Filtern
Volltext vorhanden
- ja (25)
Gehört zur Bibliographie
- ja (25)
Erscheinungsjahr
Dokumenttyp
Schlagworte
- Medizin (3)
- liraglutide (3)
- obesity (3)
- MIZ1 (2)
- MYC (2)
- Roux-en-Y gastric bypass surgery (2)
- chemotherapy (2)
- colorectal cancer (2)
- gastric bypass (2)
- peptide tyrosine tyrosine (PYY) (2)
- 5-fluorouracil (1)
- AAA (1)
- Barrett-Ösophagus (1)
- CRC (1)
- CX5461 (1)
- Chirurgie (1)
- Claudin2 (1)
- Dsg2 (1)
- FWGE (1)
- Fn14 (1)
- GLP-1 (1)
- HUWE1 (1)
- Krebs (1)
- Lebertransplantat-Spontantoleranz (1)
- MAPK signaling cascades (1)
- MHC molecules (1)
- NAFLD (1)
- NASH (1)
- NFκB (1)
- PI-3-kinase (1)
- PYY3-36 (1)
- RNAPOL1 (1)
- RT-qPCT (1)
- RYGB (1)
- Regulator T-Lymphozyten (1)
- TKTL1 (1)
- TNF (1)
- TWEAK (1)
- Transplantation (1)
- Y-gastric bypass (1)
- Zucker fatty fa/fa rats (1)
- adipose-derived stromal/stem cells (ASCs) (1)
- agonistic antibodies (1)
- allogene MHC-Peptide (1)
- anti-tumor effects (1)
- antigen-specific therapy (1)
- antigenspezifische Therapie (1)
- autophagy (1)
- bariatric surgery (1)
- benzoquinone (1)
- biliopancreatic diversion (1)
- biological models (1)
- body weight (1)
- breast cancer (1)
- caco-2 cells (1)
- cancer (1)
- cancer cell lines (1)
- cancer cells (1)
- carcinomas (1)
- cell death (1)
- chemistry (1)
- colon (1)
- colorectal carcinoma (1)
- cotransporter SGLT1 (1)
- cytostatic (1)
- cytotoxicity (1)
- desmosome (1)
- digestive system (1)
- drug discovery (1)
- duodenal jejunal bypass (1)
- energy homeostasis (1)
- fatty liver (1)
- food intake (1)
- glucagon like peptide-1 (1)
- glucose homeostasis (1)
- glucose starvation (1)
- gut hormones (1)
- histologic diversity (1)
- hypothalamic gene expression (1)
- hypoxia (1)
- immunohistochemistry (1)
- inflammation (1)
- inflammatory bowel disease (1)
- intestinal barrier (1)
- intestinal glucose (1)
- ionizing radiation (1)
- ischemia (1)
- ketogenic dients (1)
- ketogenic diet (1)
- ketone bodies (1)
- leptin system (1)
- metabolic profile (1)
- metastasis (1)
- miRNA expression (1)
- mice (1)
- oxaliplatin (1)
- pathway analysis (1)
- peptide tyrosine tyrosine 3-36 (PYY3-36) (1)
- peptide tyrosine tyrosine 3-36 (PYY\(_{3-36}\)) (1)
- pharmacology (1)
- popliteal aneurysm (1)
- protein expression (1)
- reactivating p53 and inducing tumor apoptosis (RITA) (1)
- reactive oxygen species (1)
- regenerative medicine (1)
- regulatory T cells (1)
- ribosome (1)
- rygb (1)
- seahorse (1)
- secretion (1)
- small interferring RNA (1)
- spontaneous liver allograft tolerance (1)
- tight junction (1)
- translational research (1)
- transplantation (1)
- treatment (1)
- trophic factors (1)
- ubiquitination (1)
- β-Hydroxybutyrate (1)
Institut
- Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) (23)
- Theodor-Boveri-Institut für Biowissenschaften (7)
- Frauenklinik und Poliklinik (5)
- Medizinische Klinik und Poliklinik I (4)
- Institut für Anatomie und Zellbiologie (3)
- Pathologisches Institut (3)
- Comprehensive Cancer Center Mainfranken (2)
- Institut für Molekulare Infektionsbiologie (2)
- Abteilung für Molekulare Innere Medizin (in der Medizinischen Klinik und Poliklinik II) (1)
- Institut für Experimentelle Biomedizin (1)
Background: The hypothalamus is an important brain region for the regulation of energy balance. Roux-en-Y gastric bypass (RYGB) surgery and gut hormone-based treatments are known to reduce body weight, but their effects on hypothalamic gene expression and signaling pathways are poorly studied. Methods: Diet-induced obese male Wistar rats were randomized into the following groups: RYGB, sham operation, sham + body weight-matched (BWM) to the RYGB group, osmotic minipump delivering PYY3-36 (0.1 mg/kg/day), liraglutide s.c. (0.4 mg/kg/day), PYY3-36 + liraglutide, and saline. All groups (except BWM) were kept on a free choice of high- and low-fat diets. Four weeks after interventions, hypothalami were collected for RNA sequencing. Results: While rats in the RYGB, BWM, and PYY3-36 + liraglutide groups had comparable reductions in body weight, only RYGB and BWM treatment had a major impact on hypothalamic gene expression. In these groups, hypothalamic leptin receptor expression as well as the JAK–STAT, PI3K-Akt, and AMPK signaling pathways were upregulated. No significant changes could be detected in PYY3-36 + liraglutide-, liraglutide-, and PYY-treated groups. Conclusions: Despite causing similar body weight changes compared to RYGB and BWM, PYY3-36 + liraglutide treatment does not impact hypothalamic gene expression. Whether this striking difference is favorable or unfavorable to metabolic health in the long term requires further investigation.