Refine
Has Fulltext
- yes (51)
Is part of the Bibliography
- yes (51)
Year of publication
Document Type
- Journal article (42)
- Doctoral Thesis (9)
Keywords
- multiple myeloma (51) (remove)
Institute
- Medizinische Klinik und Poliklinik II (38)
- Klinik und Poliklinik für Nuklearmedizin (10)
- Abteilung für Molekulare Innere Medizin (in der Medizinischen Klinik und Poliklinik II) (7)
- Pathologisches Institut (6)
- Comprehensive Cancer Center Mainfranken (3)
- Institut für diagnostische und interventionelle Radiologie (Institut für Röntgendiagnostik) (3)
- Klinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie (3)
- Graduate School of Life Sciences (2)
- Institut für Virologie und Immunbiologie (2)
- Lehrstuhl für Tissue Engineering und Regenerative Medizin (2)
Sonstige beteiligte Institutionen
- Comprehensive Cancer Center Mainfranken (1)
- Department of Hematology and Oncology, Sana Hospital Hof, Hof, Germany (1)
- Department of Laboratory Medicine and Medicine Huddinge, Karolinska Institutet and University Hospital, Stockholm, Sweden (1)
- Department of Medicine A, University Hospital of Münster, Münster, Germany (1)
- Mildred Scheel Early Career Center (1)
The multi-agent therapy “VDT-PACE” represents an established regimen in relapsed/refractory multiple myeloma (RRMM). Here, we report on our experience with a “modified VDT-PACE” incorporating new generation anti-MM agents daratumumab and carfilzomib (“Dara-KDT-P(A)CE”). We retrospectively analyzed 38 patients with RRMM treated with “Dara-KDT-P(A)CE”. The median age was 62 (range 45–82) years, and the patients were heavily pretreated with a median of 5 (range 2–12) prior lines of therapy. Twenty-one (55%) patients suffered from penta-refractory MM. High-risk cytogenetics was present in 31 (81%) patients. The patients received a median of 2 (range 1–10) cycles of this therapy, and the overall response rate (ORR) was 70%. Patients with penta-refractory MM and high-risk cytogenetics showed similar ORR of 65% and 79%, respectively. The median progression-free survival (PFS) and overall survival were 4.1 (95% CI 2.7–5.4) and 8.4 (95% CI 6.7–10.0) months, respectively. Patients with lactate dehydrogenase >250 IU/L showed significantly shorter PFS in comparison with others patients (p = 0.006). We used this regimen as bridging therapy prior to chimeric antigen receptor T-cell infusion in four patients. In conclusion, “Dara-KDT-P(A)CE” is an effective salvage therapy for patients with heavily pretreated, multi-refractory, high-risk RRMM lacking alternative options.