Refine
Has Fulltext
- yes (31)
Is part of the Bibliography
- yes (31)
Year of publication
Document Type
- Journal article (31) (remove)
Language
- English (31)
Keywords
- heart failure (6)
- myocardial infarction (5)
- chronic heart failure (3)
- cytokines (3)
- echocardiography (3)
- inflammation (3)
- GFAP (2)
- acute heart failure (2)
- anxiety (2)
- cardiac magnetic resonance imaging (2)
- cognitive impairment (2)
- depression (2)
- glial fibrillary acidic protein (2)
- heart (2)
- left ventricular ejection fraction (2)
- mortality (2)
- natriuretic peptide (2)
- neurofilament light chain (2)
- ARDS (acute respiratory distress syndrome) (1)
- ATP generation (1)
- Alzheimer’s dementia (1)
- Bioluminescence (1)
- Brain atrophy (1)
- CD4+ T-cells (1)
- COVID-19 (1)
- COVID‐19 vaccination (1)
- Ca2+i handling (1)
- Cardiac dysfunction| Brain natriuretic peptide (1)
- CardioMEMS™ HF-System (1)
- Chronic heart failure (1)
- Chronic heart-failure (1)
- Cognitive decline (1)
- GMPcGMP-dependent protein kinase I (1)
- Germany (1)
- Glial fibrillary acidic protein (1)
- Heart failure (1)
- IP3 (1)
- Impella (1)
- MRI (1)
- Memory dysfunction (1)
- Mena/VASP (1)
- Mfn2 KO mice (1)
- NSG animals (1)
- NfL (1)
- Non‐ischaemic cardiogenic shock (1)
- Prevalence (1)
- Prognostic impact (1)
- Risk-factors (1)
- SARS‐CoV‐2 infection (1)
- SR/mitochondria metabolic feedback (1)
- ST-elevation myocardial infarction (1)
- STEMI (1)
- Stroke (1)
- T cells (1)
- Troponin (1)
- Valvular heart-desease (1)
- actin (1)
- adaptive immune response (1)
- age (1)
- aneurysm (1)
- anti-myocardial (1)
- anti‐SARS‐CoV‐2‐spike IgG (1)
- apoptosis (1)
- autoantibody (1)
- behavior (1)
- biomarkers (1)
- blood coagulation factor XIII (1)
- cancer treatment (1)
- cardiac hypertrophy (1)
- cardiac training group (1)
- cardiology (1)
- cardiovascular disease (1)
- cardiovascular magnetic resonance (1)
- cell staining (1)
- chronic distress (1)
- cluster analysis (1)
- comprehensive psychosomatic assessment (1)
- cyclic (1)
- diastolic dysfunction (1)
- dilated cardiomyopathy (1)
- endothelin-1 (1)
- extracellular matrix (1)
- gene-environment interaction (1)
- glial damage (1)
- healing and remodelling processes (1)
- health care (1)
- healthcare workers (1)
- heart failure training group (1)
- heart failure with mid-range ejection fraction (1)
- heart failure with reduced ejection fraction (1)
- immune cells (1)
- immuno-modulation (1)
- immunosenescence (1)
- infarction size (1)
- inflammaging (1)
- intensity of attention (1)
- intensive care medicine (1)
- ischemic stroke (1)
- left ventricular thrombusv (1)
- lymphocytes (1)
- m exercise training (1)
- metastasis (1)
- mice (1)
- mild (1)
- mitochondrial mRyR1 (1)
- mitofusin 2 (1)
- morbidity (1)
- myocardial aging (1)
- myocardium (1)
- neurology (1)
- neuroscience (1)
- neutrophils (1)
- pandemia (1)
- phosphorylated tau protein (1)
- prognosis (1)
- public health (1)
- pulmonary artery pressure (1)
- quality of life (1)
- randomized controlled trial (1)
- recovery (1)
- recurrent Tako-Tsubo cardiomyopathy (1)
- regulatory T cells (1)
- remote monitoring (1)
- renal function (1)
- right ventricular dysfunction (1)
- seroprevalence (1)
- serotonin transporter deficient mice (1)
- sex differences (1)
- spectrin (1)
- statins (1)
- systems biology (1)
- therapy (1)
- troponin (1)
Institute
- Medizinische Klinik und Poliklinik I (28)
- Deutsches Zentrum für Herzinsuffizienz (DZHI) (17)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (8)
- Neurologische Klinik und Poliklinik (5)
- Medizinische Klinik und Poliklinik II (4)
- Institut für Klinische Epidemiologie und Biometrie (3)
- Institut für Virologie und Immunbiologie (3)
- Institut für diagnostische und interventionelle Neuroradiologie (ehem. Abteilung für Neuroradiologie) (3)
- Institut für Informatik (2)
- Institut für Pharmakologie und Toxikologie (2)
Sonstige beteiligte Institutionen
Background
Cognitive impairment is a major comorbidity in patients with chronic heart failure (HF) with a wide range of phenotypes. In this study, we aimed to identify and compare different clusters of cognitive deficits.
Methods
The prospective cohort study “Cognition.Matters-HF” recruited 147 chronic HF patients (aged 64.5 ± 10.8 years; 16.2% female) of any etiology. All patients underwent extensive neuropsychological testing. We performed a hierarchical cluster analysis of the cognitive domains, such as intensity of attention, visual/verbal memory, and executive function. Generated clusters were compared exploratively with respect to the results of cardiological, neurological, and neuroradiological examinations without correction for multiple testing.
Results
Dendrogram and the scree plot suggested three distinct cognitive profiles: In the first cluster, 42 patients (28.6%) performed without any deficits in all domains. Exclusively, the intensity of attention deficits was seen in the second cluster, including 55 patients (37.4%). A third cluster with 50 patients (34.0%) was characterized by deficits in all cognitive domains. Age (p = 0.163) and typical clinical markers of chronic HF, such as ejection fraction (p = 0.222), 6-min walking test distance (p = 0.138), NT-proBNP (p = 0.364), and New York Heart Association class (p = 0.868) did not differ between clusters. However, we observed that women (p = 0.012) and patients with previous cardiac valve surgery (p = 0.005) prevailed in the “global deficits” cluster and the “no deficits” group had a lower prevalence of underlying arterial hypertension (p = 0.029). Total brain volume (p = 0.017) was smaller in the global deficit cluster, and serum levels of glial fibrillary acidic protein were increased (p = 0.048).
Conclusion
Apart from cognitively healthy and globally impaired HF patients, we identified a group with deficits only in the intensity of attention. Women and patients with previous cardiac valve surgery are at risk for global cognitive impairment when suffering HF and could benefit from special multimodal treatment addressing the psychosocial condition.