- Berechnungskomplexität (1)
- Bilderbuch (1)
- Biradicals (1)
- Book of Judith (1)
- Bor (1)
- Boranes (1)
- Borylene (1)
- Brandes, Mark A., 1929-2011 (1)
- Buchdruck (1)
- Burgwall (1)
- Béroul (1)
- C-H activation (1)
- C/EBP (1)
- CH activation (1)
- CMR (1)
- CO activation (1)
- CO2 fixation (1)
- CV (1)
- Cartellverband (1)
- Cartellverband der Katholischen Deutschen Studentenverbindungen (1)
- Causes of revelation (1)
- Chapters arrangement (1)
- Chemical Structure (1)
- Chronology of revelation (1)
- Clustering (1)
- Computational Chemistry (1)
- Computersimulation (1)
- Corrigenda (1)
- Crystal structure of MTR1 (1)
- Cycloaddition (1)
- DFT mechanism (1)
- DNA (1)
- DNA catalyst (1)
- DNA-based nanostructures (1)
- DNA-processing enzymes (1)
- Deep learning (1)
- Diboranes (1)
- Diborene (1)
- Digital Humanities (1)
- Digital Storytelling (1)
- Djebar, Assia / Les nuits de Strasbourg (1)
- Doppelquantenkohärenz (1)
- Drucktechnik (1)
- Dublin-III-Abkommen (1)
- Duden (1)
- E8 symmetry (1)
- EEA (1)
- Eilhart <von Oberg> (1)
- Einsamkeit (1)
- Einwanderung (1)
- Eisenproduktion (1)
- Entscheidung (1)
- Entscheidungen (1)
- Erzählen (1)
- Europa (1)
- Europas Scheitern (1)
- Europe’s failure (1)
- Evolution (1)
- Excited state dynamics (1)
- Exciton (1)
- Exciton dynamics (1)
- Exciton localization dynamics (1)
- Exziton (1)
- Flüchtlingskrise (1)
- Fragmentation (1)
- Fragmentierung (1)
- Frames (1)
- Frankreich (1)
- Französisch (1)
- Frühmittelalter (1)
- Fundamentalkonstante (1)
- GIS (1)
- García Lorca, Federico (1)
- Gedenkschrift (1)
- Genus (1)
- Geographic Information Systems (1)
- Geographisches Informationssystem (1)
- Geoinformationssystem (1)
- Germanic (1)
- Geschlechterforschung (1)
- Gothenburg Modell (1)
- Gothenburg model of collation process (1)
- Grammatik (1)
- Großstadt (1)
- Gödel (1)
- HHV-6 (1)
- HTML (1)
- Helicene diimide (1)
- Herpesvirus (1)
- High-Throughput Sequencing Method, DZ-seq (1)
- Higher-order Transient Absorption Spectroscopy (1)
- Historische Phonetik (1)
- History of Music (1)
- Hurrian (1)
- Hurritisch (1)
- Hurwitz theorem (1)
- Hydrocarbon radicals (1)
- Hydrocarbons (1)
- Hydrogen (1)
- Information Visualization (1)
- Inklusiver Unterricht (1)
- Instrumentenkunde (1)
- Inverse Probleme (1)
- Irak (1)
- Iran (1)
- Iraq (1)
- JSF (1)
- Java Frameworks (1)
- Jean Monnet (1)
- Jordanien (1)
- Judit <Buch> (1)
- Katholische Zeitschrift (1)
- Knowledge Management System (1)
- Knowledge Modeling (1)
- Knowledge representation (1)
- Knowledge-based System (1)
- Kolmogorov-Komplexität (1)
- Komplex <Algebra> (1)
- Komplexität (1)
- Kultur (1)
- Landscape Archaeology (1)
- Landschaftsarchäologie (1)
- Lawhul-Mahfuz (1)
- Layout (1)
- Lee Smolin (1)
- Lehnwort (1)
- Lewis acids (1)
- Lewis-base adducts (1)
- Literary Studies (1)
- Literaturwissenschaft (1)
- Lithographie (1)
- Ljapunov-Funktion (1)
- Low energy electron microscopy LEEM (1)
- MI-RADS (1)
- MVC <Software> (1)
- Main-group chemistry (1)
- Marine Le Pen (1)
- Mark A. Brandes (1)
- Mashup (1)
- Mashup <Internet> (1)
- Medienkompetenz (1)
- Mesopotamia (1)
- Mesopotamien (1)
- Metadynamics (1)
- Metal clusters (1)
- Metallocene (1)
- Metallocenes (1)
- Methyltransferase Ribozyme (1)
- Methyltransferase Ribozyme MTR1 (1)
- Migration (1)
- Migration Period (1)
- Minderheit (1)
- Molekülzustand (1)
- Monte Carlo simulation (1)
- Multiple bonding (1)
- Multiple bonds (1)
- Music (1)
- Musical Instruments (1)
- Musical Theorie (1)
- Musik (1)
- Musikgeschichte (1)
- Musikinstrumente (1)
- Musiktheorie (1)
- Myocardial infarction (1)
- N6-methyladenosine (1)
- N6-methyladenosine (m6A) (1)
- NMR spectroscopy (1)
- Natur (1)
- Nature constants (1)
- Naturgesetz (1)
- Natürliche Auslese (1)
- Naïve Bayesian (1)
- New York (1)
- Nicht-Transparente Medien (1)
- Non-transparency (1)
- Nonadiabatic dynamics (1)
- Notenschriften (1)
- Nucleobase Surrogate Incorporation (1)
- Ode an die Freude (1)
- Offset (1)
- Open Source (1)
- Open Source Software (1)
- Optische Spektroskopie (1)
- Organoboron chemistry (1)
- Overlapping (1)
- PET/CT (1)
- PROMISE (1)
- PSMA-PET (1)
- PSMA-RADS-3A (1)
- PSMA-RADS-3B (1)
- PSMA-targeted PET (1)
- Paläoethnologie (1)
- Pancreas (1)
- Persien (1)
- Phonetik (1)
- Photodynamics (1)
- Photoemission electron microscopy PEEM (1)
- Photoresponsive DNA Crosslinker (1)
- Physikalische Zeit (1)
- Place of revelation (1)
- Pontryagin maximum principle (1)
- Portuguese (1)
- Positron Emission Tomography (1)
- Processing Model (1)
- Processing model (1)
- Prostate Cancer (1)
- Protein kinase D1 (PKD1) (1)
- RNA (1)
- RNA Aptamer (1)
- RNA Enzymes (1)
- RNA modification (1)
- RNA-Cleaving Deoxyribozymes (1)
- RNA-catalyzed RNA methylation (1)
- Reconstruction of original text (1)
- Reference Architecture (1)
- Ribozyme-catalyzed RNA labeling (1)
- SQH method (1)
- SSTR-RADS (1)
- Sachbereich (1)
- Scar (1)
- Scatter Plot (1)
- Schulbuch (1)
- Segmentation (1)
- Septuagint (1)
- Septuaginta (1)
- Sexus (1)
- Singapore (1)
- Single-molecule microscopy (1)
- Software architecture (1)
- Software design (1)
- Soziolinguistik (1)
- Spatially resolved 2D spectroscopy (1)
- Spektroskopie (1)
- Spring (1)
- Stages of Prophet Mohammad’s messengership (1)
- Stammzelle (1)
- Statistical classifiers (1)
- Stempelkeramik (1)
- Stereotype (1)
- Stilistik (1)
- Struktur (1)
- Struts (1)
- Sumer (1)
- Support Vector Machine (1)
- Syrien (1)
- Tetrafluorodiborane (1)
- Text categorization (1)
- Text segmentation (1)
- Time hole (1)
- Time-resolved photoemission electron microscopy (1)
- Tolane-Modified Fluorescent Nucleosides (1)
- Transition metals (1)
- Tristansage (1)
- Two-color pump-probe spectroscopy (1)
- Türkei (1)
- Ultrafast spectroscopy (1)
- Umgangssprache (1)
- Umweltarchäologie (1)
- Variationslinguistik (1)
- Verbreitung (1)
- Virchow Node (1)
- Visual Text Mining (1)
- Vor- und Frühgeschichte <Fach> (1)
- Vulgata (1)
- Vulgate (1)
- Völkerwanderungszeit (1)
- Web service (1)
- Webservice Composition (1)
- Wirtschaftsarchäologie (1)
- Wissensbanksystem (1)
- Wissensrepräsentation (1)
- Wrapper (1)
- Wrappers (1)
- X-ray crystallography (1)
- XML model (1)
- YTH reader proteins (1)
- Zweidimensionale Spektroskopie (1)
- [177Lu]-DOTATATE/-DOTATOC (1)
- [68Ga] (1)
- alkene-alkyne [2+2] photocycloaddition (1)
- alkynes (1)
- amine borane dehydrocoupling (1)
- animal research (1)
- atomic mutagenesis (1)
- attention (1)
- auditory (1)
- auditory domain (1)
- benzyl radical (1)
- bit (1)
- boron chains (1)
- boronium cations (1)
- borylenes (1)
- brain activity (1)
- carbohydrates (1)
- carbon dioxide (1)
- cardiomyocytes (1)
- carsharing (1)
- catalysis (1)
- chain structures (1)
- chalcogens (1)
- chelates (1)
- conewise linear systems (1)
- conical intersections (1)
- conjugation (1)
- converse Lyapunov theorems (1)
- covalent and site-specific RNA labeling (1)
- crystal growth (1)
- crystallography (1)
- cyclic (alkyl)(amino)carbene (1)
- cycloaddition (1)
- decision (1)
- demethylase enzymes FTO and ALKBH5 (1)
- density functional calculations (1)
- deoxyribozymes (1)
- desymmetrization (1)
- diboraindanes (1)
- diborane (1)
- diborane(6) (1)
- diboration (1)
- diboron (1)
- diboryne (1)
- diradicals (1)
- discrete-time systems (1)
- distance-based classifier (1)
- disturbance (1)
- early cosmology (1)
- early medieva (1)
- electron donors (1)
- electrophiles (1)
- elektronisch angeregte Zustände (1)
- emergent gravity (1)
- energy transfer dynamics (1)
- erovalent diboron compounds (1)
- exciton dynamics (1)
- exciton-exciton (1)
- eye blinks (1)
- fatty acid (1)
- field-induced surface hopping (1)
- fine-tuning (1)
- fluorescence (1)
- fluorescence quantum yield (1)
- fluorescent protein (1)
- fluorescent resonance energy transfer (1)
- free movement (1)
- fusion and fission (1)
- gastrointestinal disease (1)
- germanic (1)
- half-sandwich complexes (1)
- helicobacter (1)
- heterocycles (1)
- heuristics (1)
- hiPSC-CM (1)
- hydration dynamics (1)
- hydroarylation (1)
- hydroboration (1)
- hydrogenation (1)
- in vitro selection (1)
- in vitro selection from a structured RNA library (1)
- induced pluripotent stem cells (1)
- inflammatory bowel disease (1)
- inflation (1)
- infrared-spectra (1)
- insertion (1)
- interactive collation of textual variants (1)
- intermolecular applications of ribozymes (1)
- interobserver (1)
- interreader (1)
- iodine (1)
- iron production (1)
- isomers (1)
- l slavic hill fort (1)
- large Stokes shift (1)
- latency (1)
- lexikalische Bedeutung (1)
- ligand exchange (1)
- light-induced interstrand DNA crosslinking (1)
- loop quantum gravity (1)
- low-valent main-group species (1)
- main-group chemistry (1)
- mapping function (1)
- meaning (1)
- miR-30 (1)
- miRNA processing (1)
- microbiota (1)
- mitochondria (1)
- mobility (1)
- modified nucleosides (1)
- multiple bonds (1)
- multiverse (1)
- near-IR chromophores (1)
- neuroendocrine neoplasia (1)
- neuroendocrine tumor (1)
- nnU-net (1)
- non-smooth optimization (1)
- nonadiabatic dynamics (1)
- nonconvex optimization (1)
- norovirus (1)
- observer (1)
- oddball (1)
- organoid culture (1)
- phase space (1)
- phonetics (1)
- photodynamics (1)
- physical time (1)
- pi-conjugation (1)
- position-specific installation of m1A in RNA (1)
- protein hydration (1)
- pyrene dimer (1)
- quantum computing (1)
- rBAM2-labeled RNA strands (1)
- reactive intermediates (1)
- rearrangement (1)
- recording methods (1)
- redox reactions (1)
- reductive coupling (1)
- refeeding syndrome (1)
- refugee crises (1)
- reporting and data system (1)
- ring expansion (1)
- rotavirus (1)
- salmonella (1)
- selection (1)
- service based software architecture (1)
- service brokerage (1)
- silylenes (1)
- slawisch (1)
- small HOMO-LUMO gap (1)
- small-molecule activation (1)
- somatostatin receptor (1)
- spectroscopy (1)
- squaraine polymer (1)
- stability analysis (1)
- standardized reporting (1)
- stem cell therapy (1)
- strained molecules (1)
- structural analysis (1)
- sustainability (1)
- synthesis (1)
- synthetic methods (1)
- taxi (1)
- text categorization (1)
- time hole (1)
- tracer (1)
- trans-acting 2'-5' adenylyl transferase ribozymes (1)
- trans-formanilide (1)
- transfer hydrogenation (1)
- transition metals (1)
- transport (1)
- tumor heterogeneity (1)
- type I interferon (1)
- unified theories (1)
- vegetarians (1)
- virtual reality (1)
- virus reactivation (1)
- visual (1)
- visual domain (1)
- water migration (1)
- Überlappung (1)
- β3 adrenergic receptor (ADRB3) (1)
Institute
- Institut für Anorganische Chemie (30)
- Institut für deutsche Philologie (25)
- Institut für Physikalische und Theoretische Chemie (19)
- Institut für Organische Chemie (14)
- Theodor-Boveri-Institut für Biowissenschaften (11)
- Institut für Altertumswissenschaften (6)
- Klinik und Poliklinik für Nuklearmedizin (6)
- Physikalisches Institut (4)
- Neuphilologisches Institut - Moderne Fremdsprachen (3)
- Rudolf-Virchow-Zentrum (3)
Schriftenreihe
Sonstige beteiligte Institutionen
- Johns Hopkins School of Medicine (3)
- International Max Planck Research School Molecular Biology, University of Göttingen, Germany (2)
- Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), Göttingen, Germany (1)
- Center for Nanosystems Chemistry (CNC), University of Würzburg (1)
- Center for Nanosystems Chemistry (CNC), Universität Würzburg (1)
- Center for Nanosystems Chemistry (CNC), Universität Würzburg, Am Hubland, 97074 Würzburg, Germany (1)
- Center of Excellence for Science and Technology - Integration of Mediterranean region (STIM), Faculty of Science, University of Split, Poljička cesta 35, 2100 Split, Croatia (1)
- Charles University, Faculty of Mathematics and Physics, Ke Karlovu 5, 121 16 Prague, Czech Republic (1)
- Departamento de Química, Facultad de Ciencias, Universidad Autónoma de Madrid, 28049 Madrid, Spain (1)
- Department of Biomedical Imaging, National Cerebral and Cardiovascular Research Center, Suita, Japan (1)
N\(^6\)-methyladenosine (m\(^6\)A) is an important modified nucleoside in cellular RNA associated with multiple cellular processes and is implicated in diseases. The enzymes associated with the dynamic installation and removal of m\(^6\)A are heavily investigated targets for drug research, which requires detailed knowledge of the recognition modes of m\(^6\)A by proteins. Here, we use atomic mutagenesis of m\(^6\)A to systematically investigate the mechanisms of the two human m\(^6\)A demethylase enzymes FTO and ALKBH5 and the binding modes of YTH reader proteins YTHDF2/DC1/DC2. Atomic mutagenesis refers to atom-specific changes that are introduced by chemical synthesis, such as the replacement of nitrogen by carbon atoms. Synthetic RNA oligonucleotides containing site-specifically incorporated 1-deaza-, 3-deaza-, and 7-deaza-m\(^6\)A nucleosides were prepared by solid-phase synthesis and their RNA binding and demethylation by recombinant proteins were evaluated. We found distinct differences in substrate recognition and transformation and revealed structural preferences for the enzymatic activity. The deaza m\(^6\)A analogues introduced in this work will be useful probes for other proteins in m\(^6\)A research.