Refine
Has Fulltext
- yes (3)
Is part of the Bibliography
- yes (3)
Document Type
- Journal article (3)
Language
- English (3)
Keywords
- ALiOS (1)
- DNA damage (1)
- NAFLD (1)
- NASH (1)
- NLRP3 (1)
- TNF-related apoptosis-inducing ligand (1)
- Western diet (1)
- apoptosis (1)
- hepatocellular carcinoma (1)
- inflammasome (1)
- interleukin 1 (1)
- interleukin 18 (1)
- pancreatic neoplasms (1)
- poly(ADP-ribose) polymerase inhibitors (1)
- systemic therapy (1)
- tyrosine-kinase inhibitor (1)
Institute
The optimal treatment sequence of tyrosine kinase inhibitor (TKI)-based therapy in patients with hepatocellular carcinoma (HCC) remains unclear. Therefore, sequential systemic therapy after first-line therapy with sorafenib or lenvatinib was compared in a retrospective real-world cohort. In total, 164 patients with HCC were included. Child B cirrhosis was present in 26 patients (16.5%), whereas 132 patients (83.5%) had preserved liver function. In total, 72 patients (44%) discontinued systemic therapy after first-line therapy while 51 (31%) and 31 (19%) patients received 2 or more treatment lines. Most notably, median overall survival (mOS) was influenced by liver functional status and patient performance status at the beginning of first-line therapy. Patients receiving a sequential therapy regimen had significantly longer mOS compared to patients that discontinued systemic therapy after omitting first-line treatment. The choice of the initial TKI did not impact mOS. A clear deterioration of liver function could be observed during the course of TKI-based treatment.