Refine
Has Fulltext
- yes (51)
Is part of the Bibliography
- yes (51)
Year of publication
- 2012 (51) (remove)
Document Type
- Journal article (51) (remove)
Language
- English (51) (remove)
Keywords
- Biologie (9)
- expression (4)
- protein (4)
- african trypanosomes (2)
- architecture (2)
- brain (2)
- cancer (2)
- combination therapy (2)
- differentiation (2)
- diversity (2)
- functional characterization (2)
- immunoreactive neurons (2)
- localization (2)
- melanogaster (2)
- olfactory memory (2)
- oncolysis (2)
- receptor (2)
- resistance (2)
- transcription (2)
- A-type lamins (1)
- Advanced snowmelt (1)
- Alps (1)
- Amazonia (1)
- Araneae (1)
- BBCH (1)
- BRCA1 positive (1)
- BRCA1/2 negative (1)
- BRCA2 positive (1)
- CENP-A (1)
- CSE4, CENP-A (1)
- Camponotus floridanus (1)
- Climate change (1)
- DNA replication (1)
- DNA-binding vesicles (1)
- DOT1 (1)
- Delayed snowmelt (1)
- EF-1A (1)
- European beech (1)
- Flowering (1)
- Functional modules (1)
- HRAS (1)
- Imd pathway (1)
- Integrated network analysis (1)
- LMNA mutations (1)
- Lamto Reserve (1)
- Medizin (1)
- Metabolic pathways (1)
- Metabolic profiles (1)
- Milnesium tardigradum (1)
- Mycoplasma (1)
- New Zealand (1)
- P15(INK4B) (1)
- P21 (1)
- POZ domain (1)
- RNA (1)
- Raf kinases (1)
- Salmonella enterica (1)
- Salmonella-containing vacuole (1)
- Savanna (1)
- T cells (1)
- Trend test (1)
- West Africa (1)
- Yolk protein (1)
- abdominal (1)
- acoustic communication (1)
- actin cortex (1)
- adaption (1)
- adult bee (1)
- adult drosophila (1)
- agonist (1)
- alagille syndrome (1)
- alignment (1)
- aminoacyl-transfer-RNA (1)
- animal communication (1)
- ant communities (1)
- anthropogenic noise (1)
- antimicrobial (1)
- aortic-valve (1)
- apoptosis (1)
- arabidopsi (1)
- arabidopsis thaliana (1)
- arabidpsis thaliana (1)
- auditory masking (1)
- autophagy (1)
- axial skeletal defects (1)
- bacterial persistence (1)
- balance (1)
- bee larva (1)
- big brown bats (1)
- bilayers (1)
- binding (1)
- biogenic amines (1)
- bitter taste (1)
- blood-stream forms (1)
- blowfly calliphora-vomitoria (1)
- brucei (1)
- burned savanna (1)
- c-myc (1)
- caenorhabditis elegans (1)
- call (1)
- cancer cells (1)
- cancer-cells (1)
- canine cancer therapy (1)
- canopy fogging (1)
- capsid protein (1)
- cardiac aging (1)
- cardiac fibrosis (1)
- cell surface (1)
- cell-cycle arrest (1)
- cell-cycle regulation (1)
- centomeres (1)
- central-nervous-system (1)
- centromere (1)
- cerebral ischemia (1)
- chain (1)
- chalinolobus-tuberculatus (1)
- chemosensory protein (1)
- chemosensory system (1)
- chemotherapy (1)
- chromatin (1)
- circadian photoreception (1)
- classification (1)
- clock (1)
- cluster (1)
- colony-stimulating factor (1)
- conjugate (1)
- connector (1)
- containing neurons (1)
- contralateral breast cancer (1)
- conversion (1)
- corticotropin-releasing hormone (1)
- courtship displays (1)
- crosstalk (1)
- cultivation (1)
- cytokine (1)
- dart-poison frog (1)
- database (1)
- decision making (1)
- dependent magnetosensitvity (1)
- depth (1)
- detoxified lipooligosaccharide (1)
- disease (1)
- dosage (1)
- drosophila embryo (1)
- drosophila melanogaster (1)
- drosophila mushroom body (1)
- drug (1)
- dwelling bat (1)
- dynamics (1)
- elementary mode analysis (1)
- elongation (1)
- engineering (1)
- environment (1)
- eptesicus-fuscus (1)
- eucera berlandi (1)
- expressed sequence tag (1)
- expression signature (1)
- factor 1-alpha (1)
- factor EEF1A2 (1)
- feeding behavior (1)
- fission yeast (1)
- flagellar (1)
- flagellum (1)
- fluorescent protein (1)
- forest (1)
- forest disturbance (1)
- forest soils (1)
- fruit fly (1)
- gamma (1)
- gene (1)
- genes (1)
- genetics (1)
- gradient (1)
- growing escherichia coli (1)
- haemolymph (1)
- head involution (1)
- hemophilus influenzae (1)
- higher pitch (1)
- hindbrain boundary (1)
- histidine kinase (1)
- homology modeling (1)
- honey bee (1)
- honey bees (1)
- honeybees (1)
- host cell death (1)
- human jagged1 (1)
- hydrodynamics (1)
- hymenoptera (1)
- hyper-IL-6 (1)
- identification (1)
- immune response (1)
- immunity (1)
- in-vivo (1)
- induction (1)
- infected bee (1)
- ingle-molecule microscopy (1)
- inhibitor (1)
- internal transcribed spacer 2 (1)
- isthmic oragnizer (1)
- laminopathies (1)
- land use (1)
- larva (1)
- learning performances (1)
- life-span regulation (1)
- light avoidance (1)
- long-term reuse (1)
- long-term-memory (1)
- lung cancer (1)
- malaria (1)
- male bees (1)
- mammalian CRY1 (1)
- mammalian cells (1)
- markers (1)
- mass spectometry (1)
- mass spectrometry (1)
- mechanism (1)
- melanoma (1)
- memory (1)
- metabolic flux (1)
- metabolism (1)
- metastasis (1)
- methylene blue (1)
- miR-22 (1)
- miRNA (1)
- mice (1)
- microRNAs (1)
- microscopy (1)
- mimecan (1)
- model (1)
- models (1)
- modules (1)
- molecular systematics (1)
- moth manduca sexta (1)
- motility (1)
- mouse (1)
- multiparticle collision dynamics (1)
- mushroom bodies (1)
- mutations (1)
- nasopharyngeal colonization (1)
- neobellieria bullata (1)
- netcar-feeding bats (1)
- neural crest (1)
- neurons form (1)
- nicotinic acetylcholine-receptors (1)
- nuclear envelope (1)
- nuclear lamina (1)
- nuclear organization (1)
- nucleosome (1)
- nucleotide exchange (1)
- nyctalus noctula (1)
- obstructive pulmonary disease (1)
- oncolytic virus (1)
- ophrys heldreichii (1)
- organization (1)
- organogenesis (1)
- oscillator (1)
- osteoblast differentiation (1)
- osteoglycin (1)
- otitis media (1)
- pathway (1)
- peptide (1)
- perception (1)
- pesticides (1)
- phagocytosis (1)
- phagosomalescape (1)
- phylogenetic tree (1)
- phylogeny (1)
- pollination (1)
- polyarcylamide gels (1)
- polymorphism (1)
- probes (1)
- promoter (1)
- propagation (1)
- propulsion (1)
- protein docking (1)
- protein familiy (1)
- protein-interaction networks (1)
- proteins (1)
- pseudomas-syringae (1)
- quali-chick chimeras (1)
- rain forest (1)
- rat calyx (1)
- recolonization (1)
- reconstruction (1)
- regulation (1)
- relative abundance (1)
- relevance (1)
- resolution (1)
- response regulator (1)
- reward (1)
- rhythm (1)
- ribosomal RNA (1)
- richtersius coronifer (1)
- root (1)
- rs112587690 (1)
- rs12628 (1)
- rural domain (1)
- sample (1)
- savanna woodland (1)
- schizosaccaromyces-pombe (1)
- secondary structure (1)
- senescence (1)
- sensitization (1)
- sensor (1)
- sequence alignment (1)
- sequestration (1)
- serotonin (1)
- set (1)
- sexual deception (1)
- signal peptides (1)
- signal transduction (1)
- signals (1)
- simulation (1)
- social calls (1)
- soil macrofauna (1)
- solvent (1)
- sonic hedghog (1)
- species composition (1)
- species richness (1)
- species richness estimation (1)
- spiroplasma (1)
- stability (1)
- staphylococcus aureus (1)
- stocks (1)
- superoxide-dismutase (1)
- superresolution (1)
- surface (1)
- survival (1)
- synthetic biology (1)
- tardigrada (1)
- target molecule (1)
- tergite (1)
- term memory (1)
- tolerance (1)
- toxicity (1)
- tracking (1)
- traffic noise (1)
- transcription activation (1)
- transcription factor (1)
- transcription factor MIZ-1 (1)
- transcriptome (1)
- transmission (1)
- trinervitermes (1)
- true diversity (1)
- trypanosome lytic factor (1)
- tumor suppressor (1)
- tyrosine phosphorylation (1)
- ubiquitin (1)
- ultrastructure (1)
- unpaired median neurons (1)
- vaccine (1)
- vaccinia virus (1)
- variants (1)
- vibrio cholerae (1)
- virulence (1)
- viscosity (1)
- vitellogenin (1)
- water stress (1)
- work bee (1)
- worker bee larva (1)
- young work bee (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (51) (remove)
Introduction: While it has been reported that the risk of contralateral breast cancer in patients from BRCA1 or BRCA2 positive families is elevated, little is known about contralateral breast cancer risk in patients from high risk families that tested negative for BRCA1/2 mutations.
Methods: A retrospective, multicenter cohort study was performed from 1996 to 2011 and comprised 6,235 women with unilateral breast cancer from 6,230 high risk families that had tested positive for BRCA1 (n = 1,154) or BRCA2 (n = 575) mutations or tested negative (n = 4,501). Cumulative contralateral breast cancer risks were calculated using the Kaplan-Meier product-limit method and were compared between groups using the log-rank test. Cox regression analysis was applied to assess the impact of the age at first breast cancer and the familial history stratified by mutation status.
Results: The cumulative risk of contralateral breast cancer 25 years after first breast cancer was 44.1% (95%CI, 37.6% to 50.6%) for patients from BRCA1 positive families, 33.5% (95%CI, 22.4% to 44.7%) for patients from BRCA2 positive families and 17.2% (95%CI, 14.5% to 19.9%) for patients from families that tested negative for BRCA1/2 mutations. Younger age at first breast cancer was associated with a higher risk of contralateral breast cancer. For women who had their first breast cancer before the age of 40 years, the cumulative risk of contralateral breast cancer after 25 years was 55.1% for BRCA1, 38.4% for BRCA2, and 28.4% for patients from BRCA1/2 negative families. If the first breast cancer was diagnosed at the age of 50 or later, 25-year cumulative risks were 21.6% for BRCA1, 15.5% for BRCA2, and 12.9% for BRCA1/2 negative families.
Conclusions: Contralateral breast cancer risk in patients from high risk families that tested negative for BRCA1/2 mutations is similar to the risk in patients with sporadic breast cancer. Thus, the mutation status should guide decision making for contralateral mastectomy.