Refine
Has Fulltext
- yes (55)
Is part of the Bibliography
- yes (55)
Year of publication
Document Type
- Doctoral Thesis (52)
- Journal article (2)
- Master Thesis (1)
Keywords
- Epigenetik (3)
- Genexpression (3)
- Angiogenese (2)
- Biofilm (2)
- Cancer (2)
- Exomsequenzierung (2)
- Guanylatcyclase (2)
- Immunotherapy (2)
- Konsanguinität (2)
- Krebs <Medizin> (2)
- Maus (2)
- Melanom (2)
- Therapie (2)
- Tissue Engineering (2)
- Vaskularisierung (2)
- microbiome (2)
- 3D (1)
- 3D Tumormodell (1)
- 3D cell culture (1)
- 3D tumour model (1)
- ADHD (1)
- APOBEC3G (1)
- Alternative methods (1)
- Alternativmethoden (1)
- Alzheimer's disease (1)
- Alzheimerkrankheit (1)
- Aminobuttersäure <gamma-> (1)
- Angeborene Immunität (1)
- Animal model (1)
- Anthropocene (1)
- Aorta (1)
- Arbeitsteilung (1)
- Aspergillus fumigatus (1)
- Aussterbedynamik (1)
- Automation (1)
- BRAF-mutant (1)
- BRAF-mutiert (1)
- Bacterial infection (1)
- Bakteriophagen (1)
- Biene (1)
- Bioengineering (1)
- Bioinformatik (1)
- Bleomycin (1)
- C. difficile (1)
- CDI (1)
- CNBP (1)
- Calciumkanal (1)
- Calpain (1)
- Cataglyphis (1)
- Catenin (1)
- Catenine (1)
- Cavβ subunit (1)
- Ceramide (1)
- Channelrhodopsin 2 (1)
- Chlamydia trachomatis (1)
- Control centrality (1)
- Craniosynostosis (1)
- Cyclo-AMP (1)
- Cyclo-GMP (1)
- DG diacyglycerol (1)
- DNA Reparatur (1)
- DNAse (1)
- Danio rerio (1)
- Darmkrebs (1)
- Deep learning (1)
- Dickdarmtumor (1)
- Dispersal (1)
- Dopamin (1)
- Drosophila melanogaster (1)
- E. coli Nissle 1917 (1)
- EHEC (1)
- Elektrophysiologie (1)
- Enterohemorrhagic Escherichia coli (1)
- Entwicklung (1)
- Evolution (1)
- Exozytose (1)
- Expansion microscopy (1)
- Expansionsmikroskopie (1)
- FOSL1 (1)
- FOXP2 (1)
- Fanconi Anämie (1)
- Farbensehen (1)
- Fetale Programmierung (1)
- Fluoreszenzmikroskopie (1)
- Folliculin (1)
- G protein-coupled receptors (1)
- GABA (1)
- GAD1 (1)
- GRM8 (1)
- Genetic etiology (1)
- Genetic regulatory networks (1)
- Genetik (1)
- Genetisches Imprinting (1)
- Genmutation (1)
- Genregulation (1)
- Glioblastom (1)
- Glioblastoma (1)
- Glucosetransportproteine (1)
- Gonococcal invasion (1)
- Guanylyl-Cyclase (1)
- HIV-1 (1)
- Hair follicle (1)
- Haut (1)
- Hautmodell (1)
- Herzhypertrophie (1)
- Herzmuskelzelle (1)
- Himmelskompass (1)
- Hirntumor (1)
- Histogenese (1)
- Histogenesis (1)
- Hochauflösungsmikroskopie (1)
- Homing (1)
- Host defense (1)
- Host-pathogen interaction (1)
- Hyperactivity (1)
- Hörstörung (1)
- Hörstörungen (1)
- Immunologie (1)
- Immunsuppression (1)
- Implantat (1)
- In vitro (1)
- Individual based model (IBM) (1)
- Induzierte Mutation (1)
- Innate immunity (1)
- Integrin (1)
- Intracellular bacteria (1)
- Intrazelluläre Bakterien (1)
- Japankärpfling (1)
- Knochenimplantat (1)
- Knochenregeneration (1)
- Knock-Out <Molekulargenetik> (1)
- Komplexauge (1)
- Kraniosynostose (1)
- Kryoelektronenmikroskopie (1)
- L-type calcium channels (1)
- LTCC-independent function of Cavβ (1)
- Lambdoide Prophagen (1)
- Locomotor activity (1)
- Lungenfibrose (1)
- MAX (1)
- MYCN (1)
- Marine sponge-derived actinomycetes (1)
- Marine sponges (1)
- Medizinprodukt (1)
- Merkel cell carcinoma (1)
- Merkel-Zellkarzinom (1)
- Messenger-RNS (1)
- Microbubbles (1)
- Mikrowellen (1)
- Mitochondria (1)
- Mitochondrien (1)
- Mitochondrium (1)
- Model Organism (1)
- Modellorganismus (1)
- Modellsystem (1)
- ModulationTregs (1)
- Murine embryonale Stammzellen (1)
- Mutation (1)
- Mycoplasma pneumoniae (1)
- Myeloid-derived suppressor cells (1)
- Myofibroblast (1)
- NO-sensitive Guanylyl-Cyclase (1)
- NO-sensitive guanylyl cyclase (1)
- Natrium/Glukose Cotransporter (1)
- Neisseria gonorrhoeae (1)
- Nephroblastom (1)
- Netzhaut (1)
- Neue Fanconi Anämie Gene (1)
- Neuroepigenomics (1)
- Neuroethologie (1)
- Neuromodulation (1)
- Neuronale Plastizität (1)
- Neuropeptide (1)
- Neuropeptidom (1)
- Neutrophils (1)
- Next Generation Sequencing (NGS) (1)
- Nichtlineare Differentialgleichung (1)
- PE Phosphoethanolamine (1)
- PRC1.6 (1)
- PTI signalling (1)
- Paternal age and BMI effects (1)
- Pcgf6 (1)
- Perizyt (1)
- Pflanzenaussterben (1)
- Pharmaceutische Biologie (1)
- Phosphodiesterase 3 (1)
- Polyomavirus (1)
- Probiotikum (1)
- Proliferation (1)
- Protein interactor (1)
- Proteinbiosynthese (1)
- Pulmonary fibrosis (1)
- Pulswellengeschwindigkeit (1)
- Quorum-Sensing (1)
- RNA binding potein CNBP (1)
- RNAlater (1)
- Rechtsmedizin (1)
- Regenerative Medizin (1)
- Rhodopsin (1)
- Riesensynapsen (1)
- SGLT (1)
- STD patients (1)
- Schlaf (1)
- Schwangerschaftsdiabetes (1)
- Schädel-Hirn-Trauma (1)
- Serotonin (1)
- Shigella flexneri (1)
- Simulation (1)
- Slice Culture (1)
- Sodium-Glucose Transporter 2 (1)
- Soziale Insekten (1)
- Spatial heterogeneity (1)
- Spatiotemporal analysis (1)
- Staphylococci (1)
- Staphylococcus aureus (1)
- Stickstoffmonoxid (1)
- Strategies to Obtain Tumor-Reactive Cells (1)
- Streptomyces (1)
- Stress (1)
- Superresolution microscopy (1)
- TIAR (1)
- TOP mRNA (1)
- Targeted therapies (1)
- Taufliege (1)
- Temporal heterogeneity (1)
- Terminal Oligopyrimidine Tract (1)
- Theoretical Ecology (1)
- Thigmotaxis (1)
- Tisuue Engineering (1)
- Tomografie (1)
- Transkriptionsfaktor (1)
- Translationsinitiation (1)
- Translationskontrolle (1)
- Trypanosoma brucei (1)
- Tumor models (1)
- USP10 (1)
- Ubiquitin (1)
- Ubiquitinligase (1)
- Ultraschall (1)
- VLA-1 (1)
- VSG (1)
- Vaskularisation (1)
- Verhaltensplastizität (1)
- Verwandtenehe (1)
- Vif (1)
- Wilms Tumor (1)
- Wnt-Proteine (1)
- Xiphophorus Melanom (1)
- Zebrafish (1)
- Zellassay (1)
- agr (1)
- antigene Variation (1)
- assay (1)
- autophagocytose (1)
- autophagy (1)
- autosomal rezessiver Erbgang (1)
- bees (1)
- bleomycin (1)
- bone (1)
- chlamydia trachomatis (1)
- circadian clock (1)
- color vision (1)
- colorectal cancer (1)
- compound eyes (1)
- cryo-EM (1)
- cryo-ET (1)
- deep learning (1)
- dopamine (1)
- extinction dynamics (1)
- fish model (1)
- flash freezing (1)
- fluoreszenz (1)
- implant (1)
- infant (1)
- insects (1)
- kolorektales Karzinom (1)
- lambdoid prophage (1)
- mRNA (1)
- mechanistische Modellierung (1)
- membrane protein (1)
- metabolic modelling (1)
- metabolic theory of ecology (1)
- metagenomics (1)
- metaproteomics (1)
- metatranscriptome (1)
- microbiota (1)
- monoallele Expression (1)
- mycoplasma (1)
- myofibroblast (1)
- neurobiology (1)
- particle picking (1)
- pericyte (1)
- plant immunity (1)
- pneumoniae (1)
- polarized epithelium (1)
- probiotica (1)
- protease (1)
- proteomics (1)
- rapid evolution (1)
- retinal development (1)
- sae (1)
- sample storage (1)
- sar (1)
- schnelle Evolution (1)
- screening (1)
- serotonin (1)
- skin (1)
- sleep (1)
- sodium-dependend glucose transporter (1)
- stx-Phagen (1)
- stx-phages (1)
- targeted therapy (1)
- tomography (1)
- transient dynamics (1)
- translation (1)
- traumatic brain injury (1)
- tumour (1)
- uORF (1)
- vascularization (1)
- vesicle trafficking (1)
- visual proteomics (1)
- zielgerichtete Behandlung (1)
Institute
- Fakultät für Biologie (55) (remove)
Sonstige beteiligte Institutionen
- EMBL Heidelberg (2)
- Fachhochschule Kaiserslautern, Campus Zweibrücken (1)
- Institut für Medizinische Mikrobiologie und Hygiene der Eberhard-Karls-Universität Tübingen (1)
- Lehrstuhl für Biochemie und molekulare Biologie (1)
- Lehrstuhl für Bioinformatik (1)
- Maastricht University, Maastricht, the Netherlands (1)
- Medizinische Universität Innsbruck (1)
- Queensland University of Technology (1)
EU-Project number / Contract (GA) number
The interaction between circadian clocks and metabolism is of increasing interest, since clock dysfunction often correlates with metabolic pathologies. Many research articles have been published analysing the impact of factors such as circadian clock, light, feeding time and diet-type on energy homeostasis in various tissues/organs of organisms with most of the findings done in mammals. Little is known about the impact of circadian clock and the above-mentioned factors on circulating lipids, especially the transport form of lipids - diacylglycerol (DG) and membrane lipids such as phosphatidylethanolamine (PE) and phosphatidylcholine (PC) in the Drosophila hemolymph. The fruit fly Drosophila is a prime model organism in circadian, behaviour and metabolism research.
To study the role of circadian clock and behaviour in metabolism, we performed an extensive comparative hemolymph lipid (diacylglycerol: DG, phosphatidylethanolamine: PE, phosphatidylcholine: PC) analysis using ultra performance liquid chromatography coupled to time-of-flight mass spectrometry (UPLC-MS) between wild-type flies (WTCS) and clock disrupted mutants (per01). In addition, clock controlled food intake– feeding behaviour was investigated. Time-dependent variation of transport (DG) and membrane lipids (PE and PC) were not rhythmic in WTCS under constant darkness and in per01 under LD, suggesting an impact of light and clock genes on daily lipid oscillations. Day-time and night-time restriction of food led to comparable lipid profiles, suggesting that lipid oscillations are not exclusively entrained by feeding but rather are endogenously regulated. Ultradian oscillations in lipid levels in WTCS under LD were masked by digested fatty acids since lipid levels peaked more robustly at the beginning and end of light phase when flies were fed a lipid- and protein-free diet. These results suggest that metabolite (DG, PE and PC) oscillation is influenced by complex interactions between nutrient-type, photic conditions, circadian clock and feeding time.
In conclusion, the results of this thesis suggest that circadian clocks determine transport and membrane lipid oscillation in Drosophila hemolymph in complex interactions between nutrient-type, photic conditions and feeding behaviour.