Refine
Has Fulltext
- yes (31)
Year of publication
Document Type
- Journal article (18)
- Doctoral Thesis (13)
Keywords
- pain (31) (remove)
Institute
- Neurologische Klinik und Poliklinik (11)
- Klinik und Poliklinik für Anästhesiologie (ab 2004) (7)
- Institut für Psychologie (3)
- Institut für Klinische Neurobiologie (2)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (2)
- Lehrstuhl für Orthopädie (2)
- Neurochirurgische Klinik und Poliklinik (2)
- Frauenklinik und Poliklinik (1)
- Graduate School of Life Sciences (1)
- Institut Mensch - Computer - Medien (1)
- Institut für Psychologie (bis Sept. 2007) (1)
- Institut für diagnostische und interventionelle Radiologie (Institut für Röntgendiagnostik) (1)
- Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) (1)
- Klinik und Poliklinik für Unfall-, Hand-, Plastische und Wiederherstellungschirurgie (Chirurgische Klinik II) (1)
- Medizinische Fakultät (1)
- Neuphilologisches Institut - Moderne Fremdsprachen (1)
- Physiologisches Institut (1)
Sonstige beteiligte Institutionen
Polyneuropathy (PNP) is a term to describe diseases of the peripheral nervous system, 50% of which present with neuropathic pain. In some types of PNP, pain is restricted to the skin distally in the leg, suggesting a local regulatory process leading to pain. In this study, we proposed a pro-inflammatory pathway mediated by NF-κB that might be involved in the development of pain in patients with painful PNP. To test this hypothesis, we have collected nerve and skin samples from patients with different etiologies and levels of pain. We performed RT-qPCR to analyze the gene expression of the proposed inflammatory pathway components in sural nerve and in distal and proximal skin samples. In sural nerve, we showed a correlation of TLR4 and TNFα to neuropathic pain, and an upregulation of TNFα in patients with severe pain. Patients with an inflammatory PNP also presented a lower expression of TRPV1 and SIRT1. In distal skin, we found a reduced expression of TLR4 and miR-146-5p, in comparison to proximal skin. Our findings thus support our hypothesis of local inflammatory processes involved in pain in PNP, and further show disturbed anti-inflammatory pathways involving TRPV1 and SIRT1 in inflammatory PNP.