Filtern
Volltext vorhanden
- ja (25)
Gehört zur Bibliographie
- ja (25)
Erscheinungsjahr
- 2018 (25) (entfernen)
Dokumenttyp
Schlagworte
- Aspergillus fumigatus (3)
- Positronen-Emissions-Tomografie (3)
- Adhärenz (2)
- CML (2)
- Dendritische Zellen (2)
- PET (2)
- PRRT (2)
- RADS (2)
- Survival (2)
- Therapietreue (2)
- chemokines (2)
- neuroendocrine tumor (2)
- theranostics (2)
- 27.9c (1)
- 68Ga-DOTATATE/-TOC (1)
- ABCG2 (1)
- ATIP (1)
- Acute myeloid leukemia (1)
- Allogeneic stem cell transplantation (1)
- Ambulante Behandlung (1)
- Antibiotikatherapie (1)
- Antiretrovirale Substanz (1)
- Antituberkulotikum (1)
- Arzneimittelüberwachung (1)
- Biomarker (1)
- C-Typ Lektin Rezeptoren (1)
- CCL4 (1)
- Chronic myeloid leukaemia (1)
- Chronisch-myeloische Leukämie (1)
- Compliance (1)
- Copy number changes (1)
- Dasatinib (1)
- Dectin-1 (1)
- Dendritische Zelle (1)
- Deutsche Gesellschaft für Hämatologie und Onkologie. Arbeitsgemeinschaft Infektiologie (1)
- Einfluss (1)
- Elderly (1)
- Expression (1)
- Follow-up (1)
- GI (1)
- Gastrointestinal (1)
- HIV-Infektion (1)
- Haploidentical (1)
- Haut (1)
- Hautmodell (1)
- Helicobacter (1)
- Helicobacter pylori (1)
- Hochdosischemotherapie (1)
- IDO-1 (1)
- IFN-gamma (1)
- Imatinib (1)
- Immunsystem (1)
- Kolorektales Karzinom (1)
- Kulturmedium (1)
- MIP-1β (1)
- MTUS1 (1)
- MUD (1)
- Merkmal (1)
- Methotrexate (1)
- Molecularly targeted therapy (1)
- NK cells (1)
- NK-Zellen (1)
- Natürliche Killerzellen (1)
- Neuroendocrine (1)
- Neuroendocrine Tumor (1)
- OSM (1)
- Oncology (1)
- Optimierung (1)
- PET/CT (1)
- Patientenversorgung (1)
- Periphere Stammzellentransplantation (1)
- Plasmozytom (1)
- Poststationär (1)
- Prediction (1)
- Qualität (1)
- Radionuclide Therapy (1)
- Radiotherapy (1)
- Resistenz (1)
- Rezidiv (1)
- Rezidivtherapie (1)
- Risk factors (1)
- SSTR (1)
- Sorafenib (1)
- Spendermerkmal (1)
- Standardisierung (1)
- Stimulating factor (1)
- Surgery (1)
- T cells (1)
- TKI (1)
- Therapie (1)
- Therapieversagen (1)
- Therapy (1)
- Translational research (1)
- Tuberkulose (1)
- Tumorsuppressorgen (1)
- ZM336372 (1)
- Zytokine (1)
- according to guidelines (1)
- acute myeloid leukemia (1)
- adherence (1)
- ambulant (1)
- ambulatory (1)
- anti-infective vaccination (1)
- antibiotic therapy (1)
- aspergillosis (1)
- autologe Stammzelltransplantation (1)
- autologous stem cell transplantation (1)
- bile (1)
- cancer (1)
- ceftriaxone (1)
- cicatricial pemphigoid (1)
- cirrhosis (1)
- compliance (1)
- cytarabine dose (1)
- cytokine (1)
- cytotoxic T cells (1)
- dendritic cell (1)
- drug-induced immune hemolytic anemia (1)
- elderly (1)
- hemolysis (1)
- hepatitis C virus (1)
- human (1)
- immune cells (1)
- immunosuppression (1)
- infection (1)
- interferon (1)
- laminin 332 (1)
- leitliniengerecht (1)
- liver diseases (1)
- mucous membrane pemphigoid (1)
- multiples Myelom (1)
- multiplicity of infection (1)
- oesophagogastroduodenoscopy (1)
- outpatient (1)
- paradoxe CRAF-Aktivierung (1)
- patient care (1)
- peptide receptor radionuclide therapy (1)
- personalized medicine (1)
- positron emission tomography (1)
- post-hospital (1)
- prostate cancer (1)
- prostate-specific membrane antigen (PSMA) (1)
- refraktär (1)
- reporting and data systems (1)
- resistance (1)
- somatostatin receptor (1)
- somatostatin receptor (SSTR) (1)
- standardization (1)
- treatment failure (1)
- Ärztliche Behandlung (1)
Institut
- Medizinische Klinik und Poliklinik II (25) (entfernen)
Sonstige beteiligte Institutionen
EU-Projektnummer / Contract (GA) number
- 701983 (3)
Background
Neoadjuvant chemotherapy (NACT) for early breast cancer can make breast-conserving surgery more feasible and might be more likely to eradicate micrometastatic disease than might the same chemotherapy given after surgery. We investigated the long-term benefits and risks of NACT and the influence of tumour characteristics on outcome with a collaborative meta-analysis of individual patient data from relevant randomised trials.
Methods
We obtained information about prerandomisation tumour characteristics, clinical tumour response, surgery, recurrence, and mortality for 4756 women in ten randomised trials in early breast cancer that began before 2005 and compared NACT with the same chemotherapy given postoperatively. Primary outcomes were tumour response, extent of local therapy, local and distant recurrence, breast cancer death, and overall mortality. Analyses by intention-to-treat used standard regression (for response and frequency of breast-conserving therapy) and log-rank methods (for recurrence and mortality).
Findings
Patients entered the trials from 1983 to 2002 and median follow-up was 9 years (IQR 5-14), with the last follow-up in 2013. Most chemotherapy was anthracycline based (3838 [81%] of 4756 women). More than two thirds (1349 [69%] of 1947) of women allocated NACT had a complete or partial clinical response. Patients allocated NACT had an increased frequency of breast-conserving therapy (1504 [65%] of 2320 treated with NACT vs 1135 [49%] of 2318 treated with adjuvant chemotherapy). NACT was associated with more frequent local recurrence than was adjuvant chemotherapy: the 15 year local recurrence was 21.4% for NACT versus 15.9% for adjuvant chemotherapy (5.5% increase [95% CI 2.4-8.6]; rate ratio 1.37 [95% CI 1.17-1.61]; p = 0.0001). No significant difference between NACT and adjuvant chemotherapy was noted for distant recurrence (15 year risk 38.2% for NACT vs 38.0% for adjuvant chemotherapy; rate ratio 1.02 [95% CI 0.92-1.14]; p = 0.66), breast cancer mortality (34.4% vs 33.7%; 1.06 [0.95-1.18]; p = 0.31), or death from any cause (40.9% vs 41.2%; 1.04 [0.94-1.15]; p = 0.45).
Interpretation
Tumours downsized by NACT might have higher local recurrence after breast-conserving therapy than might tumours of the same dimensions in women who have not received NACT. Strategies to mitigate the increased local recurrence after breast-conserving therapy in tumours downsized by NACT should be considered-eg, careful tumour localisation, detailed pathological assessment, and appropriate radiotherapy. Copyright (c) The Author(s). Published by Elsevier Ltd.