Refine
Has Fulltext
- yes (91)
Is part of the Bibliography
- yes (91)
Year of publication
Document Type
- Journal article (77)
- Conference Proceeding (8)
- Preprint (6)
Keywords
- PET (26)
- Positronen-Emissions-Tomografie (20)
- positron emission tomography (15)
- theranostics (12)
- CXCR4 (9)
- PET/CT (9)
- PRRT (9)
- multiple myeloma (9)
- molecular imaging (8)
- neuroendocrine tumor (8)
- prostate cancer (7)
- PSMA (6)
- SPECT (6)
- SSTR (6)
- RADS (5)
- somatostatin receptor (5)
- 18F-FDG (4)
- 18F-DCFPyL (3)
- 18F-LMI1195 (3)
- DaTscan (3)
- FDG (3)
- NET (3)
- Prostate Cancer (3)
- ageing (3)
- chemokine receptor (3)
- medicine (3)
- norepinephrine transporter (3)
- peptide receptor radionuclide therapy (3)
- prostate-specific membrane antigen (3)
- radioligand therapy (3)
- sympathetic nervous system (3)
- vandetanib (3)
- 11C-HED (2)
- 18F-FDG PET/CT (2)
- 18F-FDS (2)
- 68Ga-DOTATATE (2)
- DOTATOC (2)
- ECG (2)
- Ioflupane (2)
- MAG3 (2)
- MIBG (2)
- Multiple myeloma (2)
- Neuroendocrine Tumor (2)
- PSMA-PET (2)
- PSMA-RADS (2)
- Parkinson (2)
- Parkinson Disease (2)
- Parkinson-Krankheit (2)
- Positron Emission Tomography (2)
- Positron emission tomography (2)
- SSTR-RADS (2)
- Stammzelle (2)
- TKI (2)
- Virchow Node (2)
- [177Lu]-DOTATATE/-DOTATOC (2)
- [68Ga] (2)
- antidepressant (2)
- bone disease (2)
- cardiomyocytes (2)
- diabetes (2)
- fatty acid (2)
- fibroblast activation protein (2)
- glioblastoma (2)
- glioblastoma multiforme (2)
- heart failure (2)
- hiPSC-CM (2)
- induced pluripotent stem cells (2)
- kidney (2)
- medullary thyroid carcinoma (2)
- molecular medicine (2)
- myocardial sympathetic innervation imaging (2)
- personalized medicine (2)
- personalized treatment (2)
- precision medicine (2)
- prostate-specific membrane antigen (PSMA) (2)
- radionuclide therapy (2)
- relapse (2)
- reporting and data system (2)
- sarcoidosis (2)
- stem cell therapy (2)
- survival (2)
- tracer (2)
- tumor heterogeneity (2)
- tyrosine kinase inhibitor (2)
- 11C-Hydroxyephedrine (1)
- 11C-Methionine PET/CT (1)
- 11C-hydroxyephedrine (1)
- 123I-Ioflupane (1)
- 123I-mIBG (1)
- 123I-metaiodobenzylguanidine (1)
- 177Lu (1)
- 177Lu-DOTATATE (1)
- 177Lu-DOTATOC (1)
- 18F-DCFPL (1)
- 18F-flurpiridaz (1)
- 18FDG-PET/CT (1)
- 18FFBnTP (1)
- 2- deoxy-2-(18F)fluoro-D-glucose (1)
- 2-deoxy-2-(18F)fluoro-D-glucose (1)
- 2-deoxy-2-18F-fluoro-D-sorbitol (1)
- 53BP1 (1)
- 68Ga-DOTANOC (1)
- 68Ga-DOTATATE/-TOC (1)
- 68Ga-DOTATOC (1)
- 68Ga-PSMA ligand PET/CT (1)
- 68Ga-Pentixafor PET/CT (1)
- 99mTc-DTPA (1)
- <sup>18</sup>F-FDG (1)
- <sup>68</sup>Ga-Pentixafor (1)
- Antibodies (1)
- Antidepressants (1)
- Arginine (1)
- Atherosclerotic plaque (1)
- BRAF mutation (1)
- C-11-methionine pet (1)
- C-X-C motif chemokine receptor 4 (1)
- CD38 (1)
- CXCR4/SDF-1 (1)
- Capicua transcriptional repressor (1)
- Cardiovascular diseases (1)
- Cardiovascular risk factors (1)
- DNA double-strand breaks (1)
- DOTA-EB-TATE (1)
- Diabetes (1)
- Drug resistance (1)
- ECG-gated (1)
- EKG (1)
- Extramedullary disease (1)
- F-18-FDG PET (1)
- FDG PET/CT (1)
- FDG-PET/CT (1)
- GI (1)
- Ga-68 (1)
- Ganglia (1)
- Gastrointestinal (1)
- Glomerular filtration (1)
- HFmrEF (1)
- HMDP hydroxymethylene diphosphonate (1)
- Heart failure (1)
- Herz (1)
- Hyperkalaemia (1)
- IDH1/2 (1)
- Imaging pitfalls (1)
- Lysine (1)
- MDD (1)
- MI-RADS (1)
- MIBG scintigraphy (1)
- MOR202 (1)
- MPI (1)
- MRI (1)
- Macrophage (1)
- Medizin (1)
- Medullärer Schilddrüsenkrebs (1)
- Merkel cell carcinoma (1)
- Metaiodobenzylguanidine (1)
- Molecular imaging (1)
- Myeloma cells (1)
- Myelomas (1)
- Myocardial-perfusion SPECT (1)
- Myokarditis (1)
- NEC (1)
- Neuroendocrine (1)
- Nierenfunktionsstörung (1)
- Oncology (1)
- PROMISE (1)
- PSMA-RADS-3A (1)
- PSMA-RADS-3B (1)
- PSMA-targeted PET (1)
- Pancreas (1)
- Parkinson's disease (1)
- Parkinsonism (1)
- Parkinson’s disease (1)
- Pentixafor (1)
- Pitfall (1)
- Positron-Emission Tomography (1)
- Positronenemissionstomografie (1)
- Prostata (1)
- Radiofluorine (1)
- Radionuclide Therapy (1)
- Radiotracer (1)
- SOAT1 (1)
- SPECT Scanner (1)
- SPECT/CT (1)
- SSTR-PET (1)
- SUV (1)
- Single-Photon-Emissions-Computertomographie (1)
- Sodium-Glucose Cotransporters (SGLTs) (1)
- Somatostatin receptor (1)
- Somatostatin receptor expression (1)
- Standardisierung (1)
- T-shaped π-π stacking (1)
- T-shaped π–π stacking (1)
- Tracer (1)
- ZDF rats (1)
- [177Lu]/[90Y]PentixaTher (1)
- [68Ga]DOTATOC (1)
- [68Ga]PentixaFor (1)
- [68Ga]Pentixafor (1)
- [\(^{68}\)Ga] pentixafor (1)
- [\(^{68}\)Ga]Ga-FAPI (1)
- [\(^{68}\)Ga]Pentixafor (1)
- \(^{11}\)C-Methionine-PET (1)
- \(^{11}\)C-methionine (1)
- \(^{18}\)F (1)
- \(^{18}\)F-FDG (1)
- \(^{18}\)F-FDG PET/CT (1)
- \(^{18}\)F-fluorodeoxyglucose (1)
- \(^{68}\)Ga (1)
- \(^{68}\)Ga-Pentixafor (1)
- accuracy (1)
- agreement (1)
- amino acids (1)
- androgen deprivation therapy (1)
- angiogenesis (1)
- antidepressants (1)
- astrocytoma (1)
- autologous transplantation (1)
- autonomic nervous system (1)
- benzylguanidine (1)
- biokinetics (1)
- biomarker (1)
- biomarkers (1)
- biosynthesis (1)
- bone marrow cells (1)
- brain (1)
- brain tumors (1)
- cancer (1)
- cardiac (1)
- cardiac innervation imaging (1)
- cardiac neurohormonal system (1)
- cardiac sympathetic nerve system (1)
- cardiac sympathetic nervous system (1)
- cell staining (1)
- cells (1)
- cerebral gliomas (1)
- chemokine receptor-4 (1)
- clinical diagnosis (1)
- collimator (1)
- comparability (1)
- contrast agent (1)
- coronary artery disease (1)
- criteria (1)
- daratumumab (1)
- delineation (1)
- dementia (1)
- depression (1)
- detection rate (1)
- diabetic cardiomyopathy (1)
- diabetische Kardiomyopathie (1)
- diffusion weighted mri (1)
- disease (1)
- dosimetry (1)
- ejection fraction (1)
- endocrinology (1)
- endoradiotherapy (1)
- esophagogastric junction (1)
- evans blue (1)
- experience (1)
- extramedullary hematopoiesis (1)
- glioma (1)
- glomerular filtration rate (1)
- guidelines (1)
- head and neck cancer (1)
- heart (1)
- heart failure with mid-range ejection fraction (1)
- heart-to-mediastinum ratio (1)
- high risk (1)
- hydroxyephedrine (1)
- hyperkalemia (1)
- imaging (1)
- imaging techniques (1)
- immune infiltration (1)
- immunostaining (1)
- improves (1)
- in vivo imaging (1)
- inflammation (1)
- interobserver (1)
- interreader (1)
- intraindividual comparison (1)
- involvement (1)
- kidney function (1)
- left-ventricular function (1)
- lesions (1)
- linear conversion (1)
- lipid droplets (1)
- mIBG (1)
- mRNA (1)
- machine learning (1)
- macrophages (1)
- magnetic resonance imaging (1)
- major depressive disorder (1)
- malignancies (1)
- management (1)
- medium-sized animals (1)
- metabolic tumor volume (MTV) (1)
- metabolic tumour volume (MTV) (1)
- methionine (1)
- methionine pet (1)
- miRNA (1)
- microenvironment (1)
- microglial cells (1)
- mitotane (1)
- mouse (1)
- moycardial sympathetic innervation (1)
- multiple system atrophy (1)
- myocardial perfusion imaging (1)
- myocarditis (1)
- nephrology (1)
- neuroendocrine neoplasia (1)
- nonhuman primates (1)
- nuclear cardiology (1)
- nuclear medicine (1)
- ollimator (1)
- organic cation transporter (1)
- pancreas (1)
- pattern (1)
- peptide receptor (1)
- performance (1)
- peripheral nervous system (1)
- phaeochromocytoma (1)
- phenethylguanidine (1)
- pleural mesothelioma (1)
- positron emission tomography/computed tomography (1)
- positron-emission-tomography (1)
- post-reconstruction filtering (1)
- progression (1)
- quality (1)
- quantification (1)
- radiogenomics (1)
- radiotherapy (1)
- radiotracer (1)
- radiotracer kinetics (1)
- rats (1)
- recurrent prostate cancer (1)
- refractory (1)
- renal (1)
- renal failure (1)
- renal function (1)
- renal imaging (1)
- renal scintigraphy (1)
- reporting and data systems (1)
- risk (1)
- scanner (1)
- single photon emission computed tomography: sympathetic nerve (1)
- skeletal (1)
- skin biopsy (1)
- small animal SPECT (1)
- small-animal imaging (1)
- smoldering myeloma (1)
- software (1)
- solid tumors (1)
- somatostatin (1)
- somatostatin receptor (SSTR) (1)
- somatostatin receptors (1)
- spleen (1)
- split renal function (1)
- standardization (1)
- standardized reporting (1)
- stem cells (1)
- stem-cell research (1)
- stem-cell transplantation (1)
- stimulation (1)
- storage vesicle turnover (1)
- structure–activity relationships (1)
- sympathetic nerve (1)
- targeted therapy (1)
- total lesion PSMA (1)
- total lesion glycolysis (TLG) (1)
- total lesion methionine uptake (TLMU) (1)
- transcriptome (1)
- treatment response (1)
- tumor burden (1)
- tumor microenvironment (1)
- unilateral ureteral obstruction (1)
- urology (1)
- vestibular schwannoma (1)
- γ-H2AX (1)
Institute
- Klinik und Poliklinik für Nuklearmedizin (88)
- Medizinische Klinik und Poliklinik II (19)
- Medizinische Klinik und Poliklinik I (11)
- Pathologisches Institut (10)
- Deutsches Zentrum für Herzinsuffizienz (DZHI) (8)
- Institut für diagnostische und interventionelle Radiologie (Institut für Röntgendiagnostik) (8)
- Urologische Klinik und Poliklinik (4)
- Abteilung für Molekulare Innere Medizin (in der Medizinischen Klinik und Poliklinik II) (3)
- Comprehensive Cancer Center Mainfranken (3)
- Institut für Anatomie und Zellbiologie (3)
Sonstige beteiligte Institutionen
- Johns Hopkins School of Medicine (16)
- Johns Hopkins University School of Medicine (5)
- Johns Hopkins School of Medicine, Baltimore, MD, U.S. (3)
- Department of Biomedical Imaging, National Cerebral and Cardiovascular Research Center, Suita, Japan (2)
- Division of Medical Technology and Science, Department of Medical Physics and Engineering, Course of Health Science, Osaka University Graduate School of Medicine, Suita Japan (2)
- Institut for Molecular Biology and CMBI, Department of Genomics, Stem Cell Biology and Regenerative Medicine, Leopold-Franzens-University Innsbruck, Innsbruck, Austria (2)
- Johns Hopkins School of Medicine, The Russell H Morgan Department of Radiology and Radiological Science, Baltimore, MD, USA (2)
- Clinical Trial Center (CTC) / Zentrale für Klinische Studien Würzburg (ZKSW) (1)
- Department of Nuclear Medicine, Kanazawa University (1)
- Hospital Augsburg, Augsburg, Germany (1)
EU-Project number / Contract (GA) number
- 701983 (35)
Purpose
While [\(^{18}\)F]-fluorodeoxyglucose ([\(^{18}\)F]FDG) is the standard for positron emission tomography/computed tomography (PET/CT) imaging of oral squamous cell carcinoma (OSCC), diagnostic specificity is hampered by uptake in inflammatory cells such as neutrophils or macrophages. Recently, molecular imaging probes targeting fibroblast activation protein α (FAP), which is overexpressed in a variety of cancer-associated fibroblasts, have become available and might constitute a feasible alternative to FDG PET/CT.
Methods
Ten consecutive, treatment-naïve patients (8 males, 2 females; mean age, 62 ± 9 years) with biopsy-proven OSCC underwent both whole-body [\(^{18}\)F]FDG and [\(^{68}\)Ga]FAPI-04 (FAP-directed) PET/CT for primary staging prior to tumor resection and cervical lymph node dissection. Detection of the primary tumor, as well as the presence and number of lymph node and distant metastases was analysed. Intensity of tracer accumulation was assessed by means of maximum (SUV\(_{max}\)) and peak (SUV\(_{peak}\) standardized uptake values. Histological work-up including immunohistochemical staining for FAP served as standard of reference.
Results
[\(^{18}\)F]FDG and FAP-directed PET/CT detected all primary tumors with a SUVmax of 25.5 ± 13.2 (FDG) and 20.5 ± 6.4 (FAP-directed) and a SUVpeak of 16.1 ± 10.3 ([\(^{18}\)F]FDG) and 13.8 ± 3.9 (FAP-directed), respectively. Regarding cervical lymph node metastases, FAP-directed PET/CT demonstrated comparable sensitivity (81.3% vs. 87.5%; P = 0.32) and specificity (93.3% vs. 81.3%; P = 0.16) to [\(^{18}\)F]FDG PET/CT. FAP expression on the cell surface of cancer-associated fibroblasts in both primary lesions as well as lymph nodes metastases was confirmed in all samples.
Conclusion
FAP-directed PET/CT in OSCC seems feasible. Future research to investigate its potential to improve patient staging is highly warranted.