Filtern
Volltext vorhanden
- ja (17)
Gehört zur Bibliographie
- ja (17)
Dokumenttyp
Sprache
- Englisch (17)
Schlagworte
- molecular docking (6)
- Gibbs free energy of binding (3)
- blood-brain barrier (3)
- endothelial cells (3)
- blood brain barrier (2)
- in vitro (2)
- multidrug resistance (2)
- ATP-binding cassette transporter (1)
- C6 (1)
- Einfluss (1)
- Evaluation (1)
- Gene expression vectors (1)
- HIV (1)
- Lamarckian genetic algorithms (1)
- Nicardipine (1)
- P-glycoprotein (1)
- P-gp inhibitors (1)
- POLSCORE (1)
- Polymerase chain reaction (1)
- Prognose (1)
- SWCNT CNTs (1)
- Sanger sequencing (1)
- Shotgun method (1)
- Spumaviren (1)
- Synthetic biology (1)
- Transwell® system (1)
- Tyrian purple (1)
- Virtual sequencing (1)
- aggregation (1)
- alveolar epithelium in vitro model, claudin-1, claudin-3, claudin-4, claudin-5 (1)
- anthocyanin derivatives (1)
- blood–brain barrier choline transporter (1)
- capsaicin (1)
- carbon nanoparticles (1)
- carcinogen activation (1)
- central nervous system (1)
- cerebEND (1)
- cerebEND cells (1)
- comparative molecular field analysis (1)
- comparative molecular similarity index analysis (1)
- cyclodextrin formulations (1)
- cytochrome P450 3A4 (1)
- cytotoxicity (1)
- density functional theory (1)
- differentially expressed genes (1)
- diffusion (1)
- drug delivery (1)
- drug delivery vector (1)
- encephalitis dementia (1)
- ether (1)
- etomidate (1)
- fluorescein isothiocyanate (1)
- fluorescence microscopy (1)
- formulations (1)
- free energy of solvation (1)
- fullerenes (1)
- gene ontology (1)
- glucocorticoid receptor (1)
- glucocorticoids (1)
- gradient optimisation (1)
- human immunodeficiency virus (1)
- hydrochloride (1)
- hypoxia (1)
- indigo (1)
- intestinal absorption (1)
- ischemia (1)
- isosteviol sodium (1)
- mean force potential (1)
- metabolizing rate (1)
- mice (1)
- microarray (1)
- midazolam (1)
- molecular dynamics (1)
- molecular liphophilicity potential (1)
- multiwalled carbon nanotube (1)
- neuroprotection (1)
- oxygen/glucose deprivation (1)
- pharmaceutical applications (1)
- pharmacokinetic delivery (1)
- pi-pi stacking (1)
- primary microvascular endothelial cells (1)
- propranolol (1)
- protein-protein interaction network (1)
- quantum mechanics (1)
- safety (1)
- sevoflurane (1)
- shape-based approach (1)
- single-electron transistor (1)
- single-walled carbon nanotubes (1)
- stroke (1)
- three-dimensional quantitative structure–activity relationship (1)
- tight junctions (1)
- torsional energy (1)
- transition state (1)
- traumatic brain injury (1)
- trimethyl-β-cyclodextrin (1)
- ulfobutylether-\(\beta\)-cyclodextrin (1)
- virtual screening (1)
- water (1)
Institut
- Klinik und Poliklinik für Anästhesiologie (ab 2004) (17)
- Theodor-Boveri-Institut für Biowissenschaften (4)
- Deutsches Zentrum für Herzinsuffizienz (DZHI) (1)
- Institut für Pharmazie und Lebensmittelchemie (1)
- Institut für Virologie und Immunbiologie (1)
- Kinderklinik und Poliklinik (1)
- Neurochirurgische Klinik und Poliklinik (1)
Sonstige beteiligte Institutionen
Microvascular endothelial cells are an essential part of many biological barriers, such as the blood–brain barrier (BBB) and the endothelium of the arteries and veins. A reversible opening strategy to increase the permeability of drugs across the BBB could lead to improved therapies due to enhanced drug bioavailability. Vanilloids, such as capsaicin, are known to reversibly open tight junctions of epithelial and endothelial cells. In this study, we used several in vitro assays with the murine endothelial capillary brain cells (line cEND) as a BBB model to characterize the interaction between capsaicin and endothelial tight junctions.