Refine
Has Fulltext
- yes (39)
Is part of the Bibliography
- yes (39)
Document Type
- Journal article (24)
- Conference Proceeding (9)
- Preprint (6)
Keywords
- Positronen-Emissions-Tomografie (21)
- PET (19)
- positron emission tomography (12)
- neuroendocrine tumor (6)
- 18F-FDG (5)
- SPECT (5)
- SSTR (5)
- PET/CT (4)
- PRRT (4)
- RADS (4)
- prostate cancer (4)
- theranostics (4)
- 18F-DCFPyL (3)
- 18F-LMI1195 (3)
- DaTscan (3)
- PSMA (3)
- Prostate Cancer (3)
- ageing (3)
- somatostatin receptor (3)
- vandetanib (3)
- 11C-HED (2)
- 123I-mIBG (2)
- 123I-metaiodobenzylguanidine (2)
- 18F-FDS (2)
- ECG (2)
- Ioflupane (2)
- Myokarditis (2)
- Neuroendocrine Tumor (2)
- PSMA-PET (2)
- PSMA-RADS (2)
- Parkinson (2)
- Parkinson Disease (2)
- Parkinson-Krankheit (2)
- Positron Emission Tomography (2)
- Stammzelle (2)
- TKI (2)
- Virchow Node (2)
- [177Lu]-DOTATATE/-DOTATOC (2)
- [68Ga] (2)
- cardiomyocytes (2)
- fatty acid (2)
- hiPSC-CM (2)
- induced pluripotent stem cells (2)
- medullary thyroid carcinoma (2)
- molecular imaging (2)
- myocardial sympathetic innervation imaging (2)
- myocarditis (2)
- peptide receptor radionuclide therapy (2)
- personalized medicine (2)
- personalized treatment (2)
- precision medicine (2)
- prostate-specific membrane antigen (2)
- stem cell therapy (2)
- tracer (2)
- tumor heterogeneity (2)
- tyrosine kinase inhibitor (2)
- 11C-Hydroxyephedrine (1)
- 11C-hydroxyephedrine (1)
- 123I-Ioflupane (1)
- 177Lu-DOTATATE (1)
- 177Lu-DOTATOC (1)
- 18F-DCFPL (1)
- 18F-flurpiridaz (1)
- 18FFBnTP (1)
- 2- deoxy-2-(18F)fluoro-D-glucose (1)
- 2-deoxy-2-(18F)fluoro-D-glucose (1)
- 2-deoxy-2-18F-fluoro-D-sorbitol (1)
- 68Ga-DOTANOC (1)
- 68Ga-DOTATATE (1)
- 68Ga-DOTATATE/-TOC (1)
- 68Ga-DOTATOC (1)
- 99mTc-DTPA (1)
- AI (1)
- Antidepressants (1)
- CXCR4 (1)
- DCGAN (1)
- DOTATOC (1)
- Diabetes (1)
- ECG-gated (1)
- EKG (1)
- FV45 (1)
- GAN (1)
- GI (1)
- Ganglia (1)
- Gastrointestinal (1)
- Glomerular filtration (1)
- HFmrEF (1)
- Herz (1)
- ICD (1)
- Imaging pitfalls (1)
- MDD (1)
- MI-RADS (1)
- MIBG (1)
- MPI (1)
- MRI (1)
- Magnetresonanztomografie (1)
- Medullärer Schilddrüsenkrebs (1)
- Metaiodobenzylguanidine (1)
- Neuroendocrine (1)
- Nierenfunktionsstörung (1)
- Oncology (1)
- PROMISE (1)
- PSMA-RADS-3A (1)
- PSMA-RADS-3B (1)
- PSMA-targeted PET (1)
- Pancreas (1)
- Parkinsonism (1)
- Parkinson’s disease (1)
- Pitfall (1)
- Positron-Emission Tomography (1)
- Positronenemissionstomografie (1)
- Prostata (1)
- Radionuclide Therapy (1)
- Radiotracer (1)
- SPECT/CT (1)
- SSTR-PET (1)
- SSTR-RADS (1)
- Single-Photon-Emissions-Computertomographie (1)
- Standardisierung (1)
- Tracer (1)
- ZDF rats (1)
- [68Ga]DOTATOC (1)
- [\(^{68}\)Ga]Pentixafor (1)
- \(^{18}\)F-FDG (1)
- \(^{18}\)F-fluorodeoxyglucose (1)
- angiotensin II type 1 receptor (1)
- antidepressant (1)
- antidepressants (1)
- arrhythmia (1)
- artificial intelligence (1)
- autonomic nervous system (1)
- cardiac (1)
- cardiac innervation imaging (1)
- cardiac nerve (1)
- cardiac sympathetic nerve system (1)
- cardiac sympathetic nervous system (1)
- chemokine receptor (1)
- coronary artery disease (1)
- depression (1)
- diabetes (1)
- diabetic cardiomyopathy (1)
- diabetische Kardiomyopathie (1)
- heart (1)
- heart failure (1)
- heart failure with mid-range ejection fraction (1)
- hydroxyephedrine (1)
- inflammation (1)
- interobserver (1)
- interreader (1)
- kidney (1)
- mIBG (1)
- machine learning (1)
- magnetic resonance imaging (1)
- major depressive disorder (1)
- moycardial sympathetic innervation (1)
- myocardial nerve (1)
- myocardial perfusion imaging (1)
- neuroendocrine neoplasia (1)
- pancreas (1)
- phaeochromocytoma (1)
- prostate-specific membrane antigen (PSMA) (1)
- quantification (1)
- renal failure (1)
- renal imaging (1)
- renin-angiotensin system (1)
- reporting and data system (1)
- reporting and data systems (1)
- single photon emission computed tomography: sympathetic nerve (1)
- somatostatin receptor (SSTR) (1)
- split renal function (1)
- standardization (1)
- standardized reporting (1)
- storage vesicle turnover (1)
- stroke (1)
- sympathetic nerve (1)
- sympathetic nervous system (1)
- unilateral ureteral obstruction (1)
- valsartan (1)
Institute
- Klinik und Poliklinik für Nuklearmedizin (39)
- Medizinische Klinik und Poliklinik I (6)
- Medizinische Klinik und Poliklinik II (5)
- Institut für Anatomie und Zellbiologie (4)
- Institut für Pharmakologie und Toxikologie (2)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (2)
- Institut für Pharmazie und Lebensmittelchemie (1)
- Pathologisches Institut (1)
Sonstige beteiligte Institutionen
- Johns Hopkins School of Medicine (18)
- Johns Hopkins University School of Medicine (5)
- Johns Hopkins School of Medicine, Baltimore, MD, U.S. (4)
- Department of Biomedical Imaging, National Cerebral and Cardiovascular Research Center, Suita, Japan (2)
- Division of Medical Technology and Science, Department of Medical Physics and Engineering, Course of Health Science, Osaka University Graduate School of Medicine, Suita Japan (2)
- Institut for Molecular Biology and CMBI, Department of Genomics, Stem Cell Biology and Regenerative Medicine, Leopold-Franzens-University Innsbruck, Innsbruck, Austria (2)
- Johns Hopkins School of Medicine, The Russell H Morgan Department of Radiology and Radiological Science, Baltimore, MD, USA (2)
- Department of Nuclear Medicine, Kanazawa University (1)
- Hospital Augsburg, Augsburg, Germany (1)
- Johns Hopkins Medicine (1)
EU-Project number / Contract (GA) number
- 701983 (39) (remove)
Objectives: Recently, the standardized reporting and data system for prostate-specific membrane antigen (PSMA)-targeted positron emission tomography (PET) imaging studies, termed PSMA-RADS version 1.0, was introduced. We aimed to determine the interobserver agreement for applying PSMA-RADS to imaging interpretation of 18F-DCFPyL PET examinations in a prospective setting mimicking the typical clinical work-flow at a prostate cancer referral center.
Methods: Four readers (two experienced readers (ER, > 3 years of PSMA-targeted PET interpretation experience) and two inexperienced readers (IR, < 1 year of experience)), who had all read the initial publication on PSMA-RADS 1.0, assessed 50 18F-DCFPyL PET/computed tomography (CT) studies independently. Per scan, a maximum of 5 target lesions were selected by the observers and a PSMA-RADS score for every target lesion was recorded. No specific pre-existing conditions were placed on the selection of the target lesions, although PSMA-RADS 1.0 suggests that readers focus on the most highly avid or largest lesions. An overall scan impression based on PSMA-RADS was indicated and interobserver agreement rates on a target lesion-based, on an organ-based, and on an overall PSMA-RADS score-based level were computed.
Results: The number of target lesions identified by each observer were as follows: ER 1, 123; ER 2, 134; IR 1, 123; and IR 2, 120. Among those selected target lesions, 125 were chosen by at least two individual observers (all four readers selected the same target lesion in 58/125 (46.4%) instances, three readers in 40/125 (32%) and two observers in 27/125 (21.6%) instances). The interobserver agreement for PSMA-RADS scoring among identical target lesions was good (intraclass correlation coefficient (ICC) for four, three and two identical target lesions, ≥0.60, respectively). For lymph nodes, an excellent interobserver agreement was derived (ICC=0.79). The interobserver agreement for an overall scan impression based on PSMA-RADS was also excellent (ICC=0.84), with a significant difference for ER (ICC=0.97) vs. IR (ICC=0.74, P=0.005).
Conclusions: PSMA-RADS demonstrates a high concordance rate in this study, even among readers with different levels of experience. This suggests that PSMA-RADS can be effectively used for communication with clinicians and can be implemented in the collection of data for large prospective trials.