Refine
Has Fulltext
- yes (41)
Is part of the Bibliography
- yes (41)
Year of publication
Document Type
- Journal article (41)
Keywords
- nanoparticles (4)
- auditory pathway (3)
- cochlear implantation (3)
- toxicity (3)
- zinc oxide (3)
- Fabry disease (2)
- cochlea (2)
- cochlear implant (2)
- cytotoxicity (2)
- differentiation potential (2)
- discriminant analysis (2)
- epithelial-mesenchymal transition (2)
- fpVCT (2)
- genotoxicity (2)
- head and neck squamous cell carcinoma (2)
- hearing loss (2)
- human adipose-derived stromal cells (2)
- neural stem cells (2)
- neurogenesis (2)
- neurosphere (2)
- principal component analysis (2)
- stem cells (2)
- temporal bone (2)
- zinc oxide nanoparticles (2)
- 3D analysis (1)
- ASC (1)
- App-Entwicklung (1)
- BMP-6 (1)
- CDL (1)
- CIS+ (1)
- CT (1)
- Candida albicans (1)
- Chancen (1)
- Cochlear duct length (1)
- Cochlear planning software (1)
- FTIR spectroscopy (1)
- Head and neck cancers (1)
- Interleukin (1)
- Laser Doppler vibrometer (1)
- Literaturrecherche (1)
- MOC fibers (1)
- MRI (1)
- MSCT (1)
- Meniere’s disease (1)
- OPUS (1)
- Risiken (1)
- T cell activation (1)
- T cell subpopulations (1)
- TGF-ß3 (1)
- Tuberculosis (1)
- Umfrage (1)
- Univted-States (1)
- VEMP (1)
- VSOP (1)
- ZnO (1)
- ZnO-NP (1)
- active middle-ear implant (1)
- adaptive directional microphone setting (1)
- adenotonsillectromy (1)
- adipose-derived stromal cells (1)
- apps (1)
- asbestos (1)
- aspiration (1)
- atraumatic surgery (1)
- bone conduction implant (1)
- cancers and neoplasms (1)
- cardiac dysfunction (1)
- cardiomyopathy (1)
- case-control study (1)
- cavity (1)
- cell proliferation (1)
- central auditory pathway (1)
- children (1)
- chondrogenic differentiation (1)
- chronic kidney disease (1)
- chronic rhinosinusitis (1)
- cigarette smoking (1)
- cisplatin resistance (1)
- cochlear implants (1)
- cochlear nucleus (1)
- coding strategy (1)
- computed tomography (1)
- conductive hearing loss (1)
- confocal Raman imaging (1)
- couplers (1)
- deep neck infection (1)
- development (1)
- dysphagia (1)
- electric acoustic stimulation (EAS) (1)
- electromagnetic navigation (1)
- electromyographic (1)
- endochondral ossification (1)
- epithelial barrier (1)
- extrapulmonary tuberculosis (1)
- facial nerve (1)
- fibrin (1)
- fiducial registration error (1)
- fine structure processing (1)
- fixation (1)
- flexible CO2 laser (1)
- floating mass transducer (1)
- focus of infection (1)
- formaldehyde (1)
- formalin (1)
- hardwood dust (1)
- head and neck (1)
- hearing (1)
- hearing aids (1)
- hearing preservation (1)
- high-sensitivity FEES (1)
- human plasma (1)
- immunomodulation (1)
- incus (1)
- inferior colliculus (1)
- insecticides (1)
- interelectrode-distance (1)
- iron oxide nanoparticles (1)
- irradiation (1)
- jugular paraganglioma (1)
- laryngeal tuberculosis (1)
- laser surgery (1)
- lateral neck abscesses (1)
- lateral skull base (1)
- lipids (1)
- long-term exposure (1)
- lymph node tuberculosis (1)
- lysosomal storage disorder (1)
- malignant tumors (1)
- maxillary sinus (1)
- mediastinitis (1)
- mesenchymal stem cells (1)
- microbiology (1)
- microbiome (1)
- microtubules (1)
- middle ear implant (1)
- middle-ear surgery (1)
- mixed hearing loss (1)
- molecular diagnostics (1)
- monotoring (1)
- motor neuropathy (1)
- multivariate data analysis (1)
- music (1)
- narrow band imaging (NBI) (1)
- nasal cancer (1)
- nasal lavage (1)
- nasal mucosal barrier function (1)
- nasal polyps (1)
- nasal snuff (1)
- nasal spray (1)
- nasopharyngeal carcinoma (1)
- neural progenitor cells (1)
- neural stem cell potential (1)
- neuronal maturation (1)
- neuronal oscillations (1)
- obstructive sleep apnoea (1)
- occupational exposures (1)
- organic solvents (1)
- otology (1)
- outer hair cell (OHC) (1)
- oxidative DNA damage (1)
- paediatrics (1)
- paranasal sinuses (1)
- partial deafness treatment (1)
- pegylated insulin-like growth factor 1 (1)
- pitch (1)
- polyurethane (1)
- posttranslational modifications (1)
- professional image enhancement technique (PIET) (1)
- questionnaire (1)
- raman spectroscopy (1)
- real-time PCR (1)
- regenerative capacity (1)
- renal dysfunction (1)
- retrospective (1)
- risk factors (1)
- saccotomy (1)
- salivary gland neoplasia (1)
- salivary gland tumor (1)
- salivary gland tumors (1)
- salivary glands (1)
- secondary reconstruction (1)
- silver (1)
- single-sided deafness (1)
- sinonasal cancer (1)
- smoking (1)
- speech perception (1)
- surgery (1)
- surgical drainage (1)
- surgical management of paraganglioma (1)
- surgical oncology (1)
- tight junction (1)
- tight junctions (1)
- tissue preparation (1)
- tracheotomy (1)
- tubulin (1)
- tubulin-binding cofactors (1)
- tympanic paraganglioma (1)
- tympanojugular paraganglioma (1)
- vertigo (1)
- vestibular aqueduct (VA) (1)
- vibroplasty (1)
- wood dust (1)
- wound fluid (1)
Institute
- Klinik und Poliklinik für Hals-, Nasen- und Ohrenkrankheiten, plastische und ästhetische Operationen (40)
- Institut für diagnostische und interventionelle Neuroradiologie (ehem. Abteilung für Neuroradiologie) (6)
- Lehrstuhl für Tissue Engineering und Regenerative Medizin (4)
- Pathologisches Institut (3)
- Medizinische Klinik und Poliklinik I (2)
- Augenklinik und Poliklinik (1)
- Institut für Klinische Neurobiologie (1)
- Institut für Virologie und Immunbiologie (1)
- Klinik und Poliklinik für Strahlentherapie (1)
- Lehrstuhl für Orthopädie (1)
- Neurologische Klinik und Poliklinik (1)
- Physikalisches Institut (1)
Ag- but not ZnO-nanoparticles disturb the airway epithelial barrier at subtoxic concentrations
(2023)
Inhalation is considered to be the most relevant source of human exposure to nanoparticles (NPs); however, only a few investigations have addressed the influence of exposing the respiratory mucosal barrier to subcytotoxic doses. In the nasal respiratory epithelium, cells of the mucosa represent one of the first contact points of the human organism with airborne NPs. Disruption of the epithelial barrier by harmful materials can lead to inflammation in addition to potential intrinsic toxicity of the particles. The aim of this study was to investigate whether subtoxic concentrations of zinc oxide (ZnO)- and silver (Ag)-NPs have an influence on upper airway barrier integrity. Nasal epithelial cells from 17 donors were cultured at the air–liquid interface and exposed to ZnO- and Ag-NPs. Barrier function, quantified by transepithelial electrical resistance (TEER), decreased after treatment with 10 µg/mL Ag-NPs, but FITC-dextran permeability remained stable and no change in mRNA levels of tight junction proteins and E-cadherin was detected by real-time quantitative PCR (RT-qPCR). The results indicate that subtoxic concentrations of Ag-NPs may already induce damage of the upper airway epithelial barrier in vitro. The lack of similar disruption by ZnO-NPs of similar size suggests a specific effect by Ag-NPs.